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Signal Transduction and Targeted Therapy 2021年第8期6卷 2257-2258页

作者： Sabrina Ehnert Tina Histing Andreas k.nussler Department of Trauma and Reconstructive Surgery Eberhard karls University Tubingen Siegfried Weller Research InstituteBG Trauma Center TubingenTubingenGermany

In a study recently published in nature,Shen and colleagues characterized a peri-arteriolar niche in the bone marrow with highly proliferative,short-lived,leptin receptor-and osteolectin(Oln)positive stromal cells,which improved bone regeneration and supported bacterial clearance after *** proving that maintenance of these cells critically required mechanical stimulation,which in turn was affected by age,1 the authors identified possible therapeutic targets for bone healing and regeneration.

关键词： stimulation healing clearance

Stochastic Gradient Boosting Model for Twitter Spam Detection

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Computer Systems Science & Engineering 2022年第5期41卷 849-859页

作者： k.kiruthika devi G.A.Sathish kumar Information Technology Sri Venkateswara College of EngineeringSriperumbudur602117India Electronics&Communication Engineering Sri Venkateswara College of EngineeringSriperumbudur602117India

In today’s world of connectivity there is a huge amount of data than we could *** number of network users are increasing day by day and there are large number of social networks which keeps the users connected all the *** social networks give the complete independence to the user to post the data either political,commercial or entertainment *** data may be sensitive and have a greater impact on the society as a *** trustworthiness of data is important when it comes to public social network.ng sites like facebook and *** to the large user base and its openness there is a huge possibility to spread spam messages in this *** detection is a technique to identify and mark data as a false data *** are lot of machine learning approaches proposed to detect spam in social *** efficiency of any spam detection algorithm is determined by its cost factor and *** to improve the detection of spam in the social networks this study proposes using statistical based features that are modelled through the supervised boosting approach called Stochastic gradient boosting to evaluate the twitter data sets in the English *** performance of the proposed model is evaluated using simulation results.

关键词： Twitter spam stochastic gradient boosting

Experimental Investigation of Thermal Performance of novel Finned Radiators for Automotive Cooling System

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Journal of Thermal Science 2024年第5期33卷 1726-1743页

作者： SInGH Hardeep TInG David S-k READER Graham ESHTIAGHI nicky ICHIYAnAGI Mitsuhisa SUZUkI Takashi Turbulence&Energy Laboratory University of WindsorWindsor N9B 3P4Canada Chemical and Environmental Engineering School of EngineeringRMIT UniversityMelbourneVictoria 3001Australia Department of Engineering and Applied Sciences Sophia UniversityTokyo 102-8554Japan

This research investigates innovative fin-type radiators for automobile engine cooling ***-channel and helical radiators,along with straight type,were analyzed for heat transfer characteristics under various *** uniqueness of this study is evident in the design of microchannel and helical *** helical radiators,the inner rod features 4/8 helical-shaped water galleries,while the outer tube frame with embedded fins remains *** contrast,the microchannel radiators have compact trapezoidal-shaped water galleries with separate fin ***,the novelty of the research is enhanced by the utilization of 3D printing technology in the manufacturing *** constant fin height analysis at varied water and air flow rate,Microchannel Water Air Radiator with fin height 10.5 mm(MCWAR10.5)depicted a higher heat transfer rate amongst the *** comparison to Straight Water Air Radiator with fin height 9.5 mm(SWAR9.5),the heat transfer rate is 30.3%and 1.3 times ***,in constant fin surface area analysis,microchannel radiator(MCWAR3.2)illustrates lower heat dissipation than Helical radiator(HWAR138)but higher than HWAR134 and Straight radiator(SWAR6).The examination of pumping loss indicated that the Micro-channel radiator outperformed helical radiators due to its lower pressure *** average pressure loss for Micro-channel radiators was 0.74 kPa,mak.ng it 1.2 times higher than that of a straight radiator(0.62 kPa),indicating a better trade-off.

