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骨纤维发育不良致股骨近端畸形的手术治疗进展

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中华骨科杂志 2024年第15期44卷 1040-1047页

作者：蔡成阔张净宇邓书贞刘艳成胡永成天津市天津医院骨与软组织肿瘤科天津300211

骨纤维发育不良(fibrous dysplasia of bone,FD)是一种以髓内纤维性病变为特征的类肿瘤样疾病,病变区域骨的发育停滞在未成熟的编织骨阶段,无法形成正常的骨小梁,导致骨的结构改变和力学强度降低;在负重时常出现反复的病理性骨折,进而... 详细信息

骨纤维发育不良(fibrous dysplasia of bone,FD)是一种以髓内纤维性病变为特征的类肿瘤样疾病,病变区域骨的发育停滞在未成熟的编织骨阶段,无法形成正常的骨小梁,导致骨的结构改变和力学强度降低;在负重时常出现反复的病理性骨折,进而继发受累骨的弯曲畸形、肢体短缩及步态异常。股骨近端是FD肢体畸形常累及的部位,畸形类型和程度复杂多样,多表现为逐渐加重的髋关节内翻及骨干弯曲。矫正畸形的目的是恢复股骨正常的机械轴线和长度,从而恢复肢体的功能,避免畸形进展以及缓解因反复的病理性微骨折而导致的疼痛症状,这较病灶本身的治疗更加重要。术前应根据病变的位置、范围以及病变类型个体化制定每一例患者的治疗方案,术后需对患者长期随访,进行矫形方案的调整。是否应进行病灶刮除植骨以及使用植骨材料的种类仍存在争议,应基于矫形原则对FD股骨进行畸形分析,确定畸形类型及畸形顶点位置,设计截骨方案,并进行术前模拟。虽然截骨后髓内或髓外固定方式均可提供足够的生物学稳定,但应根据术中具体情况决定使用何种固定装置。FD患者骨的愈合以及再生均无明显异常,但是生成的骨痂中包括发育不良的骨组织。FD患者在肢体畸形治疗后容易出现畸形复发,需长期密切随访以便进行矫形方案的调整。

关键词：骨纤维发育不良肌肉骨骼畸形截骨术

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耐力训练大鼠下丘脑的比较蛋白质组学研究

体育科学 2009年第10期29卷 42-45页

作者：姜振盐城师范学院体育学院江苏盐城224002

目的:运用比较蛋白质组学方法研究耐力训练与对照组大鼠下丘脑蛋白质组表达图谱。方法:16只雄性SD大鼠随机按体重配对分为安静对照组(8只)、耐力训练组(8只)。运动后30min和安静对照组大鼠同时断头处死,提取下丘脑全蛋白质做双向凝胶电... 详细信息

目的:运用比较蛋白质组学方法研究耐力训练与对照组大鼠下丘脑蛋白质组表达图谱。方法:16只雄性SD大鼠随机按体重配对分为安静对照组(8只)、耐力训练组(8只)。运动后30min和安静对照组大鼠同时断头处死,提取下丘脑全蛋白质做双向凝胶电泳,应用质谱鉴定差异表达的蛋白。结果:安静组和运动组各获得801±37和783±32个蛋白质点,蛋白质点的匹配率为77.38%,应用质谱鉴定了8种结构明确的蛋白质,分别为代谢酶、抗氧化酶、细胞骨架蛋白、热休克蛋白、信号传导蛋白以及一个未知功能的蛋白质。结论:应用比较蛋白质组学技术能够发现耐力训练大鼠下丘脑蛋白质组表达的变化,为研究运动对下丘脑代谢与神经内分泌功能的影响提供依据与参考。

关键词：运动下丘脑蛋白质组学鼠动物实验

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剩余格与正则剩余格的特征定理

数学学报（中文版） 2002年第2期45卷 271-278页

作者：裴道武西安交通大学理学院

本文进一步研究了具有广泛应用的一类模糊逻辑代数系统——剩余格，并引入了正则剩余格的概念，对剩余格与正则剩余格的定义进行了讨论，给出了剩余格与正则剩余格的特征定理，其中包含剩余格与正则剩余格的等式特征，从而这两个格类都... 详细信息

本文进一步研究了具有广泛应用的一类模糊逻辑代数系统——剩余格，并引入了正则剩余格的概念，对剩余格与正则剩余格的定义进行了讨论，给出了剩余格与正则剩余格的特征定理，其中包含剩余格与正则剩余格的等式特征，从而这两个格类都构成簇．本文还讨论了剩余格与正则剩余格公理系统的独立性，以及它们与相近代数结构的关系．

