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World Journal of Pediatrics 2024年第6期20卷 590-601页

作者： Meng-Jie Tang Xiao-Li Ma Xiang-Ling He Wei-Hua Pan Xiao-Hong Zhang Sha-Yi Jiang Ju Gao fu Li Wei Yao Song Gu Wei-Ling Zhang Qiang Zhao Shi-Hao huang Yong-Jun Fang Wei Liu Hui-Zhong Niu Chun-Mei wang Li-Rong Sun Hui Gao Yun-Peng Dai Shun-Gen huang Zhi-Yong Zhong Xi-Ge wang Zhong-Rong Li liang-Chun Yang Ye-Ming Wu Huan-Min wang Xin Sun Xiao-Jun Yuan department of Pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadYangpu DistrictShanghai 200092China medical Oncology department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China department of Hematology/Oncology Children's Medical CenterHunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 41005China department of Pediatric Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China department of Hematology/Oncology Guangzhou Women and Children's Medical CenterNational Children's Medical Center for South Central RegionGuangzhou 510623China department of Hematology Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041China department of Hematology/Oncology Qilu Children's Hospital of Shandong UniversityJinan 250022China department of Pediatric Surgery Children's Hospital of Fudan UniversityShanghai 201102China department of General Surgery Shanghai Children's Medical Center(National Children's Medical Center-Shanghai)Shanghai Jiao Tong University School of MedicineShanghai 200127China department of Pediatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China department of Hematology/Oncology Children's Hospital of Nanjing Medical UniversityNanjing 210008China department of Hematology/Oncology Henan Children's HospitalZhengzhou 450018China department of Pediatric General Surgery Hebei Children's Hospital of Hebei Medical UniversityShijiazhuang City 050031China Children's hospital the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China department of Paediatric

Background This study aimed to identify survival risk factors in Chinese children with hepatoblastoma(HB)and assess the effectiveness of the new treatment protocol proposed by the Chinese Children's Cancer Group(CCCG)in *** A multicenter,prospective study that included 399 patients with HB from January 2015 to June 2020 was *** demographics,treatment protocols,and other related information were *** regression models and Kaplan-Meier curve methods were *** The 4-year event-free survival(EFS)and overall survival(OS)were 76.9 and 93.5%,*** 4-year EFS rates for the very-low-risk,low-risk,intermediate-risk,and high-risk groups were 100%,91.6%,81.7%,and 51.0%,*** 4-year 0S was 100%,97.3%,94.4%,and 86.8%,*** regression analysis found that age,tumor rupture(R+),and extrahepatic tumor extension(E+)were independent prognostic factors.A total of 299 patients had complete remission,and 19 *** with declining alpha-fetoprotein(AFP)>75%after the first two cycles of neoadjuvant chemotherapy had a better EFS and OS than those≤75%.Conclusions The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2016 ***≥8 years,R+,and E+were independent risk factors for *** with a declining AFP>75%after the first two cycles of neoadjuvant chemotherapy had better EFS and OS.

关键词： Alpha-fetoprotein Hepatoblastoma Multicenter Prospective study Survival

Evaluation of a new frequency-volume chart for children with primary monosymptomatic nocturnal enuresis:a prospective,comparative study

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World Journal of Pediatrics 2021年第6期17卷 643-652页

