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Assessment of clinical depression metrics in cardiac patients using the patient health Questionnaire-9 before and after phase-II cardiac rehabilitation

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Sports Medicine and Health Science 2024年第3期6卷 240-245页

作者： John C.Quindry Michael mcnamara Carrie Oser Crystelle Fogle Integrative Physiology and Athletic Training University of MontanaMissoulaMTUSA St.Patrick's Hospital MissoulaMTUSA Cardiovascular Health Program–Montana Department of Public Health and Human Services HelenaMTUSA

Cardiovascular disease remains a leading cause of morbidity and mortality,a fact that is commonly associated with co-morbidities such as clinical *** phase II cardiac rehabilitation is an established intervention for those with cardiovascular disease,its effect on patients who also suffer from depression are under ***:To quantify Pre-and Post-cardiac rehabilitation questionnaire scores collected from a large patient data *** this investigation,27670 patients completed Patient Health Questionnaire-9 questionnaires both Pre-and Post-rehabilitation(averaging[28.08.7]phase II sessions).Findings reveal that questionnaire scores decreased by 40%–48%across all groups,a finding that was independent of assigned sex,race,and ***,when data were stratified for questionnaire scores that may indicate major and minor depressive disorder,phase II cardiac rehabilitation outcomes were lower by 61%and 49%*** all groups exhibited lower questionnaire scores following cardiac rehabilitation participation,numerical differences at Preand Post-rehabilitation time points indicate that males and White patients have more favorable *** latter observation,while not confirmed currently,appears to be linked to referral rates to phase II cardiac rehabilitation,which remain poor for females,racial and ethnic minorities.

关键词： Clinical depression Exercise Psychological health

Exploring Loss and Damage at the International Climate Change Talks

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International Journal of Disaster Risk Science 2014年第3期5卷 242-246页

作者： Karen Elizabeth mcnamara School of Geography Planning and Environmental ManagementThe University of QueenslandBrisbaneQLD 4072Australia

In recent years, there has been a growing need to address loss and damage as a result of climate change through international processes. At the most recent November 2013 international climate change talks in Warsaw, 194 countries negotiated the best way to establish institutional arrangements for loss and damage under the United Nations Framework Convention on Climate Change. Such a decision to establish these arrangements was made in 2012 in Doha in a decision known as the‘‘Doha Gateway.’’ While the 19th(2013) Conference of the Parties succeeded in delivering the Warsaw International Mechanism for Loss and Damage Associated with Climate Change Impacts, there was concern by some negotiators earlier into the conference that this would never transpire given the staunch disagreements between countries and lobbying blocks on a way forward. This article provides a brief historical overview of loss and damage at the climate change talks, and examines the key discourses defining this issue between 2011 and 2013 by analyzing submissions by lobbying blocks and member countries, and final negotiated texts. These discourses revolve around causality and solutions, compensation, and the relationship between loss and damage and adaptation.

关键词： Adaptation Climate change Loss and damage Mitigation United Nations

Helicobacter pylori:High dose amoxicillin does not improve primary or secondary eradication rates in an Irish cohort

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World Journal of Clinical Cases 2024年第16期12卷 2773-2779页

作者： Conor Costigan Aoife M O'Sullivan Jim O'Connell Shreyashee Sengupta Thomas Butler Stephen Molloy Fintan John O'Hara Barbara Ryan Niall Breslin Sarah O'Donnell Anthony O'Connor Sinead Smith Deirdre mcnamara Trinity Academic Gastroenterology Group School of Medicine-Trinity College DublinDublin D2Ireland Department of Gastroenterology Tallaght University HospitalDublin D24 NR0AIreland

BACKGROUND Helicobacter pylori(***)eradication rates have fallen globally,likely in large part due to increasing antibiotic resistance to traditional *** areas of high clarithromycin and metronidazole resistance such as ours,Maastricht VI guidelines suggest high dose amoxicillin dual therapy(HDADT)can be considered,subject to evidence for local *** this study we assess efficacy of HDADT therapy for *** eradication in an Irish *** To assess the efficacy of HDADT therapy for *** eradication in an Irish cohort as both first line,and subsequent therapy for patients diagnosed with *** All patients testing positive for *** in a tertiary centre were treated prospectively with HDADT(amoxicillin 1 g tid and esomeprazole 40 mg bid×14 d)over a period of 8 *** was confirmed with Urea Breath Test at least 4 wk after cessation of therapy.A delta-over-baseline>4%was considered *** demographics and treatment outcomes were recorded,analysed and controlled for basic demographics and prior *** *** One hundred and ninety-eight patients were identified with *** infection,10 patients were excluded due to penicillin allergy and 38 patients refused follow up *** all 139 were included in the analysis,55%(n=76)were female,mean age was 46.6 ***,93(67%)of patients were treatment-naïve and 46(33%)had received at least one previous course of *** groups were statistically ***-reported compliance with HDADT was 97%,mild side-effects occurred in 7%.There were no serious adverse drug *** the eradication rate for our cohort was 56%(78/139).Eradication rates were worse for those with previous treatment[43%(20/46)vs 62%(58/93),P=0.0458,odds ratio=2.15].Age and Gender had no effect on eradication *** Overall eradication rates with HDADT were *** being a simple and possibly better tolerated regime,these results do not