关键词： heat exchangers multi-channel helical heat exchanger heat transfer 3D printing

Diagnostic Power of Diffusion-weighted Magnetic Resonance Imaging for the Presence of Lymph node Metastasis:A Meta-analysis

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2017年第4期37卷 469-474页

作者：孔祥闯熊凌云 Emre Gazyak.n Holger Engel Ulrich kneser Andreas k.nüssler Christoph Hirche 孔祥泉 Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Plastic and Reconstructive Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Hand-Plastic and Reconstructive Surgery Burn CenterBG Trauma Center LudwigshafenUniversity of Heidelberg Department of Hand-Plastic and Reconstructive Surgery Medical Center Kassel Eberhard-karls-University Tuebingen BG Trauma CenterSiegfried Weller Institut

Present work was designed to quantitatively evaluate the performance of diffusion-weighted magnetic resonance imaging（DWI） in the diagnosis of the presence of metastasis in lymph nodes（Lns）. Eligible studies were identified from systematical Pub Med and EMBASE searches. Data were extracted. Meta-analyses were performed to generate pooled sensitivity and specificity on the basis of per-node, per-lesion and per-patient, respectively. Fourteen publications（2458 Lns, 404 lesions and 334 patients） were eligible. Per-node basis demonstrated the pooled sensitivity and specificity was 0.82（P〈0.0001） and 0.90（P〈0.0001）, respectively. Per-lesion basis illustrated the pooled sensitivity and specificity was 0.73（P=0.0036） and 0.85（P〈0.0001）, respectively. Per-patient basis indicated the pooled sensitivity and specificity was 0.67（P=0.0909） and 0.86（P〈0.0001）, respectively. In conclusion, DWI has rather a negative predictive value for the diagnosis of Ln metastasis presence. The difference of the mean apparent diffusion coefficients between benign and malignant Lns is not yet stable. Therefore, the DWI technique has to be further improved.

关键词： Meta-analysis magnetic resonance imaging lymph node metastasis diffusion-weighted

Extended Deep Learning Algorithm for Improved Brain Tumor Diagnosis System

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Intelligent Automation & Soft Computing 2024年第1期39卷 33-55页

作者： M.Adimoolam k.Maithili n.M.Balamurugan R.Rajkumar S.Leelavathy Raju k.nnadasan Mohd Anul Haq Ilyas khan ElSayed M.Tag El Din Arfat Ahmad khan Department of Computer Engineering Government Polytechnic CollegeSevvapetTiruvallurTamil Nadu602025India Department of Computer Science and Engineering KG Reddy College of Engineering and TechnologyHyderabadTelangana500075India Department of Computer Science and Engineering Sri Venkateswara College of EngineeringSriperumbudurChennai602117India Department of Computer Science and Engineering Annamalai UniversityChidambaramTamil Nadu608002India Department of Computer Science and Engineering Aarupadai Veedu Institute of TechnologyVinayaka Mission Research FoundationPaiyanurTamil Nadu603104India Department of Electrical and Electronics Engineering Sri Venkateswara College of EngineeringSriperumbudur602117India Department of Computer Science College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia Department of Mathematics College of Science Al-ZulfiMajmaah UniversityAl-Majmaah11952Saudi Arabia Electrical Engineering Department Faculty of Engineering&TechnologyFuture University in EgyptNew Cairo11835Egypt Department of Computer Science College of ComputingKhon Kaen UniversityKhon Kaen40002Thailand

