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Adalimumab efficacy in enteropathic spondyloarthritis: A 12-mo observational multidisciplinary study

World Journal of Gastroenterology 2017年第39期23卷 7139-7149页

作者： Michele Maria Luchetti devis benfaremo Francesco Ciccia Laura Bolognini Monia Ciferri Alessia Farinelli Matteo Rossini Piergiorgio Mosca Giovanni Triolo Armando Gabrielli Dipartimento Scienze Cliniche e Molecolari Clinica MedicaUniversità Politecnica delle Marche Dipartimento Biomedico di Medicina Interna e Specialistica Sezione di Reumatologia Università degli Studi di Palermo Dipartimento Gastro-enterologico e dei Trapianti Polo Ospedaliero--Universitario 'Umberto I-G.M. Lancisi- G. Salesi'

AIM To report adalimumab(Ada) efficacy on articulargastrointestinal disease and health-related quality of life(HRQo L) in patients with enteropathic spondyloarthritis(ES).METHODS A cohort of 52 patients with ES was evaluated in the departments of gastroenterology and internal medicine. At baseline, all patients underwent assessment by an integrated gastro-rheumatologic evaluation of articular and gastrointestinal activity, as well patient reported outcomes(PROs) of the HRQo L questionnaires. After this integrated evaluation and following a specific working flowchart, the Ada anti-tumor necrosis factor(TNF)-inhibitor was assigned to a cohort of 30 patients and its clinical efficacy was evaluated at baseline and after 6-mo and 12-mo treatment by the following tests:(1) Ankylosing Spondylitis Disease Activity ScoreC-Reactive Protein(ASDAS-CRP); Bath Ankylosing Spondylitis Disease Activity Index(BASDAI), Bath Ankylosing Spondylitis Functional Index(BASFI) and Bath Ankylosing Spondylitis Metrology Index(BASMI) for articular activity;(2) Inflammatory Bowel Disease Questionnaire(IBDQ), Crohn's Disease Activity Index(CDAI) and partial Mayo(p Mayo) score for gastrointestinal symptoms and activity; and(3) Health Assessment Questionnaire(HAQ), Patient Global Assessment(PGA) and Short Form-36 health survey(SF-36) questionnaires for PROs of the HRQo *** Integrated evaluation and management of the patients affected by ES, carried out simultaneously by a gastroenterologist and a rheumatologist, allowed clinicians to choose the optimal therapeutic strategy. In a cohort of 30 ES patients affected by active articular and gastrointestinal disease, or axial active articular inflammation, Ada led to fast and sustained improvement of both articular and gastrointestinal disease activities. In fact, all the clinimetric evaluation tests exploring articular or gastrointestinal activity, as well as all the HRQo L scores, showed a significant improvement having been achieved at the earli

关键词： Clinimetric assessment Patient reported outcomes Inflammatory bowel diseases Enteropathic spondyloarthritis Tumor necrosis factor-inhibitors Multidisciplinary evaluation

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Molecular engineering binuclear copper catalysts for selective CO_(2) reduction to C_(2) products

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Journal of Energy Chemistry 2024年第6期93卷 166-173,I0005页

作者： Qi Zhao Kai Lei Bao Yu Xia Rachel Crespo-Otero devis Di Tommaso Department of Chemistry School of Physical and Chemical SciencesQueen Mary University of LondonLondonE14NSUK Key Laboratory of Material Chemistry for Energy Conversion and Storage(Ministry of Education) Hubei Key Laboratory of Material Chemistry and Service FailureState Key Laboratory of Materials Processing and Die&Mould TechnologySchool of Chemistry and Chemical EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074HubeiChina Department of Chemistry University College LondonLondonWC1H 0AJUK Digital Environment Research Institute Queen Mary University of LondonEmpire HouseLondon E11HHUK