关键词： Helicobacter pylori eradication Helicobacter pylori High dose amoxicillin High dose amoxicillin dual therapy Triple therapy

A Framework for Disaster Vulnerability in a Small Island in the Southwest Pacific: A Case Study of Emae Island, Vanuatu

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International Journal of Disaster Risk Science 2017年第4期8卷 358-373页

作者： Guy Jackson Karen mcnamara Bradd Witt School of Earth and Environmental Science The University of Queensland

The societal costs of disasters around the world are continuing to increase and Pacific Island countries are considered some of the most vulnerable. This is primarily due to a combination of high hazard exposure coupled with a range of social, economic, physical, and political vulnerabilities. This article contributes to the growing body of work that aims to understand the causal factors of disaster vulnerability, but with a specific focus on small island developing states. The article first develops a framework for understanding disaster vulnerability, drawing on extensive literature and the well-established Methods for the Improvement of Vulnerability in Europe(MOVE)framework, and second, applies this adapted framework using empirically-derived data from fieldwork on Emae Island, Vanuatu to provide a working understanding of the causal elements of disaster vulnerability. Drawn from a significant body of scholarship at the time, the MOVE framework was primarily developed as a heuristic tool in which disaster vulnerability is considered to be a function of exposure, susceptibility(socially, economically, physically, culturally, environmentally, institutionally), and a lack of resilience. We posit that this adapted framework for small islands should also include historical susceptibility,and we prefer livelihood resilience(as capabilities, social capital, knowledge, participation, and human rights) over lack of resilience. We maintain that understanding disaster vulnerability holistically, which is inclusive of both strengths and drawbacks, is crucial to ensure that limited resources can target the causal factors that produce vulnerability and help safeguard and improve livelihoods in both the short and long term.

关键词： Disaster risk reduction Disaster vulnerability Livelihood resilience Small islands Vanuatu

Residential electrical vehicle charging strategies:the good,the bad and the ugly

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Journal of Modern Power Systems and Clean Energy 2015年第2期3卷 190-202页

作者： Mingming LIU Paul mcnamara Robert SHORTEN Sean MCLOONE Hamilton Institute Maynooth UniversityMaynoothCo.KildareIreland Department of Electronic Engineering Maynooth UniversityMaynoothCo.KildareIreland BM Research DublinIreland School of Electronics Electrical Engineering and Computer ScienceQueen’s University BelfastBelfastUK

In recent years,a wide variety of centralised and decentralised algorithms have been proposed for residential charging of electric vehicles(EVs).In this paper,we present a mathematical framework which casts the EV charging scenarios addressed by these algorithms as optimisation problems having either temporal or instantaneous optimisation objectives with respect to the different actors in the power *** this framework and a realistic distribution network simulation testbed,we provide a comparative evaluation of a range of different residential EV charging strategies,highlighting in each case positive and negative characteristics.

关键词： Electric vehicle Smart grid Decentralised control Centralised control Demand side management

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巴黎奥运期间运动员怎样才能睡好觉

新体育 2024年第8期 13-13页

作者： Paul mcnamara 不详

一些专家警告说,如果运动员每晚睡眠达不到黄金标准,后果可能很严重。2023年,一项针对122名运动员的研究显示,如果运动员每晚睡眠时间少于8小时,受伤的风险就会增加65%。睡眠和恢复专家安娜·韦斯特说:“如今,运动员只要晚上没睡好觉,... 详细信息

一些专家警告说,如果运动员每晚睡眠达不到黄金标准,后果可能很严重。2023年,一项针对122名运动员的研究显示,如果运动员每晚睡眠时间少于8小时,受伤的风险就会增加65%。睡眠和恢复专家安娜·韦斯特说:“如今,运动员只要晚上没睡好觉,第二天上午就会问:‘我会受伤吗?’”韦斯特的客户包括英超俱乐部阿森纳和布伦特福德。按照她的说法,过去的8年里,人们越来越关注高质量睡眠与卓越竞技成绩之间的关系。运动员对睡眠的重要性有更深刻的了解,却也常常为此感到焦虑。很多运动员甚至对安眠药产生了依赖。

