检索结果-南通市图书馆

NeCAB family of neuronal calcium-binding proteins in health and disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Review of current method to determine outburst threshold limits in Australian underground coal mines

在线全文

学校读者我要写书评

暂无评论

International journal of Mining Science and Technology 2019年第6期29卷 859-865页

作者： dennis j.Black CoalGAS Department of Civil Mining and Environmental Engineering University of Wollongong

Desorption rate index(DRI)was presented to the Australian underground coal industry in 1995 as a means for determining outburst threshold limits for Australian coal *** is a measure of the gas volume released from a coal sample in the first 30 s of crushing during the Q3 stage of gas content testing,multiplied by the ratio between measured Q3 and *** were identified between QM and DRI for both CO2 and CH4 rich coal samples collected from the Bulli Seam at West Cliff Colliery and that identified relationship was referred to as the Bulli Seam *** outburst mining gas content threshold limit values specified for the Bulli Seam at that time,when applied to the QM-DRI Bulli Seam benchmark,was shown to closely align with a DRI value of 900(DRI900),for both CO2 and CH4 rich seam gas *** Australian coal industry adopted the DRI900 as the basis for determining outburst gas content TLV for Australian coal *** mining experience in Australia has shown that gas content is not the only significant factor that impacts outburst risk,as all significant outburst events have been associated with abnormal geological conditions,such as faults and ***,assessing the potential application of additional outburst risk factors,to accurately define outburst risk zones,set safe mining threshold levels,and determine appropriate mining controls,warrants further *** Australian coal mines have implemented mining procedures enabling mining to continue in areas with gas content greater than the TLV determined using the DRI900 approach,without inducing an *** is a broad lack of understanding among Australian coal mine operators as to the procedure and calculations used to determine ***,there has been growing concern regarding the accuracy and validity of the DRI900 method for determining outburst TLV.A comprehensive set of gas data has been collected from Australian coal seams,including the Bulli Seam,and t

关键词： Outburst Desorption rate DRI Threshold limit

Review of coal and gas outburst in Australian underground coal mines

在线全文

学校读者我要写书评

暂无评论

International journal of Mining Science and Technology 2019年第6期29卷 815-824页

作者： dennis j.Black CoalGAS Department of Civil Mining and Environmental Engineering University of Wollongong

Outburst of coal and gas represents a significant risk to the health and safety of mine personnel working in development and longwall production face *** have been over 878 outburst events recorded in twenty-two Australian underground coal *** outburst incidents have been associated with abnormal geological *** of Australian outburst incidents and mining experience in conditions where gas content was above current threshold levels are presented and *** experience suggests that for gas con-tent below 9.0 m^3/t,mining in carbon dioxide(CO2)rich seam gas conditions does not pose a greater risk of outburst than mining in CH4 rich seam gas *** experience also suggests that where no abnormal geological structures are present that mining in areas with gas content greater than the current accepted threshold levels can be undertaken with no discernible increase in outburst *** current approach to determining gas content threshold limits in Australian mines has been effective in prevent-ing injury from outburst,however operational experience suggests the current method is overly conser-vative and in some cases the threshold limits are low to the point that they provide no significant reduction in outburst *** factors that affect outburst risk,such as gas pressure,coal toughness and stress and geological structures are presently not incorporated into outburst threshold limits adopted in Australian *** factors and the development of an outburst risk index applicable to Australian underground coal mining conditions are the subject of ongoing research.

关键词： Outburst Desorption rate DRI Threshold limit

Investigations into the identification and control of outburst risk in Australian underground coal mines

在线全文

学校读者我要写书评

暂无评论

International journal of Mining Science and Technology 2017年第5期27卷 749-753页

作者： dennis j.Black PacificMGM Bulli 2516Australia Department of Civil Mining and Environmental EngineeringUniversity of WollongongWollongong 2500Australia

Australian coal mines currently use gas content to assess outburst risk. The gas content threshold values for each mine are indirectly determined from measurement of gas volume liberated from 150 g coal samples during Q_3 residual gas content testing. It has been more than twenty years since this method, known as desorption rate index(DRI), was presented to the Australian coal industry, and in that time, there have been significant changes in mining conditions and the outburst threshold limits used at the benchmark Bulli seam mines. NSW Regulations list matters to be considered in developing control measures to manage the risk of gas outburst, and specifies that gas content, or DRI method, is used as the basis for determining outburst control zone. Whilst Queensland Regulations state that a coal or rock outburst is a high potential incident, there is no guidance provided to assist mine operators to define outburst prone conditions. A research project is planned at UOW to investigate the application of the DRI method and other potentially significant factors, such as gas pressure, coal toughness and permeability, which can be utilised by mine operators to assess outburst risk and determine appropriate outburst threshold limits and controls.

关键词： Outburst Desorption rate DRI Threshold limit

Dietary enrichment of edible insects with omega 3 fatty acids

在线全文

学校读者我要写书评

暂无评论

Insect Science 2020年第3期27卷 500-509页

作者： dennis G.A.B.Oonincx Sophie Laurent Margot e.Veenenbos joop j.A.van Loon Department of Animal Sciences Animal Nutrition GroupWageningen UniversityWageningenthe Netherlands Laboratory of entomology Department of Plant SciencesWageningen UniversityWageningenthe Netherlands Sophie Laurent ON IRISFood Process EngineeringUMR CNRS 6144 GEPEANantes Cedex 3France

