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Validation of an Algorithm based on parameters in Non-Contrast Computerized Tomogram for selection of upper ureteral stone for shock wave lithotripsy

Validation of an Algorithm based on parameters in Non-Contra...

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第十五届全国泌尿外科学术会议

作者： Chi-Fai Ng Annie Wong deyond siu Kak-tak Wong Eddie Chan Department of Surgery and Department of Diagnostic Radiology and Organ Imaging The Chinese University of Hong Kong

Introduction and Objective: There is increase recognition of the role of various parameters measured by non-contrast computerized tomogram (NCCT) in predicting treatment outcomes of urinary stone by shockwave lithotripsy (SWL). In our previous analysis, a clinical algorithm, based on stone volume (SV), mean stone density (MSD) and skin-to-stone distance (SSD), was formulated. (J Urol 2007;177 supp: A1316) Therefore, we would like to use our subsequent patients to validate the usefulness of this algorithm. Methods: After our first part of study, a further prospective collection of data from patients diagnosed to have solitary upper ureteral stone by NCCT and received primary SWL was performed. The primary outcome was the stone free rate at 3-month after one session of SWL by Sonolith 4000+. Pre-treatment NCCT were reviewed by a single radiologist with SV, MSD and SSD measured. These patient parameters were then applied into our algorithm to assess its validity in predicting treatment outcome. Results: 37 patients (24 males and 13 females) were recruited. The overall stone free rate was 45.9%. By applying the algorithms, for patients with either SV ≤ 0.2cc or MSD ≤600 or SDep ≤ 85mm, the stone free rate was 52.2% (95% CI 31.7%, 72.7%). For those patients without any favourable factors, the stone free rate was 35.7% (95% CI 10.6%, 60.8%). Although the difference was not statistically significant, a trend of difference can still be observed in this small sample. Conclusions: Clinical algorithm based on the measurement of stone volume, mean stone density and skin to stone distance from NCCT can help to predict the treatment outcome of SWL in upper ureteral stone.

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Correlation between MGMT methylation status and the development of pseudoprogression

Correlation between MGMT methylation status and the developm...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Danny TM Chan Rebecca YT Ng XL Zhu deyond YW siu Michael KM Kam Brigette BY Ma Jesse Pang HK Ng WS Poon The CUHK Brain Tumour Centre Prince of Wales Hospital The Chinese University of Hong Kong

＜正＞Background With the introduction of the oral chemotherapeutic agent,temozolomide,it is now the standard of care to offer concomitant chemoradiotherapy to patients with glioblastoma *** was reported that around 2...

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