Molecular copper catalysts serve as exemplary models for correlating the structure-reaction-mechanism relationship in the electrochemical CO_(2) reduction(eCO_(2)R),owing to their adaptable environments surrounding the copper metal *** investigation,employing density functional theory calculations,focuses on a novel family of binuclear Cu molecular *** modulation of their coordination configuration through the introduction of organic groups aims to assess their efficacy in converting CO_(2) to C_(2)*** findings highlight the crucial role of chemical valence state in shaping the characteristics of binuclear Cu catalysts,consequently influencing the eCO_(2)R behaviour,Notably,the Cu(Ⅱ)Cu(Ⅱ)macrocycle catalyst exhibits enhanced suppression of the hydrogen evolution reaction(HER),facilitating proton trans fer and the eCO_(2)R *** rthermore,we explo re the impact of diverse electro n-withdrawing and electron-donating groups coordinated to the macrocycle(R=-F,-H,and-OCH_3)on the electron distribution in the molecular *** placement of-OCH_3 groups in the macrocycles leads to a favourable oxidation state of the Cu centres and subsequent C-C coupling to form C_(2) *** research provides fundamental insights into the design and optimization of binuclear Cu molecular catalysts for the electrochemical conversion of CO_(2) to value-added C_(2) products.

关键词： Molecular catalyst design Selective CO_(2)reduction C_(2)products Density functional theory calculations

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The role of copper in enhancing the performance of heteronuclear diatomic catalysts for the electrochemical CO_(2)conversion to C_(1) chemicals

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Journal of Energy Chemistry 2023年第10期85卷 490-500,I0013页

作者： Qi Zhao Rachel Crespo-Otero devis Di Tommaso Department of Chemistry School of Physical and Chemical SciencesQueen Mary University of LondonLondon E14NSUK Department of Chemistry University College LondonLondon WC1H 0AJUK

Diatomic catalysts(DACs)with two adjacent metal atoms supported on graphene can offer diverse functionalities,overcoming the inherent limitations of single atom catalysts(SACs).In this study,density functional theory calculations were conducted to investigate the reactivity of the carbon dioxide(CO_(2))reduction reaction(CO_(2)RR)on metal sites of both DACs and SACs,as well as their synergistic effects on activity and *** of the Gibbs free energies of CO_(2)RR and associated values of the limiting potentials to generate C_(1) products showed that Cu acts as a promoter rather than an active catalytic centre in the catalytic CO_(2)conversion on heteronuclear DACs(CuN_(4)-MN_(4)),improving the catalytic activity on the other metal compared to the related SAC MN_(4).Cu enhances the initial reduction of CO_(2)by promoting orbital hybridization between the key intermediate*COOH 2p-orbitals and the metals 3d-orbitals around the Fermi *** degree of hybridization in the DACs CuN_(4)-MN_(4) decreases from Fe to Co,Ni,and *** work demonstrates how Cu regulates the CO_(2)RR performance of heteronuclear DACs,offering an effective approach to designing practical,stable,and high-performing diatomic catalysts for CO_(2)electroreduction.

关键词： Electrocatalytic CO_(2)reduction Single atom catalysts Diatomic catalysts Graphene Density functional theory calculations

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La roloj de Esperanto en interhoma rilato

La roloj de Esperanto en interhoma rilato

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2005年世界语研讨会

作者： devis

Unu el la grandvaloraj posedoj de la homo estas la kapablo paroli. Helpe de tiu ci kaj aliaj, ni povas fari multe da aferoj kiuj bestoj, nek nun povas, nek estonte povos fari. Por rilati unu kun la alia, ni bezonas la...

