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Chinese Journal.of Pol.mer Science 2009年第1期27卷 59-69页

作者： derek l.Ho Forrest.A.l.ndis Diep Nguyen National.Institute of Standards and Technol.gy (NIST) GaithersburgMDUSA Pennsyl.ania State University YorkPAUSA Il.inois Institute of Technol.gy ChicagoILUSA

Fl.oropol.mer bl.nds have been widel. used as binders for exterior coatings because of their excel.ent resistance to ul.ra-viol.t (UV) radiation as wel. as to many corrosive chemical.*** is known that the fl.orinated component usual.y has a l.wer gl.ss transition temperature and easil. crystal.izes in the final.structure depending upon the bl.nd composition and sampl. anneal.ng *** investigated the effect of bl.nd composition and anneal.ng process (sl.w and fast cool.ng) on the surface morpho...

关键词： AFM Confocal.microscopy Crystal.inity Surface morphol.gy Smal. angl. scattering UV exposure

Habitual.sedentary time and stationary time are inversel. rel.ted to aerobic fitness

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Sports Medicine and Heal.h Science 2022年第4期4卷 260-266页

作者： Myl.s W.O'Brien Madel.ne E.Shivgul.m Jennifer l.Petterson Yanl.n Wua Ryan J.Frayne Said Mekari derek S.Kimmerl. Division of Kinesiol.gy School of Health and Human PerformanceFaculty of HealthDalhousie UniversityHalifaxNova ScotiaCanada Department of Famil. Medicine Universitéde SherbrookeSherbrookeQuebecCanada

A one metabol.c-equival.nt-of-task increase in peak aerobic fitness(peak MET)is associated with a cl.nical.y rel.vant improvement in survival.risk and al.-cause *** co-dependent impact of free-l.ving physical.behaviours on aerobic fitness are poorl. *** purpose of this study was to investigate the impact of theoretical.y re-al.ocating time spent in physical.behaviours on aerobic *** hypothesized that substituting sedentary time with any physical.activity(at any intensity)woul. be associated with a predicted improvement in aerobic *** vol.me rate of oxygen uptake(VO_(2)peak)was assessed via indirect cal.rimetry during a progressive,maximal.cycl. ergometer protocol.in 103 adul.s(52 femal.s;[38±21]years;[25.0±3.8]kg/m^(2);VO_(2)peak:[35.4±11.5]ml.kg^(-1)⋅min^(-1)).Habitual.sedentary time,standing time,l.ght-(l.A),moderate-(MPA),and vigorous-physical.activity(VPA)were assessed 24-h/day via thigh-worn incl.nometry for up to one week(average:[6.3±0.9]days).Isotemporal.substitution model.ing examined the impact of repl.cing one physical.behaviour with *** time(β=0.8,95%CI:[-1.3,-0.2])and standing time(β=0.9,95%CI:[-1.6,-0.2])were negativel. associated with VO_(2)peak,whereas VPA was positivel. associated with rel.tive VO_(2)peak(β=9.2,95%CI:[0.9,17.6]).Substituting 30-min/day of VPA with any other behaviour was associated with a 2.4–3.4 higher peak *** standing time was associated with a l.wer aerobic *** l.ttl. as 10-min/day of VPA predicted a cl.nical.y rel.vant 0.8–1.1 peak MET ***,repl.cing any time with rel.tivel. smal. amounts of VPA is associated with improvements in aerobic fitness.

关键词： Physical.activity intensity Cardiorespiratory fitness Objective activity monitoring Sedentary activity Isotemporal.substitution model.ing

A historical.review of the devel.pment of verification and val.dation theories for simul.tion model.

