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试用玄府理论探讨新型冠状病毒感染的防治方略

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云南中医药大学学报 2024年第1期47卷 17-23页

作者：李宏颖王德元李谖李一明张东岩李宏丽瑞士中医药大学瑞士Bad Zurzach CH-5300 澳大利亚高德生命科学研究院澳大利亚墨尔本3052 沈阳市第六人民医院中国沈阳110001 奥地利宏爱中医和预防医学学会奥地利维也纳1070

“玄府”一词始见于《黄帝内经》,玄府理论经历代医家补充而逐渐完善。玄府作为人体气机升降的通道存在于机体各处,其功能具有广泛存在性和开阖通利性。现代医学的肺泡毛细血管屏障与玄府功能相关,为玄府理论在新冠感染防治中的应用提... 详细信息

“玄府”一词始见于《黄帝内经》,玄府理论经历代医家补充而逐渐完善。玄府作为人体气机升降的通道存在于机体各处,其功能具有广泛存在性和开阖通利性。现代医学的肺泡毛细血管屏障与玄府功能相关,为玄府理论在新冠感染防治中的应用提供了现代的科学依据。新冠感染的中医病理机制主要为湿毒郁肺、玄府郁闭。因此,开通玄府是新冠感染防治的基本治则。本文结合奥地利和澳大利亚的临床实践,阐述了玄府理论防治新冠感染的5种方略:祛邪开玄、理气开玄、通络开玄、化湿开玄、扶正固玄。经上百例临床实践表明,开通玄府对新冠感染的防治是确切有效的。本文从玄府开阖的角度解析新冠感染的机理,整合中西医学理念拟定其防治方略,对新冠感染和未来“疫病”的防治具有一定的指导意义。

关键词：玄府玄府理论开通玄府新冠感染

Magnetization of microorganism cells by sol-gel method

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Science China(Technological Sciences) 2008年第5期51卷 591-597页

作者： CHEN Bo ZHAN TianZhuo LIAN ZhiYang zhang deyuan 705 Lab Department of Mechanical Engineering and AutomationBeihang UniversityBeijing 100083China

Microorganism cells could be used as templates during fabrication of magnetic or conductive microstructures in different standard shapes. In this paper, feasibility of magnetizing microorganism cells by sol-gel method, which is to coat cells of Spirulina (a type of natural micro-helical microorganism) with the ferrite (a kind of magnetic material), was discussed and investigated. Then the cell form, components and the phase structure were observed and analyzed using various tools including optical microscopy, scanning electron microscopy (SEM), energy dispersive X-ray detector (EDX), transmission electron microscopy (TEM), and X-ray diffraction analysis (XRD). Results showed that spirulina cells could be coated with ferrite after the sol-gel process, with the shape of natural helixes well kept, that the components of different sampling points on the surface layer were consistent and the thickness of layer was uniform, and that the type of the surface ferrite layer formed was cubic Fe3O4. It was also observed that there were nano-particles yielded in the cells and certain deposit on the walls between cells. The kinetics of the cell magnetization technology by sol-gel was also discussed.

关键词： bio-machining bio-limited machining hollow micro-helixes magnetic particles ferrite

The role of serum and urinary biomarkers in the diagnosis of early diabetic nephropathy in patients with type 2 diabetes

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The role of serum and urinary biomarkers in the diagnosis of...

Bio-replicated forming of the biomimetic drag-reducing surfaces in large area based on shark skin

第十二次全国中西医结合内分泌代谢病学术大会暨糖尿病、甲状腺疾病高峰论坛

作者： deyuan zhang Shandong Ye Tianrong Pan Department of Endocrinology The second Affiliated Hospital of Anhui Medical University

Background:Previous studies have shown that a variety of bio markers are closely related to the occurrence and development of early-stage di abetic nephropathy(DN) in patients.The aim of this study wa

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来源： cnki会议评论

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Chinese Science Bulletin 2008年第10期53卷 1587-1592页

作者： HAN Xin zhang deyuan LI Xiang LI YuanYue School of Mechanical Engineering and Automation Beihang University Beijing 100083 China

On the investigation of biomimetic drag-reducing surface, direct replication of the firm scarfskins on low-resistance creatures to form biomimetic drag-reducing surfaces with relatively vivid morphology relative to the living prototype is a new attempt of the bio-replicated forming technology.Taking shark skin as the bio-replication template, the hot embossing method was applied to the microreplication of its outward morphology. Furthermore, the skins were jointed together to form the drag-reducing surface in large area. The results of the resistance measurements in a water tunnel according to the flat-plate sample pieces have shown that the biomimetic shark-skin coating fabricated by the bio-replicated forming method has significant drag reduction effect, and that the drag reduction efficiency reached 8.25% in the test conditions.