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Clinical Significance of Apurinic/Apyrimidinic Endodeoxyribonuclease 1 and MicroRNA Axis in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2023年第6期11卷 1291-1307页

作者： Giovanna Mangiapane devis Pascut Emiliano Dalla Giulia Antoniali Monica Degrassi Lory Saveria Crocè Veronica De Sanctis Silvano Piazza Giulia Canarutto Claudio Tiribelli Gianluca Tell Laboratory of Molecular Biology and DNA Repair Department of MedicineUniversity of UdineUdineItaly Fondazione Italiana Fegato-ONLUS Liver Cancer UnitTriesteItaly Department of Medical Sciences University of TriesteTriesteItaly Clinica Patologie Fegato Azienda Sanitaria Universitaria Giuliano Isontina(ASUGI)TriesteItaly NGS Core Facility Department CIBIOUniversity of TrentoTrentoItaly Computational Biology International Centre for Genetic Engineering and BiotechnologyICGEBTriesteItaly

Background and Aims:Identification of prognostic factors for hepatocellular carcinoma(HCC)opens new perspectives for *** and cellular onco-miRNAs are noncoding RNAs which can control the expression of genes involved in oncogenesis through post-transcriptional *** microRNAs(miRNAs)are considered novel prognostic and predictive factors in *** apurinic/apyrimidinic endodeoxyribonuclease 1(APE1)contributes to the quality control and processing of specific onco-miRNAs and is a negative prognostic factor in several *** present work aims to:a)define APE1 prognostic value in HCC;b)identify miRNAs regulated by APE1 and their relative target genes and c)study their prognostic ***:We used The Cancer Genome Atlas(commonly known as TCGA)data analysis to evaluate the expression of APE1 in *** identify differentially-expressed miRNAs(DEmiRNAs)upon APE1 depletion through specific small interfering RNA,we used NGS and nanostring approaches in the JHH-6 HCC tumor cell *** analyses were performed to identify signaling pathways involving APE1-regulated *** analysis was performed to identify miRNAs correlating with serum APE1 ***:APE1 is considerably overexpressed in HCC tissues compared to normal liver,according to the TCGA-liver HCC(known as LIHC)*** analyses showed that APE1-regulated miRNAs are implicated in signaling and metabolic pathways linked to cell proliferation,transformation,and angiogenesis,identifying Cyclin Dependent Kinase 6 and Lysosomal Associated Membrane Protein 2 as ***-33a-5p,miR-769,and miR-877 are related to lower overall survival in HCC *** array profiling,we identified eight circulating DE-miRNAs associated with APE1 overexpression.A training phase identified positive association between sAPE1 and miR-3180-3p and ***:APE1 regulates specific miRNAs having prognostic value in HCC.

关键词： APE1 miRNAs Prognostic factors Hepatocellular carcinoma

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这里的风景，归你了

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天天爱学习（五年级） 2018年第13期 20-21页

作者： Anna devis Daniel Rueda

风景无言，静默如谜。你轻轻地来了，你静静地站在那里。它便成了只属于你的风景——旅行的意义正在于此。

关键词：小学生语文学习阅读知识课外阅读

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沉积深度、构造上升和火山作用对西太平洋弧后盆地的控制作用

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海洋石油 1986年第3期 21-30页

作者： George devis Klein 袁大中

自从 Bertrand 提出沉积相和构造有一定的关系以来,沉积作用和构造事件间的协同作用受到了地质学家的注意。在尝试将沉积相与构造事件进行联系时有下列几个重要问题。第一个,也是最重要的问题是构造作用是如何影响沉积作用的?何故?第二... 详细信息

自从 Bertrand 提出沉积相和构造有一定的关系以来,沉积作用和构造事件间的协同作用受到了地质学家的注意。在尝试将沉积相与构造事件进行联系时有下列几个重要问题。第一个,也是最重要的问题是构造作用是如何影响沉积作用的?何故?第二个同题是是否能在对沉积作用和只经历单一次构造旋回和变形旋回的现代构造影响范围

关键词：盆地岩屑生物成因碳酸盐岩 DSDP 地质构造有机成因化学岩海底三角洲海底扇裂谷作用沉积物类型沉积构造地质作用火山作用井位碎屑岩粉砂岩西太平洋

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