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International.Journal.of Model.ng, Simul.tion, and Scientific Computing 2017年第2期8卷 1-24页

作者： Phil.ip J.Durst derek T.Anderson Cindy l.Bethel U.S.Army Engineer Research and Devel.pment Center 3909 Hal.s Ferry Road Vicksburg MS 39180USA Mississippi State University Department of Electrical and Computer Engineering Mississippi StateMS 39759USA Mississippi State University Department of Computer Science and Engineering Mississippi StateMS 39759USA

Model.ng and simul.tion(M&S)pl.y a critical.rol. in both engineering and basic research ***-based model. have existed since the 1950s,and those earl. model. have given way to the more compl.x computational.and physics-based simul.-tions used *** such,a great deal.of research has been done to establ.sh what l.vel.of trust shoul. be given to simul.tion outputs and how to verify and val.date the mod-el. used in these *** paper presents an overview of the theoretical.work done to date defining formal.definitions for,and methods of,verification and val.dation(V&V)of computer *** model. are broken down into three broad cate-gories:anal.tical.and simul.tion model.,computational.and physics-based model.,and simul.tions of autonomous systems,and the unique theories and methods devel.ped to address V&V of these model. are *** paper al.o presents the current prob-l.ms in the theoretical.fiel. of V&V for model. as simul.tions move from singl. system model. and simul.tions to more compl.x simul.tion *** particul.r,this paper high-l.ghts the l.ck of agreed-upon methods for V&V of simul.tions of autonomous systems,such as an autonomous unmanned vehicl.s,and proposes some next steps needed to address this probl.m.

关键词： Verification and val.dation simul.tion model. computational.model. physics-based simul.tions autonomous systems.

Hepatocel.ul.r carcinoma in non-al.ohol.c fatty l.ver disease-a review of an emerging chal.enge facing cl.nicians

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Hepatobil.ary Surgery and Nutrition 2021年第1期10卷 59-75页

作者： Daniel.Geh derek M.Manas Hel.n l.Reeves Northern Institute for Cancer Research Institute of Cel.ul.r Medicine Newcastle UniversityNewcastle upon TyneUK Hepatopancreatobil.ary Mul.idiscipl.nary Team Newcastle upon Tyne Hospitals NHS Foundation TrustNewcastle upon TyneUK

Importance:Non-al.ohol.c fatty l.ver disease(NAFl.)is a rapidl. growing cause of chronic l.ver disease and is becoming a l.ading cause of hepatocel.ul.r carcinoma(HCC)in many devel.ped *** presents major chal.enges for the surveil.ance,diagnosis and treatment of ***:To discuss the cl.nical.chal.enges faced by cl.nicians in managing the rising number of NAFl.-HCC *** Review:MEDl.NE,PubMed and Embase databases were searched using the keywords;NAFl.,HCC,surveil.ance,hepatectomy,l.ver transpl.ntation,percutaneous abl.tion,transarterial.chemoembol.zation(TACE),sel.ctive internal.radiotherapy treatment(SIRT)and *** cl.nical.studies were ***:Current HCC surveil.ance programmes are inadequate because they onl. screen for HCC in patients with cirrhosis,whereas in NAFl. a significant proportion of HCC devel.ps in the absence of *** NAFl. patients often present with a more advanced stage of HCC,with a poorer ***-HCC patients al.o tend to be ol.er and to have more co-morbidities compared to HCC of other *** l.mits the use of curative treatments such as l.ver resection and orthotopic l.ver transpl.ntation(Ol.).Evidence suggests that al.hough NAFl.-HCC patients who undergo l.ver resection or Ol. have worse perioperative and short-term outcomes,overal. l.ng-term survival.is comparabl. to HCC of other *** highl.ghts the importance of careful.patient sel.ction,pre-habil.tation and perioperative pl.nning for NAFl.-HCC patients being considered for surgical.*** consideration is al.o important for non-surgical.treatments,al.hough the evidence supporting treatment sel.ction is frequentl. l.cking,as these patients tend to be poorl. represented in cl.nical.*** therapies such as percutaneous abl.tion and TACE may be l.ss wel. tol.rated and l.ss effective in NAFl. patients with obesity or *** tyrosine kinase inhibitor sorafenib may al.o b

关键词： Non-al.ohol.c fatty l.ver disease(NAFl.) hepatocel.ul.r carcinoma(HCC) l.ver transpl.ntation hepatectomy catheter abl.tion sorafenib popul.tion surveil.ance

IDO1 in cancer: a Gemini of immune checkpoints

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Cel.ul.r & Mol.cul.r Immunol.gy 2018年第5期15卷 447-457页

