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溶瘤病毒在结直肠癌治疗中的研究进展

医学综述 2024年第13期30卷 1563-1567,1573页

作者：秦颖赵博文薛政昊蒋德生武俸羽哈尔滨体育学院哈尔滨150008

结直肠癌(CRC)是最常见的消化道恶性肿瘤之一,给全球公共卫生带来了严峻挑战。传统的CRC手术治疗主要以开腹手术为主,虽然部分患者能够达到根治的目的,但创伤较大,手术出血量较多、术后恢复时间较长,且术后并发症的发生率较高,对其预后... 详细信息

结直肠癌(CRC)是最常见的消化道恶性肿瘤之一,给全球公共卫生带来了严峻挑战。传统的CRC手术治疗主要以开腹手术为主,虽然部分患者能够达到根治的目的,但创伤较大,手术出血量较多、术后恢复时间较长,且术后并发症的发生率较高,对其预后造成严重影响。与传统治疗方式相比,溶瘤病毒具有杀伤肿瘤途径多、杀伤力强、靶向性好、不良反应小、低耐药性以及低成本等优势,在CRC的治疗上具有广阔的应用前景。

关键词：结直肠癌溶瘤病毒疗法基因修饰

Phosphotungstic acid ionic liquid for efficient photocatalytic desulfurization:Synthesis,application and mechanism

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Chinese Journal of Chemical Engineering 2024年第5期69卷 101-111页

作者： Chenchao Hu Suhang Xun desheng Liu Junjie Zhang Minqiang He Wei jiang Huaming Li Wenshuai Zhu Institute of Environmental Health and Ecological Security School of Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China School of Chemistry and Chemical Engineering Institute for Energy ResearchJiangsu UniversityZhenjiang 212013China jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment Suzhou University of Science and TechnologySuzhou 215009China

An efficient mass transfer process is a critical factor for regulating catalytic activity in a photocatalytic desulfurization ***,a phosphotungstic acid(HPW)active center is successfully composited with a quaternary ammonium phosphotungstate-based hexadecyltrimethylammonium chloride ionic liquid(CTAC-HPW)by the ion exchange method for the photocatalytic oxidative desulfurization of dibenzothiophene *** keggin structure of HPW and highly mass transfer performance of organic cations synergistically enhanced the photocatalytic activity towards the effective convertion of dibenzothiophene(DBT)with the excitation of visible *** deep desulfurization(<10 mg·kg^(-1))is attained within 30 min,and well stability is demonstrated within 25 ***,the CTAC-HPW photocatalyst projects well selectivity to interference from coexisting compounds such as olefins and aromatic hydrocarbons and universality of dibenzothiophenes,for example,4-methyldibenzothiophene(4-MDBT)and 4,6-dimethyldibenzothiophene(4,6-DMDBT).Ultimately,a possible photocatalytic desulfurization mechanism is proposed according to the Gaschromatography-mass spectrometry(GC-MS),proving that the final product is the corresponding *** trapping experiment and electron spin resonance(ESR)analysis confirmed that h^(+)and,COOH played critical roles in the oxidation *** work offers a practicable strategy for efficiently converting DBT to DBTO_(2) with added value.

关键词： Photocatalytic desulfurization Extraction Ionic liquid CTAC-HPW

Digital monitoring for heavy duty mechanical equipment based on fiber Bragg grating sensor

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Science China(Technological Sciences) 2009年第2期52卷 285-293页

作者： ZHOU ZuDe jiang desheng ZHANG DongSheng School of Mechatronics Engineering Wuhan University of TechnologyHubei 430070China Key Laboratory of Fiber Optic Sensing Technology and Information Processing(Wuhan University of Technology) Ministry of EducationHubei 430070China

The digital monitoring principle and technologies for heavy duty mechanical equipment based on fiber Bragg grating (FBG) technology are introduced in this paper. The fundamentals of new-style FBG sensing technology, including the photorefractive effect of FBG, the physical formation, and the relation between optical properties and grating parameters, are investigated. The plaster, encapsulation and distribution planning of FBG sensor (FBGS), which is used to monitor heavy duty mechanical equipment under abominable environment and extreme conditions, are also studied. In addition, theoretical and experimental researches on the strain, temperature, displacement, and stress transmission characteristics between FBGS and detection interface are presented. The principle and method for temperature compensation in non-uniformity temperature field are described in detail as well. Comparing with the traditional sensing monitoring techniques, the application of FBGS technology on digital monitoring and diagnosis for heavy duty mechanical equipment has a number of significant technical advantages and will make a new breakthrough in this field.

