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Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Frontiers of Medicine 2015年第3期9卷 368-373页

作者： Naci Topaloglu Adem Kucuk Sule Yildirm Mustafa Tekin Havva Erdem Mustafa deniz Canakkale Onsekiz Mart University Medical Faculty Department of Pediatrics Canakkale Turkey Diizce Atatiirk State Hospital Department of Pediatric Surgery Diizce Turkey Diizce University Medical Faculty Department of Pathology Diizce Turkey Canakkale Onsekiz Mart University Medical Faculty Department of Physiology Canakkale Turkey

Glucagon-like peptide-2 （GLP-2） has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion （I/R） injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups （n = 8）. The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion （HIR, vehicle saline-treated） group; and the third group was the GLP-2 pretreated I/R （GLP2-IR） group. Each rat in the third group was intraperitoneally administered 5 ~tg GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the fiver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline- treated HIR group （P 〈 0.001）, whereas GLP-2 pretreatment significantly decreased their levels （P 〈 0.01）. Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.

关键词： ischemia/reperfusion liver glucagon-like peptide-2 alanine aminotransferase

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Assessment of glass fiber-reinforced polyester pipe powder in soil improvement

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Frontiers of Structural and Civil Engineering 2021年第3期15卷 742-753页

作者： Baki BAGRIACIK Ahmet BEYCIOGLU Szymon TOPOLINSKI Emre AKMAZ Sedat SERT Esra deniz GUNER Department of Civil Engineering Çukurova UniversityAdana 01330Turkey Department of Civil Engineering Adana Alparslan TürkeşScience and Technology UniversityAdana 01250Turkey Department of Civil Engineering UTP Science and Technology UniversityBydgoszcz 85796Poland Geoenvironmental Infrastructure(SGI)Research Group George Mason UniversityFairfaxVA 22030USA Department of Civil Engineering Sakarya UniversitySakarya 54187Turkey Department of Environmental Engineering Çukurova UniversityAdana 01330Turkey

This study investigates the use of glass fiber-reinforced polyester(GRP)pipe powder(PP)for improving the bearing capacity of sandy *** a series of direct share tests,the optimum PP addition for improving the bearing capacity of soils was found to be 12%.Then,using the optimum PP addition,the bearing capacity of the soil was estimated through a series of loading tests on a shallow foundation model placed in a test *** bearing capacity of sandy soil was improved by up to 30.7%.The ratio of the depth of the PP-reinforced soil to the diameter of the foundation model(H/D)of 1.25 could sufficiently strengthen sandy soil when the optimum PP ratio was *** analyses showed that the increase in the bearing capacity can be attributed to the chopped fibers in the PP and their multiaxial distribution in the *** improving the engineering properties of soils,using PP as an additive in soils would reduce the accumulation of the industrial waste,thus providing a twofold benefit.

关键词： shallow foundation sandy soil bearing capacity soil improvement pipe powder

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A novel polymer critical re-melting treatment for improving corrosion resistance of magnesium alloy stent

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Journal of Materials Science & Technology 2019年第1期35卷 19-22页

作者： Shanshan Chen Peng Wan Bingchun Zhang deniz Eren Eri?en Hui Yang Ke Yang Institute of Metal Research Chinese Academy of Sciences School of Mechanical Engineering Dongguan University of Technology University of Science and Technology of China

Polymer coating was widely used as a protective coating on Mg alloy stent due to its excellent deformability. However, the polymer coating with lots of macro-and micro-holes after solvent evaporation during forming process would make corrosion medium permeate easier and decrease the corrosion resistance of Mg alloy stent. In this study, a novel critical re-melting method was adopted to improve the polymer coating densification, which was evaluated by the surface morphology of coating. The corrosion resistance of Mg alloy stent after critical re-melting treatment was examined by the electrochemical and immersion tests. The results indicated that the corrosion resistance of Mg alloy stent with polymer coating was improved significantly by polymer critical re-melting treatment.

关键词： Mg alloy stent Polymer coating Critical re-melting treatment Corrosion resistance

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Meckel's diverticulum manifested by a subcutaneous abscess

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World Journal of Gastroenterology 2009年第48期15卷 6123-6125页

作者： Oguzhan Karatepe Gokhan Adas Merih Altiok deniz Ozcan Sedat Kamali Servet Karahan Department of General Surgery Okmeydam Training and Research Hospital Department of Pathology Okmeydam Training and Research Hospital

This case report describes an extremely rare complication of a Meckel's diverticulum:enterocutaneous fistula of the *** presence of Meckel's diverticulum is a well known entity,but subcutaneous perforation of the diverticulum is very *** we report the case of a patient with the complaint of a right lower quadrant abscess,preoperatively diagnosed as enterocutaneous fistula,which was determined intraoperatively to be a fistula resulting from Meckel's diverticulum.

