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Bionic immunoactivator copresenting autophagy promoting and costimulatory molecules for synergistic cancer immunotherapy

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Nano Research 2024年第3期17卷 1710-1724页

作者： Yiwei Peng Yiliang Yang Zhenzhen Yang datong Gao Jiajia Li Qi Sun Yitian Du Meng Lin Xianrong Qi Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System School of Pharmaceutical SciencesPeking UniversityBeijing 100191China

Immunotherapy has great promise in improving malignant tumor ***,the efficacy of existing strategies is often limited by the immunosuppressive ***,we demonstrate an in situ bionic immunoactivator,PLT-Bec1/DTA-1,with possessed natural advantages of platelets for tumor recruitment and activation,on which DTA-1(CD357 monoclonal antibody)and Bec1 were tethered as combined immune ***-Bec1/DTA-1,as a self-triggered release repository,can deliver the pre-tethered Bec1 and DTA-1 deeply through the secretion of platelet microparticles(PMPs),thereby cooperate tacitly and exhibit superiority in immune activation of dendritic cells(DCs)and T cells via autophagy inducibility,coupled with glucocorticoid-induced tumor necrosis factor receptor(GITR)-triggered T_(Reg) suppression,remodeled the immunosuppressive network of tumor ***-Bec1/DTA-1 promoted antigen presentation and T cell proliferation,and alleviated the low activity state of bone marrow-derived dendritic cells(BMDCs)in tumor suppressive ***-Bec1/DTA-1 inhibited tumor recurrence(5-and 13-fold lower of control group in tumor volume)and CD8^(+)T/T_(Reg) ratio(6.3-and 8.8-fold *** group)in mouse tumor model after intravenous or subcutaneous ***,PLT-Bec1/DTA-1 prevented tumor colonization in lung through in situ immune activation,and was slightly superior to the combined of Bec1 and *** findings highlight the promise of delivering immunostimulatory payloads via bionic carriers,eliciting automatic in situ activation of effector immune cells in tumor microenvironment for tumor *** these results provide promising prospects into the application of immunoactivator in improving cancer synergistic immunotherapy to overcome the bottlenecks in clinic.

关键词： in situ bionic immunoactivator autophagy glucocorticoid-induced tumor necrosis factor receptor(GITR)agonist platelets and platelet microparticles cancer immunotherapy

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Quantum statistical entropy corresponding to cosmic horizon in five-dimensional spacetime

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Science China(Physics,Mechanics & Astronomy) 2008年第2期51卷 140-146页

作者： ZHAO Ren1,2.& ZHANG ShengLi1 1 department of Applied Physics, Xi’an Jiaotong university, Xi’an 710049, China 2.department of Physics, shanxi datong university, datong 037009, China department of Applied Physics Xi’an Jiaotong University Xi’an 710049 China department of Physics Shanxi Datong University Datong 037009 China

The generalized uncertainty relation is introduced to calculate the quantum statis-tical entropy corresponding to cosmic horizon. By using the new equation of state density motivated by the generalized uncertainty relation, we discuss entropies of Bose field and Fermi field on the background of five-dimensional spacetime. In our calculation, we need not introduce cutoff. There is no divergent logarithmic term in the original brick-wall method. And it is obtained that the quantum statistical en-tropy corresponding to cosmic horizon is proportional to the area of the horizon. Further it is shown that the entropy corresponding to cosmic horizon is the entropy of quantum state on the surface of horizon. The black hole's entropy is the intrinsic property of the black hole. The entropy is a quantum effect. In our calculation, by using the quantum statistical method, we obtain the partition function of Bose field and Fermi field on the background of five-dimensional spacetime. We provide a way to study the quantum statistical entropy corresponding to cosmic horizon in the higher-dimensional spacetime.

关键词： quantum statistical entropy generalized uncertainty relation high-dimensional spacetime

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Tests for nonparametric parts on partially linear single index models

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Science China mathematics 2007年第3期50卷 439-449页

作者： Ri-quan ZHANG department of Statistics, East China Normal university, Shanghai 2.0062. China {2., shanxi datong university, datong 037009, China department of Statistics East China Normal University Shanghai 200062China

Tests for nonparametric parts on partially linear single index models are considered in this paper. Based on the estimates obtained by the local linear method, the generalized likelihood ratio tests for the models are established. Under the null hypotheses the normalized tests follow asymptotically the χ2.distribution with the scale constants and the degrees of freedom being independent of the nuisance parameters, which is called the Wilks phenomenon. A simulated example is used to evaluate the performances of the testing procedures empirically.

关键词： local linear method partially linear single index models generalized likelihood ratio test Wilks phenomenon χ 2.distribution 62.10 62.2.

