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The Green formula and heredity of algebras

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Science China mathematics 2005年第5期48卷 610-617页

作者： ZHANG Guanglian & WANG Shuai department of Mathematical Sciences, Tsinghua university, Beijing 100084, China Yancheng Teachers College, Yancheng 224002, China department of mathematics, johns hopkins university, baltimore, md21218, U.S.A. department of Mathematical Sciences Tsinghua University Beijing China Yancheng Teachers College Yancheng China department of mathematics Johns Hopkins University Baltimore USA

Let Λ be a finite dimensional algebra over a fieldκ with q elements. It is shown that the Green formula is true in mod-Λ if and only if Λ is a hereditary algebra.

关键词： Green formula idempotent ideal hereditary algebra.

RECENT PROGRESS IN GAS BUBBLE DYNAMICS

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Journal of Hydrodynamics 1989年第3期1卷 1-10页

作者： Andrea Prosperetti department of Mechanical Engineering The Johns Hopkins University Baltimore MD 21218' USA

Some recent work on bubble dynamics and bubbly liquids is outlined. The problem of compressibility corrections to the equation of motion of the bubble radius is addressed. A precise method for the calculation of the bubble internal pressure is described and some limit cases considered. Some numerical examples are included to illustrate the theoretical predictions. An experimental indication of the correctness of the theory is given by 'bubble-levitation' experiments. For bubbly liquids at small gas volume fractions results are shown for a 'shock-tube' problem and for the propagation of a sinusoidal pressure pulse through a thin layer of bubbly liquid.

关键词： RECENT PROGRESS IN GAS BUBBLE DYNAMICS

Microarray, SAGE and their applications to cardiovascular diseases

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Cell Research 2002年第2期12卷 105-115页

作者： SHUI QING YE, TERA LAVOIE, DAVID C USHER, LI Q. ZHANG1 Division of Pulmonary and Critical Care Medicine, johns hopkins university, School of Medicine, baltimore, md 21224, usa.department of Biological Science, university of Delaware, Newark, DE 19716, usa Division of Pulmonary and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore USA department of Biological Science University of Delaware Newark USA department of Surgery University of Maryland Baltimore USA

The wealth of DNA data generated by the human genome project coupling with recently invented high-throughput gene expression profiling techniques has dramatically sped up the process for biomedical researchers on elucidating the role of genes in human diseases. One powerful method to reveal insight into gene functions is the systematic analysis of gene expression. Two popular high-throughput gene expression technologies, microarray and Serial Analysis of Gene Expression (SAGE) are capable of producing large amounts of gene expression data with the potential of providing novel insights into fundamental disease processes, especially complex syndromes such as cardiovascular disease, whose etiologies are due to multiple genetic factors and their interplay with the environment. Microarray and SAGE have already been used to examine gene expression patterns of cell-culture, animal and human tissues models of cardiovascular diseases. In this review, we will first give a brief introduction of microarray and SAGE

关键词： Microarray SAGE cardiovascular diseases RNA gene expression profiling.

PROBING THE EARLY UNIVERSE WITH DEEP OBSERVATIONS AND LARGE SURVEYS

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中国科学院上海天文台年刊 2001年 147-163页

作者： Zheng Wei (department of Physics and Astronomy, The johns hopkins university baltimore, md 21218-2686, usa. (Center for Astrophysics university of Science and Technology of China, Hefei, AnHui, 230026) department of Physics and Astronomy The Johns Hopkins University BaltimoreMD 21218 - 2686USA Center for Astrophysics university of Science and Technology of China HefeiAnHui230026

Recent advances in astronomy have enabled scientists to reach the early universe to an unprecedented depth. With the new telescopes such as the Chandra, FUSE, and with the Sloan Digital Sky Survey (SDSS), we have gained critical insights into the "Origin of our Universe", i.e. how the intergalactic medium evolves to form galaxies and quasars. SDSS has broken a ten-year barrier of z=5 to reach the very early universe, with the discovery of five quasars at z  5.0. The survey will find more than ten thousa.ds of quasars, enabling us to carry out the most comprehensive classification of quasars. FUSE finds traces of the primordial matter at z ～3, which corresponds to hydrogen column density as low as 10 -11 cm -2 and cannot be detected even with the largest optical telescope. The finding suggests that the intergalactic medium is an evolving and complex entity, and it is ionized mainly by the accumulated radiation from quasars. The Chandra telescope has taken a million second deep exposure of a selected region, reaching about twenty times deeper than ROSAT to a limiting flux of 5 × 10 -17 ergs s -1 cm -2 in the 0.5-2 keV band. The sources found so far can account for up to 90% of the hard X-ray background field, and they consist of Seyfert-2 and normal galaxies at z < 1 and quasars at z < 4.5. In the near future, the Next Generation Space Telescope and others will reveal the first generation of baryonic objects after the Big Bang.