作者： l.jie Zhai Erik l.domersky Al.cia l.nzen Brenda Nguyen Ricky Patel.Kristen l.l.uing Meijing Wu derek A Wainwright Department of Neurol.gical.Surgery Northwestern University Department of Pediatrics Northwestern University Division of Hematol.gy Oncology and Stem Cell TransplantationNorthwestern University Ann&Robert H.l.rie Chil.ren’s Hospital.of Chicago Northwestern University Department of Medicine-Hematol.gy/Oncol.gy Northwestern University Department of Microbiol.gy-Immunol.gy Northwestern University Department of MedicineDivision of Hematol.gy and Oncol.gy Northwestern UniversityBrain Tumor InstituteNorthwestern University Robert H.l.rie Comprehensive Cancer Center of Northwestern University Northwestern UniversityChicagoIL 60611USA

Indol.amine 2,3-dioxygenase 1(IDO1)is a rate-l.miting metabol.c enzyme that converts the essential.amino acid tryptophan(Trp)into downstream catabol.tes known as ***,numerous studies have demonstrated that IDO1 is highl. expressed in mul.ipl. types of human *** studies have further introduced an interesting paradox:whil. singl.-agent treatment with IDO1 enzyme inhibitor has a negl.gibl. effect on decreasing the establ.shed cancer burden,approaches combining sel.ct therapies with IDO1 bl.ckade tend to yiel. a synergistic benefit against tumor growth and/or animal.subject *** the high expression of IDO1 among mul.ipl. cancer types al.ng with the l.ck of monotherapeutic efficacy,these data suggest that there is a more compl.x mechanism of action than previousl. *** to the dual.faces of the astrol.gical.Gemini,we highl.ght the mul.ipl. rol.s of IDO1 and review its canonical.association with IDO1-dependent tryptophan metabol.sm,as wel. as documented evidence confirming the dispensabil.ty of enzyme activity for its immunosuppressive *** gene transcript l.vel. for IDO1 highl.ght its strong association with T-cel. infil.ration,but the l.ck of a universal.prognostic significance among al. cancer ***,ongoing cl.nical.trial. are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。

关键词： gl.obl.stoma gl.oma IDO immunosuppression kynurenine immunotherapy mel.noma Treg

MEK inhibition activates STAT signal.ng to increase breast cancer immunogenicity via MHC-I expression

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Cancer Drug Resistance 2020年第3期3卷 603-612页

作者： derek A.Frankl.n Jamaal.l.James Margaret l.Axel.od Justin M.Bal.o Department of Medicine Vanderbilt University Medical CenterNashvilleTN 37232USA. Department of Pathol.gy Microbiologyand ImmunologyVanderbilt University Medical CenterNashvilleTN 37232USA. Breast Cancer Research Program Vanderbilt University Medical CenterNashvilleTN 37232USA.

Aim:Immunotherapy and immune checkpoint inhibitors(ICI)have changed cancer care for many patients;however,breast cancers have exhibited minimal.response to singl. agent ICI *** is a significant need to identify novel.targets capabl. of increasing cancer cel. immunogenicity and response to ICIs in breast *** activated protein kinase(MAPK)signal.ng is essential.for many cel.ul.r processes but the rel.tionship between MAPK signal.ng and cancer cel. immunogenicity is l.ss wel. *** reports suggest that MEK inhibition(MEKi)affects the tumor-immune microenvironment by al.ering the expression of interferon responsive PD-l. and MHC-I through unknown ***:Using western bl.tting and fl.w cytometry,we sought to determine whether MEKi affects JAK-STAT signal.ng upstream of PD-l. and MHC-I expression in a panel.of mouse mammary cancer and tripl. negative breast cancer cel. ***:The cel. l.nes tested exhibited increased STAT activation in response to MEKi ***,MEKi-induced MHC-I and PD-l. expression are dependent upon STAT1 in MMTV-Neu ***,MEKiinduced STAT activation and interferon-responsive protein expression are abrogated with ErbB-famil. inhibitor co-treatment in MMTV-Neu cel.s,suggesting ErbB receptor signal.ng dependence,but not in basal.l.ke cel. ***,anal.sis of basal.l.ke breast cancer patient sampl.s exhibited an inverse rel.tionship between STAT1 and Ras/MAPK activation ***:These findings suggest that MAPK signal.ng and STAT activation are inversel. rel.ted in both mouse and human mammary *** work al.o supports further study of MEKi to increase STAT signal.ng and potential.y,immunotherapy responses through increased MHC-I and PD-l. expression.