关键词：韦斯特阿森纳竞技成绩睡眠时间布伦特运动员英超俱乐部

Editorial comment on: development and external validation of a model to predict overall survival in patients with resected gallbladder cancer

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 147-149页

作者： Mairéad G.mcnamara Division of Cancer Sciences University of Manchester&The Christie NHS Foundation TrustManchesterUK

The incidence of biliary tract cancer(BTC)(1),including gallbladder cancer(GBC)(2),is *** curative surgery is possible in only approximately 20%,and adjuvant capecitabine,versus observation after resection,has been reported to improve survival in a prespecified sensitivity and per-protocol analyses of the phase 3 randomised trial BILCAP(capecitabine compared with observation in resected BTC)(adjusting for minimisation factors,nodal status,grade,and gender)(3,4).The prognosis for patients with advanced BTC is poor;the median overall survival(OS)for patients receiving standard of care cisplatin/gemcitabine in the first-line setting was 11.7 months in the Advanced Biliary Cancer-02(ABC-02)study(5).There has been no alteration in the established choice of first-line systemic treatment for advanced BTC for over a ***,a recent press release announced that the phase 3 randomised study of durvalumab in combination with cisplatin/gemcitabine versus placebo with cisplatin/gemcitabine as a first-line treatment for patients with advanced BTC(TOPAZ-1)had met its primary endpoint of OS at the interim analysis;detailed results are awaited(NCT03875235).

关键词： patients gallbladder cancer

Assessment of Cognitive skills via Human-robot Interaction and Cloud Computing

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Journal of Bionic Engineering 2019年第3期16卷 526-539页

作者： Alessandro Di Nuovo Simone Varrasi Alexandr Lucas Daniela Conti John mcnamara Alessandro Soranzo Sheffield Hallam University Sheffield S1 1WB United Kingdom IBM Hursley Lab Winchester SO21 2JN United Kingdom

Technological advances are increasing the range of applications for artificial intelligence, especially through its embodiment within humanoid robotics platforms. This promotes the development of novel systems for automated screening of neurological conditions to assist the clinical practitioners in the detection of early signs of mild cognitive impairments. This article presents the implementation and the experimental validation of the first robotic system for cognitive assessment, based on one of the most popular platforms for social robotics, Softbank "Pepper", which administers and records a set of multi-modal interactive tasks to engage the user cognitive abilities. The robot intelligence is programmed using the state-of-the-art IBM Watson AI Cloud services, which provide the necessary capabilities for improving the social interaction and scoring the tests. The system has been tested by healthy adults (N= 35) and we found a significant correlation between the automated scoring and one of the most widely used Paper-and-Pencil tests. We conclude that the system can be considered as a screening instrument for cognitive assessment.

关键词： socially assistive robotics brief cognitive testing human-robot interaction neurological screening cloud computing

Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance

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World Journal of Gastroenterology 2014年第29期20卷 9912-9921页

作者： Sinéad M Smith Colm O’Morain Deirdre mcnamara Department of Clinical Medicine Trinity College DublinTrinity CentreAdelaide and Meath Hospital School of Pharmacy and Pharmaceutical Sciences Trinity College Dublin Department of Gastroenterology Adelaide and Meath Hospital

The gram-negative bacterium Helicobacter pylori(***)causes chronic gastritis,gastric and duodenal ulcers,gastric cancer and mucosa-associated lymphoid tissue *** is recommended in all symptomatic *** current treatment options for *** infection are outlined in this review in light of the recent challenges in eradication success,largely due to the rapid emergence of antibiotic resistant strains of *** resistance is a constantly evolving process and numerous studies have shown that the prevalence of *** antibiotic resistance varies significantly from country to country,and even between regions within the same *** addition,recent data has shown that previous antibiotic use is associated with harbouring antibiotic resistant *** surveillance of antibiotic resistance is warranted to guide clinicians in their choice of *** resistance is assessed by *** culture and antimicrobial susceptibility *** developed molecular tests offer an attractive alternative to culture and allow for the rapid molecular genetic identification of *** and resistance-associated mutations directly from biopsy samples or bacterial culture *** evidence indicates that surveillance of antimicrobial resistance by susceptibility testing is feasible and necessary to inform clinicians in their choice of therapy for management of *** infection.

关键词： Helicobacter pylori Antibiotic resistance Antimicrobial susceptibility testing Polymerase chain reaction Molecular test