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Effect of Bcl-2 and caspase-3 on calcium distribution in apoptosis of HL-60 cells

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Cell Research 2000年第3期10卷 213-220页

作者： ZHANG MIN, HONG QING ZHANG, SHAO BAI XUE (department of Biology, beijing Normal University, beijing 100875, china) department of Biology Beijing Normal University Beijing China

Apoptosis manifests in two major execution programs downstream of the death signal: the caspase pathway and organelle dysfunction. An important antiapoptosis factor, Bcl-2 protein, contributes in caspase pathway of apoptosis. Calcium, an important intracellular signal element in cells, is also observed to have changes during apoptosis, which maybe affected by Bcl-2 protein. We have previously reported that in Harringtonine (HT) induced apoptosis of HL-60 cells, there’s a change of intracellular calcium distribution, moving from cytoplast especially Golgi’s apparatus to nucleus and accumulating there with the highest concentration. We report here that caspase-3 becomes activated in HT-induced apoptosis of HL-60 cells, which can be inhibited by overexpression of Bcl-2 protein. No sign of apoptosis or intracellular calcium movement from Golgi’s apparatus to nucleus in HL-60 cells overexpressing Bcl-2 or treated with Ac-DEVD-CHO, a specific inhibitor of caspase-3. The results indicate that activated caspase-3 can promote the movement of intracellular calcium from Golgi’s apparatus to nucleus, and the process is inhibited by Ac-DEVD-CHO (inhibitor of caspase-3), and that Bcl-2 can inhibit the movement and accumulation of intracellular calcium in nucleus through its inhibition on caspase3. Calcium relocalization in apoptosis seems to be irreversible, which is different from the intracellular calcium changes caused by growth factor.

关键词： Apoptosis calcium caspase-3 bcl-2 laser scanning confocal microscopy (LSCM).

Multi-parameter infinite-dimensional(r,δ)-OU process

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Chinese Science Bulletin 1999年第5期44卷 418-423页

作者： WANG ZikunInstitute of Mathematics, Shantou University, Shantou 515063, china department of Mathematics, beijing Normal University, beijing 100875, china Institute of Mathematics Shantou University Shantou China department of Mathematics Beijing Normal University Beijing China

The definition of n-parameter infinite-dimensional (r, δ) -Ornstein-Uhlenbeck process {X_t (·)}((r,δ)-OUP_n~∞ for short) is given. The absolute continuity of distribution μ_t of X_t(·) and the limit of X_t(·) w... 详细信息

关键词： multi-parameter (r δ)-OUPn∞ absolute continuity in hierarchy.

AVERAGE σ-K WIDTH OF CLASS OF L_p(R^n) IN L_q (R^n)

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Chinese Annals of Mathematics,Series B 1995年第3期16卷 351-360页

作者： LIU YONGPING(department of Mathematics, beijing Normal University, Beliing 100875, china.) beijing NORMAL UNIV DEPT MATHBEIJING 100875PEOPLES R CHINA

The average σ-K width of the Sobolev-Wiener class in Lq(Rn) is studied for and the asymptotic behaviour of this quantity is determined. The exact value of average σ-K width of some class of smooth functions in L2(Rn... 详细信息

关键词： Average σ-K width Optimal subspace,Sobolev-Wiener class,Riesz potential.

On asymptotics of t-type regression estimation in multiple linear model

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Science china Mathematics 2004年第4期47卷 628-639页

作者： GUI Hengjiandepartment of Mathematics, beijing Normal University, beijing 100875, china department of Mathematics Beijing Normal University Beijing China

We consider a robust estimator (t-type regression estimator) of multiple linear regression model by maximizing marginal likelihood of a scaled t-type error *** marginal likelihood can also be applied to the de-correlated response when the withinsubject correlation can be consistently estimated from an initial estimate of the model based on the independent working assumption. This paper shows that such a t-type estimator is consistent.

关键词： t-type regression estimator, M-estimator, one-step estimate, consistency, asymptotic normality.

Theoretical study on the reaction mechanism of(CH_3)_3CO+CO

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Science china Chemistry 2005年第1期48卷 18-24页

作者： ZHAO Hongmei1,2,3, SUN Chengke1,4. ZHANG Rongchang3, XI Hongmin3 & LI Zonghe1 1. department of Chemistry, beijing Normal University, beijing 100875, china 2. The Laboratory of Molecular Reaction Dynamics, Institute of Chemistry, Chinese Academy of Sciences, beijing 100080, china 3. department of Chemistry, Beihua University, Jilin 132013, china 4. department of Chemistry, Qujing Normal University, Yunnan 655000, china department of Chemistry Beijing Normal University Beijing China The Laboratory of Molecular Reaction Dynamics Institute of Chemistry Chinese Academy of Sciences Beijing China department of Chemistry Beihua University Jilin China department of Chemistry Qujing Normal University Yunnan China

The reaction mechanism of (CH3)3CO with CO has been theoretically investigated using density-functional theory (DFT) calculations at B3LYP/6-31G* level. In order to get more reliable energy values the single-point energy is evaluated at CCSD (T)/6-31++G** level. The results show that the reaction is multi-channel and the reaction of (CH3)3CO radical with CO mostly produces (CH3)3C + CO2. The reaction could play a role in eliminating air pollution.