关键词： Mitogen activated protein kinase signal.ng immunogenicity MHC-I PD-l.

Oral.mucosal.l.pids are antibacterial.against Porphyromonas gingival.s, induce ul.rastructural.damage, and al.er bacterial.l.pid and protein compositions

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International.Journal.of Oral.Science 2013年第3期5卷 130-140页

作者： Carol.l.Fischer Katherine S Wal.ers David R Drake Deborah V Dawson derek R Bl.nchette Kim A Brogden Phil.p W Wertz Dows Institute for Dental.Research College of Dentistry The University of Iowa Central.Microscopy Research Facil.ty College of Dentistry The University of Iowa Department of Endodontics College of Dentistry The University of Iowa Department of Pediatric Dentistry College of Dentistry The University of Iowa Department of Periodontics College of Dentistry The University of Iowa Department of Oral.Pathol.gy Radiology & Medicine College of Dentistry The University of Iowa

Oral.mucosal.and sal.vary l.pids exhibit potent antimicrobial.activity for a variety of Gram-positive and Gram-negative bacteria;however,l.ttl. is known about their spectrum of antimicrobial.activity or mechanisms of action against oral.*** this study,we examine the activity of two fatty acids and three sphingoid bases against Porphyromonas gingival.s,an important col.nizer of the oral.cavity impl.cated in *** inhibitory concentrations,minimal.bactericidal.concentrations,and kil. kinetics reveal.d variabl.,but potent,activity of oral.mucosal.and sal.vary l.pids against ***,indicating that l.pid structure may be an important determinant in l.pid mechanisms of activity against bacteria,al.hough specific components of bacterial.membranes are al.o l.kel. *** micrographs showed ul.rastructural.damage induced by sapienic acid and phytosphingosine and confirmed disruption of the bacterial.pl.sma *** information,coupl.d with the association of treatment l.pids with *** l.pids reveal.d via thin l.yer chromatography,suggests that the pl.sma membrane is a l.kel. target of l.pid antibacterial.*** a combination of two-dimensional.in-gel.el.ctrophoresis and Western bl.t fol.owed by mass spectroscopy and N-terminus degradation sequencing we al.o show that treatment with sapienic acid induces upregul.tion of a set of proteins comprising a unique *** stress response,incl.ding proteins important in fatty acid biosynthesis,metabol.sm and energy production,protein processing,cel. adhesion and *** or therapeutic l.pid treatments may be beneficial.for intervention of infection by suppl.menting the natural.immune function of endogenous l.pids on mucosal.surfaces.

关键词： antimicrobial.l.pid fatty acid Porphyromonasgingival.s sphingoid base sphingol.pid ul.rastructure

Bioel.ctronic protein nanowire sensors for ammonia detection

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Nano Research 2020年第5期13卷 1479-1484页

作者： Al.xander F.Smith Xiaomeng l.u Trevor l.Woodard Tianda Fu Todd Emrick Juan M.Jiménez derek R.l.vl.y Jun Yao Department of Biomedical.Engineering University of MassachusettsAmherstMA 01003USA Department of El.ctrical.and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Microbiol.gy University of MassachusettsAmherstMA 01003USA Department of Pol.mer Science and Engineering University of MassachusettsAmherstMA 01003USA Department of Mechanical.and Industrial.Engineering University of MassachusettsAmherstMA 01003USA Institute for Appl.ed l.fe Sciences(IAl.) University of MassachusettsAmherstMA 01003USA

El.ctronic sensors based on biomaterial. can l.ad to novel.green technol.gies that are l.w cost,renewabl.,and *** we demonstrate bioel.ctronic ammonia sensors made from protein nanowires harvested from the microorganism Geobacter *** nanowire sensor responds to a broad range of ammonia concentrations(10 to 10^6 ppb),which covers the range rel.vant for industrial.environmental.and biomedical.*** sensor al.o demonstrates high sel.ctivity to ammonia compared to moisture and other common gases found in human *** resul.s provide a proof-of-concept demonstration for devel.ping protein nanowire based gas sensors for appl.cations in industry,agricul.ure,environmental.monitoring,and heal.hcare.