作者： Jing-Jing wang Dong-Jie wang Hai-Dong fu De-Xuan wang Qing Yang Xiao-Jie Peng Rui fu Huan-Dan Yang Rui-Feng Zhang Xiao-Wen wang Jiang-Wei Luan Fei Zhao Qiu-Xia Chen Fang-Fang liang Lu Cao Jian-Jiang Zhang Ying-Jie Li Yang Dong Hui-Mei huang Ying Bao Xiao-Yu Shen Wei Zhou guang-Hai Cao Cui-Hua Liu Yan-Yan Jin Mei-Lin Ma Li Jiang Qian Shen Hong Xu Jian-Hua Mao department of Nephrology TChildren's Hospital of Zhejiang University School of MedicineNational Clinical Research Center of Child HealthHangzhouChina department of Nephrology The Second Attiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhouChina department of Nephrology Jiangxi Provincial Children's HospitalNanchangChina department of Nephrology Xuzhou Children's HospitalXuzhou Medical UniversityXuzhouChina department of Nephrology Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina department of Nephrology Children's Hospital of Nanjing Medical UniversityNanjingChina department of Rheumatology Shenzhen Children's HospitalShenzhenChina department of Pediatrics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina department of Nephrology Guangzhou Women and Children's Medical CenterGuangzhouChina department of Nephrology Anhui Provincial Children's HospitalHefeiChina department of Nephrology The Affiliated Children Hospital of Xi'an Jiaotong UniversityXi'anChina department of Nephrology Shanghai Children's Medical CenterShanghaiChina department of Nephrology and Rheumatology Children's Hospital Affiliated to ZhengZhou UniversityHenan Children's HospitalZhengZhou Children's HospitalZhengZhouChina medical Affairs department Ferring Pharmaceuticals(Asia)Company LimitedShanghaiChina Marketing department Ferring Pharmaceuticals(Asia)Company LimitedShanghaiChina department of Nephrology The Children's Hospital of Fudan UniversityShanghaiChina

Introduction To improve compliance with voiding diaries in children with primary monosymptomatic nocturnal enuresis(PMNE),a new modified 3-day weekend frequency-volume chart(FVC)was designed,and the compliance and validity of this modified FVC was evaluated by comparing with the International Children's Continence Society(ICCS)recommended voiding *** A total of 1200 patients with PMNE were enrolled in the study from 13 centers in china and were randomly assigned to record this modified FVC or the ICCS-recommended voiding *** primary outcome measure was the compliance,assessed by comparing the completing index and the quality score of diaries between two *** secondary outcome measure was the validity,evaluated by comparing the constituent of subtypes,micturition parameters and response rate to *** Among the 1200 participants enrolled in the study,447 patients completed the ICCS-recommended voiding diary and 469 completed the modified *** diurnal completing index and the quality score of the modified FVC group were better than those of the ICCS *** addition,there was no significant difference between these two groups in the subtype classification,or in the response rate to *** The modified FVC could be applied to obtain the voiding characteristics of children with PMNE as the ICCS-recommended voiding diary does and offers a reasonable and better choice for children with PMNE from the unselected population in the future.

关键词： Children Compliance Nocturnal enuresis Voiding diary

Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia(2021 Edition)

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Military medical Research 2022年第5期9卷 515-533页

作者： Xian-Tao Zeng Ying-Hui Jin tong-Zu Liu Fang-Ming Chen De-Gang Ding Meng fu Xin-Quan Gu Bang-Min Han Xing huang Zhi Hou Wan-Li Hu Xin-Li Kang Gong-Hui Li Jian-Xing Li Pei-Jun Li Chao-Zhao liang Xiu-Heng Liu Zhi-Yu Liu Chun-Xiao Liu Jiu-Min Liu guang-Heng Luo Yi Luo Wei-Jun Qin Jian-Hong Qiu Jian-Xin Qiu Xue-Jun Shang Ben-Kang Shi Fa Sun Guo-Xiang Tian Ye Tian Feng wang Feng wang Yin-Huai wang Yu-Jie wang Zhi-ping wang Zhong wang Qiang Wei Min-Hui Xiao Wan-Hai Xu Fa-Xian Yi Chao-Yang Zhu Qian-Yuan Zhuang Li-Qun Zhou Xiao-Feng Zou Nian-Zeng Xing Da-Lin He Xing-Huan wang 无 department of Urology Institute of UrologyZhongnan Hospital of Wuhan UniversityWuhan430071China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan430071China department of Urology Tianjin Third Central Hospital Affiliated To Nankai UniversityTianjin300170China department of Urology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou450003China department of Urology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China department of Urology China-Japan Union Hospital of Jilin UniversityChangchun130033China department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China department of Urology Qinghai University Affiliated HospitalXi’ning810012China department of Urology People’s Hospital of Hainan ProvinceHainan Affiliated Hospital of Hainan Medical University HaikouHaikou570311China department of Urology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016China department of Urology General Hospital of Ningxia Medical UniversityYinchuan750003China department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China department of Urology Renmin Hospital of Wuhan UniversityWuhan430060China department of Urology The Second Hospital of Dalian Medical UniversityDalian116023LiaoningChina department of Urology Zhujiang Hospital of Southern Medical UniversityGuangzhou510282China department of Urology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China department of Urology Surgery Guizhou Province People’s HospitalGuiyang550002China department of Urology Xijing Hospital of Air Force Military Medical UniversityXi’an710032China department of Urology The 980St Hospital of the PLA Joint Logistics Support Force(Bethune International Peace Hospital of PLA)Shijiazhuang050082China department of Urology

Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Transurethral plasmakinetic resection of prostate (TUPKP) is one of the foremost surgical procedures for the treatment of BPH. It has become well established in clinical practice with good efficacy and safety. In 2018, we issued the guideline “2018 Standard Edition”. However much new direct evidence has now emerged and this may change some of previous recommendations. The time is ripe to develop new evidence-based guidelines, so we formed a working group of clinical experts and methodologists. The steering group members posed 31 questions relevant to the management of TUPKP for BPH covering the following areas: questions relevant to the perioperative period (preoperative, intraoperative, and postoperative) of TUPKP in the treatment of BPH, postoperative complications and the level of surgeons’ surgical skill. We searched the literature for direct evidence on the management of TUPKP for BPH, and assessed its certainty generated recommendations using the grade criteria by the European Association of Urology. Recommendations were either strong or weak, or in the form of an ungraded consensus-based statement. Finally, we issued 36 statements. Among them, 23 carried strong recommendations, and 13 carried weak recommendations for the stated procedure. They covered questions relevant to the aforementioned three areas. The preoperative period for TUPKP in the treatment of BPH included indications and contraindications for TUPKP, precautions for preoperative preparation in patients with renal impairment and urinary tract infection due to urinary retention, and preoperative prophylactic use of antibiotics. Questions relevant to the intraoperative period incorporated surgical operation techniques and prevention and management of bladder explosion. The application to different

关键词： Transurethral plasmakinetic resection of prostate Benign prostatic hyperplasia Recommendation Treatment Guideline

Diagnosis and Treatment of Cholangiocarcinoma: A Consensus from Surgical Specialists of china

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Journal of Huazhong University of Science and Technology(medical Sciences) 2014年第4期34卷 469-475页

作者： Jian-qiang Cai Shou-wang Cai Wen-ming Cong Min-shan Chen ping Chen Xiao-ping Chen Yan-ling Chen Yi-fa Chen Chao-liu Dai Qiang huang Zhi-yong huang Bo Jiang Bin Jiang Ke-wei Jiang Bo Li Zong-fangLi Li-jian liang Bin Liu Hui-chun Liu Lian-xin Liu Qing-guang Liu Rong Liu Ying-bin Liu Jian-guo Lu Shi-chun Lu Yi Lu Yi-lei Mao Bin Mei Jun Niu Bao-gang Peng Xiao Qin Yu-dong Qiu guang-yi wang Yao-don wangg Zhi-ming wang Ren-hua Wan Ya-fu Wu Bao-cai Xing Feng Xia Ge-liang Xu Jia-mei Yang Xiao-fang Yu Yong Zeng Yong-yi Zeng Bi-xiang Zhang Bin-hao Zhang Qi-yu Zhang Shui-jun Zhang Wan-guang Zhang Yong-jie Zhang Zhi-wei Zhang Dong Zhou Wei-ping Zhou Cancer Institute and hospital Chinese Academy of Medical Sciences Chinese PLA General hospital Eastern Hepatobiliary Surgery hospital of second Military medical University Sun Yat-sen University Cancer Center Daping hospital of Third Military medical University tongji hospital Tongji Medical CollegeHuazhong University of Science and Technology fujian medical University Union hospital Shengjing hospital of china medical University Anhui Provincial hospital Hunan Provincial People’s hospital Taihe hospital affiliated to Hubei University of Medicine Peking University People’s hospital West china hospital Sichuan University The second affiliated hospital of Xi’an Jiao tong University The First affiliated hospital Sun Yat-sen University First affiliated hospital of Kunming medical University The First affiliated hospital of Bengbu medical college The First affiliated hospital of Harbin medical University The First affiliated hospital of Xi’an Jiao tong University Xinhua hospital affiliated to Shanghai Jiao tong University School of Medicine Tangdu hospital of Fourth Military medical University Peking Union medical college hospital Qilu hospital of Shandong University The First affiliated hospital of guangxi medical University Nanjing Drum Tower hospital The First affiliated hospital of Jilin University fujian Provincial hospital Xiangya hospital of Central South University The First affiliated hospital of Nanchang University Beijing Cancer hospital Southwest hospital of Third Military medical University Shenzhen People’s hospital The First affiliated hospital of fujian medical University The First affiliated hospital of wenzhou medical University The First affiliated hospital of Zhengzhou University fujian Provincial Cancer hospital