关键词： Meckel's diverticulum Enterocutaneous fistula Abscess

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Uses of a dedicated 3D reconstruction software with augmented and mixed reality in planning and performing advanced liver surgery and living donor liver transplantation(with videos)

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 455-461页

作者： deniz Balci Elvan Onur Kirimker Dimitri Aristotle Raptis Yujia Gao Alfred Wei Chieh Kow Department of Surgery Medical Park Goztepe Hastanesi Organ Nakli Merkezi Nisan SokBahce se hir UniversityNo.23 Merdivenkoy KadıkoyIstanbulTurkiye Department of Surgery Ankara UniversityAnkaraTurkiye Clinical Service of HPB Surgery and Liver Transplantation NHS Foundation TrustRoyal Free London HospitalLondonUK Division of Surgery&Interventional Science University College LondonLondonUK Division of Hepatobiliary&Pancreatic Surgery Department of SurgeryNational University of SingaporeSingapore Liver Transplant Program National University Center for Organ Transplantation(NUCOT)National University Health SystemSingapore

The development of digital intelligent diagnostic and treatment technology has opened countless new opportunities for liver surgery from the era of digital anatomy to a new era of digital diagnostics,virtual surgery simulation and using the created scenarios in real-time surgery using mixed *** this article,we described our experience on developing a dedicated 3 dimensional visualization and reconstruction software for surgeons to be used in advanced liver surgery and living donor liver ***,we shared the recent developments in the field by explaining the outreach of the software from virtual reality to augmented reality and mixed reality.

关键词： Living donor liver transplantation 3D reconstruction software 3D volumetry Precision medicine Augmented reality Mixed reality

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Molecularly Imprinted Polymers Based Surface Plasmon Resonance Sensor for Sulfamethoxazole Detection

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Photonic Sensors 2022年第4期12卷 66-80页

作者： Önder KURÇ deniz TÜRKMEN Department of Chemistry Hacettepe UniversityAnkara 06800Turkey

Sulfamethoxazole(SMX)is a sulfonamide antibiotic primarily used to treat urinary tract infections and used in veterinary and industrialized husbandry to treat diseases and food *** other antibiotics,SMX is considered as a pollutant in water and food that threaten local *** study developed a surface plasmon resonance(SPR)sensor chip that is fast,highly selective,and reusable,and requires no pretreatment for detecting *** a receptor,SMX imprinted methacrylic acid-2-hydroxyethyl methacrylate-ethylene glycol dimethacrylate polymer[poly(MAA-HEMA-EGDMA)]was *** surface of the gold SPR chips was coated with a drop-casting *** nanofilm coated chips were characterized by scanning electron microscopy(SEM),atomic force microscopy(AFM),ellipsometer,contact angle measurement,and Fourier-transform infrared spectrometry(FTIR).Imprinting factor(IF)was calculated as:ΔR[MIP(molecularly imprinted polymers)]/ΔR[NIP(non-imprinted)]=12/3.5=*** of detection(LOD)and limit of quantification(LOQ)values were calculated with 3 s/m and 10 s/m methods,and the results were found to be 0.0011μg/L for LOD 0.0034μg/L for *** studies on both standard SMX solution and commercial milk samples were ***,we investigated the developed chip’s reusability,storability,and selectivity with amoxicillin and cefalexin.

关键词： Antibiotic sulfamethoxazole nanofilm chip molecularly imprinted polymers(MIP) surface plasmon resonance(SPR)

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Recent Near-surface Temperature Trends in the Antarctic Peninsula from Observed,Reanalysis and Regional Climate Model Data

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Advances in Atmospheric Sciences 2020年第5期37卷 477-493页

作者： deniz BOZKURT David HBROMWICH Jorge CARRASCO Keith MHINES Juan Carlos MAUREIRA and Roberto RONDANELLI Department of Meteorology University of ValparaísoValparaíso 2340000Chile Center for Climate and Resilience Research(CR)2 Santiago 8320000Chile Polar Meteorology Group Byrd Polar and Climate Research CenterThe Ohio State UniversityColumbusOH 43210USA Centro de Investigacion GAIA Antártica Universidad de MagallanesPunta Arenas 6200000Chile Center for Mathematical Modeling(CMM) University of ChileSantiago 8320000Chile Department of Geophysics University of ChileSantiago 8320000Chile

This study investigates the recent near-surface temperature trends over the Antarctic *** make use of available surface observations,ECMWF’s ERA5 and its predecessor ERA-Interim,as well as numerical simulations,allowing us to contrast different data *** use hindcast simulations performed with Polar-WRF over the Antarctic Peninsula on a nested domain configuration at 45 km(PWRF-45)and 15 km(PWRF-15)spatial resolutions for the period 1991?*** addition,we include hindcast simulations of KNMI-RACMO21P obtained from the CORDEX-Antarctica domain(~50 km)for further *** show that there is a marked windward warming trend except during *** windward warming trend is particularly notable in the autumn season and likely to be associated with the recent deepening of the Amundsen/Bellingshausen Sea low and warm advection towards the Antarctic *** the other hand,an overall summer cooling is characterized by the strengthening of the Weddell Sea low as well as an anticyclonic trend over the Amundsen Sea accompanied by northward *** persistent cooling trend observed at the Larsen Ice Shelf station is not captured by ERA-Interim,whereas hindcast simulations indicate that there is a clear pattern of windward warming and leeward ***,larger temporal correlations and lower differences exhibited by PWRF-15 illustrate the existence of the added value in the higher spatial resolution simulation.