关键词： fiber Bragg grating sensor (FBGS) heavy duty mechanical equipment digital monitoring temperature compensation

Drawing Tower In-Line Fabrication and the Spectrum Analysis of Sampled Fiber Grating

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Photonic Sensors 2020年第1期10卷 80-87页

作者： Yu ZHENG Wenjing GAO Haihu YU Huiyong GUO Shan jiang desheng jiang National Engineering Laboratory for Fiber Optic Sensing Technology Wuhan University of TechnologyWuhan 430070China WUTOS Technology Co. LtdWuhan 430223China

Sampled fiber grating is a special superstructure fiber Bragg grating with a wide range of applications in many *** this work,based on drawing tower in-line fabrication system,a new preparation method of the sampled fiber grating is proposed and experimentally *** result shows that the obtained sampled fiber gratings possess dense reflection spectra,with a minimum reflection peak interval of only 0.09 *** method exhibits promising application prospect in the fabrication of the high-quality sampled fiber *** the other hand,the spectral characteristics of the sampled fiber grating are analyzed when the sub-grating is affected by the external physical quantities such as,in this paper,*** shift and intensity change in the reflection peak of the spectra indicate that the grating is affected differently by micro strains,due to the different spatial positions along the axis of the sampled fiber *** work is aimed at exploring the potential applications of the sampled fiber grating in quasi-distributed micro-area sensing with the millimeter level.

关键词： Sampled fiber grating drawing tower in-line fabrication spectrum analysis grating array sensing application

Macro-superlubricity in sputtered MoS_(2)-based films by decreasing edge pinning effect

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Friction 2024年第1期12卷 52-63页

作者： Chunmeng DONG Dong jiang Yanlong FU desheng WANG Qinqin WANG Lijun WENG Ming HU Xiaoming GAO Jiayi SUN State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

To date,MoS_(2) can only be achieved at *** pinning effect caused by structure defects is the most obvious barrier to expand the size of structural superlubricity to ***,we plan to pin edge planes of MoS_(2) with nanospheres,and then the incommensurate structure can be formed between adjacent rolling nanoparticles to reduce *** sputtered MoS_(2) film was prepared by the physical vapor deposition(PVD)in *** enough Cu_(2)O nanospheres(~40 nm)were generated in situ at the edge plane of MoS_(2) layers by liquid phase *** incommensurate structure(mismatch angle(θ)=8°)caused by MoS_(2) layers was formed before *** friction coefficient of the films(5 N,1,000 r/min)was~6.0×10^(−3) at the *** friction,MoS_(2) layers pinned on numerous of Cu_(2)O nanoparticles reduced its edge pinning effect and decreased ***,much more incommensurate was formed,developing macro-superlubricity.

关键词： sputtered MoS_(2)film Cu_(2)O nanospheres edge pinning effect macro-superlubricity

Slippery hydrogel with desiccation-tolerant‘skin’for high-precision additive manufacturing

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International Journal of Extreme Manufacturing 2024年第2期6卷 486-500页

作者： desheng Liu Pan jiang Yue Hu Yaozhong Lu Yixian Wang Jiayu Wu Danli Hu Tao Wu Xiaolong Wang State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000People’s Republic of China CAS Key Laboratory of Chemistry of Northwestern Plant Resources Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000People’s Republic of China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai Zhongke Research Institute of Advanced Materials and Green Chemical EngineeringYantai 264006People’s Republic of China Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832003People’s Republic of China