Cholangiocarcinoma refers to malignant tumors that develop in epithelial lining of biliary system, and it is divided into two categories according to tumor location, intrahepatic cholangiocarcinoma （ICC） and extrahepatic cholangiocarcinoma （ECC）. ICC occurs from the epithelial cells of the intrahepatic bile duct, its branches and interlobular biliary tree; and ECC is divided into hilar cholangiocarcinoma and distal cholangiocarcinoma by the circumscription at the confluence of cystic duct and the common hepatic duct.

关键词： A Consensus from Surgical Specialists of china Diagnosis and Treatment of Cholangiocarcinoma

Application of Keyhole Microneurosurgery in china

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Chinese medical Journal 2017年第16期130卷 1987-1994页

作者： Li-Gang Chen Shu-Da Chen guang-fu huang Ying huang De-Zhi Kang Qing Lan Gang Li Xin-Gang Li Zhi-Xiong Liu Song-Tao Qi Xin-Hua Tian Guo-liang wang Shuo wang Xiang-Yu wang Yong-Fei wang Yun-Jie wang Chao You Yan-Bing Yu Shu-Yuan Yue Dong Zhang Jian-Min Zhang Jian-Ning Zhang Jun-Ting Zhang Shi-Zhong Zhang Xian Zhang Ya-Zhuo Zhang Ji-Zong Zhao Wei-Guo Zhao Yuan-Li Zhao Ding-Biao Zhou liang-fu Zhou department of Neurosurgery The Affiliated Hospital of Southwest Medical University Luzhou Sichuan 646000 China department of Neurosurgery Zhejiang Provincial People's Hospital Hangzhou Zhejiang 310014 China department of Neurosurgery Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China department of Neurosurgery Tianjin Huanhu Hospital Tianjin 300060 China department of Neurosurgery The First Affiliated Hospital of Fujian Medical University Fuzhou Fujian 350005 China department of Neurosurgery The Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China department of Neurosurgery Qilu Hospital of Shandong University Jinan Shandong 250012 China department of Neurosurgery Xiangya Hospital of Central South University Changsha Hunan 410008 China department of Neurosurgery Nanfang Hospital of Southern Medical University Guangzhou Guangdong 510515 China department of Neurosurgery The Affiliated Zhongshan Hospital of Xiamen University Xiamen Fujian 361004 China department of Neurosurgery General Hospital of Guangzhou Military Command of PLA Guangzhou Guangdong 510010 China department of Neurosurgery The Affiliated Beijing Tiantan Hospital of Capital Medical University Beijing 100050 China department of Neurosurgery The First Affiliated Hospital of Jinan University Guangzhou Guangdong 510630 China department of Neurosurgery The Affiliated Huashan Hospital of Fudan University Shanghai 200040 China department of Neurosurgery The First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China department of Neurosurgery West China Hospital of Sichuan University Chengdu Sichuan 610041 China department of Neurosurgery Sino-Japanese Friendship Hospital Beijing 100029 China department of Neurosurgery General Hospital of Tianjin Medical University Tianjin 300052 China department of Neurosurgery The Second Affiliated Hospital of Zhejiang University Medical College Hangzhou Zhejiang 310009 China department of

INTRODUCTIONMicroneurosurgery made its debut in the early 1960s. It became popular in the medical field and became a primary operation method in neurosurgery since it improved the efficacy of neurosurgery with a less surgery-related injury. Over the past five decades, the accumulation of experience of microsurgery, improvement of microsurgery techniques, refined micro-instruments, and advanced preoperative diagnostic imaging allowed the evolution of microneurosurgery techniques and further reduced surgery-related trauma.

