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在大井眼中用LWD声波测量来探测浅层钻井危险区

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国外测井技术 2011年第1期31卷 71-73,70页

作者：韩璐 j.Prilliman derek Buster X．Tang 刘红岐魏小龙廖茂杰杜玉荣康志磊西南石油大学石油工程测井实验室西南石油大学资源与环境学院

美国内务部,矿物管理服务（MMS）要求在潜在的浅层钻井危险区必须安装导管柱和表层套管。但在LWD测井确认出的安全区域MMS对使用导管柱和表层套管不作要求,且LWD代替电缆测井评估浅地层有明显优势。模型显示在纵波慢度接近钻井泥浆慢度... 详细信息

美国内务部,矿物管理服务（MMS）要求在潜在的浅层钻井危险区必须安装导管柱和表层套管。但在LWD测井确认出的安全区域MMS对使用导管柱和表层套管不作要求,且LWD代替电缆测井评估浅地层有明显优势。模型显示在纵波慢度接近钻井泥浆慢度时LWD可以测量出纵波慢度。在大井眼和超慢速地层,91/2in的LWD声波仪器采集浅层数据是非常合适的。因此钻井时,实时的LWD测井可以确证出该地层有没有浅层气藏,且被MMS接受。这样,在多井项目操作中,可以降低电缆项目的操作费用,也节省出拆卸导管柱和表层套管的费用,可以节约215万USD左右。

关键词：浅层钻井危险区 LWD声波测量大井眼

Nature:寨卡病毒导致小鼠睾丸体积缩小、结构破坏

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现代生物医学进展 2017年第6期17卷 I0001-I0001页

作者： j.nnifer Govero, j.stin M. Richner, Elizabeth A. Caine, Vanessa Salazar Michael S. Diamond Prabagaran Esakky, Suzanne M. Scheaffer, Andrea Drury Kelle H. Moley Estefania Fernandez, Matthew j. Gorman Michael S. Diamond derek j. Platt Michael S. Diamond Kelle H. Moley Michael S. Diamond Department of Medicine Washington University School of Medicine Saint Louis Missouri 63110 USA Department of Obstetrics and Gynecology Washington University School of Medicine Saint Louis Missouri 63110 USA Department of Pathology and Immunology Washington University School of Medicine Saint Louis Missouri 63110 USA Department of Molecular Microbiology Washington University School of Medicine Saint Louis Missouri 63110 USA Department of Cell Biology and Physiology Washington University School of Medicine Saint Louis Missouri 63110 USA The Center for Human Immunology and Immunotherapy Programs Washington University School of Medicine Saint Louis Missouri 63110 USA

大部分针对寨卡病毒（Zika Virus）的研究发现。寨卡病毒感染的影响主要集中在孕妇和出生缺陷。但在小鼠中。新的研究发现了寨卡病毒对于小鼠雄性生殖系统的严重损伤，引起了人们对人类男性可能遭受得到的威胁的严重关切。美国华盛顿大... 详细信息

大部分针对寨卡病毒（Zika Virus）的研究发现。寨卡病毒感染的影响主要集中在孕妇和出生缺陷。但在小鼠中。新的研究发现了寨卡病毒对于小鼠雄性生殖系统的严重损伤，引起了人们对人类男性可能遭受得到的威胁的严重关切。美国华盛顿大学医学院的研究人员们，通过在《Nature》上的研究文章，报道了寨卡病毒对于雄性小鼠的生殖系统的损害。

关键词：病毒感染雄性小鼠睾丸体积结构破坏《Nature》雄性生殖系统华盛顿大学出生缺陷

一项科学学的国际科学奖——普赖斯奖章——1984年12月20日首届普赖斯奖授奖仪式上的讲话

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世界科学 1986年第5期 34-35页

作者： M. j. Moravcsik 赵红州蒋国华

今年九月三日,恰是世界著名科学学家、已故美国耶鲁大学教授普赖斯博士(derek de Solla Price)逝世三周年纪念日。我们在本期特刊登了一组关于科学计量学的译文,以志纪念。大家知道,物理学、化学、医学等有诺贝尔奖,数学则有菲尔兹奖。... 详细信息

