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固体氧化物燃料电池阴极气体传输的研究

电源技术 2007年第10期31卷 777-778,807页

作者：倪萌 leung MIcHAEL K H leung dennis y c 香港大学机械工程系

建立了一个数值模型,来计算并论述在固体氧化物燃料电池(SOFc)阴极中的扩散和渗透共同作用下的传质现象。经过对比分析,研究了阴极内压力梯度对气体传输、气体分布,以及浓度过电压的影响。研究表明,文献中所采用的扩散模型可近似模拟SOF... 详细信息

建立了一个数值模型,来计算并论述在固体氧化物燃料电池(SOFc)阴极中的扩散和渗透共同作用下的传质现象。经过对比分析,研究了阴极内压力梯度对气体传输、气体分布,以及浓度过电压的影响。研究表明,文献中所采用的扩散模型可近似模拟SOFc阴极的浓度过电压。但是,对于气体成份沿阴极的分布,则必须考虑压力梯度的影响。在此提出的模型可进一步深化,以优化SOFc电极的多孔结构。

关键词：固体氧化物燃料电池阴极浓度过电压 Fick模型传质

Sequence assembly using next generation sequencing data —challenges and solutions

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Science china(Life Sciences) 2014年第11期57卷 1140-1148页

作者： cHIN Francis y.L. leung Henry.c.M. yIU S.M. Department of computer Science The University of Hong Kong

Sequence assembling is an important step for bioinformatics *** the help of next generation sequencing(NGS)technology,high throughput DNA fragment(reads)can be randomly sampled from DNA or RNA molecular ***,as the positions of reads being sampled are unknown,assembling process is required for combining overlapped reads to reconstruct the original DNA or RNA *** with traditional Sanger sequencing methods,although the throughput of NGS reads increases,the read length is shorter and the error rate is *** introduces several problems in ***,paired-end reads instead of single-end reads can be sampled which contain more *** existing assemblers cannot fully utilize this information and fails to assemble longer *** this article,we will revisit the major problems of assembling NGS reads on genomic,transcriptomic,metagenomic and metatranscriptomic *** will also describe our IDBA package for solving these *** package has adopted several novel ideas in assembling,including using multiple k,local assembling and progressive depth *** with existence assemblers,IDBA has better performance on many simulated and real sequencing datasets.

关键词： genomic assembling de Bruijn graph paired-end reads next generation sequencing

Big data and machine learning in geoscience and geoengineering:Introduction

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Geoscience Frontiers 2021年第1期12卷 327-329页

作者： Wengang Zhang Jianye ching Anthony T.c.Goh Andy y.F.leung School of civil Engineering Chongqing UniversityChongqing 400045China Department of civil Engineering National Taiwan UniversityChinese Taipei School of civil and Environmental Engineering Nanyang Technological UniversitySingapore Department of civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina

In recent years,we have entered the so-called Fourth Paradigm with the regular production of huge amount of observational *** data is often characterized by the three‘V's:Volume of data,Variety and *** concept of big data can potentially address some existing issues in areas of geoscience and ***-scale,comprehensive,multidirectional and multifield geotechnical monitoring is becoming a reality in the very near future.

关键词： becoming engineering. Velocity

高掺量粉煤灰高延性水泥基复合材料的制备和性能

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硅酸盐学报 2009年第12期37卷 2071-2077页

作者：庞超明 leung c K y 孙伟东南大学材料科学与工程学院江苏省土木工程材料重点实验室南京211189 香港科技大学土木工程与环境学院中国香港九龙

高延性水泥基复合材料(high ductility.c.mentitious composites,HDcc)是一种具有应变硬化、多缝开裂和高延性等特性的新型纤维增强水泥基复合材料,其材料设计必须取得基体韧度、界面黏结和纤维特性三者的最优组合,因此,HDcc的制备必须... 详细信息

高延性水泥基复合材料(high ductility.c.mentitious composites,HDcc)是一种具有应变硬化、多缝开裂和高延性等特性的新型纤维增强水泥基复合材料,其材料设计必须取得基体韧度、界面黏结和纤维特性三者的最优组合,因此,HDcc的制备必须优选原材料和优化配合比,以取得最优的材料制备技术。从配合比设计入手,研究了粉煤灰含量、胶砂比等对HDcc力学性能的影响,优化了特定材料下的材料制备技术。结果表明:粉煤灰含量、胶砂比和养护条件对HDcc的拉伸性能均具有较大的影响。随着粉煤灰掺量的增大,砂含量的降低,拉伸应变增大。当砂含量较高时,基体开裂韧度较高,基体的极限拉伸应力下对应的极限拉伸应变较小,然而随着应力的下降,复合材料仍然能维持相当大的应变。