关键词： dynamical downscaling cloud computing added value reanalysis Amundsen/Bellingshausen Sea Weddell Sea temperature trend

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Effect of Ball Scribing on Power Loss Separation of Fe-3%Si Grain-oriented Silicon Steel

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Journal of Wuhan University of Technology(Materials Science) 2016年第2期31卷 435-439页

作者：王浩李长生 ZHAN Jianbo YU Zhenhua JI Yafeng WANG Guanglei PERIN deniz Materials Research Institute Technical Center of China Tobacco Yunnan Industrial Co.Ltd.Kunming 650231China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Engineering Research Center for Department of Heavy Machinery Education Taiyuan University of Science and TechnologyTaiyuan 030024China Nanjing Iron and Steel Co.Ltd. Nanjing 210035China Department of Physics Balikesir UniversityBalikesir 10145Turkey

Power loss of Fe-3%Sigrain-oriented silicon steelwas measured after ballscribing with different spacing using a self-designed *** different sections of power loss,including hysteresis loss,abnormalloss,and eddy current loss,were measured and calculated,*** loss variation and ratio were analyzed based on the *** 1.0 T,hysteresis loss of tested steelwith scribing spacing of 8 mm descends by 8.2% compared to samples without scribing,which is similar to the totalloss variation,and abnormalloss descends by 16.8%.At 1.0 T,hysteresis loss ratio of the steelwith scribing spacing of 16 mm ascends from 55.7% to 57.9%,and eddy current loss increases from 17.4% to 24.1%,while abnormalloss descends from 26.9% to 23.7%.The experimentalresults show that the reduction of power loss after scribing is mainly due to decreasing of hysteresis loss and abnormalloss.

关键词： Fe-3%Si grain-oriented silicon steel ball scribing hysteresis loss eddy current loss abnormal loss

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Epidemiological and clinical features of paediatric open globe injuries in southwestern Turkey

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 855-860页

作者： Hatice deniz Ilhan Ahmet Burak Bilgin Ash Cetinkaya Mustafa Unal Iclal Yucel Department of Ophthalmology Akdeniz University

AIM:To evaluate the epidemiologic,anatomic,and clinical features of open globe injuries in ***:The medical files of patients under the age of 16 who had been operated for an open globe injury at Akdeniz University Hospital’s Department of Ophthalmology were retrospectively ***:A total of 90 patients were evaluated in this *** these patients,26(28.9%)were female and64(71.1%)were *** mean age of the patients was7.7±4.2 *** male/female ratio was observed to increase with increasing age(P=0.006,P=7.48).Injuries were most likely to occur in spring and autumn(P=0.028).The time interval between the injury and the surgical repair was 9.36±***(44.4%)of the injuries occurred in the home,27(30%)occurred in the yard,and 21(23.3%)happened while playing in the *** most common causes of injury were sharp metal objects(P<0.001).Injury to the cornea occurred in47(52.2%)of the patients(P<0.001).The most common complication to occur was cataract *** operations were necessary for 37(41.1%)of the *** final visual acuity was correlated with both the initial visual acuity of the wounded eye prior to surgery and the length of the wound(P<0.001,r=0.502 and P<0.001,r=-0.442,respectively).CONCLUSION:Open globe injuries that are suffered in childhood generally occur either at home,in the yard,or on the street,with sharp metal objects being the most common cause of *** initial visual acuity and the length of the wound are the most important determinants of the final visual acuity.

关键词： childhood epidemiology open globe injury prevention visual acuity

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The aggregate and sectoral time‑varying market efficiency during crisis periods in Turkey:a comparative analysis with COVID‑19 outbreak and the global financial crisis

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Financial Innovation 2023年第1期9卷 2165-2189页

作者： deniz Erer Elif Erer Selim Güngör School of Applied Sciences Manisa Celal Bayar UniversityManisaTurkey Independent Researcher IzmirTurkey Resadiye Vocational School Tokat Gaziosmanpasa UniversityTokatTurkey

This study aims to examine the time-varying efficiency of the Turkish stock market’s major stock index and eight sectoral indices,including the industrial,financial,service,information technology,basic metals,tourism,real estate investment,and chemical petrol plastic,during the COVID-19 outbreak and the global financial crisis(GFC)within the framework of the adaptive market *** study employs multifractal detrended fluctuation analysis to illustrate these sectors’multifractality and short-and long-term *** results show that all sectoral returns have greater persis-tence during the COVID-19 outbreak than during the ***,the real estate and information technology industries had the lowest levels of efficiency during the GFC and the COVID-19 ***,the fat-tailed distribution has a greater effect on multifractality in these *** results validate the conclusions of the adaptive market hypothesis,according to which arbitrage opportunities vary over time,and contribute to policy formulation for future outbreak-induced economic crises.

关键词： MF-DFA Adaptive market hypothesis Global financial crisis COVID-19 outbreak Sectoral indices

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