今年九月三日,恰是世界著名科学学家、已故美国耶鲁大学教授普赖斯博士(derek de Solla Price)逝世三周年纪念日。我们在本期特刊登了一组关于科学计量学的译文,以志纪念。大家知道,物理学、化学、医学等有诺贝尔奖,数学则有菲尔兹奖。如今年轻的科学学也有了自己的国际科学单项奖,跻身于世人敬慕的二十多项国际科学奖的行列。钱三强教授指出:“普赖斯科学学奖的设立,表示世界对交叉科学的重视”。他勉励我国科学家,尤其是中青年科学家,志存高远,为赢得像诺贝尔奖、菲尔兹奖、普赖斯奖等国际科学奖而努力奋斗,为国争光。

关键词：普赖斯科学奖科学计量学科学学

VERDICT MRI对胶质瘤微观结构的无创性评估：与组织学的相关性

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国际医学放射学杂志 2019年第6期 753-753页

作者： F.Zaccagna F.Riemer A.N.Priest M.A.mclean K.Allinson j.T.Grist 方少伯 Department of Radiology School of Clinical MedicineUniversity of Cambridge Cambridge Biomedical Campus

摘要目的该前瞻性研究评估了肿瘤细胞的血管、细胞外和限制性扩散(VERDICT)MRI在胶质瘤组织微结构的使用价值。VERDICT衍生参数与组织学特征及肿瘤亚型有相

关键词：胶质瘤 VERDICT MRI 微观结构

通过药物基因组学鉴别直肠癌化疗中新的反应决定因子

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中国处方药 2006年第5期5卷 25-25页

作者： Boyer j.Allen WL mclean EG 菅鑫妍

使用5-氟尿嘧啶(5-fluorouracil,5-FU)或者奥沙利铂(oxaliplatin)治疗结肠直肠癌,挑选其中抗药的细胞HCT116,通过DNA微阵列分析HCT116细胞的转录谱。通过生物信息学分析鉴别在抗药细胞中构成失调的以及亲本细胞急性照射后短暂改变的基... 详细信息

使用5-氟尿嘧啶(5-fluorouracil,5-FU)或者奥沙利铂(oxaliplatin)治疗结肠直肠癌,挑选其中抗药的细胞HCT116,通过DNA微阵列分析HCT116细胞的转录谱。通过生物信息学分析鉴别在抗药细胞中构成失调的以及亲本细胞急性照射后短暂改变的基因集合。我们认为这些基因集合可能代表着对5-FU和oxaliplatin敏感的生物标记。[第一段]

关键词：药物基因组学结肠直肠癌 HCT116细胞决定因子 oxaliplatin 鉴别 DNA微阵列分析生物信息学分析反应化疗

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Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents

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Signal Transduction and Targeted Therapy 2023年第1期8卷 266-275页

作者： Xiaofeng Mu Carolyn A.Cohen Daniel Leung j.ime S.Rosa Duque Samuel M.S.Cheng Yuet Chung Howard H.W.Wong Amos M.T.Lee Wing Yan Li Issan Y.S.Tam j.nnifer H.Y.Lam derek H.L.Lee Sau Man Chan Leo C.H.Tsang Karl C.K.Chan j.hn K.C.Li Leo L.H.Luk Sara Chaothai Kelvin K.H.Kwan Nym Coco Chu Masashi Mori Trushar j.evan Ahmed Kandeil Richard j.ebby Wenwei Tu Sophie A.Valkenburg Malik Peiris Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina HKU-Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Infectious Diseases St Jude Children’s Research HospitalMemphisTNUSA Department of Microbiology and Immunology Peter Doherty Institute for Infection and ImmunityUniversity of MelbourneMelbourneVICAustralia Centre for Immunology&Infection C2i Hong KongChina

