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Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model

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World Journal of Gastroenterology 2005年第6期11卷 912-916页

作者： Upendra R Gumaste Mukund M Joshi devendra t mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole Division of Biochemistry Department of Surgery Microbial Containment Complex

AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. therefore a biochemical parameter with greater sensitivity needs to be identified. MEtHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). the Serum glutamic acid pyruvate transaminase (SGPt) was also estimated in blood from portal vein and right ventricle of heart. RESULtS: A significant increase (Pthe levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively) as compared to the control group (46.39±21.69 EU and 65.389±30.55 EU, respectively) were observed. Similarly, increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14 EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU, respectively). However, in test animals there was significant increase in SGPt in portal blood (P= 0.054) without much increase in heart blood. CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPt in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagno

关键词： Intestinal ischemia ADH Biochemical parameter

On the transmission pattern of Kyasanur Forest disease (KFD) in India

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Infectious Diseases of Poverty 2015年第1期4卷 271-274页

作者： Manoj V.Murhekar Gudadappa S.Kasabi Sanjay M.Mehendale devendra t.mourya Pragya DYadav Babasaheb V.tale National Institute of Epidemiology Indian Council of Medical Research(ICMR)ChennaiTamil NaduIndia Department of Health and Family Welfare ShimogaIndia National Institute of Virology ICMRPune

Kyasanur Forest disease(KFD),a tick-borne viral hemorrhagic fever,is endemic in five districts of Karnataka state,*** reports of the spread of disease to neighboring districts of the Western Ghats,namely Chamarajanagar district in Karnataka,Nilgiri district in tamil Nadu,Wayanad and Malappuram districts in Kerala,and Pali village in Goa are a cause for *** vaccination of the affected population,establishing an event-based surveillance system for monkey deaths in the national parks,wildlife sanctuaries and reserve forests of the Western Ghats would help detect the disease early and thereby help implement appropriate control measures.

关键词： Kyasanur Forest disease ticks Virus disease Disease outbreak transmission India

Numerical solution of time-fractional three-species food chain model arising in the realm of mathematical ecology

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International Journal of Biomathematics 2020年第2期13卷 53-74页

作者： Ved Prakash Dubey Rajnesh Kumar devendra Kumar Faculty of Mathematical and Statistical Sciences Shri RamswaroopMemorial University Lucknow-Deva Road Barabanki 225003Uttar PradeshIndia Department of Mathematics University of Rajasthan Jaipur 302004RajasthanIndia

t'his research paper implements the fractional homotopy analysis transform technique to compute the approximate analytical solution of the nonlinear three-species food chain model with time-fractional *** offered technique is a fantastic blend of homotopy analysis method(HAM)and Laplace transform(Lt)operator and has been used fruitfully in the numerical computation of various fractional differential equations(FDEs).this paper involves the fractional derivatives of Caputo *** numerical solutions of this selected fractional-order food chain model are evaluated by making use of the associated initial *** is revealed by the adopting procedure that the more desirable estimation of the solution can be easily acquired through the calculation of some number of iteration terms only-a fact which authenticates the easiness and soundness of the suggested hybrid *** variations of fractional order of time derivative on the solutions for different specific cases have been depicted through graphical *** outcomes demonstrated through the graphs expound that the adopted scheme is very fantastic and accurate.

关键词： three-species food chain model homotopy analysis transform method Laplace transform fractional order FDEs

Effect of Surface Roughness on Laser Induced Nonlinear Optical Properties of Annealed ZnO thin Films

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Journal of Materials Science & technology 2012年第6期28卷 506-511页

作者： Vinay Kumari Vinod Kumar devendra Mohan Purnima B.P.Malik R.M.Mehra Department of Physics BMIETSonepat 131001India Department of Physics DCRUSTMurthal 131027India Materials Science Group Inter University Accelerator CentreAruna Asaf Ali MargNew Delhi 110067India Department of Applied Physics GJUS&THisar 125001India School of Engineering and technology Sharda UniversityGreater Noida 201306India

Variation of nonlinear optical properties with surface roughness of ZnO thin films deposited on coming glass substrates at different annealing temperature （tA） was reported. the films were characterized by X-ray diffraction （XRD）, UV-Vis-NIR transmission and single beam z-scan technique using second harmonics of Nd：YAG laser. Surface morphology of the samples was investigated by atomic force microscopy （AFM）. Surface roughness was found minimum （8.4 nm） for ZnO sample annealed at 450℃. the nonlinear optical properties （NLO） were found to be dependent on surface roughness and the highest value of third order nonlinear susceptibility （X（3）=4.3x 10-7 esu） was obtained for ZnO at tA 450℃.

