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Vasoactive intestinal polypeptide (VIP) corrects chronic inflammatory response syndrome (CIRS) acquired following exposure to water-damaged buildings

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Health 2013年第3期5卷 396-401页

作者： Ritchie C. Shoemaker dennis house James C. Ryan Center for Research on Biotoxin Associated Illnesses Pocomoke City USA Proteogenomics LLC Vero Beach USA

Exposure in water-damaged buildings (WDB) to airborne bioaerosols including metabolic products of toxigenic fungi, bacteria and actinomycetes;and inflammagens, can lead to a persistent innate immune inflammatory illness. This illness, termed a chronic inflammatory response syndrome (CIRS-WDB), is systemic with symptoms acquired from multiple organ systems. Treatment of CIRS-WDB has progressed rapidly as a better understanding of the inflammatory pathophysiology has led to targeted, sequential therapies. The fundamental basis of uncontrolled innate immune responses, the humoral deficiency of regulatory neuropeptides melanocyte stimulating hormone (MSH) or vasoactive intestinal polypeptide (VIP), seen in over 98% of pa tients, has not consistently responded to any treatment modality. Use of replacement VIP has been attempted anecdotally;VIP replacement therapies show promise in short term studies but longer therapies have not been attempted. Here we report an open label trial of 20 patients with refractory CIRS-WDB illness who took replacement VIP in a nasal spray for at least 18 months with confirmation of durable efficacy and absence of significant side effects. These 20 patients were similar in symptoms and lab find- ings to three previously published cohorts in- volving 1829 patients and 169 controls. Dosage of VIP was titrated downwards from four to zero doses a day to determine minimum effective dose, and retitrated upwards for maximum improvement over time. The trial showed that VIP therapy safely 1) reduced refractory symptoms to equal controls;2) corrected inflammatory parameters C4a, TGF beta-1, VEGF, MMP9;3) corrected estradiol, testosterone and 25-OH Vitamin D;4) returned pulmonary artery systolic pressure (PASP) during exercise to normal;and 5) enhanced quality of life in 100% of trial patients. Subsequent identification of correction of T-regulatory cell levels supports the potential role of VIP in both innate and adaptive immune function.

关键词： Vasoactive Intestinal Polypeptide (VIP) Chronic Inflammatory Response Syndrome (CIRS) TGF Beta-1 C4a MSH T Regulatory Cells Water-Damaged Buildings

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Dietary enrichment of edible insects with omega 3 fatty acids

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Insect Science 2020年第3期27卷 500-509页

作者： dennis G.A.B.Oonincx Sophie Laurent Margot E.Veenenbos Joop J.A.van Loon Department of Animal Sciences Animal Nutrition GroupWageningen UniversityWageningenthe Netherlands Laboratory of Entomology Department of Plant SciencesWageningen UniversityWageningenthe Netherlands Sophie Laurent ON IRISFood Process EngineeringUMR CNRS 6144 GEPEANantes Cedex 3France

Edible insects are advocated as sustainable and healthy food and ***,commercially produced insects are often low in n‐3 fatty acids and have suboptimal n‐6/n‐3 ratios.A certain amount and proportion of these FAs is required to optimize human *** oil consists primarily(57%)out of alpha‐linolenic *** experiment was conducted to quantify the effect of flaxseed oil provision on fatty acid composition and to determine the quantity needed to attain a beneficial n‐6/n‐3 *** species were used in the experiment:house crickets(Acheta domesticus[L.]),lesser mealworms(Alphitobius diaperinus[Pfanzer])and black soldier flies(Hermetia illucens[L.]).These were provided with either a control diet or a diet enriched with 1%,2%,or 4%flaxseed oil during their larval/nymphal *** acid profiles of diets and insects were determined via GC‐*** three species had distinct fatty acid profiles on all four diets,but responded similarly to flaxseed oil *** each percent added to the diet,the alpha‐linolenic acid content of the insects increased by 2.3%–2.7%.Four percent addition increased the n‐3 fatty acid content 10–20 fold in the three species and thereby strongly decreased n‐6/n‐3 ratios from 18–36 to 0.8–2.4.A ratio below 5 is considered optimal for human health and was achieved by 2%flaxseed oil inclusion for house crickets and lesser mealworms,and at 1%inclusion for black soldier *** a source of n‐3 fatty acids to insect diets can thus improve the nutritional quality of insects.

关键词： Acheta domesticus Alphitobius diaperinus diet fatty acids Hermetia illucens

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发生于乳房假体置入女性的间变性大细胞淋巴瘤：173例临床分析

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中国美容整形外科杂志 2015年第12期26卷 J0001-J0010页

作者： Garry S. Brody dennis Deapen Clive R. Taylor Lauren Pinter-Brown Sarah Rose house-Lightner James S. Andersen Grant Carlson Melissa G. Lechner Alan L. Epstein 朱利娜高景恒张晨袁继龙美国加利福尼亚州洛杉矶和杜瓦迪、南加利福尼亚大学Keck医学院流行病学与病理学部整形外科加利福尼亚大学大卫格芬医学院肿瘤学和血液学部埃默里大学医学院整形外科希望之城肿瘤医院《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科辽宁省人民医院整形外科

背景与目的1962年，首例硅胶乳房假体被成功置人体内。1997年，报道了首例与硅胶乳房假体相关的间变性大细胞淋巴瘤（ALCL）。笔者回顾了已发表的37篇文献报道，共79例患者，并收集了94例未报道的病例。方法复习全世界文献。向作者和主... 详细信息

背景与目的1962年，首例硅胶乳房假体被成功置人体内。1997年，报道了首例与硅胶乳房假体相关的间变性大细胞淋巴瘤（ALCL）。笔者回顾了已发表的37篇文献报道，共79例患者，并收集了94例未报道的病例。方法复习全世界文献。向作者和主治医师寻求文献或病例中缺少的临床和实验数据。由于需要收集的病例信息很多，有时需要在多个地点获得完整的病例信息。因为不是所有被询问的作者和主治医师均提供了信息，所以造成了数据的不完整。结果ALCL病变首先在假体周围血清肿内发现，其肿块附着于包膜，肿块可侵及皮肤，可在区域淋巴结发生，也可在乳房矫形手术中被发现。临床特点呈现多样化，有的仅表现为细胞学阳性结果，肿块自发消退；有的表现为转移性、难治性肿瘤，甚至死亡。其与假体填充物（盐水或硅胶）和置入假体目的（隆乳或乳房再造）没有相关性。在假体信息完整的病例中，患者体内至少置入过1个毛面假体；18例肿块扩散至包膜外，其中9例是致命的。主要的组织化学标记物是cD-30和Alk-1；其他标记物出现频率较低。乳房假体置入女性发生ALCL的风险评估范围是1／500000—1／3000000。结论与乳房假体相关的ALCL是一种新的淋巴瘤，其起源于瘢痕，具有部位和材料特异性，且临床表现呈现多样化，由多因素引起。

关键词：间变性大细胞淋巴瘤硅胶乳房假体假体置入临床分析女性 ALCL 实验数据主治医师

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现代城市的乌托邦理想与复杂性

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世界建筑 2007年第3期 118-126页

作者：丹尼斯·夏普孙凌波 AA学院历史艺术与历史系不详

本文试图关注当前存在的一种两难局面：如何处理过去的存在,如何认知它并且由它开始创造,既不切断过去,也不压制对未来的设计。

关键词：现代城市复杂性乌托邦理想

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