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Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)-a fine balance

Hepatobiliary Surgery and Nutrition 2023年第2期12卷 269-271页

作者： Kai Tai derek yeung Mikael H.Sodergren Department of Surgery and Cancer Imperial College LondonLondonUK

We read with interest the paper by Li et ***“Associating liver partition and portal vein ligation for staged hepatectomy versus sequential transarterial chemoembolization and portal vein embolization in staged hepate... 详细信息

关键词： Hepatitis B virus(HBV) hepatocellular carcinoma(HCC) portal vein embolization(PVE) associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)

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Resection margin influences the outcome of patients with bilobar colorectal liver metastases

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World Journal of Hepatology 2016年第34期8卷 1502-1510页

作者： Sara Di Carlo derek yeung Jamie Mills Abed Zaitoun Iain Cameron Dhanny Gomez Department of General Surgery University of Rome Department of Hepatobiliary Surgery and Pancreatic Surgery Queen’s Medical CentreNottingham University Hospitals NHS Trust Department of Oncology Queen’s Medical CentreNottingham University Hospitals NHS Trust Department of Histo-pathology Queen’s Medical CentreNottingham University Hospitals NHS Trust NIHR Nottingham Digestive Disease Biomedical research Unit University of Nottingham

AIMTo evaluate the outcome of patients with bilobar colorectal liver metastases (CRLM) and identify clinico-pathological variables that influenced survival. METHODSPatients with bilobar CRLM were identified from a prospectively maintained hepatobiliary database during the study period (January 2010-June 2014). Collated data included demographics, primary tumour treatment, surgical data, histopathology analysis and clinical outcome. Down-staging therapy included Oxaliplatin- or Irinotecan- based regimens, and Cetuximab was also used in patients that were K-RAS wild-type. Response to neo-adjuvant therapy was assessed at the multi-disciplinary team meeting and considered for surgery if all macroscopic CRLM were resectable with a clear margin while preserving sufficient liver parenchyma. RESULTSOf the 136 patients included, thirty-two (23.5%) patients were considered inoperable and referred for palliative chemotherapy, and thirty-four (25%) patients underwent liver resection. Seventy (51.4%) patients underwent down-staging therapy, of which 37 (52.8%) patients responded sufficiently to undergo liver resection. Patients that failed to respond to down-staging therapy (n = 33, 47.1%) were referred for palliative therapy. There was a significant difference in overall survival between the three groups (surgery vs down-staging therapy vs inoperable disease, P P P = 0.017). On multi-variate analysis, R0 resection (P = 0.030) and female (P = 0.036) gender significantly influenced overall survival. CONCLUSIONPatients undergoing liver resection with bilobar CRLM have a significantly better survival outcome. R0 resection is associated with improved disease-free and overall survival in this patient group.

关键词： Colorectal liver metastases Chemotherapy Liver resection

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Using MRE to Quantitatively Measure the Effects of Acupuncture on Muscle Stiffness

Using MRE to Quantitatively Measure the Effects of Acupunctu...

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第十四届全国中药和天然药物学术研讨会

作者： derek Hang Chun Kwok Geng Li Jason Wan Man Fung Kiu Ngai So Ye Zhang Ying Zheng Sun Yiu Chong Simon Sze Man yeung Qi Yuan Ma Time Medical Limited

＜正＞Background Magnetic Resonance Elastography（MRE）is a non-invasive technique that quantitatively measures tissue stiffness[1].It consists of generating shear waves in tissue;acquiring MR images of the induced sh...

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