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Differential expression and function of the endogenous lactate receptor, GPR81, in ERα-positive/HER2-positive epithelial vs. post-EMT triple-negative mesenchymal breast cancer cells

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Journal of Cancer Metastasis and Treatment 2019年第6期4卷 1-14页

作者： denisse Tafur Patrick Svrcek Bruce White Department of Cell Biology University of Connecticut HealthFarmingtonCT 06032USA University of Connecticut School of Medicine University of Connecticut HealthFarmingtonCT 06032USA.

Aim:Lactate can signal through the endogenous lactate receptor,GPR81,which is expressed in some *** metabolism is altered by the metastasis-promoting process of epithelial-mesenchymal transition(EMT).This study examined the expression and function of GPR81 in breast cancer samples,and in receptor-positive epithelial ***-negative post-EMT mesenchymal breast cancer ***:GPR81 mRNA expression was examined by breast cancer microarray,and by a Kaplan-Meier survival *** 3-dimensional culture conditions,GPR81 mRNA expression in epithelial and mesenchymal breast cancer cell lines was measured by ***81 siRNA was used to assess the role of GPR81,alone or in conjunction with tamoxifen,in the regulation of MCT1 and MCT4 lactate transporters,intracellular lactate,and cell proliferation and ***:GPR81 mRNA levels were elevated in receptor-positive breast cancer,relative to non-tumor and triple-negative samples,and correlated with increased ***81 expression was elevated in the two epithelial breast cancer cell lines *** corresponding post-EMT mesenchymal cell ***81 knock-down in epithelial MCF7 cells caused:1,selectively lower mRNA and protein expression of the MCT1 transporter,but not MCT2 or MCT4 ;transporters;2,lower levels of intracellular lactate;and 3,decreased proliferation and survival in lactate only-containing ***81 siRNA plus tamoxifen displayed additive suppressive effects on MCT1 expression and cell ***:GPR81 promotes the ability of epithelial breast cancer cells to import lactate for energy *** such,GPR81 represents a potential target for treatment of hormone-positive breast cancer cells,and may be prognostic for higher grade breast cancer.

关键词： GPR81 lactate metabolism MCT transporters MCT1 tamoxifen

Weight changes and patterns of weight measurements in hospitalized burn patients:a contemporary analysis

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Burns & Trauma 2018年第4期6卷 262-268页

作者： denisse Mendez-Romero Audra T Clark Alana Christie Steven E Wolf Department of Surgery Division of BurnTraumaand Critical CareUniversity of Texas Southwestern Medical CenterE05514B5323 Harry Hines BlvdDallasTX 75390USA

Background:Severe burn is associated with significant changes in body weight due to resuscitation volumes, fluid shifts, a hypermetabolic state, prolonged bed rest, and caloric intake. Our goal was to quantify and describe trends in weight change in patients with burns of all severities under modern treatment conditions and to identify the time points at which these changes occur. Methods: An institutional review board-approved chart review was conducted of acute burn patients treated at an American Burn Association-verified regional burn center from February 2016 to November 2016. Patients were then divided into three groups based on percent of total burn surface area (%TBSA) burn:1–19%, 20–39%, and≥40%. Weight was expressed as percent change of weight from baseline. Regression analysis was conducted on percent weight changes for each TBSA group. Results:We identified 197 burn patients with a length of stay (LOS) of≥7 days. Of the study cohort, 149 had TBSA burn of 1–19%, 27 had TBSA burn of 20–39%, and 21 had TBSA burn of≥40%. All groups had a majority of White male, non-Hispanic patients with mean ages between 40 and 42 years. Burn patients with>20%TBSA burn had a median increase in weight above baseline of approximately 5 to 8%likely due to resuscitation fluids within the first week of hospitalization. Weight loss below baseline often did not exceed 10% and was more pronounced as LOS increased, mostly in patients with >20% TBSA burn. Whereas patients with 1–19% TBSA burn on average returned to baseline weight at last measurement, patients with 20–39% TBSA and ≥40%TBSA burn continued a decline in weight at 4 weeks (r2=0.57 and 0.55, respectively) on the same trajectory. Conclusions:Burn patients with>20%TBSA burn had an increase in weight above baseline of up to 8%, likely due to resuscitation fluids within the first week of hospitalization. Weight loss below baseline often did not exceed 10%and was more pronounced as LOS increased, mostly in patients with>20%TBS

