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Revealing the Host-Dependent Nature of an Engineered Genetic Inverter in Concordance with Physiology

BioDesign Research 2023年第1期5卷 106-120页

作者： dennis tin chat chan Geoff S.Baldwin Hans C.Bernstein Faculty of Biosciences Fisheries and EconomicsUiTThe Arctic University of Norway9019 TromsøNorway. Department of Life Sciences Imperial College LondonSouth KensingtonLondon SW72AZUK. Imperial College Centre for Synthetic Biology Imperial College LondonSouth KensingtonLondon SW72AZUK. The Arctic Centre for Sustainable Energy UiTThe Arctic University of Norway9019 TromsøNorway.

Broad-host-range synthetic biology is an emerging frontier that aims to expand our current engineerable domain of microbial hosts for biodesign *** more novel species are brought to“model status,”synthetic biologists are discovering that identically engineered genetic circuits can exhibit different performances depending on the organism it operates within,an observation referred to as the“chassis effect.”It remains a major challenge to uncover which genome-encoded and biological determinants will underpin chassis effects that govern the performance of engineered genetic *** this study,we compared model and novel bacterial hosts to ask whether phylogenomic relatedness or similarity in host physiology is a better predictor of genetic circuit *** was accomplished using a comparative framework based on multivariate statistical approaches to systematically demonstrate the chassis effect and characterize the performance dynamics of a genetic inverter circuit operating within 6 *** results solidify the notion that genetic devices are strongly impacted by the host ***,we formally determined that hosts exhibiting more similar metrics of growth and molecular physiology also exhibit more similar performance of the genetic inverter,indicating that specific bacterial physiology underpins measurable chassis *** result of this study contributes to the field of broad-host-range synthetic biology by lending increased predictive power to the implementation of genetic devices in less-established microbial hosts.

关键词： inverter Engine formally

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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi dennis Yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

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The Study of Deposition Parameters, Properties for PVD Ti_xN and Cr_xN Coatings Using a Closed Field Unbalanced Magnetron Sputter Ion Plating System

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材料热处理学报 2004年第5B期25卷 841-846页

作者： HailinSun SusanField JianChen dennis.G.Teer TeerCoatingsLtd. WestStoneHouseBerryHillIndustrialEstateDroitwichWR99ASUK StateKeyLaboratoryofMechanicalBehaviourforMaterialss Xi＇anJiaotongUniversityP.R.CHINA

Closed Field Unbalanced Magnetron Sputter Ion Plating (CFUBMSIP) systems have been used increasingly for PVD coating in recent years. tin and CrN coatings, commonly used as the basic coating for a number of different hard coatings, have been chosen to study the coating process parameters for the CFUBMSIP system. In this paper, the process parameters, such as substrate temperature, substrate bias and OEM control, have been carefully examined to achieve hard and wear-resistance coatings with good adhesion. The coating structure and orientation were found to change according to the coating parameters. The Rockwell test and Scratch test were carried out to examine the coating adhesion; pin-on-disc testing was used to estimate the wear-resistant; micro-hardness was also used to determine coating hardness. HSS drill testing has been carried out to study the general properties of the coating for cutting tool application. A combination of process parameters can be selected to achieve good performance for the tin and CrN coatings.

关键词： PVD 衬底温度磁控管溅射 TixN涂层 CrxN涂层 OEM

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Degradation study on tin- and bismuth-based gas-diffusion electrodes during electrochemical CO_(2) reduction in highly alkaline media

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Journal of Energy Chemistry 2021年第11期30卷 367-376,I0008页

作者： Fabian Bienen Armin Lowe Joachim Hildebrand Sebastian Hertle Dana Schonvogel dennis Kopljar Norbert Wagner Elias Klemm Kaspar Andreas Friedrich Institute of Engineering Thermodynamics German Aerospace CenterPfaffenwaldring 38-4070569 StuttgartGermany Institute of Building Energetics Thermal Engineering and Energy StorageUniversity of StuttgartPfaffenwaldring 3170569 StuttgartGermany Institute of Technical Chemistry University of StuttgartPfaffenwaldring 5570569 StuttgartGermany Institute of Engineering Thermodynamics German Aerospace CenterCarl-von-Ossietzky-Straße 1526129 OldenburgGermany

This work investigated the degradation of tin – based gas-diffusion electrodes (GDE) and also a promising Bi2O3 GDE in electrochemical CO_(2) reduction in highly alkaline media which has not been studied before. The contributions of the electrode wetting (or flooding, if excessively) and catalyst leaching on the degradation were analyzed. Therefore, electrochemical impedance spectroscopy was used to monitor the wetted surface area of the GDE in combination with post-mortem analysis of the penetration depth by visualizing the electrolyte’s cation in the GDE cross-section. Furthermore, to reveal a possible degradation of the electrocatalyst, its distribution was mapped in the GDEs cross-section after operation while the catholyte was additionally analyzed via ICP-MS. The results clearly demonstrate that the SnO_(2) catalyst dissolves in the reaction zone inside the GDE and might be partially redeposited near the GDEs surface. Since the redeposition process occurs only partially a steady loss of catalyst was observed impeding a clear distinction of the two degradation phenomena. Nevertheless, the deterioration of the electrode performance measured as faraday efficiency (FE) of the parasitic hydrogen evolution reaction (HER) qualitatively correlates with the differential double layer capacitance (Cdl). A significant difference of the rate of increase for the hydrogen FE and Cdl can be ascribed to the superposition of both above-mentioned degradation mechanisms. The demonstrated instability of SnO_(2) contrasts with the behavior of Bi2O3 GDE which is stabilized during CO_(2) conversion by redeposition of the diluted dissolved species as metallic Bi which is active for the CO_(2) reduction reaction.

关键词： Electrochemical CO_(2)reduction Heterogeneous catalysis Gas-diffusion electrode Electrochemical impedance spectroscopy Catalyst leaching

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