关键词： DFT, B3LYP, (CH3)3CO, radical.

The kink-soliton and antikink-soliton in quasi-one-dimensional nonlinear monoatomic lattice

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Science china(physics,Mechanics & Astronomy) 2005年第2期48卷 150-157页

作者： XU Quan1 & TIAN Qiang2 1. Scientific and Technological Office, Daqing Teacher College, Daqing 163712, china 2. department of physics , beijing Normal University, beijing 100875, china Scientific and Technological Office Daqing Teacher College Daqing China department of physics Beijing Normal University Beijing China

The quasi-one-dimensional nonlinear monoatomic lattice is analyzed. The kink-soliton and antikink-soliton are presented. When the interaction of the lattice is strong in the x-direction and weak in the y-direction, the two-dimensional (2D) lattice changes to a quasi-one-dimensional lattice. Taking nearest-neighbor interaction into account, the vibration equation can be transformed into the KPI, KPII and MKP equation. Considering the cubic nonlinear potential of the vibration in the lattice, the kink-soliton solution is presented. Considering the quartic nonlinear potential and the cubic interaction potential, the kink-soliton and antikink-soliton solutions are presented.

关键词： two-dimensional nonlinear lattice, quasi-one-dimensional nonlinear lattice, kink-soliton, antikink-soliton.

THE HAUSDORFF MEASURE FOR THE SAMPLE PATH OF THE WESTWATER PROCESS

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Chinese Annals of Mathematics,Series B 1996年第3期17卷 375-388页

作者： ZHOU XIANYIN(Depatment of Mathematics, beijing Normal University beijing 100875, china) department of Mathematics Beijing Normal University Beijing 100875 China

It is proved that φ(s) = s2 log |logs| is the correct function to give the Hausdorff measureof a sample path of the Westwater process.

关键词： Hausdorff measure Wiener process Westwater process Sojourn time

Entropy product measure for multipartite pure states

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Science china(physics,Mechanics & Astronomy) 2006年第5期49卷 606-615页

作者： CAO Wancang1,2, LIU Dan2, PAN Feng3 & LONG Guilu2,4.1. department of physics, Chifeng College, Chifeng 024.01, china 2. Key Laboratory for Quantum Information and Measurements, department of physics, Tsinghua University, beijing 100084. china 3. department of physics, Liaoning Normal University, Dalian 116029, china 4. Key Laboratory for Atomic and Molecular Nano-Sciences, Tsinghua University, beijing 100084. china Correspondence should be addressed to Long Guilu department of physics Chifeng College Chifeng China Key Laboratory for Quantum Information and Measurements Department of Physics Tsinghua University Beijing China department of physics Liaoning Normal University Dalian China Key Laboratory for Atomic and Molecular Nano-Sciences Tsinghua University Beijing China

An entanglement measure for multipartite pure states is formulated using the product of the von Neumann entropy of the reduced density matrices of the constituents. Based on this new measure, all possible ways of the maximal entanglement of the triqubit pure states are studied in detail and all types of the maximal entanglement have been compared with the result of ‘the average entropy’. The new measure can be used to calculate the degree of entanglement, and an improvement is given in the area near the zero entropy.

关键词： multipartite pure state von Neumann entropy entanglement measure

Theoretical studies on the mechanism of the thermal decarboxylation and decarbonylation of a number of α-keto-acids

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Chinese Journal of Chemistry 1995年第6期13卷 487-492页

作者： CHEN,Li-Tao CHEN,Guang-Ju FU,Xiao-YuanChemistry department,beijing Normal University,beijing 100875,{4. Chemistry department Beijing Normal University Beijing 100875 China

Both processes of decarboxylation and decarbonylation of a number of acids including RCOCO2H,R=H,CH3,CH2F,CF3,CH=CH2,Ph,OH have been studied by semi-empirical MO theory AMI method to verify the reaction mechanism of each process and the effect of different substituents on *** calculated results are consistent with the experimental reports and can be summed up as follows:(1) The decarboxylation of these acids to form aldehydes and carbon dioxide is concerted and takes place through a 4.membered ring transition state in which a partial negative charge develops on the carbon of the α-carbonyl group,so that the inductive effect of some substituents is favourable for this process.(2) Their decarbonylation into carboxylic acids and carbon monoxide however is the attack of the OH on the carbon of the alkyl portion of the acid,forming a 3-membered ring transition state.(3) The activation energy of decarbonylation is lower than that of decarboxylation,since oxygen is more nucleophilic than hydrogen and also the strong OH bond need not to be broken.

关键词： Decarboxylation decarbonylation a-keto-acid