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联合应用弹性成像、彩色多普勒超声和B型超声对致密型乳腺女性筛查乳腺肿块的价值:一项多中心前瞻性研究

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国际医学放射学杂志 2018年第1期 99-99页

作者： s.Lee J.Chun H.Choi s.Choi E.B.Ryu K.H.Ko 张俊峰 department of Radiology and medical Research Collaborating center Seoul National University Hospital

摘要目的探究联合应用弹性成像、彩色多普勒超声和B型超声(B-Us)对致密型乳腺女性筛查乳腺肿块的价值。材料与方法此前瞻性多中心性研究纳入了2013年11月—

关键词：弹性成像乳腺肿块彩色多普勒超声致密型乳腺型超声联合应用

保乳手术至术后放疗的间隔时间对老年乳腺癌患者局部复发的影响：回顾性队列分析（摘要）

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英国医学杂志中文版 2010年第5期13卷 305-306页

作者： Rinaa s Ptmglia Aldko M saito Bridget A Neville Craig C Earle Jane C Weeks 刘雨桃(译) 王燕(校) Departmcnt of Radiation Oneology Dana-Farber Cancer Institute Boston MA 02115 USA department of medical Oncology Dana-Father Cancer Institute Boston Laboratory of Clinical Epideraiological and Health Services Research Clinical Research Center National Hospital Organization Nagoya Medical Center Aichi Japan Institute for Cainical Evaluative sciences Toronto ON Canada 中国医学科学院肿瘤医院内科

目的探讨保乳手术至术后开始放疗的间隔时间长短是否对老年乳腺癌患者局部复发产生影响，以及可能引起放疗推迟的原因。

关键词：乳腺癌患者术后放疗局部复发间隔时间保乳手术队列分析老年摘要

Highlights of the 2nd International symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer

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Acta Pharmaceutica sinica B 2019年第2期9卷 443-454页

作者： Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren s. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco shuang shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang shanshan Liu Jinmei Yu Zhuowei Hu state Key Laboratory of Bioactive substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College department of Biochemistry Institute of Integrative Biology University of Liverpool Division of Molecular Biology and Biochemistry School of Biological Sciences University of Missouri-Kansas City school of Biological sciences Nanyang Technological University Lee Kong Chian school of Medicine Nanyang Technological University Institute of Molecular and Cell Biology KK women's and children Hospital Biochemistry department School of Biomedical Sciences University of Otago Centre for Biomedical Research (CBMR) University of Algarve Campus de Gambelas department of Biomedical sciences and Medicine University of Algarve Algarve Biomedical center (ABC) University of Algarve Campus de Gambelas department of Infection Immunity and Cardiovascular Disease University of Sheffield Paul O'Gorman Leukaemia Research Centre Institute of Cancer Sciences University of Glasgow Division of Carcinogenesis The Cancer Institute Japanese Foundation for Cancer Research department of Pathology and Laboratory Medicine Abramson Family Cancer Research Institute Perelman School of Medicine at the University of Pennsylvania Centre de Recherche en Transplantation et Immunologie (ou CRTI) Inserm Université de Nantes Nantes France Institut de Transplantation Urologie Néphrologie (ou ITUN) CIC bioGUNE CIBERONC Ikerbasque Basque Foundation for Science Biochemistry and Molecular Biology department University of the Basque Country (UPV/EHU) Institute for Diabetes and Cancer IDC Helmholtz Center Munich Joint Heidelberg-IDC Translational Diabetes Program University Hospital Heidelberg Molecular Metabolic Control Medical Faculty Technical University Munich German center for Diabetes Research (DZD) Division of Cardiology Department of Medicine Columbia University Irving Medical Center school of sport and Health sciences Cardiff Metropolitan Universit

The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases.