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Radiation spectrum of a high-dimensional rotating black hole

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Science China(Physics,Mechanics & Astronomy) 2010年第3期53卷 504-507页

作者： ZHAO Ren, LI HuaiFan, ZHANG LiChun & WU YueQin Institute of Theoretical Physics, shanxi datong university department of Physics, shanxi datong university, datong 037009, China 1. Institute of Theoretical Physics Shanxi Datong University Datong 037009 China

This study extends the classical Damour-Ruffini method and discusses Hawking radiation in a (n + 4)-dimensional rotating black hole. Under the condition that the total energy and angular momentum of spacetime are conservative, but angular momentum a = J/M of unit mass of the black hole is variable, taking into consideration the reaction of the radiation of the particle to the spacetime, a new Tortoise coordinate transformation and discuss the black hole radiation spectrum is discussed. The radiation spectrum that satisfies the unitary principle in the general case is derived.

关键词： Damour-Ruffini method Hawking radiation Tortoise coordinate transformation high-dimensional rotating spacetime

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考虑离合器摩擦性能衰减的湿式DCT车辆起步控制研究

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重庆大学学报 2024年第5期47卷 57-66页

作者：饶坤胡明辉秦大同重庆大学机械传动国家重点实验室重庆400044

建立了考虑离合器摩擦系数变化及离合器性能衰减的湿式双离合变速器(dual clutch transmission,DCT)车辆起步过程动力学模型,以车辆起步过程冲击度、滑摩功和起步滑摩时间为优化目标,采用线性二次型最优控制方法获得了车辆起步过程离合... 详细信息

建立了考虑离合器摩擦系数变化及离合器性能衰减的湿式双离合变速器(dual clutch transmission,DCT)车辆起步过程动力学模型,以车辆起步过程冲击度、滑摩功和起步滑摩时间为优化目标,采用线性二次型最优控制方法获得了车辆起步过程离合器最优传递转矩。针对离合器摩擦系数变化及离合器性能衰减对车辆起步过程离合器压力控制的影响,提出了一种离合器压力非线性鲁棒控制策略,以实现对离合器最优传递转矩的跟踪。结果表明,所提出的非线性鲁棒控制策略能够在离合器摩擦系数变化的情况下实现对离合器最优传递转矩的有效跟踪,跟踪误差不大于0.02.N·m,且能够适应摩擦性能衰减导致不同寿命阶段摩擦系数的不同变化规律,与比例-积分-微分(proportion-integral-differential,PID)控制策略相比具有更精确的控制效果和更强的鲁棒性。

关键词：湿式双离合器变速器起步摩擦性能衰减鲁棒控制

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Synthesis　of　an　N^5N^（10）－methenyltetrahydrofolate　Model　and　Its　Substituted　One－Carbon　Unit　Transfer　Reaction

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Chinese Chemical Letters 1996年第9期7卷 803-806页

作者： Jian Xin CHEN Chi Zhong XIA and Jin Pei CHENG(datong Medical College,datong,{2.,037008)(department of Chemistry,{2. university,Taiyuan, 030006.)(Nankai university,Tianjin,300071) datong Medical College Datong Shanxi 037008 department of Chemistry Shanxi University Taiyuan 030006 Nankai university Tianjin 300071

Substituted imidazolinium salt,1,2.dimethyl-3-(p-methoxybenzenesulfonyl) imidazolinium iodide,as a tetrahydrofolate model in terms of the ability to transfer a substituted one-carbon unit (ethylidyne,nitromethylethylidene),can react with a variety of mono-and bifunctional nucleophiles and lead to some carboline alkaloids and other heterocyclic compounds.

关键词： Synthesis an N~5N Its Carbon

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Minimal Rank Preserving Additive Mappings on Upper Triangular Matrices

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Journal of Mathematical Research and Exposition 2011年第6期31卷 951-964页

作者： Yu GUO1,2.3,Jin Chuan HOU2.3 1.department of mathematics,shanxi {2. university,shanxi 037009,P.R.China 2.department of mathematics,shanxi university,shanxi 030006,P.R.China 3.department of mathematics,Taiyuan university of Technology,shanxi 03002.,P.R.China department of mathematics Shanxi Datong University department of mathematics Shanxi University department of mathematics Taiyuan University of Technology

The additive mappings that preserve the minimal rank on the algebra of all n × n upper triangular matrices over a field of characteristic 0 are characterized.