关键词： SPIE Nature

Cell-specific Regulation of APOBEC3F by Interferons

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Acta Biochimica et Biophysica Sinica 2007年第4期39卷 297-304页

作者： Songcheng YING~1# Xuzhao ZHANG~1# Phuong Thi Nguyen SARKIS~2# Rongzhen XU~1 Xiaofang YU~(1,2*) 1 Second Affiliated Hospital,Cancer Institute,School of Medicine,Zhejiang university,Hangzhou 310009,China 2 department of Molecular Microbiology and Immunology,johns hopkins BIoomberg School of Public Health,baltimore.Maryland 21205,usa Second Affiliated Hospital Cancer Institute School of Medicine Zhejiang UniversityHangzhou 310009 China department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public HealthBaltimore Maryland 21205 USA

Human cytidine deaminase APOBEC3F（A3F）has broad anti-viral activity against hepatitis Bvirus and retroviruses including human immunodeficiency virus type ***,its regulation in viralnatural target cells such CD4+T lymphocytes,macrophages,and primary liver cells has not been *** we showed that A3F was up-regulated by interferon（IFN）-α in primary hepatocytes andmultiple liver cell lines as well as *** the IFN-α signaling pathway was active in Tlymphoid cells and induction of other IFN stimulated genes such as PKR was detected,A3F and APOBEC3G（A3G）were not induced by IFN-α in these ***,additional factors other than known IFN-stimulatedgenes also regulated IFN-α-induced A3F expression distinctly.A3F and A3G expression levels in primaryhepatocytes,especially after IFN-α stimulation,were comparable to those in CD4~ T lymphocytes in *** variations of A3F and A3G expression in primary hepatocytes from various subjectswere *** variations in A3F and/or A3G regulation and expression might influence the clinicaloutcomes of hepatitis B infection.

关键词： APOBEC3F interferon human immunodeficiency virus type 1 hepatitis B virus cytidine deaminase

Antiferomagnetic Exchange Coupling Through an Amorphous Metallic Layer

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电子显微学报 1997年第4期 53-56页

作者： John Q.Xiao\ C.L.Chien * (Dept. of Physics and Astronomy, university of Delaware, Newark, DE 19716 *Dept. of physics and Astronomy, The johns hopkins university, baltimore, md 21218)

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关键词： μΩ Metallic Exchange Coupling Through Layer Antiferomagnetic Amorphous

Modeling and simulation of ion channels and action potentials in taste receptor cells

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Science China(Life Sciences) 2009年第11期52卷 1036-1047页

作者： CHEN PeiHua1, LIU Xiao-dong2, ZHANG Wei1, ZHOU Jun1, WANG Ping1, YANG Wei3 & LUO JianHong3 1Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, department of Biomedical Engineering, Zhejiang university, Hangzhou 310027, China 2Calcium Signals Lab, department of Biomedical Engineering and Neuroscience, johns hopkins university, baltimore, md 21205, usa.3department of Neurobiology, Institute for Neuroscience, Zhejiang university School of Medicine, Hangzhou 310058, China Biosensor National Special Laboratory Key Laboratory of Biomedical Engineering of Ministry of Education Department of Biomedical Engineering Zhejiang University Hangzhou China Calcium Signals Lab Department of Biomedical Engineering and Neuroscience Johns Hopkins University Baltimore USA department of Neurobiology Institute for Neuroscience Zhejiang University School of Medicine Hangzhou China

Based on patch clamp data on the ionic currents of rat taste receptor cells, a mathematical model of mammalian taste receptor cells was constructed to simulate the action potentials of taste receptor cells and their corresponding ionic components, including voltage-gated Na+ currents and outward delayed rectifier K+ currents. Our simulations reproduced the action potentials of taste receptor cells in response to electrical stimuli or sour tastants. The kinetics of ion channels and their roles in action potentials of taste receptor cells were also analyzed. Our prototype model of single taste receptor cell and simulation results presented in this paper provide the basis for the further study of taste information processing in the gustatory system.

关键词： taste receptor cell action potential modeling and simulation Na+ channel delayed rectifier K+ channel

Structural immunology of costimualtory and coinhibitory molecules

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Science China(Life Sciences) 2010年第2期53卷 183-189页

作者： WANG ShengDian1 & CHEN LiePing1,2 1Center for Infection and Immunity,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2department of Oncology,johns hopkins university School of Medicine,baltimore,Maryland,usa Center for Infection and Immunity Institute of Biophysics Chinese Academy of Sciences Beijing China department of Oncology Johns Hopkins University School of Medicine Baltimore USA

The T cell costimulatory pathways are central to regulating immune responses,and targeting these pathways represents one of the most promising approaches for achieving *** molecular structures of costimulation revealed invaluable mechanistic insights underlying costimulatory receptor/ligand specificity,affinity,oligomeric state,and valency,which provided the bases for better manipulation of these signaling *** incredible growth of this field led to identification of new members and unexpected interactions,revealing a complicated regulatory network of immune *** advances in structural biology of costimulation will promise unprecedented opportunities for furthering our understanding and therapeutic application of T cell costimulatory pathways.

关键词： costimulatory molecules T cells molecular structure immunotherapy

Recent Development of OCT Technologies

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生物物理学报 2009年第S1期25卷 162-162页

作者： Xingde Li department of Biomedical Engineering, johns hopkins university, baltimore, md 21205

Optical coherence tomography (OCT) was first reported about 18 years ago. OCT was originally developed for imaging the relatively transparent eye tissue, and later applied

关键词： OCT optical biopsy functional imaging