关键词：模糊逻辑代数系统剩余格正则剩余格特征定理多值逻辑

Standing surface acoustic wave-assisted fabrication of patterned microstructures for enhancing cell migration

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Bio-Design and Manufacturing 2020年第2期3卷 87-97页

作者： yancheng Wang Yue Wang Deqing Mei Zongkai Yu Dai Xue State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China department of Aerospace and Mechanical Engineering The George Washington UniversityWashingtonDC 20052USA

Microfluidic device with patterned microstructures on the substrate surface was used to regulate cell adhesion,morphology,and functions in tissue *** developed a microfluidic device which employing microscale patterned microstructures to achieve enhanced cell adhesion and *** hydrogel substrates with micro-wavy and lattice-patterned microstructures were fabricated using standing surface acoustic waves and ultraviolet *** seeding the L929 mouse fibroblast cells onto the patterned substrate of the microfluidic device,we determined that the viability and proliferation rate of cell migration can be greatly ***,L929 cells showed two types of gathering modes after 48 h of *** growth was guided by the patterned substrate used in the microfluidic device and showed differences in the location ***,the developed microfluidic device with patterned microstructures can extend the application of in vitro cell culturing for future drug development and disease diagnosis.

关键词： Standing surface acoustic waves(SSAWs) Micropatterned structure Dynamic cell culture Microfluidic device

EXISTENCE AND UNIQUENESS OF ENDEMIC STATES FOR THE AGE-STRUCTURED SEIR EPIDEMIC MODEL

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Journal of Systems Science & Complexity 2006年第1期19卷 114-127页

作者： Xuezhi LI Jing CHEN department of mathematics Xinyang Teachers College Xinyang 464000 China college of Science China Agriculture University Beijing 100080 China

An age-structured SEIR epidemic model of a vertically as well as horizontally transmitted disease is investigated. Threshold results for the existence of endemic states are established for most cases. Under certain conditions, uniqueness is also shown. Threshold used are explicitly computable in term of demographic and epiderniological parameters of the model.

关键词： Age structure positive endemic state SEIR epidemic model threshold value vertical transmission.

Phylogeny of Ptychostomum (Bryaceae,Musci) inferred from sequences of nuclear ribosomal DNA internal transcribed spacer (ITS) and chloroplast rps4

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Journal of Systematics and Evolution 2009年第4期47卷 311-320页

作者： ~(1,2)Chen-Ying WANG ~1Jian-Cheng ZHAO~* 1(college of Life Science,Hebei Normal University,Shijiazhuang 050016,china) 2(department of Life Science,Zhengzhou teachers college,Zhengzhou 450044,china) (college of Life Science Hebei Normal University Shijiazhuang 050016 China) (department of Life Science Zhengzhou Teachers College Zhengzhou 450044 China)

The phylogeny of Ptychostomum was first undertaken based on analysis of the internal transcribed spacer(ITS)region of the nuclear ribosomal(nr)DNA and by combining data from nrDNA ITS and chloroplast DNA rps4 *** parsimony,maximum likelihood,and Bayesian analyses all support the conclusion that the reinstated genus Ptychostomum is not *** funkii(Schw(a|¨)gr.)*** (≡Bryum funkii Schw(a|¨)gr.)is placed within a clade containing the type species of Bryum,*** Hedw. The remaining members of Ptychostomum investigated in the present study constitute another well-supported clade. The results are congruent with previous molecular *** the basis of phylogenetic evidence,we agree with transferring *** Mü***.(≡***(Brid.)Turton≡Bryum archangelicum Bruch & Schimp.), Bryum lonchocaulon Mü***.,Bryum pallescens *** Schw(a|¨)gr.,and Bryum pallens *** Ptychostomum.

关键词： Bryum molecular phylogeny nuclear ribosomal DNA internal transcribed spacer sequences Ptychostomum rps4 sequences.