关键词：高延性纤维增强水泥基复合材料拉伸性能粉煤灰含量胶砂比

Residues of Polychlorinated Biphenyls (PcBs) in Fish, Water and Sediment from Shing Mun River

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Biomedical and Environmental Sciences 1991年第4期4卷 399-408页

作者： V.W.D.cHUI T.c.cHAN S.y.LAM-leung Department of Biology Hong Kong Baptist college 224 Waterloo Road Kowloon Hong KongDepartment of Biology Hong Kong Baptist College 224 Waterloo Road Kowloon Hong KongDepartment of Chemistry Hong Kong Baptist College 224 Waterloo Road Kowloon Hong Kong

The level and pattern of contamination by polychlorinated biphenyls (PcBs) were investigated in tilapia, Oreochromis mossambicus (Peters), sediment, and water from the Shing Mun River. The range of total PcBs was 12.9 ng/g to 181.6 ng/g wet weight in tilapia, 12.7 ng/g to 46.0 ng/g freeze-dried weight in sediment, and 3.8 ng/L to 13.6 ng/L in water. The effect of biomagnification was also observed, PcB concentrations increased from water to sediment to tilapia. PcB congeners occurred in such a way that lower chlorinated PcBs comprised a higher fraction of the total PcBs in water, sediment, and tilapia muscle, whereas higher chlorinated PcBs were more commonly found only in tilapia.

关键词： PcBs Residues of Polychlorinated Biphenyls Water and Sediment from Shing Mun River in Fish

Optical and thermal performance analysis of aerogel glazing technology in a commercial building of Hong Kong

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能源与人工环境(英文) 2020年第2期1卷 215-223页

作者： c.K.leung L.Lu y.Liu H.S.cheng Jeff H.Tse Department of Building Services Engineering The Hong Kong Polytechnic UniversityZS850Block ZHung HomKowloonHong KongChina college of civil Engineering Hunan UniversityChangshaHunan 410082China Electrical and Mechanical Services Department HKSARHong KongChina

Improving the thermal insulation of glazing units is a common strategy of reducing building energy use for spacing *** paper newly examined the application of aerogel glazing technology in Hong Kong by the means of laboratory testing and *** prototypes of granular aerogel glazing were selected to examine their optical properties,and the measured optical properties of aerogel were used to calculate the total window thermal performance indices.A typical 40-story.c.mmercial office building was chosen for energy simulation to compare the thermal performance of aerogel glazing with different glazing technologies in Hong *** results showed that aerogel glazing could achieve the promising reduction of window heat gain up to 57%and cooling energy up to 8.5%compared with double *** heat insulation performance of aerogel glazing is even better than the double glazing with low-E coating in Hong ***,aerogel glazing can be a good alternative of glazing to comply with the existing local Overall Thermal Transfer Value(OTTV)requirement and to reduce the building energy use for space cooling in Hong Kong and other regions.

关键词： Glazing technology Aerogel glazing Building energy saving

cDc7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through Myc degradation

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3519-3532页

作者： Alvaro Quintanal-Villalonga Kenta Kawasaki Esther Redin Fathema Uddin Swanand Rakhade Vidushi Durani Amin Sabet Moniquetta Shafer Wouter R.Karthaus Samir Zaidi yingqian A.Zhan Parvathy Manoj Harsha Sridhar dennis Kinyua Hong Zhong Barbara P.Mello Metamia ciampricotti Umesh K.Bhanot Irina Linkov Juan Qiu Radhika A.Patel colm Morrsey Sanjoy Mehta Jesse Barnes Michael c.Haffner Nichlas D.Socci Richard P.Koche Elisa de Stanchina Sonia Molina-Pinelo Sohrab Salehi Helena A.yu Joseph M.chan charles M.Rudin Department of Medicine Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNYUSA cancer Biology and Genetics Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Vagelos college of Physicians and Surgeons Columbia UniversityNew YorkNYUSA Weill cornell Graduate School of Medical Sciences Weill Cornell MedicineNew YorkNYUA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNYUSA center for Epigenetics Research Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Pathology.c.re Facilty Department of Pathology and Laboratory MedicineMSKCCNew YorkNYUSA Antitumor Assessment core Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Divisionsof Human Biology and clinical Research Fred Hutchinon Cancer CenterSeattleWAUSA Deparmentof Urology University of WashingtonSeattleWAUSA Gene Editing&Screening core Facility Memorial Sloan Kettering cancer center New YorkNYUSA Department of Laboratory Medicine and Pathology University of WashingtonSeattleWAUSA Bioinfomatics coreFacility Memorial Soan Kettering Cancer CenterNew YorkNYUSA Institute of Biomedicine of Seille(Bis) HURCSCUniversidad de SevillaSevilleSpain computational Oncology Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Well cornell Medical college New york NYUSA Present address:Swiss Institute for Experimental cancer Research(ISREc) School of Life SciencesEPFLLausanneSwitzerland