关键词： rank minimal rank upper triangular matrices additive mappings

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Effects of Chuanxiongqin hydrochloride on increasing the fluidity of brain cell membrane and scavenging free radicals in model rats with ischemia/reperfusion injury

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Neural Regeneration Research 2006年第8期1卷 721-724页

作者： Chenxu Li Institute of Brain Sciences department of Physiology, Medical College, datong {2., datong 037008, shanxi Province, China Institute of Barin Sciences Department of Physiology Datong University Datong 037008 Shanxi Province China

BACKGROUND: The fluidity of cell membrane can be affected by various factors. Many experiments have confirmed that the ischemia/reperfusion of organic tissue can increase the contents of free radicals, which lead to high rigidity and low fluidity of cell membrane, and the conditions can be changed by Chuanxiongqin. OBJECTIVE: To observe the effect and mechanism of Chuanxiongqin hydrochloride on the fluidity of brain cell membrane in rat models of ischemia/reperfusion. DESIGN: A completely randomized controlled animal trial. SETTINGS: Institute of Brain Sciences; department of Physiology, Medical College, datong {2.. MATERIALS: Twenty male grade Ⅰ Wistar rats of 170-2.0 g were randomly divided into model group (n =10) and control group (n =10). Chuanxiongqin hydrochloride (molecular mass was 172.2. was purchased from the National Institute for the Control of Pharmaceutical and Biological Products (batch number: 0817-9803); Spin labelers: 5-doxyl-stearlic acid methylester (5DS), 16-doxyl-stearlic acid methylester (16DS), xanthine, xanthine oxidase (XOD) and 5,5-dimeth-1-pyrroline- N-oxide (DMPO) from Sigma Company; Bruker ESP 300 electron paramagnetic resonance (EPR) spectrometer by Bruker Company (Germany). METHODS: The experiments were carried out in the State Key Laboratory of Natural and Biomimetic Drugs, Peking {2. from June 2.01 to July 2.02. In the model group, rats were made into models of cerebral ischemia by 30-minute ligation and 2.hour reperfusion of common carotid arteries; The rats in the control group were not made into models. The order parameter (S) and rotational correlation time (τc) were detected with the ESR spectrometer by means of spin labeling. The greater the S and τc, the smaller the fluidity. Meanwhile, the clearance rate of free radicals was detected with ESR spin trapping. The measurement data were compared using the t test. MAIN OUTCOME MEASURES: The S, τc and clearance rates of O2.· and OH· free radicals were compared betwe

关键词： Effects of Chuanxiongqin hydrochloride on increasing the fluidity of brain cell membrane and scavenging free radicals in model rats with ischemia/reperfusion injury cell free

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Rearrangement of Hydrolysis Products of Tetrahydrofolate model compound

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Chinese Chemical Letters 1999年第9期10卷 727-728页

作者： Jian Xin CHENI Jun Sheng HAO Wei GUO Chi Zhong XIA(1datong Medical College,datong,{2. 0370082.3} of Chemistry. {2. university, Taiyuan 030006) datong Med Coll Datong 037008 Shanxi Peoples R China shanxi Univ Dept Chem Taiyuan 030006 Peoples R China

The hydrolysis products of tetrahydrofolate model compound 4 were a mixture of 6 and 7 and the rearrangement reaction between 6 and 7 via 5 was in a state of equilibrium, confirmed by (HNMR)-H-1 and IR spectra.

关键词： tetrahydrofolate hydrolysis rearrangement

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壳体柔性对风电齿轮箱-发电机集成系统动态特性影响

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重庆大学学报 2024年第3期47卷 120-131页

作者：陈锐博秦大同刘长钊重庆大学机械传动国家重点实验室重庆400044

针对风电传动系统集成化结构,提出了一种可用于风力发电机变速-变载工况下的机电-刚柔耦合动力学模型,不仅考虑了齿轮的时变啮合刚度、相位关系、轴和壳体的结构柔性等机械因素,同时计入了发电机系统中永磁体磁饱和特性、电磁径向力波... 详细信息

针对风电传动系统集成化结构,提出了一种可用于风力发电机变速-变载工况下的机电-刚柔耦合动力学模型,不仅考虑了齿轮的时变啮合刚度、相位关系、轴和壳体的结构柔性等机械因素,同时计入了发电机系统中永磁体磁饱和特性、电磁径向力波以及空间谐波等电磁因素。探究齿轮箱-发电机集成系统机电耦合动态特性,讨论了壳体柔性对系统动态特性的影响,提出了一种升速分析法,找寻了系统的共振转速。结合模态能量法和阵型矢量分布原理,找寻了共振时的潜在危险构件。研究表明:齿轮系统与发电机存在强耦合特性,壳体的柔性对系统机电耦合特性影响显著。针对集成化系统而言,齿轮内激励为共振转速下的主要激励源;但采用薄壁壳体时,发电机电磁激励不容忽视,易激发新的共振转速。选择合理的壁厚可有效提高系统的安全可靠性,减少共振区域,减轻系统构件的损坏。

关键词：风力发电机电磁激励啮合刚度机电耦合共振甄别

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