edible insects are advocated as sustainable and healthy food and ***,commercially produced insects are often low in n‐3 fatty acids and have suboptimal n‐6/n‐3 ratios.A certain amount and proportion of these FAs is required to optimize human *** oil consists primarily(57%)out of alpha‐linolenic *** experiment was conducted to quantify the effect of flaxseed oil provision on fatty acid composition and to determine the quantity needed to attain a beneficial n‐6/n‐3 *** species were used in the experiment:house crickets(Acheta domesticus[L.]),lesser mealworms(Alphitobius diaperinus[Pfanzer])and black soldier flies(Hermetia illucens[L.]).These were provided with either a control diet or a diet enriched with 1%,2%,or 4%flaxseed oil during their larval/nymphal *** acid profiles of diets and insects were determined via GC‐*** three species had distinct fatty acid profiles on all four diets,but responded similarly to flaxseed oil *** each percent added to the diet,the alpha‐linolenic acid content of the insects increased by 2.3%–2.7%.Four percent addition increased the n‐3 fatty acid content 10–20 fold in the three species and thereby strongly decreased n‐6/n‐3 ratios from 18–36 to 0.8–2.4.A ratio below 5 is considered optimal for human health and was achieved by 2%flaxseed oil inclusion for house crickets and lesser mealworms,and at 1%inclusion for black soldier *** a source of n‐3 fatty acids to insect diets can thus improve the nutritional quality of insects.

关键词： Acheta domesticus Alphitobius diaperinus diet fatty acids Hermetia illucens

Nuclear mechanics during constricted migration

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2019年第2期35卷 299-308页

作者： Yuntao Xia Charlotte R. Pfeifer dennis e. Discher Physical Sciences Oncology Center at Pennsylvania (PSOC@Penn) University of Pennsylvania PhiladelphiaPA 19104USA Molecular and Cell Biophysics Lab University of PennsylvaniaPhiladelphiaPA 19104 USA Department of Physics and Astronomy University of Pennsylvania Philadelphia PA 19104USA

Cell migration through narrow interstitial space in tissues is commonly seen in both physiological and pathological conditions. For example, immune cells have to squeeze through vasculature and extracellular matrix to reach the wound or diseased sites, and similarly cancer cells need to crawl through porous space in tissues to invade surrounding tumor-free regions. Therefore, the bulky stiff nucleus in the cell becomes a barrier during constricted migration making such process pore-size dependent with smaller pores exponentially alleviate the passage capability. However, in some cases, cells can actively deform their nuclei to squeeze through constrictions although some price needs to be paid. In this review, we focus on:(1) nuclear structures and morphological regulations,(2) proposed mechanisms that drive constricted migration,(3) short-term consequences such as nuclear envelope (Ne) rupture and DNA damage during such process,(4) biophysical factors that facilitate Ne rupture, and (5) long term consequences such as genomic variation caused by repetitive Ne rupture. Both experimental results and modeling are provided with the intention to better understand the constricted migration.

关键词： Constricted migration Nuclear envelope rupture DNA damage

effect of prophylactic clip placement following endoscopic mucosal resection of large colorectal lesions on delayed polypectomy bleeding: A meta-analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2019年第18期25卷 2251-2263页

作者： Fares Ayoub Donevan R Westerveld justin j Forde Christopher e Forsmark Peter V Draganov dennis Yang Department of Medicine University of Florida Division of Gastroenterology Hepatology and Nutrition University of Florida

BACKGROUND The role of prophylactic clipping for the prevention of delayed polypectomy bleeding(DPB) remains unclear and conclusions from prior meta-analyses are limited due to the inclusion of variety of resection techniques and polyp *** To conduct a meta-analysis on the effect of clipping on DPB following endoscopic mucosal resection(eMR) of colorectal lesions ≥ 20 *** We performed a search of PubMed and the Cochrane library for studies comparing the effect of clipping vs no clipping on DPB following endoscopic resection. The Cochran Q test and I^2 were used to test for heterogeneity. Pooling was conducted using a random-effects *** Thirteen studies with a total of 7794 polyps were identified, of which data was available on 1701 cases of eMR of lesions ≥ 20 mm. Prophylactic clipping was associated with a lower rate of DPB(1.4%) when compared to no clipping(5.2%)(pooled OR: 0.24, 95%CI: 0.12-0.50, P eMR of lesions ≥ 20 *** was no significant heterogeneity among the studies(I^2 = 0%, P = 0.67).CONLUSION Prophylactic clipping may reduce DPB following eMR of large colorectal *** trials are needed to further identify risk factors and stratify high risk cases in order to implement a cost-effective preventive strategy.

关键词： Meta-analysis Clipping endoscopic resection endoscopic mucosal resection

Acoustic measurements of models of military style supersonic nozzle jets

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese journal of Aeronautics 2014年第1期27卷 23-33页

作者： Ching-Wen Kuo jérémy Veltin dennis K.McLaughlin Department of Aerospace engineering The Pennsylvania State UniversityUniversity Park TNO Science and Industry

Modern military aircraft jet engines are designed with variable-geometry nozzles to provide optimal thrust in different operating conditions, depending on the flight envelope. How- ever, acoustic measurements for such nozzles are scarce, due to the cost involved in making full- scale measurements and the lack of details about the exact geometries of these nozzles. Thus the present effort at Pennsylvania State University （PSU） in partnership with Ge Aviation and the NASA Glenn Research Center is aiming to study and characterize the acoustic field produced by supersonic jets issuing from converging-diverging military style nozzles, and to identify and test promising noise reduction techniques. An equally important objective is to develop methodology for using data obtained from small- and moderate-scale experiments to reliably predict the full-scale engine noise. The experimental results presented show reasonable agreement between small-scale and medium-scale jets, as well as between heated jets and heat-simulated ones.

关键词： Aeroacoustics Acoustic noise measurement jet noise jets Nozzle Supersonic flow

Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos j.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis