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Regulative Function of Low Molecular Chitosan on Blood Sugar in Experimental Diabetic Rats

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生物医学工程学杂志 2005年第S1期22卷 167-168页

作者： Hua-Bing YANG Yong WU (department of Preclinical Medicine, Hubei college of traditional chinese Medicine, Wuhan 430061,china) department of Preclinical Medicine Hubei College of Traditional Chinese Medicine Wuhan 430061 China

1 IntroductionChitosan has good action on reducing blood sugar with low poisonous side-effect. Low molecular chitosan(LMC) is the oxide of high molecular chitosan, which has water-solubility and the function of lowering blood sugar of diabetic rats. In this experiment, STZ was adopted to duplicate the model rats of Type Ⅱ diabetes mellitus, the regulative function of LMC on Type Ⅱ diabetic blood sugar was observed for further inquiry into its functionary mechanism.

关键词： STZ Regulative Function of Low Molecular Chitosan on Blood Sugar in Experimental Diabetic Rats

Outcome assessment of stroke convalescence using multiple scales based on different dimensions

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Neural Regeneration Research 2006年第8期1卷 710-713页

作者： Yingrong Lao1, Xinfeng Guo1,2, Shilong Lai1,2, Weixiong Liang1,2, Zehuai Wen1,2, Qi Wang1,2, Peixin Huang3, Yan Huang3 1Unit of Applied Clinical Epidemiology, second affiliated hospital of Guangzhou University of traditional chinese Medicine (Guangzhou Provincial hospital of traditional chinese Medicine), Guangzhou 510120, Guangdong Province, china 3department of Neurology, second affiliated hospital of Guangzhou University of traditional chinese Medicine (Guangzhou Provincial hospital of traditional chinese Medicine), Guangzhou 510120, Guangdong Province, china 2National Center for Training of Design, Measurement and Evaluation in Clinical Research, Guangzhou University of traditional chinese Medicine, Guangzhou 510405, Guangdong Province, china Unit of Applied Clinical Epidemiology Hospital of Guangzhou University of Traditional Chinese Medicine Guangzhou Provincial Hospital of Traditional Chinese Medicine Guangzhou 510120 Guangdong Province China National Center for Training of Design Measurement and Evaluation in Clinical Research Guangzhou University of Tradiational Chinese Medicine Guangzhou 510405 Guangdong Province China department of Neurology Hospital of Guangzhou University of Traditional Chinese Medicine Guangzhou Provincial Hospital of Traditional Chinese Medicine Guangzhou 510120 Guangdong Province China

BACKGROUND: Convalescence is an important stage of stroke treatment. A lot of patients have somatic and mental disorders at various degrees. The primary standard can only reflect partial conditions of somatic disorder; in addition, multiple dimensions of patients at the phase of stroke convalescence are further observed by using a lot of standards, such as signs and symptoms of traditional chinese medicine, daily activity and psychological status. OBJECTIVE: To analyze the outcome assessments of the cases of stroke convalescence measured with different criteria consisting of various dimensions by a cross-sectional investigation of the condition of stroke convalescent patients. DESIGN: Scale evaluation. SETTING: departments of Clinical Epidemiology Exploratory Development and Neurology, the second affiliated hospital of Guangzhou University of traditional chinese Medicine; National Center for Training of Design, Measurement and Evaluation in Clinical Research,Guangzhou University of traditional chinese Medicine. PARTICIPANTS: A total of 194 stroke convalescent patients treated in the second affiliated hospital of Guangzhou University of traditional chinese Medicine from July 26, 2000 to February 28, 2001 were taken as subjects of the study. There were 126 males and 68 females aged from 40 to 89 years, and the illness course ranged from 14 to 181 days. All patients met diagnosis-treatment criteria of stroke (the second version)[DTCS(V2.0)] and various kinds of diagnostic points of cerebrovascular diseases; moreover, all patients provided confirmed consents. METHODS: They were assessed by assessment methods including the following assessment instruments: DTCS(V2.0), self-designed scale of traditional chinese medicine (TCM) symptoms (28 symptoms and physical signs were scored as 0, 1, 2 marks from none to severity), modified Edinburgh-Scandinavia stroke scale (a total of 45 marks, 0 to 15 marks as mild defect, 16 to 30 as moderate defect, 31 to 45 as severe defect), mod

关键词： Outcome assessment of stroke convalescence using multiple scales based on different dimensions ADL

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腹主动脉瘤临床护理规范专家共识

军事护理 2024年第8期41卷 1-7页

作者：国际血管联盟中国分部护理专业委员会海军军医大学第一附属医院血管外科李海燕陆清声植艳茹邹秋红张昊不详海军军医大学第一附属医院

腹主动脉瘤(abdominal aortic aneurysm,AAA)是指腹主动脉局部呈瘤样扩张,直径大于动脉瘤近端正常腹主动脉直径1.5倍的动脉疾病[1]。腹主动脉瘤一旦发生破裂,患者总死亡率可高达80%[2]。目前,AAA诊治技术已较为成熟,然而,国内尚缺乏AAA... 详细信息

腹主动脉瘤(abdominal aortic aneurysm,AAA)是指腹主动脉局部呈瘤样扩张,直径大于动脉瘤近端正常腹主动脉直径1.5倍的动脉疾病[1]。腹主动脉瘤一旦发生破裂,患者总死亡率可高达80%[2]。目前,AAA诊治技术已较为成熟,然而,国内尚缺乏AAA临床护理规范。为此,国际血管联盟中国分部护理专业委员会组织国内血管外科及相关领域医护专家共同制订《腹主动脉瘤临床护理规范专家共识》(以下简称《共识》),以期为AAA的规范护理提供参考依据。

关键词：腹主动脉瘤围术期护理规范专家共识

Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B

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Acta Pharmacologica Sinica 2005年第3期26卷 345-352页

作者： Yong WU~(2,3) Jing-ping OU-YANG~(2,5) Ke WU~2 Ya WANG~2 Yun-feng ZHOU~2 Chong-yuan WEN~42 department of Pathophysiology medical college of Wuhan University,3 department of Physiology Hubei college of traditional chinese Medicine4 department of Endocrinopathic Sciences,Renmin hospital,Wuhan University,Wuhan 430060,china department of Pathophysiology Medical College of Wuhan University Wuhan China department of Physiology Hubei College of Traditional Chinese Medicine Wuhan China department of Endocrinopathic Sciences Renmin Hospital Wuhan University Wuhan China

Aim:To examine the effects ofAstragalus polysaccharide (APS),a component ofan aqueous extract of Astragalus membranaceus roots,on protein tyrosine phos-phatase 1B (PTP1B),a negative regulator of insulin-receptor (IR) signaltransduction,and its potential role in the amelioration of insulin ***:Ten-week-old fat-fed streptozotocin (STZ)-treated rats,an animal modelof type Ⅱ diabetes mellitus (TIIDM),were treated with APS (400 mg/kg po) for *** sensitivity was identified by the insulin-tolerance *** analy-ses on the possible changes in insulin signaling occurring in skeletal muscle andliver were performed by immunoprecipitation or Western ***1B activ-ity was measured by an assay ***:The diabetic rats responded to APSwith a significant decrease in body weight,plasma glucose,and improved *** activity and expression of PTP1B were elevated in the skeletalmuscle and liver of TIIDM *** the insulin signaling in target tissues *** reduced both PTP1B protein level and activity in the muscle,but not in the iiver of TIIDM ***-induced tyrosine phosphorylation of theIR β-subunit and insulin receptor substrate-1 (IRS-1) were increased in the muscle,but not in the liver of APS-treated TIIDM *** was no change in the activityor expression of PTP1B in APS-treated normal rats,and blood insulin levels didnot change in TIIDM rats after treatment with ***:APS enablesinsulin-sensitizing and hypoglycemic activity at least in part by decreasing theelevated expression and activity of PTP1B in the skeletal muscles of TIIDM rats.

关键词： Astragalus membranaceus polysaccharides PTP1B type Ⅱdiabetes mellitus insulin resistance streptozotocin

Effects of Dan-Shao-Hua-Xian on the expression of collagen type I and III in rats with hepatic fibrosis

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Hepatobiliary & Pancreatic Diseases International 2004年第4期3卷 558-563页

作者： Xiao-Xia Geng, Qin Yang, Ru-Jia Xie, Xin-Hua Luo, Cheng-Xiu Li and Ming-Liang Cheng Guizhou, china department of Infectious Diseases, affiliated hospital of Guiyang medical college department of Pathophysiology, Guiyang medical college Depart- ment of Infectious Diseases, People’ s hospital of Guizhou Province and department of Pharmacology, Guiyang medical college department of Infectious Diseases Affiliated Hospital of Guiyang Medical College Guizhou 550004 China.

BACKGROUND: Hepatic fibrosis is the common patholo gical change in various chronic liver diseases,and its major cause is the imbalance between the production and degra dation of the extracellular matrix, which is mainly com posed of collagens. Dan-Shao-Hua-Xian ( DSHX) cap sule, a traditional chinese herbal compound, has shown marked preventive effects on hepatic fibrosis in rats in our previous studies. The present study was designed to further investigate its therapeutic actions on hepatic fibrosis in rats and its possible mechanisms. METHODS: Eighty male Wistar rats were randomly divid- ed into normal control group, hepatic fibrosis group, non DSHX-treated group, low-dose-treated group, and high dose-treated group. The rat models of hepatic fibrosis were established by subcutaneous injecton of CC14 , drinking al- cohol , giving diet of hyperliprosis and hypoprotein for 8 weeks. The two DSHX-treated groups were treated respec- tively with low dose (0.5 g/kg) and high dose (1.0 g/kg) of DSHX capsule p. o. everyday for 8 weeks. At the end of the experiment, liver indexes were calculated in each group in addition to the levels of the serum hyaluronic acid and alanine aminotransferase. Their degree of hepatic fibrosis and urinary excretion of hydroxyproline and expression of collagen , were detected. RESULTS: Comparison of the indexes of the hepatic fibro- sis group and non-DSHX-treated group revealed that the liver indexes, levels of serum hyaluronic acid and alanine aminotransferase, and stage of hepatic fibrosis were all sig- nificantly reduced in the two DSHX treated groups. The urinary excretion of hydroxyproline was increased and the expression of collagen I and HI in liver tissue was lessened. These alterations were more obviously observed in the high-dose-treated group. CONCLUSION: DSHX capsule has certain therapeutic effect on hepatic fibrosis in rats.

关键词： liver fibrosis collagen hyaluronic acid hydroxyproline traditional chinese herbs

血管内皮源性舒张因子对血管平滑肌钙激活钾通道活性影响的对比研究

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中国实用内科杂志 2005年第2期25卷 134-136页

作者：罗兴林何川杨艳李秀琴泸州医学院附属医院心内科 646000

目的　探讨血管内皮源性舒张因子对高血压及非高血压患者血管平滑肌钙激活钾通道 (KCa)活性的影响。方法　选择 2 0 0 1～ 2 0 0 3年泸州医学院附属医院 2 1例高血压病患者及 18例非高血压者 ,切取肠系膜动脉小分支节段用酶消化法获取... 详细信息

目的　探讨血管内皮源性舒张因子对高血压及非高血压患者血管平滑肌钙激活钾通道 (KCa)活性的影响。方法　选择 2 0 0 1～ 2 0 0 3年泸州医学院附属医院 2 1例高血压病患者及 18例非高血压者 ,切取肠系膜动脉小分支节段用酶消化法获取血管平滑肌细胞 ,以膜片钳技术检测KCa通道的活性 ,通过Pclamp专用软件实时采样记录其平均开放时间 (To)、平均关闭时间 (Tc)、平均开放概率 (Po)等。采用硝酸还原法测定血浆一氧化氮(NO)含量 ,用比色法测定血浆一氧化氮合成酶 (NOS)含量。结果　 (1)两组对象KCa通道活性变化 :于细胞内面向外膜片下 ,高血压病组与非高血压组比较 ,前者KCa通道Po增加 ,Tc延长、To缩短。在浴液中分别加入Ca2 +后 ,两组KCa通道均被明显激活 ,与加Ca2 + 前比较 ,非高血压组Po的增加显著高于高血压病组 (P <0 0 1) ,说明高血压病组KCa通道对Ca2 + 的敏感性显著低于血压正常组。 (2 )高血压患者血浆NO、NOS较非高血压组显著降低。 (3)非高血压组血浆NO与KCa通道Po、To呈正相关 ,与Tc呈负相关。高血压病组NO与KCa通道Po、To、Tc的相关性明显弱于非高血压组。结论　高血压病患者肠系膜动脉平滑肌KCa通道活性明显增高 ,血管内皮源性舒张因子对非高血压及高血压病患者血管平滑肌KCa通道均有激活作?

关键词：高血压病血管平滑肌血管内皮患者钙激活钾通道肠系膜动脉血浆一氧化氮开放时间结论概率

EFFECTIVENESS OF ELECTROCHEMICAL TREATMENT OF PRIMARY PULMONARY MALIGNANT TUMORS

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chinese medical Journal 1995年第1期108卷 66-67页

作者：宋玉忱张逊杜喜群王增林陈宇 department of Thoracic surgery Fourth Affiliated Hospital Hebei Medical College Shijiazhuang.