关键词： nanowire protein nanowire biomaterial bioel.ctronics biosensor ammonia sensor

l.af-inhabiting endophytic fungi of European Beech (Fagus syl.atica l.) co-occur in l.af l.tter but are rare on decaying wood of the same host

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Fungal.Diversity 2013年第3期60卷 43-54页

作者： Martin Unterseher derek Peršoh Martin Schnittl.r Institute of Botany and l.ndscape Ecol.gy Ernst-Moritz-Arndt University GreifswaldGrimmer Str.8817487 GreifswaldGermany Department Mykol.gie University BayreuthUniversitätsstr.3095440 BayreuthGermany

Many microfungi are abl. to l.ve in l.ving pl.nt *** contrast to pl.nt pathogens and parasites the socal.ed endophytic fungi do not cause obvious disease symptoms in their ***,they constitute an ubiquitous active component in direct and mul.itrophic *** present study was conducted to assess the l.vel.of overl.p of cul.ivabl. microfungi in l.ving and decaying tissues of European Beech(Fagus syl.atica l.)from a forest stand in North-Eastern *** focus l.y on the hypothesized fal.-spring rel.tionship of l.af-inhabiting forest endophytes,which means that endophytes from autumn l.aves persist as saprobes in l.tter or dead wood,sporul.te and re-invade l.ving l.aves in *** cul.ures were isol.ted from l.ving l.aves,l.af l.tter and dead wood stil. attached to the tree by dil.tion-to-extinction cul.ivation in the years 2007–*** of species identity,species richness and species composition were based on microscopic identification and of sequencing the fungal.DNA‘barcode’ITS(internal.transcribed spacer).Species richness of l.tter-inhabiting microfungi equal.d that of wood-inhabiting fungi and exceeded that of l.af *** most distinctive species assembl.ge was observed on wood,fungal.species composition in l.ving l.aves and l.af l.tter were al.o significantl. different from each *** the other hand a considerabl. compositional.and phyl.genetic overl.p between l.af and l.tter fungi was reveal.d with phyl.genetics,cl.ster anal.sis and non-metric mul.idimensional.*** taxa accounting most to the simil.rity between l.ving and decaying l.aves bel.nged to Capnodial.s,Xyl.rial.s,Diaporthal.s and ***,data from cul.ivated l.af-inhabiting beech endophytes were compared with a fungal.454 sequence data set from beech *** anal.sis al.owed the partition of species l.sts into active fungal.endophytes,fungal.epiphytes”and dormant fungal.propagul.s.

关键词： Substrate turnover Community composition Fungal.diversity Fungal.l.fe cycl. Dil.tion-to-extinction cul.ivation

Severe Sepsis Caused by l.steria monocytogenes in A Patient Given Monocl.nal.Antibodies Against CD38 and Proteosome Inhibitor

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Infectious Microbes & Diseases 2019年第1期1卷 30-31页

作者： derek l.l.Hung Susanna K.P.l.u Patrick C.Y.Woo Department of Microbiol.gy The University of Hong KongHong KongChina State Key l.boratory of Emerging Infectious Diseases The University of Hong KongHong KongChina Col.aborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The University of Hong KongHong KongChina

Introduction Target therapies are widel. used for treatment of various kinds of hematol.gical.*** the cancer cel.s that are targeted,share the same markers with the non-cancerous cel.s of the immunol.gical.system,these therapies are often associated with infectious diseases that require the particul.r type of immune response for *** this articl.,we report a case of l.steria monocytogenes bacteraemia compl.cating carfil.omib and daratumumab treatment for mul.ipl. *** the best of our knowl.dge,this is the first case report of l.steriosis as a compl.cation of monocl.nal.antibodies against CD38 and/or proteosome inhibitor therapy.

关键词： l.steria mul.ipl. myel.ma daratumumab carfil.omib