茯苓酸对肾癌细胞上皮间质转化和免疫逃逸的影响

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南开大学学报（自然科学版） 2024年第2期57卷 22-27页

作者：李伟博何春艳张玲玲王静邸彦橙牡丹江医学院附属红旗医院泌尿外科黑龙江牡丹江157011 牡丹江医学院基础医学院黑龙江牡丹江157011

选取786-O细胞随机分为空白组、茯苓酸组、CXCL12组、CXCL12-CXCR4抑制剂-AMD3100组、茯苓酸+CXCL12组、茯苓酸+AMD3100组,CCK-8检测细胞增殖;Transwell检测细胞迁移、侵袭;免疫荧光检测EMT相关因子-E-钙粘素(E-Cadherin)、锌指转录因子... 详细信息

选取786-O细胞随机分为空白组、茯苓酸组、CXCL12组、CXCL12-CXCR4抑制剂-AMD3100组、茯苓酸+CXCL12组、茯苓酸+AMD3100组,CCK-8检测细胞增殖;Transwell检测细胞迁移、侵袭;免疫荧光检测EMT相关因子-E-钙粘素(E-Cadherin)、锌指转录因子(Snail)、N-钙黏素(N-Cadherin)的表达;与CD8+T细胞共培养,Elisa检测上清液中免疫逃逸相关因子-白细胞介素(IL)-4和IL-10、干扰素(IFN)-γ水平;Western blot检测CXCL12、CXCR4、CXCR7及免疫逃逸蛋白PD-L1表达.探讨茯苓酸调节CXCL12-CXCR4/CXCR7信号通路对肾癌细胞上皮间质转化(EMT)和免疫逃逸的影响.结果显示与空白组相比,茯苓酸组细胞增殖率、迁移、侵袭数、Snail、N-Cadherin IOD值、IL-10水平、CXCL12、CXCR4、CXCR7以及PD-L1表达显著降低,E-Cadherin IOD值、IFN-γ、IL-4水平显著增加(P<0.05);与茯苓酸组相比,茯苓酸+CXCL12组细胞增殖率、迁移、侵袭数、Snail、N-Cadherin IOD值、IL-10水平、CXCL12、CXCR4、CXCR7以及PD-L1表达显著增加,E-Cadherin IOD值、IFN-γ、IL-4水平显著降低(P<0.05);与CXCL12组相比,茯苓酸+CXCL12组细胞增殖率、迁移、侵袭数、Snail、N-Cadherin IOD值、IL-10水平、CXCL12、CXCR4、CXCR7以及PD-L1表达显著降低,E-Cadherin IOD值、IFN-γ、IL-4水平显著增加(P<0.05);与茯苓酸组、AMD3100组相比,茯苓酸+AMD3100组细胞增殖率、迁移、侵袭数、Snail、N-Cadherin IOD值、IL-10水平、CXCL12、CXCR4、CXCR7以及PD-L1表达显著降低,E-Cadherin IOD值、IFN-γ、IL-4水平显著增加(P<0.05).表明茯苓酸可调节CXCL12-CXCR4/CXCR7信号通路阻止肾癌细胞免疫逃逸及EMT.

关键词：茯苓酸 CXCL12-CXCR4/CXCR7信号通路肾癌细胞免疫逃逸上皮间质转化

On mathematical arbitrariness of some papers on the potential homologous linear rule investigation

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Chinese Science Bulletin 2000年第23期45卷 2203-2208页

作者： SUN Yukundepartment of Chemistry, Hainan teachers college, Haikou 571158, china department of Chemistry Hainan Teachers College Haikou China

The history of homologous linear rule investigation is reviewed simply. The author puts forward a problem worth paying attention to in the recent potential homologous linear rule investigation, especially some mistakes made in these investigations on mathematical foundations. The author also exposes the mathematical arbitrariness of some papers on their potential homologous linear rule investigation.

关键词： homologous linear rule investigation conjugated systems multiring aromatic hydrocarbon potentials.

Injective Homogeneity and Homological Homogeneity of the Ore Extensions

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Acta Mathematica Sinica,English Series 1997年第4期13卷 433-442页

作者： Yi Zhong department of mathematics, Guangxi teachers University, Guilin 541004. china 广西师范大学数学系广西桂林

In this paper we prove that under some natural conditions, the Ore extensions and skew Laurent polynomial rings are injectively homogeneous or homologically homogeneous if so are their coefficient rings. Specifically, we prove that if R is a commutative Noetherian ring of positive characteristic, then An（R）, the nth Weyl algebra over R, is injectively homogeneous （resp. homologically homogeneous） if R has finite injective dimension （resp. global dimension）.

关键词： Injectively homogeneous ring Homologically homogeneous ring Ore extension Quotient ring