关键词： Tribbles Immunology Metabolism Cell biology Kinase inhibitor Tumorigenesis Metastasis TRIB1 TRIB2 TRIB3 Pseudokinase Inflammation Atomic structure Protein quality control Ubiqutin

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双侧对比剂增强双能量数字乳腺钼靶摄影:在女性乳腺癌病人中的可行性并与传统数字乳腺钼靶摄影及MRI对比

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国际医学放射学杂志 2013年第3期 263-263页

作者： M.s.Jochelson D.D.Dershaw J.s.sung A.s.Heerdt C.Thornton C.s.Moskowitz 江峰 department of Radiology Memorial Sloan-Kettering Cancer Center

目的探讨双侧双能量(DE)对比剂增强(CE)数字乳腺钼靶摄影的可行性,并与传统数字乳腺钼靶摄影及MR成像对比,从而评估其在女性乳腺癌病人中的应用价值。材料与方法本研究经过伦理委员会批准,符合HIPAA并获得了书面知情同意书。病人纳入时... 详细信息

目的探讨双侧双能量(DE)对比剂增强(CE)数字乳腺钼靶摄影的可行性,并与传统数字乳腺钼靶摄影及MR成像对比,从而评估其在女性乳腺癌病人中的应用价值。材料与方法本研究经过伦理委员会批准,符合HIPAA并获得了书面知情同意书。病人纳入时间为2010年3月—2011年8月,病人年龄25～74岁,平均49.6岁。10例新近诊断为乳腺癌的女性按每千克体质量静脉注射1.5mL碘海醇,并在注射后2.5～10min内采集图像以评估可行性。当可行性得到证实后,52例近期经乳腺MR检查诊断为乳腺癌的女性病人将接受DECE数字乳腺钼靶摄影检查。阳性结果与病理结果对照。结果可行性被证实,并且无不良反应。对比剂注射后可见肿瘤强化时间长达10min,肿瘤的强化与时间无关。MR成像与DECE数字乳腺钼靶摄影均在52例肿瘤中检测出50例(96%);传统数字乳腺钼靶摄影检测出42例(81%)。使用DECE数字乳腺钼靶摄影检出病灶大小为4～67mm(中间值17mm)。DECE数字乳腺钼靶摄影在25个同侧额外肿瘤病灶中检测出14个(56%),MRI检测出22个(88%)。在DECE数字乳腺钼靶摄影中有2例假阳性结果,而MR成像中出现13例假阳性结果。有1例对侧癌灶在各项检查中均未显示。结论双侧DECE数字乳腺钼靶摄影可行且容易实施。它对于已知原发肿瘤的检出率与MR成像相当,高于传统数字乳腺钼靶摄影。DECE数字乳腺钼靶摄影对于额外的同侧肿瘤病灶检出敏感性较MR成像低,但特异性更高。

关键词：乳腺钼靶摄影传统数字双侧乳腺癌乳腺肿瘤对比剂增强双能量病人 MRI 女性

高原地区新型冠状病毒肺炎重症患者(重型/危重型)诊疗专家共识

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中华重症医学电子杂志 2022年第4期8卷 340-346页

作者：刘玲李绪言徐永昊赵慧颖罗巧侠欧晓峰宋雷程渊周娟曾以萍刘爱华边巴穷达张烁吕杰王玺鲁燕云陈佰绪达珍俞云邵佳中华医学会重症医学分会重症呼吸学组西藏医学会高原医学暨心血管专业委员会中国医师协会重症医学医师分会格桑罗布康焰邱海波江苏省重症医学重点实验室、东南大学附属中大医院重症医学科南京210009 首都医科大学附属北京朝阳医院呼吸与危重症医学科、北京市呼吸疾病研究所北京100020 广州医科大学附属第一医院重症医学科、国家呼吸医学中心广州510120 北京大学人民医院重症医学科北京100044 西藏自治区第三人民医院肺一科拉萨850000 四川大学华西医院重症医学科成都610041 中国医学科学院、北京协和医学院、国家心血管病中心、阜外医院冠心病中心北京100037 北京大学第一医院呼吸和危重症医学科北京100034 西藏民族大学附属医院内科陕西咸阳712082 西藏自治区人民政府驻成都办事处医院呼吸与危重症医学科成都610041 北京医院风湿免疫科北京100730 西藏自治区人民医院呼吸与危重症科拉萨850000 北京大学第一医院急诊科北京100034 西藏自治区第二人民医院、西藏大学第一附属医院重症医学科拉萨850001 西藏自治区妇产儿童医院儿科拉萨850000 不详