The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet *** this analysis,our study(NCT04800133)aims to evaluate the humoral and cellular responses against wild-type and Omicron(BA.1,BA.2 and/or BA.5)SARS-CoV-2 before and after a third dose of BNT162b2 in healthy *** 5 months after 2 doses,S IgG,S IgG Fc receptor-binding,and neutralising antibody responses waned significantly,yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 *** antibody responses and S-specific IFN-γ^(+)and IL-2^(+)CD8^(+)T cell responses were significantly boosted in healthy adolescents after a homologous third dose of *** to adults,humoral responses for the third dose were non-inferior or superior in *** S-specific IFN-γ^(+)and IL-2^(+)CD4^(+)and CD8^(+)T cell responses in adolescents and adults were comparable or ***,after 3 doses,adolescents had preserved S IgG,S IgG avidity,S IgG FcγRIIIa-binding,against Omicron BA.2,as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1,BA.2 and *** from 100 and 96%of adolescents tested at 1 and 5 months after two doses could also neutralise *** study found high antibody and T cell responses,including potent cross-variant reactivity,after three doses of BNT162b2 vaccine in adolescents in its current formulation,suggesting that current vaccines can be protective against symptomatic Omicron disease.

关键词： doses neutral protective

2021亚太心脏病学会P2Y12受体拮抗剂应用于亚太特殊人群的共识

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中华心血管病杂志 2023年第1期51卷 19-31页

作者： j.ck Wei Chieh Tan derek P Chew Kin Lam Tsui Doreen Tan Dmitry Duplyakov Ayman Hammoudeh 张波李毅徐凯 Paul j.Ong DoniFirman Habib Gamra Wael Almahmeed j.mshed Dalal Lihua Tan Gabriel Steg Quang N Nguyen j.nya Ako j.ssim Al Suwaidi Mark Chan Mohamed Sobhy Abdulla Shehab Wacin Buddhari 王祖禄 Alan Yean Yip Fong Bilgehan Karadag Byeong-Keuk Kim Usman Baber Chee Tang Chin 韩雅玲新加坡国立心脏中心新加坡盛港综合医院澳大利亚弗林德斯大学医学与公共卫生学院香港特别行政区东区尤德夫人那打素医院新加坡国立大学理学院药学系俄罗斯萨马拉地区心脏病医院约旦安曼Istishari医院心脏病科大连医科大学第一附属医院心内科大连116000 北部战区总医院心内科沈阳110840 新加坡伊丽莎白诺维娜医院新加坡陈笃生医院印度尼西亚Harapan Kita国家心血管中心、印度尼西亚大学医学院心脏病学和血管医学系突尼斯Fattouma Bourguiba大学医院/莫纳斯提尔大学心脏病科阿拉伯联合酋长国阿布扎比克利夫兰诊所印度孟买Kokilaben Dhirubhai Ambani医院心脏中心香港特别行政区广华医院法国巴黎比夏医院心脏病科越南河内医科大学心脏病科日本神奈川县相模原市北里大学医学院心血管内科卡塔尔多哈哈马德医疗公司成人心脏病科新加坡国立大学心脏中心埃及亚历山大大学医学院阿拉伯联合酋长国阿联酋大学医学与健康科学学院泰国曼谷朱拉隆功国王纪念医院马来西亚砂拉越哥打三马拉汉心脏中心土耳其伊斯坦布尔大学-Cerrahpasa医学院韩国首尔延世大学医学院Severance心血管医院心脏病科美国俄克拉荷马大学健康科学中心

高龄、糖尿病(DM)和慢性肾脏疾病(CKD)不仅会增加慢性冠状动脉综合征(CCS)患者缺血事件的风险,还会增加其接受抗血小板治疗期间的出血风险。此类特殊人群可能需要调整治疗方案,尤其是亚洲的特殊人群,往往表现出与西方人群不同的临床特... 详细信息

高龄、糖尿病(DM)和慢性肾脏疾病(CKD)不仅会增加慢性冠状动脉综合征(CCS)患者缺血事件的风险,还会增加其接受抗血小板治疗期间的出血风险。此类特殊人群可能需要调整治疗方案,尤其是亚洲的特殊人群,往往表现出与西方人群不同的临床特征。关于亚洲人群CCS高风险的分类和急性冠状动脉综合征(ACS)后使用新一代强效P2Y12受体抑制剂(如替格瑞洛和普拉格雷)的国际指南已相继发表。本共识总结了在特殊人群中使用强效P2Y12受体抑制剂的相关证据,提出了在冠状动脉疾病(CAD)特殊人群中应用标准疗程双联抗血小板治疗(DAPT)、短期DAPT和单一抗血小板治疗的推荐意见。本共识的特殊人群包括从ACS过渡至CCS,老年,或患有CKD、DM、多血管CAD和治疗期间发生出血并发症等特征的患者。

