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Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product

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Modern Research in Inflammation 2014年第1期3卷 19-25页

作者： Kevin J. Ruff Dale P. devore ESM Technologies LLC Carthage USA Membrell LLC Carthage USA

NEM®?brand eggshell membrane is a novel dietary supplement that has been clinically shown to alleviate arthritis joint pain and stiffness;however the mechanism of action is not well understood. Preliminary evidence from an?in vitro?study of?NEM®?indicated that the mechanism of action may be based on the reduction of pro-inflammatory cytokines.?In vivo?studies were therefore initiated to evaluate the effects of?NEM®?on pro-inflammatory and anti-inflammatory cytokines following oral administration in rats.?NEM®?was administered daily at doses of 6.13 mg/kg bw/day (Study 1), 10.0 mg/kg bw/day (Study 2), or at doses of 0 (control), 26.0 or 52.0 mg/kg bw/day (Study 3) by oral gavage for 7 consecutive days. Inflammation was induced in the Study 3 rats by intraperitoneal injection of lipopolysaccharide. Changes in plasma cytokine levels from baseline following 7 days of oral supplementation with?NEM®?at 6.13 mg/kg bw/ day (Study 1) were statistically significant at Day 8 for IL-2, TIMP-1 and VEGF, at Day 21 for IL-10, and at Day 35 for MCP-1, MCP-3 and TIMP-1, and at 10.0 mg/kg bw/day (Study 2) were statistically significant at Day 8 for VEGF, at Day 21 for MIP-1β, MIP-2 and VEGF, and at Day 35 for MCP-3, MIP-1β, MIP-2 and VEGF. Changes in serum cytokine levels versus control at 26.0 mg/kg bw/day (Study 3) were statistically significant at all time-points for IL-1β?and at 1.5 hours for IL-10, and at 52.0 mg/kg bw/day (Study 3) were statistically significant at 1.5 hours for IFN-γ, IL-1β?and IL-10, and at 3 hours for IL-1β, and at 24 hours for IL-10. Taken together, these studies demonstrate that oral supplementation with?NEM®?can influence both early-phase pro-inflammatory cytokines like IL-1β?and TNF-α?(Study 3), as well as later-phase cytokines like MCP-1, MIP-1α?&?β, RANTES and VEGF (Study 1 & 2). These studies provide a possible basis for the mechanism of action of?NEM®?in vivo.

关键词： Pro-Inflammatory Cytokines Eggshell Membrane

Probability and statistics for engineering and the sciences /.5th ed 5th ed.

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Probability and statistics for engineering and the sciences

2000年

作者： devore Jay L.

来源：畅想之星图书光盘版（南... 评论

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Probability and statistics for engineering and the sciences /

1000年

作者： devore Jay L.

来源：畅想之星图书光盘版（南... 评论

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2004年

作者： devore Jay L.

来源：畅想之星图书光盘版（南... 评论

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网络管理，敢问路在何方

网管员世界 2007年第23期 21-22页

作者： Dudley devore Avocent公司管理系统部全球品牌市场高级副总裁

准确的把握未来的发展趋势是一个人获得成功的前提条件之一，网络管理者同样如此。

关键词：网络管理发展趋势管理需求刀片服务器虚拟化技术

The Thermal Decomposition of Ammonium Meta-Vanadate under Restricted Flow Conditions

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American Journal of Analytical Chemistry 2017年第1期8卷 35-50页

作者： Lori R. Brock Jeff W. Keister Michelle France Nathan Fierro Thomas C. devore Department of Chemistry James Madison University Harrisonburg VA USA

The products obtained during the thermal decomposition of ammonium meta-vanadate depend on the configuration of the container, the mass of the sample, the heating rate and the composition of the carrier gas. The decomposition in an uncapped container produced (NH4)2V4O11, NH4V3O8, and V2O5 as the apparent stable products while the products in a capped container were NH4V3O8, and V2Ox where x was between 4 and 5. These differences are attributed to the different amounts of the evolved gases in the cell. EGA-FTIR clearly established that the reduced final product in the capped cell resulted from a reaction between NH3 and the V2O5 formed during the decomposition. A pre-equilibrium kinetics model where the rate of the reverse reaction depends on the partial pressure of the gaseous products in the cell could explain the different reaction intermediates. This model provides a possible explanation for the different apparent activation energies that have been reported for the thermal decomposition of other compounds where a reversible step could occur in the decomposition mechanism.

关键词： Ammonium Meta-Vanadate Thermal Decomposition Kinetics Activation Energy

Viscoelastic Evaluation of Different Hyaluronic Acid Based Fillers Using Vibrational Optical Coherence Tomography

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Materials Sciences and Applications 2019年第5期10卷 423-431页

作者： Frederick H. Silver Ruchit G. Shah Nikita Kelkar Dominick Benedetto Dale devore Justin Cohen Department of Pathology and Laboratory Medicine Robert Wood Johnson Medical School Rutgers The State University of New Jersey Piscataway NJ USA OptoVibronex LLC Mt. Bethel Pa USA Graduate Program in Biomedical Engineering Rutgers The State University of New Jersey Piscataway NJ USA Center for Advanced Eye Care Vero Beach FL USA DV Consulting Chelmsford MA USA Glasgold Group Princeton NJ USA

Hylauronic acid (HA) is used as a viscoelastic in Ophthalmology during cataract surgery based on its high viscosity at rest, its ability to shear thin and dissipate energy during phacoemulsification. However, these properties of HA solutions would make them susceptible to migration when used as dermal filler materials. In this study, we apply a new technique termed vibrational optical coherence tomography (VOCT) to compare the physical properties of different HA solutions and fillers used in facial aesthetics. Results presented in this study suggest that HA solutions and HA dermal fillers have markedly different physical properties. HA solutions are highly viscoelastic with high % viscous losses while fillers tend to have lower viscous energy dissipation properties. Clinical observations suggest that the high loss fillers are injected more superficially in the face where tension and internal and external forces are more likely minimized giving tissue of the hands and lips more volume and allowing more natural movement. In contrast, the lower loss gels that are used to lift tissue, generally have a higher G’, and are injected deeper into the face where injection and internal forces are likely to be higher. It is concluded that HA filler gel design can be optimized by use of VOCT to evaluate the % viscous energy loss both in vitro and in vivo.

关键词： Hyaluronic Acid Injectable Filler Dermal Filler Plastic Surgery Cosmetic Surgery Viscoelastic Mechanical Properties Facial Surgery Optical Coherence Tomography Vibrational Optical Coherence Tomography