关键词： china: Keyhole Surgery Microneurosurgery

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-liang Li Ming-Sheng huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua huang Wei Mu Shan-Zhi Gu Jia-ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-wang Yuan Wei-Dong wang Ming huang Wei Zhao Jian-Bing Wu Song wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian wang Feng Dai Dui-ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China department of Interventional Radiology Nantong First People’s HospitalNantong 226001China department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

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Biomarkers of aging

Science china(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao liang Rui liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang wang Qiaoran wang Siyuan wang Xuan wang Yaning wang Yuhan wang Rimo Wu Kai Xia fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen wang Si wang Xia wang Xiaoning wang Yan-Jiang wang Yunfang wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei guang-Hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 227-252,I0011-I0014页

作者： Hui-Chuan Sun Jian Zhou Zheng wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao huang Zhiyong huang Deyu Li Gang Li Tao Li Xiangcheng Li guangming Li Xiao liang Jingfeng Liu fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song guang Tan Yunqiang Tang Kaishan Tao Chidan Wan guangyi wang Lu wang Shunxiang wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin wang Tingbo liang Jiahong Dong Xiaoping Chen Xuehao wang Shusen Zheng Jia Fan 无 department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina department of medical Oncology of PLA Cancer Center Jinling HospitalNanjingChina department of Infectious Disease Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of Liver Surgery The First Affiliated Hospital of USTCHefeiChina Minimally Invasive Interventional Division Sun Yat-sen University Cancer CenterGuangzhouChina department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina department of Radiation Oncology Beijing Tsinghua Changgung HospitalBeijingChina department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina department of Pathology Fudan University Shanghai Cancer CentreShanghaiChina department of Liver Surgery Sun Yat-sen University Cancer CentreGuangzhouChina department of Hepatobiliary Surgery Clinical Medical CollegeYangzhou UniversityYangzhouChina department of Hepatobiliopancreatic Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Division of Hepatobiliary Surgery Department of General SurgeryRuijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina department of Hepatobiliary and Splenic Surgery Shengjing Hospital Affiliated to China Medical UniversityShenyangChina The department of Hepatobiliary Oncology of Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouChina department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Sarcoma CenterPeking University Cancer Hospital and InstituteBeijingChina department of Hepatobili

Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response *** has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’***,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being *** the evidence for conversion therapy in HCC and develop consensus statements to guide clinical *** review:Many research centers in china have accumulated significant experience implementing HCC conversion *** findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related *** order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical *** consensus statements on the implementation of conversion therapy for HCC were *** statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.

关键词： Hepatocellular carcinoma(HCC) conversion therapy surgical resection systematic treatment locoregional treatment consensus china

Lung-protective Ventilation in Patients with Brain Injury： A Multicenter Cross-sectional Study and Questionnaire Survey in china

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Chinese medical Journal 2016年第14期129卷 1643-1651页