高原地区海拔高、合并慢性高原病等基础疾病多,常常存在基础疾病导致的低氧血症,使得新型冠状病毒肺炎(简称新冠肺炎)重症患者的临床识别和诊断困难。为规范高原新冠肺炎的诊疗行为,笔者依据新冠肺炎诊疗方案(试行第九版)、国内外最新... 详细信息

高原地区海拔高、合并慢性高原病等基础疾病多,常常存在基础疾病导致的低氧血症,使得新型冠状病毒肺炎(简称新冠肺炎)重症患者的临床识别和诊断困难。为规范高原新冠肺炎的诊疗行为,笔者依据新冠肺炎诊疗方案(试行第九版)、国内外最新研究进展及专家意见,针对高原新冠肺炎诊疗实践中常见的重要问题,采用共识会议的方法形成本共识,为高原地区新冠肺炎重症患者的规范诊疗提供依据。

关键词：高原地区新型冠状病毒肺炎重症患者专家共识

乳腺MRI筛查对于乳腺癌不同风险指标升高的女性的作用

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国际医学放射学杂志 2019年第5期 606-606页

作者： D.sippo K.Burk s.Mercaldo G.Rutledge C.Edmonds Z.Guan 张晓程 department of Radiology Massachusetts General HospitalAvon Comprehensive Breast Evaluation Center

摘要对具有BRCA突变或曾有胸部X线照射的女性,建议进行乳腺MRI筛查。但对于有乳腺癌史或高危病变的女性,目前乳腺MRI筛查的指南并不明确。目的评估乳腺

关键词：乳腺癌 MRI 风险指标

双能量增强数字乳腺摄影在乳腺癌高危女性筛查的性能

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国际医学放射学杂志 2019年第6期 735-735页

作者： J.s.sung L.Lebron D.Keating D.D.Alessio C.E.Comstock C.H.Lee 周茜洋 department of Radiology Memorial Sloan-Kettering Cancer Center

摘要在诊断中,已证明对比剂增强数字乳腺X线摄影(CEDM)比二维全视野数字乳腺X线摄影的敏感性和特异性高,然而很少有研究报道其在筛查环境中的性能。目的评

关键词：乳腺癌数字乳腺摄影高危女性

医疗卫生保健系统对乳腺癌和宫颈癌妇女的作用

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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 61-61页

作者： Kirsner R.s. Fleming L. 高雪莲 University of Miami/Ve terans Administration medical center Department of Dermatology 1201 NW 16th St reet Miami FL 33125 United States Dr.

OBJECTIVE: Two common health care delivery systems in the United states are fe e-for-service and managed care systems, including health maintenance organizat ions (HMOs). Differences may exist in patient outcomes depending upon the health care delivery system in which they are enrolled. We evaluated possible differen ces in the stage at diagnosis for breast and cervical cancer between 2 Medicare health care delivery systems (ie, fee for service and HMO) over the period 1985 -2001. METHODs: We used a linkage of 2 national databases: the Medicare databas e from the centers for Medicare and Medicaid services and the National Cancer In stitute’s surveillance, Epidemiology, and End Results program database to evalu ate differences in stage at diagnosis between HMO and fee for service for breast and cervical cancer. REsULTs: We studied 130,336 Medicare-aged women with brea st cancer (83%Medicare fee for service) and 6,758 women with cervical cancer (8 7%Medicare fee for service). We found an earlier stage of diagnosis for HMO pat ients, which remained significant after adjusting for potential confounding vari ables. women enrolled in HMOs with breast cancer were 17%more likely and those with cervical cancer 35%more likely to be diagnosed at an in situ stage of diag nosis than fee-for-service patients. It is of note that when women had other c ancer diagnoses, no statistically significant differences were seen in stage at diagnosis for either cancer between fee-for-service and HMO patients. CONCLUsI ON: Differences exist in stage at diagnosis between Medicare patients enrolled i n HMOs compared with fee for service. This is likely due in part to use of or ac cess to care.

关键词：医疗卫生保健医疗保健收费服务原位癌卫生保健系统国家癌症研究所癌症诊断维持组织项目数据库混杂变量

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Global Pediatric Pulmonology Alliance(GPPA)proposal for COVID-19 vaccination in children

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World Journal of Pediatrics 2021年第5期17卷 458-461页

作者： Lance E.Rodewald Kun-Ling shen Yong-Hong Yang Gary Wing-Kin Wong Leyla Namazova-Baranova Lanny J.Rosenwasser Adel s.Alharbi Anne B.Chang Jim Buttery Basil Elnazir Ruth A.Etzel Anne Goh Hilary Hoey Rosemary Home Eitan Kerem Antonella Muraro Chris O’Callaghan Kazunobu Ouchi Varinder singh Jiu-Yao Wang spencer Li Yu Guanon Yue-Jie Zheng Zhengde Xie Gen Lu Yi Jiang Xing-Wang Li Rong-Meng Jiang Xiao-Chuan Wang Ji-Kui Deng Xiao-Xia Lu Bao-Ping Xu Zhuang Wei Lu-Zhao Feng Zheng-Yan Zhao the Global Pediatric Pulmonology Alliance(GPPA)Counci Global Pediatric Pulmonology Alliance(GPPA)Expert Panel on Infectious Diseases and COVID-19 National Immunization Program Chinese Center for Disease Control and Prevention.BeijingChina China National Clinical Research center of Respiratory Diseases Department of RespiratoryBeijing Children's hospital.Capital Medical UniversityNational Center for Children's HealthBeijingChina Beijing children's Hospital Capital Medical UniversityNational Center for Children's HealthBeijingChina Chinese University of Hong Kong.Hong Kong sAR China Pediatrics and Child Health Research Institute Central Clinical HospitalRussian Academy of SciencesMoscowRussian Federation University of Missouri-Kansas City school of Medicine Kansas CityMOUSA Prince sultan Military medical City(PsMMC) Ministry of DefenseRiyadhSaudi Arabia Queensland children's Hospital.Brisbane Australia and Menzies School of Health ResearchDarwinAustralia Monash children's Hospital Monash UniversityMelbourneAustralia children's Health Ireland and Trinity College Dublin DublinIreland George Washington University WashingtonDCUSA KK women’s and children’s Hospital SingaporeSingapore department of Pediatrics University of Dublin Trinity CollegeDublinIreland Monash University MelbourneAustralia department of Pediatrics Hadassah Hebrew University Medical CenterJerusalem.Israel Food Allergy Referral Centre Veneto Region Padua University Hospital PaduaItaly UCL Great Ormond street Institute of Child Health Great Ormond Street Hospital(GOSH)BRCUniversity College LondonLondonUK department of Pediatrics.Kawasaki medical school Kurashiki-cityJapan Lady Hardinge medical College and Assoc Kalawati saran children's Hospital Bangla Sahib MargNew DelhiIndia College of Medicine National Cheng Kung UniversityTainan CityTaiwanChina VITUP International Hospital DalianLiaoningChina China Medicine Education Association Pediatric Committee BeijingChina department of Respiratory Disease Shenzhen Children's Hospital.ShenzhenChina Research Unit of Critical Infection in children Chinese Academy of Medical Sciences2019RU016National Clinical Rese

Coronavirus disease 2019(COVID-19)remains a global *** of August 18,2021,the number of reported cases has exceeded 207 million globally,with more than 4.3 million ***-19 has brought devastating losses to human *** overall crude mortality rate is 1-3%.Although pediatric deaths from COVID-19 are rare,they do occur,as over 9,000 children have died from COVID-19 globally to date[1].With the gradual and broad application of COVID-19 vaccines around the world,the rising proportion of cases among children and unvaccinated young adults demands *** to World Health Organization surveillance data.

关键词： mortality globally Alliance