Hydrogels inevitably undergo dehydration,structural collapse,and shrinkage deformation due to the uninterrupted evaporation in the atmosphere,thereby losing their flexibility,slipperiness,and manufacturing ***,we propose a novel bioinspired strategy to construct a spontaneously formed‘skin’on the slippery hydrogels by incorporating biological stress metabolites trehalose into the hydrogel network,which can generate robust hydrogen bonding interactions to restrain water *** contents of trehalose in hydrogel matrix can also regulate the desiccation-tolerance,mechanical properties,and lubricating performance of slippery hydrogels in a wide *** vat photopolymerization three-dimensional printing and trehalose-modified slippery hydrogels enables to achieve the structural hydrogels with high resolution,shape fidelity,and sophisticated architectures,instead of structural collapse and shrinkage deformation caused by *** thus,this proposed functional hydrogel adapts to manufacture large-scale hydrogels with sophisticated architectures in a long-term *** a proof-of-concept demonstration,a high-precision and sophisticated slippery hydrogel vascular phantom was easily fabricated to imitate guidewire ***,the proposed protocol is universally applicable to diverse types of hydrogel *** strategy opens up a versatile methodology to fabricate dry-resistant slippery hydrogel for functional structures and devices,expanding their high-precision processing and broad applications in the atmosphere.

关键词： slippery hydrogel trehalose desiccation tolerance vat photopolymerization 3D printing hydrogen bonding

基于CiteSpace的青少年力量训练研究可视化分析

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体育科技文献通报 2024年第7期32卷 59-63页

作者：刘梦琪薛政昊张瑞鹏安永东秦颖蒋德生赵文艳哈尔滨体育学院研究生院黑龙江哈尔滨150008 哈尔滨体育学院运动人体科学学院黑龙江哈尔滨150008

目的:分析青少年力量训练领域的研究现状与热点,探寻该领域未来的发展趋势。方法:通过中国知网(CNKI)和Web of Science(WOS)核心数据库,检索2014年1月1日—2023年12月31日关于青少年力量训练领域研究的相关文献,利用CiteSpace软件对作... 详细信息

目的:分析青少年力量训练领域的研究现状与热点,探寻该领域未来的发展趋势。方法:通过中国知网(CNKI)和Web of Science(WOS)核心数据库,检索2014年1月1日—2023年12月31日关于青少年力量训练领域研究的相关文献,利用CiteSpace软件对作者、研究机构、关键词等信息进行可视化分析。结果:(1)青少年力量训练领域的研究文献数量呈显著增长趋势,其中美国、澳大利亚和英国在发文数量上位居前列,发文量最多的是来自米歇利运动损伤预防中心的Howell、David R;而国内研究主要集中于体育院校。(2)研究热点涵盖了体能训练、核心力量和训练方法等方面。国外研究更侧重于儿童体力活动和运动表现等。特别值得注意的是,近年来,专项体能、专项力量训练以及运动损伤预防逐渐成为研究的新热点。结论:当前对于青少年力量训练领域的研究更多地集中在力量训练、核心力量及训练方法方面,而青少年专项力量、专项体能及青少年运动损伤等领域正逐渐成为新的热点趋势。

关键词：青少年力量训练可视化分析

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A Novel TiNi/AlSi Composite with High Strength and High Damping Capacity

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Journal of Materials Science & Technology 2008年第6期24卷 903-906页

作者： Shuwei LIU Xiuyan LI desheng YAN Haichang jiang Lijian RONG Institute of Metal Research Chinese Academy of Science Shenyang 110016 China

A novel TiNi/AlSi composite with high compressive strength and high damping capacity was obtained by infiltrating Al-12%Si alloy into porous TiNi *** had been found that the high compressive strength (440 MPa) of TiNi/AlSi composite is due to the increase of effective carrying area after infiltrating Al-12%Si alloy,while the high damping capacity is contributed to TiNi carcass,Al-12%Si filling material and micro- slipping at the interface.

关键词： TiNi/AlSi 复合材料阻尼容量压缩强度

Huge Capacity Fiber-Optic Sensing Network Based on Ultra-Weak Draw Tower Gratings

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Photonic Sensors 2016年第1期6卷 26-41页

作者： Minghong YANG Wei BAI Huiyong GUO Hongqiao WEN Haihu YU desheng jiang National Engineering Laboratory for Fiber Optic Sensing Technology Wuhan University of Technology Wuhan 430070 China

This paper reviews the work on huge capacity fiber-optic sensing network based on ultra-weak draw tower gratings developed at the National Engineering Laboratory for Fiber Optic Sensing Technology （NEL-FOST）, Wuhan University of Technology, China. A versatile drawing tower grating sensor network based on ultra-weak fiber Bragg gratings （FBGs） is firstly proposed and demonstrated. The sensing network is interrogated with time- and wavelength-division multiplexing method, which is very promising for the large-scale sensing network.

关键词： Ultra-weak FBG optical fiber sensors sensing network