作者： Xu-Ying Luo Ying-Hong Hu Xiang-Yuan Cao Yan Kang Li-ping Liu Shou-Hong wang Rong-Guo Yu Xiang-You Yu Xia Zhang Bao-Shan Li Zeng-Xiang Ma Yi-Bing Weng Heng Zhang De-Chang Chen Wei Chen Wen-Jin Chen Xiu-Mei Chen Bin Du Mei-Li Duan Jin Hu Yun-Feng Hoang Gui-Jun Jia Li-Hong Li Yu-Min liang Bing-Yu Qin Xian-Dong wang Jian Xiong Li-Mei Yan Zheng-ping Yang Chen-Ming Dong Dong-Xin wang Qing-Yuan Zhan Shuang-Lin fu Lin Zhao Qi-Bing huang Ying-guang Xie Xiao-Bo huang Guo-Bin Zhang wang-Bin Xu Yuan Xu YaLing Liu He-Ling Zhao Rong-Qing Sun Ming Sun Qing-Hong Cheng Xin Qu Xiao-Feng Yang Ming Xu Zhong-Hua Shi Han Chen Xuan He Yan-Lin Yang guang-Qiang Chen Xiu-Mei Sun Jian-Xin Zhou department of Critical Care Medicine Beijing Tiantan Hospital Capital Medical University Beijing 100050 China department of Critical Care Medicine Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China department of Critical Care Medicine General Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China department of Critical Care Medicine West China Hospital Sichuan University Chengdu Sichuan 610041 China Neurological Intensive Care Unit Beijing Tiantan Hospital Capital Medical University Beijing 100050 China department of Critical Care Medicine Guangdong General Hospital Guangzhou Guangdong 510000 China Surgical Intensive Care Unit Fujian Province Hospital Fuzhou Fujian 350000 China department of Critical Care Medicine First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China department of Critical Care Medicine Bethune International Peace Hospital Shijiazhuang Hebei 050000 China department of Critical Care Medicine Yuncheng Central Hospital Yuncheng Shanxi 044000 China department of Emergency and Critical Care Medicine Cangzhou People's Hospital Cangzhou Hebei 061000 China department of Critical Care Medicine Beijing Luhe Hospital Capital Medical University Beijing 101100 China department of Critical Care Medicine First Hospital of China Medical University Shenyang Liaoning 110000 China department of Critical Care Medicine Shanghai Changzheng Hospital Shanghai 200000 China department of Critical Care Medicine Beijing Shijitan Hospital Capital Medical University Beijing 100038 China department of Critical Care Medicine Xuanwu Hospital Capital Medical University Beijing 100053 China department of Critical Care Medicine Miyun County Hospital Beijing 100038 China medical Intensive Care Unit Peking Union Medical College Hospital Beijing 101500 China department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 Chin

Background： Over the years, the mechanical ventilation （MV） strategy has changed worldwide. The aim of the present study was to describe the ventilation practices, particularly lung-protective ventilation （LPV）, among brain-injured patients in china. Methods： This study was a multicenter, 1-day, cross-sectional study in 47 Intensive Care Units （ICUs） across china. Mechanically ventilated patients （18 years and older） with brain injury in a participating ICU during the time of the study, including traumatic brain injury, stroke, postoperation with intracranial tumor, hypoxic-ischemic encephalopathy, intracranial infection, and idiopathic epilepsy, were enrolled. Demographic data, primary diagnoses, indications for MV, MV modes and settings, and prognoses on the 60th day were collected. Multivariable logistic analysis was used to assess factors that might affect the use of LPV. Results： A total of 104 patients were enrolled in the present study, 87 （83.7%） of whom were identified with severe brain injury based on a Glasgow Coma Scale 〈8 points. Synchronized intermittent mandatory ventilation （SIMV） was the most frequent ventilator mode, accounting for 46.2% of the entire cohort. The median tidal volume was set to 8.0 ml/kg （interquartile range [IQR], 7.0-8.9 ml/kg） of the predicted body weight; 50 （48.1%） patients received LPV. The median positive end-expiratory pressure （PEEP） was set to 5 cmH20 （IQR, 5-5 cmH20）. No PEEP values were higher than 10 cmH20. Compared with partially mandatory ventilation, supportive and spontaneous ventilation practices were associated with LPV. There were no significant differences in mortality and MV duration between patients subjected to LPV and those were not. Conclusions： Among brain-injured patients in china, SIMV was the most frequent ventilation mode. Nearly one-half of the brain-injured patients received LPV. Patients under supportive and spontaneous ventilation were more likely to receive LPV.

关键词： Brain Injury Epidemiology Lung-protective Ventilation Mechanical Ventilation