At present,the prediction of brain tumors is performed using Machine Learning(ML)and Deep Learning(DL)*** various ML and DL algorithms are adapted to predict brain tumors to some range,some concerns still need enhancement,particularly accuracy,sensitivity,false positive and false negative,to improve the brain tumor prediction system ***,this work proposed an Extended Deep Learning Algorithm(EDLA)to measure performance parameters such as accuracy,sensitivity,and false positive and false negative *** addition,these iterated measures were analyzed by comparing the EDLA method with the Convolutional neural network(Cnn)way further using the SPSS tool,and respective graphical illustrations were *** results were that the mean performance measures for the proposed EDLA algorithm were calculated,and those measured were accuracy(97.665%),sensitivity(97.939%),false positive(3.012%),and false negative(3.182%)for ten *** in the case of the Cnn,the algorithm means accuracy gained was 94.287%,mean sensitivity 95.612%,mean false positive 5.328%,and mean false negative 4.756%.These results show that the proposed EDLA method has outperformed existing algorithms,including Cnn,and ensures symmetrically improved *** EDLA algorithm introduces novelty concerning its performance and particular activation *** proposed method will be utilized effectively in brain tumor detection in a precise and accurate *** algorithm would apply to brain tumor diagnosis and be involved in various medical diagnoses *** the quantity of dataset records is enormous,then themethod’s computation power has to be updated.

关键词： Brain tumor extended deep learning algorithm convolution neural network tumor detection deep learning

Impacts of PI3k/protein k.nase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytok.nes,and influencing the immune *** phosphoinositide 3-k.nase(PI3k)/protein k.nase B(AkT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3k/AkT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3k/AkT/connexin 43,and notch/PI3k/AkT *** targeting the inactivation of the PI3k/AkT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3k/AkT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-k.nase reactive astrocytes signal transduction Thy-1(CD90)

TRISO fuel volume fraction and homogeneity:a nondestructive characterization

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nuclear Science and Techniques 2019年第3期30卷 46-52页

作者： k. V. Vrinda devi J. n. Dubey Jyoti Gupta I. H. Shaikh Radiometallurgy Division Bhabha Atomic Research CentreMumbaiIndia

A new nondestructive method to estimate the volume fraction and homogeneity of tristructural isotropic(TRISO)-coated fuel particles in fuel compacts designed for high-temperature reactors has been developed using image analysis of conventional X-radiographs. The method is demonstrated on surrogate fuel compacts containing TRISO-coated particles with kernels made of zirconium dioxide. The methodology incorporates a correction for superimposed images of TRISO particles such that a single X-ray image obtained in any one random orientation is sufficient to characterize the fuel compact in terms of volume fraction and homogeneity. The method is based on the virtual segregation of images of each particle inside the compact with the aid of a calibration standard.

关键词： TRISO Volume fraction Homogeneity Radiography

Blockchain Based Consensus Algorithm and Trustworthy Evaluation of Authenticated Subgraph Queries

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Computer Systems Science & Engineering 2023年第5期45卷 1743-1758页

作者： G.Sharmila M.k.kavitha devi Department of Computer Science&Engineering Syed Ammal Engineering CollegeRamanathapuram623502India Department of Computer Science&Engineering Thiagarajar College of EngineeringMadurai625015India

Over the past era,subgraph mining from a large collection of graph database is a crucial *** addition,scalability is another big problem due to insufficient *** are several security challenges associated with subgraph mining in today’s on-demand *** address this downside,our proposed work introduces a Blockchain-based Consensus algorithm for Authenticated query search in the Large-Scale Dynamic Graphs(BCCA-LSDG).The two-fold process is handled in the proposed BCCA-LSDG:graph indexing and authenticated query search(query processing).A blockchain-based reputation system is meant to maintain the trust blockchain and cloud server of the proposed *** resolve the issues and provide safe big data transmission,the proposed technique also combines blockchain with a consensus algorithm *** of the big data is ensured by dividing the BC network into distinct networks,each with a restricted number of allowed entities,data kept in the cloud gate server,and data analysis in the *** consensus algorithm is crucial for maintaining the speed,performance and security of the *** Dual Similarity based MapReduce helps in mapping and reducing the relevant subgraphs with the use of optimal feature ***,the graph index refinement process is undertak.n to improve the query *** query error,fuzzy logic is used to refine the index of the graph *** proposed technique outperforms advanced methodologies in both blockchain and non-blockchain systems,and the combination of blockchain and subgraph provides a secure communication platform,according to the findings.