Neuroendocrine(NE)transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor *** to date,even if patients at high risk of transformation can be identified by the occurrence of Tumor Protein P53(TP53)and Retinoblastoma Transcriptional corepressor 1(RB1)mutations in their tumors,no therapeutic strategies are available to prevent or delay histological *** of the cell cycle kinase cell Division cycle 7(cDc7)occurred in tumors during the initial steps of NE transformation,already after TP53/RB1 co-inactivation,leading to induced sensitivity to the cDc7 inhibitor ***7 inhibition suppressed NE transdifferentiation and extended response to targeted therapy in in vivo models of NE transformation by inducing the proteasome-mediated degradation of the Myc Proto-Oncogen(Myc),implicated in stemness and histological *** overexpression of a degradation-resistant Myc isoform reestablished the NE transformation phenotype observed on targeted therapy,even in the presence of ***7 inhibition also markedly extended response to standard cytotoxics(cisplatin,irinotecan)in lung and prostate small cell carcinoma *** results nominate cDc7 inhibition as a therapeutic strategy to constrain lineage plasticity,as well as to effectively treat NE tumors de novo or after *** simurosertib clinical efficacy trials are ongoing,this concept could be readily translated for patients at risk oftransformation.

关键词： tumors markedly transformation

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水泥基材料断裂性能与微孔结构研究

建筑材料学报 2011年第4期14卷 523-527页

作者：庞超明 leung c.K.y. 孙伟徐剑东南大学材料科学与工程学院江苏南京211189 东南大学江苏省土木工程材料重点实验室江苏南京211189 香港科技大学土木工程与环境系江苏省交通科学研究院股份有限公司长大桥梁健康检测与诊断交通行业重点实验室江苏南京211112

以高掺量粉煤灰HDcc配合比为基础,测试了不同龄期基体的抗压强度、断裂韧度,同时采用MIP测试了其微孔结构.结果表明:养护28d主要改善基体大于50nm的大毛细孔结构,养护28d后再热养护7d主要改善其小于200nm的微孔分布,而养护28d后再继续... 详细信息

以高掺量粉煤灰HDcc配合比为基础,测试了不同龄期基体的抗压强度、断裂韧度,同时采用MIP测试了其微孔结构.结果表明:养护28d主要改善基体大于50nm的大毛细孔结构,养护28d后再热养护7d主要改善其小于200nm的微孔分布,而养护28d后再继续热养护7d以上则仅仅改善其小于20nm的微孔分布,且改善效果不大;龄期、水胶比、粉煤灰品种及其掺量对基体抗压强度的影响大于它们对断裂韧度的影响,粉煤灰品种对抗压强度影响较大,但对断裂韧度的影响很小;断裂韧度与孔隙率的相关性大大低于抗压强度与孔隙率,如果在相关关系的拟合曲线中考虑小于20nm微孔含量的影响,则置信水平可大大提高.

关键词：水泥基复合材料微孔分布微观性能

A variational energy approach for electromechanical analysis of thick piezoelectric beam

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第9期6卷 962-966页

作者： LAU c.W.H. LIM c.W. leung A.y.T Department of Building and construction City University of Hong KongDepartment of Building and Construction City University of Hong Kong Hong Kong ChinaDepartment of Building and Construction City University of Hong Kong Hong Kong China Hong Kong China Department of construction Institute of Vocational Education (Tsing Yi) Hong Kong China

A new two dimensional coupled electromechanical model for a thick, laminated beam with piezoelectric and isotropic lamina subjected to static external electric loading is developed. The model combined the first order shear deformation theory for the relatively thick elastic core and linear piezoelectric theory for the piezoelectric lamina. The actuation response is induced through the application of external electric voltage. Rayleigh-Ritz method is adopted to model the displacement and potential fields of the beam and governing equations were finally derived from the variational energy principle. The model allows the piezoelectric lamina to be formulated via a two-dimensional model because of the strong electro-mechanical coupling and the presence of a two-dimensional electric field. Numerical examples of piezoelectric laminated beam are presented. It is shown in this paper that a one-dimensional model for the piezoelectric beam-like layer is inadequate.

关键词： Energy Electromechanical Linear piezoelectricity Ritz method Thick beam