关键词：鲨鱼皮生物复制成型热压纹生物学

High-precision bio-replication of synthetic drag reduction shark skin

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Chinese Science Bulletin 2011年第9期56卷 938-944页

作者： zhang deyuan LI YuanYue HAN Xin LI Xiang CHEN HuaWei Bionic and Micro/Nano/Bio Manufacturing Technology Research Center Beihang University Beijing 100191 China School of Agricultural and Food Engineering Shandong University of Technology Zibo 255049 China

Nano-long chains were grafted over the replicated micro-grooves of shark skin in a novel attempt to replicate bio-synthetic drag reduction structure with high precision through synthetic bio-replication. Pre-treated shark skin was used as casting template to prepare a flexible female die of silicone rubber by soft die formation. A waterborne epoxy resin was then used to graft long-chains of drag reduction agent and prepare a synthetic drag reduction shark skin with nano-long chain drag reduction interface and lifelike micro-grooves. Replication precision analysis shows that this technology could replicate the complicated three-dimensional morphology of a biological drag reduction surface with high precision. Drag reduction experiments show that the material had an excellent synthetic drag reduction effect, with a maximal drag reduction rate of up to 24.6% over the velocities tested.

关键词：生物合成减阻剂鲨鱼皮高精度复制水性环氧树脂铸造模具精度分析

Fine mapping and validation of a stable QTL for thousand-kernel weight in wheat(Triticum aestivum L.)

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作物学报:英文版 2023年第5期11卷 1491-1500页

作者： deyuan Meng Aamana Batool Yazhou Xuan Ruiqing Pan Na zhang Wei zhang Liya Zhi Xiaoli Ren Wenqing Li Jijie Li Yanxiao Niu Shuzhi Zheng Jun Ji Xiaoli Shi Lei Wang Hongqing Ling Chunhua Zhao Fa Cui Xigang Liu Junming Li Liqiang Song Center for Agricultural Resources Research Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesShijiazhuang 050022HebeiChina Ministry of Education Key Laboratory of Molecular and Cellular Biology Hebei Research Center of the Basic Discipline of Cell BiologyHebei Key Laboratory of Molecular and Cellular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuang 050024HebeiChina State Key Laboratory of North China Crop Improvement and Regulation College of AgronomyHebei Agricultural UniversityBaoding 071000HebeiChina State Key Laboratory of Plant Cell and Chromosome Engineering Chinese Academy of SciencesBeijing 100101China Key Laboratory of Molecular Module-Based Breeding of High Yield and Abiotic Resistant Plants in Universities of Shandong School of AgricultureLudong UniversityYantai 264025ShandongChina Hebei Collaboration Innovation Center for Cell Signaling Shijiazhuang 050024HebeiChina College of Life Science University of Chinese Academy of SciencesBeijing 100049China

Thousand-kernel weight(TKW)is a measure of grain weight,a target of wheat breeding.The object of this study was to fine-map a stable quantitative trait loci(QTL)for TKW and identify its candidate gene in a recombinant inbred line(RIL)population derived from the cross of Kenong 9204(KN9204)and Jing411(J411).On a high-density genetic linkage map,24,26 and 25 QTL were associated with TKW,kernel length(KL),and kernel width(KW),respectively.A major and stable QTL,QTkw-2D,was mapped to an8.3 cM interval on chromosome arm 2DL.By saturation of polymorphic markers in its target region,QTkw-2D was confined to a 9.13 Mb physical interval using a secondary mapping population derived from a residually heterozygous line(F6:7).This interval was further narrowed to 2.52 Mb using QTkw-2D near-isogenic lines(NILs).NILs~(KN9204)had higher fresh and dry weights than NILsJ411at various grain-filling stages.The TKW and KW of NILs~(KN9204)were much higher than those of NILsJ411in field trials.By comparison of both DNA sequence and expression between KN9204 and J411,TraesCS2D02G460300.1(TraesKN2D01HG49350)was assigned as a candidate gene for QTkw-2D.This was confirmed by RNA sequencing(RNA-seq)of QTkw-2D NILs.These results provide the basis of map-based cloning of QTkw-2D,and DNA markers linked to the candidate gene may be used in marker-assisted selection.