Electrochemical therapy is a new therapy for the treatment of *** January 1989 to November 1991

关键词： In EFFECTIVENESS OF ELECTROCHEMICAL TREATMENT OF PRIMARY PULMONARY MALIGNANT TUMORS

钇‑90微球选择性内放射治疗肝脏恶性肿瘤规范化操作专家共识(2024版)

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中华消化外科杂志 2024年第2期23卷 165-178页

作者：中国医师协会介入医师分会临床诊疗指南专委会中国研究型医院学会肝胆胰外科专业委员会董家鸿滕皋军朱海东张琳贾中芝刘加成陆建不详清华大学附属北京清华长庚医院肝胆胰外科北京102218 东南大学附属中大医院介入与血管外科、教育部医药基础研究创新中心南京210009 东南大学附属中大医院介入与血管外科清华大学附属北京清华长庚医院肝胆胰中心介入科南京医科大学附属常州第二人民医院介入血管科东南大学附属中大医院核医学科

钇‑90微球选择性内放射治疗(90Y‑SIRT)肝脏恶性肿瘤已有50余年临床应用史,大规模临床应用亦超过20年,其安全性和疗效已被证实,但在我国仍处于起步阶段。90Y‑SIRT操作复杂,涉及多学科团队协作,对操作者要求较高,一旦发生90Y微球异位分布... 详细信息

钇‑90微球选择性内放射治疗(90Y‑SIRT)肝脏恶性肿瘤已有50余年临床应用史,大规模临床应用亦超过20年,其安全性和疗效已被证实,但在我国仍处于起步阶段。90Y‑SIRT操作复杂,涉及多学科团队协作,对操作者要求较高,一旦发生90Y微球异位分布可能会导致严重并发症。因此,规范90Y‑SIRT操作技术,对促进90Y‑SIRT在我国稳步推广至关重要。中国医师协会介入医师分会临床诊疗指南专委会联合中国研究型医院学会肝胆胰外科专业委员会组织国内相关领域专家,基于现有文献证据并结合我国临床实践,围绕患者筛选、术前影像学评估、90Y‑SIRT方案、处方剂量计算、90Y‑SIRT实施、术后管理、常见不良反应与并发症等,共同制订本专家共识,规范90Y‑SIRT操作,保证疗效,降低并发症发生率,促进90Y‑SIRT在国内的推广和普及。

关键词：肝肿瘤钇‑90 微球选择性内放射治疗共识

Clinical and endoscopic features of chinese reflux esophagitis patients

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World Journal of Gastroenterology 2008年第12期14卷 1866-1871页

作者： Wei Li, Shu-Tian Zhang, Zhong-Lin Yu, department of Gastroenterology, Beijing Friendship hospital affiliated to Capital medical University Faculty of Gastroenterology, Capital medical University Beijing Digestive Disease Center, Beijing 100050, china department of Gastroenterology Beijing Friendship Hospital Affiliated to Capital Medical University Beijing Digestive Disease Center Beijing 100050 China.

AIM： To analyze the clinical and endoscopic features of chinese patients with reflux esophagitis （RE）. METHODS： A total of 1405 RE patients were analyzed retrospectively. Data on gender, age, presence/absence of H pylori infection and associated esophageal hiatal hernia were collected. Esophagitis was divided into different grades according to Los Angeles Classification. RESULTS： Of 18823 patients, 1405 were diagnosed as RE. The ratio of male to female patients was 1.75：1 （P 〈 0.01）. The mean age of male and female patients was significantly different （P = 0.01）. The peak age at onset of the disease was 40-60 years. According to Los Angeles Classification, there were significant differences in the age of patients with grades A and B compared to patients with grades C and D （P 〈 0.01）. Two hundred and seventy-seven patients were infected with H pyiorl, the infection rate was low （P 〈 0.01）. Complication of esophageal hiatal hernia was found to be significantly associated with the severity of esophagitis and age in 195 patients （P 〈 0.01）. Esophageal mucosa damages were mainly located at the right esophageal wall. CONCLUSION： The peak age of onset of RE is 40-60 years and higher in males than in females. The mean age of onset of RE is lower in males than in females. The infection rate of Hpylori is significantly decreased in patients with esophagitis. Old age and esophageal hiatal hernia are associated with more severe esophagitis. Right esophageal mucosal damage can occur more often in RE patients.

关键词： Esophagitis Los Angeles Classification Helicobacterpylori Hiatal hernia