关键词： ZnO films Sol-gel Annealing temperature Nonlinear optical properties thirdorder nonlinear susceptibility z-scan

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Strength Characterization of E-glass Fiber Reinforced Epoxy Composites with Filler Materials

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Journal of Minerals and Materials Characterization and Engineering 2013年第6期1卷 353-357页

作者： K. devendra t. Rangaswamy Department of Mechanical Engineering Government Engineering College (GEC) Hassan India Department of Mechanical Engineering SKSVMACET Laxmeshwar India

In this research work, an investigation was made on the mechanical properties of E-glass fiber reinforced epoxy composites filled by various filler materials. Composites filled with varying concentrations of fly ash, aluminum oxide (Al2O3), magnesium hydroxide (Mg(OH)2) and hematite powder were fabricated by standard method and the mechanical properties such as ultimate tensile strength, impact strength and hardness of the fabricated composites were studied. the test results show that composites filled by 10% volume Mg(OH)2 exhibited maximum ultimate tensile strength and hardness. Fly ash filled composites exhibited maximum impact strength.

关键词： Composites Fillers Mechanical Properties Strength

On the Growth Properties of Solutions for a Generalized Bi-Axially Symmetric Schr?dinger Equation

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Journal of Mathematical Research with Applications 2017年第2期37卷 214-222页

作者： devendra KUMAR Payal BISHNOI Mohammed HARFAOUI Department of Mathematics Faculty of Sciences Al-Baha University Department of Mathematics M.M.H. College University Hassan II-Casablanca Laboratory of MathematicsCryptography and MechanicsF.S.T

In this paper, we have considered the generalized bi-axially symmetric Schr?dinger equation ?;φ/?x;+?;φ/?y;+（2ν/x）?φ/?x+（2μ/y）?φ/?y+ {K;- V（r）}φ = 0,where μ, ν≥ 0, and r V（r） is an entire function of r = +（x;+ y;）;corresponding to a scattering potential V（r）. Growth parameters of entire function solutions in terms of their expansion coefficients, which are analogous to the formulas for order and type occurring in classical function theory, have been obtained. Our results are applicable for the scattering of particles in quantum mechanics.

关键词： Schro?dinger equation scattering potential Jacobi polynomials order and type

Future applications of exosomes delivering resolvins and cytokines in facilitating diabetic foot ulcer healing

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World Journal of Diabetes 2023年第1期14卷 35-47页

作者： Joshua P B Littig Rebecca Moellmer devendra K Agrawal Vikrant Rai translational Research Western University of Health SciencesPomonaCA 91766United States College of Podiatry Western University of Health SciencesPomonaCA 91766United States

type 2 diabetes mellitus(t2DM)increases the risk of many lethal and debilitating *** them,foot ulceration due to neuropathy,vascular disease,or trauma affects the quality of life of millions in the United States and around the *** wound healing is stalled in the inflammatory phase by the chronicity of inflammation without proceeding to the resolution *** advanced treatment,diabetic foot ulcers(DFUs)are associated with a risk of ***,there is a need for novel therapies to address chronic inflammation,decreased angiogenesis,and impaired granulation tissue formation contributing to the non-healing of *** have shown promising results with resolvins(Rv)and anti-inflammatory therapies that resolve inflammation and enhance tissue *** many of these studies have encountered difficulty in the delivery of Rv in terms of efficiency,tissue targetability,and *** review summarized the perspective of optimizing the therapeutic application of Rv and cytokines by pairing them with exosomes as a novel strategy for targeted tissue delivery to treat non-healing chronic *** articles discussing the t2DM disease state,current research on Rv for treating inflammation,the role of Rv in enhancing wound healing,and exosomes as a delivery vehicle were critically reviewed to find support for the proposition of using Rv and exosomes in combination for DFUs *** literature reviewed suggests the beneficial role of Rv and exosomes and exosomes loaded with antiinflammatory agents as promising therapeutic agents in ulcer healing.

