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Liver-specific drug delivery platforms: Applications for the treatment of alcohol-associated liver disease

World Journal of Gastroenterology 2022年第36期28卷 5280-5299页

作者： Jeffrey Barr warner Steven Corrigan Guenthner Josiah Everett Hardesty Craig James McClain dennis ray warner Irina Andreyevna Kirpich Department of Medicine Division of GastroenterologyHepatology and NutritionUniversity of Louisville School of MedicineLouisvilleKY 40202United States Department of Pharmacology and Toxicology University of Louisville School of MedicineLouisvilleKY 40202United States Alcohol Research Center University of Louisville School of MedicineLouisvilleKY 40202United States Hepatobiology and Toxicology Center University of Louisville School of MedicineLouisvilleKY 40202United States Veterans Health Administration Robley Rex Veterans Medical CenterLouisvilleKY 40206United States Department of Microbiology and Immunology University of Louisville School of MedicineLouisvilleKY 40202United States

Alcohol-associated liver disease(ALD)is a common chronic liver disease and major contributor to liver disease-related deaths *** its prevalence,there are few effective pharmacological options for the severe stages of this *** much pre-clinical research attention is paid to drug development in ALD,many of these experimental therapeutics have limitations such as poor pharmacokinetics,poor efficacy,or off-target side effects due to systemic *** means of addressing these limitations is through liver-targeted drug delivery,which can be accomplished with different platforms including liposomes,polymeric nanoparticles,exosomes,bacteria,and adenoassociated viruses,among *** platforms allow drugs to target the liver passively or actively,thereby reducing systemic circulation and increasing the‘effective dose’in the *** many studies,some clinical,have applied targeted delivery systems to other liver diseases such as viral hepatitis or hepatocellular carcinoma,only few have investigated their efficacy in *** review provides basic information on these liver-targeting drug delivery platforms,including their benefits and limitations,and summarizes the current research efforts to apply them to the treatment of ALD in rodent *** also discuss gaps in knowledge in the field,which when addressed,may help to increase the efficacy of novel therapies and better translate them to humans.

关键词： Liver targeted delivery Nanoparticles Liposomes Polymeric nanoparticles Precision medicine Alcohol associated liver disease

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Dietary fatty acids and bioactive fatty acid metabolites in alcoholic liver disease

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Liver Research 2019年第3期3卷 206-217页

作者： Kara H.Zirnheld dennis R.warner Jeffrey B.warner Josiah E.Hardesty Craig J.McClain Irina A.Kirpich Division of Gastroenterology Hepatologyand NutritionDepartment of MedicineUniversity of Louisville School of MedicineLouisvilleKYUSA Department of Pharmacology and Toxicology University of Louisville School of MedicineLouisvilleKYUSA University of Louisville Alcohol Center University of Louisville School of MedicineLouisvilleKYUSA Robley Rex Veterans Medical Center LouisvilleKYUSA

Alcoholic liver disease(ALD)comprises a spectrum of liver pathology,including steatosis,steatohepatitis,and *** work from our group and others suggests that dietary fat,both the amount and composition,plays a pivotal role in ALD development and progression;however,the impact of specific dietary fatty acids on ALD pathogenesis is not fully *** rodent models of ALD revealed the deleterious effects of omega-6 polyunsaturated fatty acids(n-6 PUFAs),specifically linoleic acid(LA),and this may be partially attributed to the increased levels of pro-inflammatory oxidized LA *** is limited understanding regarding the role of omega-3 polyunsaturated fatty acids(n-3 PUFAs,such as alpha-linolenic acid,eicosapentaenoic acid,and docosahexaenoic acid),and bioactive n-3 PUFAderived lipid molecules in *** that majority of n-6 and n-3 PUFAs-derived metabolites are potent endogenous signaling molecules,knowledge regarding the changes in these lipid mediators may shed new light on the mechanisms contributing to ALD pathogenesis and reveal novel therapeutic targets and biomarkers of this *** current review summarizes relevant scientific literature regarding the role of dietary fat,distinct fatty acids,and bioactive fatty acid metabolites in ALD,and highlights recent advances in the field.

关键词： Dietary fatty acids Bioactive fatty acid metabolites Alcoholic liver disease(ALD) Omega-6 polyunsaturated fatty acids(n-6 PUFAs) Omega-3 polyunsaturated fatty acids(n-3 PUFAs)

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VSAT用户网络实例

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成都信息工程学院学报 1993年第2期15卷 78-88页

作者： K.M.Sundara Murthy Barry O'Neal Jay Alan Josepth J.Sanchez John Barry N.seshagiri Barry G.Evans dennis Shanley Neville Miller Jim Stratigos Robert Mullinax John W.warner Paul Noble 王春芳

本文简要介绍具有代表性的几种VSAT网。这些网络的选择是研究了世界各地正在运行的不同类型的VSAT网后作出的。选择样本时考虑了如下几种因素,以便读者能够获取有用的信息,并对当前VSAT的状况有一个真实的了解。这些因素包括网络种类(... 详细信息

本文简要介绍具有代表性的几种VSAT网。这些网络的选择是研究了世界各地正在运行的不同类型的VSAT网后作出的。选择样本时考虑了如下几种因素,以便读者能够获取有用的信息,并对当前VSAT的状况有一个真实的了解。这些因素包括网络种类(共享的还是专用的)、区域(全球范围)、技术应用、业务、销售、用户(按生意种类分)、网络状态等。

关键词： VSAT 用户网络卫星网数据传送用户服务话音业务 Chrysler 地面网络主机系统业务网

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