关键词： Wheat Thousand-kernel weight Fine mapping Candidate gene

Microstructures and formation mechanism of hypoeutectic white cast iron by isothermal electromagnetic rheocast process

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China Foundry 2010年第2期7卷 113-116页

作者： zhang Wanning Song Dan zhang Hongbing Li deyuan Yuan Xiaoguang Qiu Keqiang Shenyang Government Investment Project Evaluation Center Shenyang 1100141 China School of Materials Science and Engineering Shenyang University of Technology Shenyang 110870 China

An investigation was made on the evolution of microstructures of hypoeutectic white cast iron slurry containing 2.5wt.%C and 1.8wt.%Si produced by rheocasting in which the solidifying alloy was vigorously agitated by electromagnetic stirrer during isothermal cooling processes.The results indicated that under the proper agitating temperatures and speeds applied,the dendrite structures in white cast iron slurry were gradually evolved into spherical structures during a certain agitating time.It also revealed that the bent dendrites were formed by either convection force or by the growth of the dendrites themselves in the bending direction;then,as they were in solidifying,they were gradually being alternated into separated particles and into more spherical structures at the end of the isothermal cooling process.Especially,the dendrites were granulated as the bending process proceeding,which suggested that they were caused by unwanted elements such as sulfur and phosphor usually contained in engineering cast iron.Convective-ow of the melt caused corrosion on the dendritic segments where they were weaker in strength and lower in melting temperature because of higher concentration of sulfur or phosphor.And the granulation process for such dendrites formed in the melt became possible under the condition.Certainly,dendrite fragments are another factors considerable to function for spherical particles formation.A new mechanism,regarding to the rheocast structure formation of white cast iron,was suggested based on the structural evolution observed in the study.

关键词：电磁搅拌器微观结构等温过程白口铸铁亚共晶机制弯曲过程球形微粒

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航空航天难加工材料高速超声波动式切削方法

航空学报 2022年第4期43卷 60-78页

作者：彭振龙张翔宇张德远北京航空航天大学机械工程及自动化学院北京100083 北京航空航天大学仿生与微纳系统研究所北京100083

传统超声振动切削一直没有突破极低分离切削速度限问题,即只有在很低切削速度下才有明显的分离切削降力、降热工艺效果。以解决难加工材料加工效率低、加工质量差为出发点,提出高速超声波动式切削方法,阐明了高速分离、相位控制、切挤一... 详细信息

传统超声振动切削一直没有突破极低分离切削速度限问题,即只有在很低切削速度下才有明显的分离切削降力、降热工艺效果。以解决难加工材料加工效率低、加工质量差为出发点,提出高速超声波动式切削方法,阐明了高速分离、相位控制、切挤一体3方面的基本机理,通过对改善切削加工性、提升刀具寿命、改善表面完整性3个方面的讨论,充分体现高速超声波动式切削技术的优势,丰富难加工材料高表面完整性的加工工艺,为航空航天领域难加工材料高质量加工提供理论和技术基础。

关键词：超声振动高速切削高温合金钛合金复合材料表面完整性

Functional markers developed from TaGS3, a negative regulator of grain weight and size, for marker-assisted selection in wheat

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The Crop Journal 2020年第6期8卷 943-952页

作者： Wei zhang Huifang Li Liya Zhi Qiannan Su Jiajia Liu Xiaoli Ren deyuan Meng Na zhang Jun Ji Xueyong zhang Junming Li Center for Agricultural Resources Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050022HebeiChina Key Laboratory of Crop Gene Resources and Germplasm Enhancement Ministry of Agriculture/The National Key Facility for Crop Gene Resources and Genetic ImprovementInstitute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Hebei University of Economics and Business Shijiazhuang 050061HebeiChina State Key Laboratory of Plant Cell and Chromosome Engineering Chinese Academy of SciencesBeijing 100101China The Innovative Academy of Seed Design Chinese Academy of SciencesBeijing 100101China

The TaGS3 homoeologous genes(homoeologs)located on chromosomes 7 A,4 A,and7 D in hexaploid wheat were cloned.Relative expression analysis of the three Ta GS3 homoeologs revealed that the expression levels of TaGS3-4 A and TaGS3-7 D in developing grains were higher than that of TaGS3-7 A.Genetic evidence showed that Ta GS3 was a negative regulator of grain weight and grain size.Fifteen polymorphic sites and five haplotypes were detected in TaGS3-4 A.Two molecular markers were developed to distinguish the five haplotypes.Association analysis using 260 accessions from Chinese wheat mini-core collection(MCC)indicated that TaGS3-4 A affected thousand grain weight(TGW)and grain length(GL).HAP-4 A-1 and HAP-4 A-2 were favorable haplotypes that increased TGW and GL and had undergone strong selection during domestication of wheat.In addition,interaction of the TaGS3-4 A and TaGS3-7 D homoeologs had significant additive effects on the grain traits.Hap-4 A-1/Hap-7 D-2 was the best haplotype combination in increasing TGW and GL.The frequencies and geographic distributions of favorable TaGS3 haplotypes among 1388 wheat accessions from worldwide sources provided clues for selection of yield-related traits.Our findings demonstrated that TaGS3-4 A had significant effects on TGW and GL.Marker-assisted selection of HAP-4 A-1/2 combined with HAP-7 D-2 has potential to increase wheat yields.

关键词： TaGS3 Grain yield Haplotype MAS Triticum aestivum