关键词： Diabetic foot ulcer Chronic inflammation Amputation Exosomes Cytokines Resolvins

Lead Induced Oxidative Stress: Beneficial Effects of Kombucha tea

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Biomedical and Environmental Sciences 2003年第3期16卷 276-282页

作者： P.DIPtI B.YOGESH A.K.KAIN t.PAULINE B.ANJU M.SAIRAM B.SINGH S.S.MONGIA G.ILAVAZHAGAN devendra KUMAR W.SELVAMURtHY Defence Institute of Physiology and Allied Sciences Lucknow RoadTimarpurDelhi-110054.India

Objective to evaluate the effect of oral administration of Kombucha tea (K-tea) on lead induced oxidative stress. Methods Sprague Dawley rats were administered 1 mL of 3.8% lead acetate solution daily alone or in combination with K-tea orally for 45 d, and the antioxidant status and lipid peroxidation were evaluated. Results Oral administration of lead acetate to rats enhanced lipid peroxidation and release of creatine phosphokinase and decreased levels of reduced glutathione (GSH) and antioxidant enzymes (superoxide dismutase, SOD and glutathione peroxidase, GPx). Lead treatment did not alter humoral immunity, but inhibited DtH response when compared to the control. Lead administration also increased DNA fragmentation in liver. Oral administration of Kombucha tea to rats exposed to lead decreased lipid peroxidation and DNA damage with a concomitant increase in the reduced glutathione level and GPx activity. Kombucha tea supplementation relieved the lead induced immunosuppression to appreciable levels. Conclusion the results suggest that K-tea has potent antioxidant and immunomodulating properties.

关键词： Lead Oxidative stress Kombucha tea Antioxidant activity

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Comparison of functional outcomes among subtypes of Fraser’s typeⅡfloating knee

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Chinese Journal of traumatology 2021年第1期24卷 25-29页

作者： Deepak Chouhan devendra K.Chouhan Rajendra K.Kanojia Prateek Behera Department of Orthopedics Post Graduate Institute of Medical Education&ResearchChandigarh160012India Department of Orthopedics All India Institute of Medical SciencesBhopalMadhya Pradesh462020India

Purpose the poor prognosis in patients with floating knee injuries is mainly contributed to articular involvement(Fraser’s typeⅡ).this study aims to evaluate and compare the functional outcomes among different Fraser’s typeⅡfloating knee injuries after surgical *** twenty-seven patients with Fraser’s typeⅡfloating knee injuries(54 fractures)between September 2014 and December 2015 were enrolled prospectively in this study and were distributed according to Fraser’s floating knee classification into three different groups as typeⅡA(ipsilateral femoral shaft and tibial intra-articular involvement,n=11),typeⅡB(ipsilateral tibial shaft and femoral intra-articular involvement,n=9)and typeⅡC(both femoral and tibial intra-articular involvement,n=7).the differences among the groups were evaluated and *** functional outcomes of these injuries at one year were analyzed using Knee Injury and Osteoarthritis Outcome Score(KOOS)which covers 5 subscales of pain,other symptoms,activities of daily living,sports and recreation,and quality of *** result was also compared with standardized age-sex matched healthy population using paired samples *** All the patients were male,and the injury mechanism was solely roadside *** mean age was 29.8 years and injury severity score 17.9(comparable in all the three groups).Most injuries were observed on the right side(20 cases,74.1%).Based on paired samples t-test,the KOOS score of patients with Fraser’s typeⅡA was found to be better than that of typeⅡB and typeⅡ*** with the reference age-sex matched control group,patients with Fraser’s typeⅡB andⅡC fractures had significantly lower mean score in all KOOS subscales(all ptypeⅡA only revealed significant difference regarding the subscales of activities of daily living(pts and recreation(pty of life(pthe results of this study show that patients with Fraser’s typeⅡA fractu

关键词： Floating knee Femur fractures tibia fractures Outcome

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