关键词： Big data blockchain consensus algorithm trust management graph index

Distinct Electrical and Mechanical Responses of a Cu-10Fe Composite Prepared by Hot-Pressed Sintering and Post Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 255-265页

作者： X.Y.Yue S.Y.Peng X.Zhang C.n.He Y.Z.Tian key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China School of Materials Science and Engineering and Tianjin key Laboratory of Composite and Functional Materials Tianjin UniversityTianjin300350China Research Centre for Metallic Wires Northeastern UniversityShenyang110819China

A Cu-10wt%Fe composite was prepared through hot-pressed sintering,and the material was subsequently solution *** hot-pressed sintered and solution treated materials were rolled and *** precipitation behavior and performance changes were systematically studied by using scanning electron microscopy and transmission electron *** contrast to the hot-pressed sintered specimen,the solution treatment significantly affects the thermal stability and properties of the Cu-10wt%Fe *** Cu-10wt%Fe composite was prepared after solid solution,cold rolling and aging at 773 k for 1 h,and it obtained excellent tensile strength of 494 MPa,uniform elongation of 16.3%,electrical conductivity of 51.1%IACS and softening temperature of 838 *** for the distinct difference in thermal stability and properties between hot-pressed sintered and solution treated specimens were *** findings provide a theoretical basis for designing high-performance Cu-based in-situ composites by post treatment.

关键词： Cu-Fe composite Hot-pressed sintering Thermal stability Strength Electrical conductivity

Crystal structure and luminescence dynamics of highly pure LiM(PO_(3))_(3):Eu^(3+)(M=Sr,Ca) red phosphors for white light emitting diodes

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Journal of Rare Earths 2024年第8期42卷 1470-1478,I0002页

作者： Payal khajuria M.Manhas A.k.Bedyal Ankush Vij H.C.Swart Vinay kumar Department of Physics and Astronomical Sciences Central University of JammuRahy-Suchani.Samba1143J&KIndia Department of Physics School of SciencesCluster University of JammuCanal RoadJammu180001India Department of Physics University of Petroleum and Energy StudiesDehradunUttarakhand248007India Department of Physics University of the Free StateP.O.Box 339BloemfonteinZA 9300South Africa

Highly pure red phosphors LiM(PO_(3))_(3):Eu^(3+)(M=Sr,Ca) doped with Eu^(3+)(1 mol%) were synthesized via solution combustion method and their crystal structure and luminescence dynamics were studied to explore its suitability in white light emitting *** Rietveld refinement analysis of the powder Xray diffraction patterns reveals that the phosphors belong to the pure triclinic phase of LiSr(PO_(3))_(3) and LiCa(PO_(3)) with space group P-1(2).The scanning electron microscopy images showed the agglomerated *** photoluminescence emission spectra under 393 nm show an orange band at 594 nm and a red band at 613 nm ascribed to ^(5)D_(0)→^(7)F_(1).^(5)D_(0)→^(7)F_(2) transitions of Eu^(3+)ion in both the ***,the spectroscopic properties such as luminescence behaviour,and Stark splitting were used to examine the symmetry of Eu^(3+)ions in LiM(PO_(3))_(3):Es^(3+)(M=Sr,Ca) phosphors in terms of distortion induced upon *** Stark splitting shows that the actual site symmetry for Eu^(3+)ion was estimated to be D_(2) type for both *** photometric properties of LiCa(PO_(3))_(3):Eu^(3+)such as Commission International de l'Eclairage coordinates(x=0.64,y=0.36) near to the standard one(red),high color purity(95%) and higher brightness reveal that the phosphor has the capability of acting as a red component in n-UV white light emitting diodes.

关键词： Photoluminescence Phosphate WLEDs Stark splitting Rare earths