关键词：血小板聚集抑制剂亚洲心肌缺血共识双联抗血小板治疗

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The advent of structural biology in situ by single particle cryo-electron tomography

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Biophysics Reports 2017年第Z1期3卷 17-35页

作者： j.sús G.Galaz-Montoya Steven j.Ludtke National Center for Macromolecular Imaging Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine

Single particle tomography(SPT), also known as subtomogram averaging, is a powerful technique uniquely poised to address questions in structural biology that are not amenable to more traditional approaches like X-ray crystallography, nuclear magnetic resonance, and conventional cryoEM single particle analysis. Owing to its potential for in situ structural biology at subnanometer resolution, SPT has been gaining enormous momentum in the last five years and is becoming a prominent, widely used technique. This method can be applied to unambiguously determine the structures of macromolecular complexes that exhibit compositional and conformational heterogeneity, both in vitro and in situ. Here we review the development of SPT, highlighting its applications and identifying areas of ongoing development.

关键词： Cryo-electron tomography Single particle tomography Subtomogram averaging Direct detection device Contrast transfer function

A review of chlorinated paraffin contamination in Arctic ecosystems

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Emerging Contaminants 2019年第1期5卷 219-231页

作者： Katrin Vorkamp j.nnifer Balmer Hayley Hung Robert j.Letcher Frank F.Riget Aarhus University Department of Environmental ScienceArctic Research CentreRoskildeDenmark Arctic Monitoring and Assessment Programme TromsøNorway Environment and Climate Change Canada Air Quality Processes Research SectionTorontoCanada Ecotoxicology and Wildlife Health Division Environment and Climate Change CanadaNational Wildlife Research CentreCarleton UniversityOttawaCanada Aarhus University Department of BioscienceArctic Research CentreRoskildeDenmark Greenland Institute of Natural Resources NuukGreenland Present address:The Citadel Department of BiologyCharlestonSCUSA

Chlorinated paraffins(CPs)present a complex mixture of congeners which are often analysed and assessed as short-,medium-and long-chain CPs,***(C10eC13),SMCCP(C14eC17)and SLCCP(C18).Their complexity makes the chemical analysis challenging,in particular in terms of accurate quantification,but promising developments involving ultra-high resolution mass spectrometry have been presented *** Arctic data exist for SCCPs,while LCCPs have not yet been studied in the *** concentrations in Arctic air often exceeded those of SMCCP,usually with a predominance of the most volatile C10 congeners,and of banned persistent organic pollutants(POPs),such as polychlorinated biphenyls(PCBs).The presence of SCCPs and MCCPs in Arctic air,as well as in the Antarctic and in the remote regions of the Tibetan plateau,provides evidence of their long-range transport including sufficient environmental persistence to reach the *** vegetation accumulated SCCPs partly from air and partly through root uptake from soil,with consequences for the SCCP profile found in Arctic *** results have yet been reported for CPs in terrestrial Arctic *** for freshwater sediment and fish confirmed the long-range transport of SCCPs and MCCPs and documented their *** additional PCB data were available,SPCB was usually higher than SSCCP in freshwater *** SCCPs and MCCPs were widely present in marine Arctic biota(***,fish,seabirds,seals,whales,polar bears).In mussels and Atlantic cod,SMCCP concentrations exceeded those of SSCCP,while this was less clear for other marine *** mammals and the long-lived Greenland shark roughly had SSCCP concentrations of 100e500 ng/g lipid weight,often dominated by C11 *** appeared to be more pronounced for SSCCP than for SMCCP,but more studies will be *** SSCCP concentrations were observed in Arctic air and sediment over time,but not in beluga monitored since

关键词： Bioaccumulation Biomagnification Long-range transport MCCPs Persistent organic pollutants SCCPs