关键词： Burn Weight Nutrition Metabolism Critical care

Universalities of earthquake-network characteristics

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Chinese Science Bulletin 2011年第34期56卷 3697-3701页

作者： ABE Sumiyoshi PASTN denisse MUOZ Víctor SUZUKI Norikazu Department of Physical Engineering Mie University Institut Supérieur des Matériaux et Mécaniques Avancés Departamento de Física Facultad de Ciencias Universidad de Chile College of Science and Technology Nihon University

The scale-free and small-world properties are studied in detail for the complex earthquake networks constructed from the seismic data sets taken from California (USA), Japan, Iran and Chile. It is found that, in all these geographical regions, both the exponent / of the power-law connectivity distribution and the clustering coefficient C take the universal invariant values /≈1 and C≈0.85, respectively, as the cell size, which is the scale of coarse graining needed for construction of network, becomes larger than a certain value. A possible physical interpretation is given to the emergence of such remarkable invariance.

关键词：地震网络普遍性加利福尼亚州构造复杂聚类系数地理区域网络建设物理解释

Trypanosoma rangeli:growth in mammalian cells in vitro and action of a repositioned drug(17-AAG)and a natural extract(Artemisia *** oil)

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BIOCELL 2019年第1期43卷 13-19页

作者： Ana Laura CIMADOR Emeli Luciana GALANTE Lucila Ibel MUNOZ Patricia Silvia ROMANO Antonella denisse LOSINNO Maria Cristina VANRELL Facultad de Farmacia y Bioquimica Universidad Juan Agustin Maza.MendozaArgentina Facultad de Ciencias Medicas Universidad Nacional de Cuyo.MendozaArgentina Laboratorio de Biologia de Trypanosoma cruzi y la celula hospedadora-Instituto de Histologia y Embriologia“Dr.Mario H.Burgos”IHEM-CONICET-Universidad Nacional de Cuyo.Mendoza Argentina

Trypanosoma rangeli and *** are both parasitic unicellular species that infect *** ***,the causative agent of Chagas disease,*** is an infective and non-pathogenic parasite for humans,but pathogenic for vectors from the Rhodnius *** both species can coexist in different hosts and overlap their infective cycles but very little is known about the infection of *** in mammalian cells,we decided to characterize both the development of this parasite in cell culture and the effect of therapeutic agents with potential trypanocidal action on *** found that *** exhibits a cycle of infection in Vero cells similar to that for *** and that the repurposed drug,17-AAG,and the natural extract Artemisia *** oil produce a toxic effect on epimastigotes showing a trypanocidal action from the fifth day of *** treatments also affected the infection of trypomastigotes and reduced the capacity of replication of amastigotes of *** ***/*** coinfection cases have been reported,the finding of drugs with potential activity against both species could be significant in the ***,studies of susceptibility of both species to drugs could also help to know the different mechanisms of pathogenicity in humans displayed by *** that are absent in ***.

关键词： Life-cycle Treatment Trypanosoma rangeli

Photoinactivation of Escherichia coli using five photosensitizers and the same number of photons

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Journal of Innovative Optical Health Sciences 2022年第6期15卷 53-67页

作者： Daniel Ortega-Zambrano denisse Fuentes-López Hilda Mercado-Uribe CINVESTAV-Monterrey Parque PIITAutopista al Aeropuerto km.9.5ApodacaNL 66600Mexico

Bacterial resistance is today a matter of great medical concern,so it is urgent to investigate alternatives to alleviate *** inactivation(PDI)is a method that has been endorsed to inactivate diferent pathogens,including bacteria,fungi and *** is achieved by using a photosensitizer(PS)molecule which generates reactive oxygen species under visible or UV *** use visible light and UV-A radiation to excite four commercial PSs(methylene blue,rose bengal,riboflavin and curcumin),and nanopartides synthesized in our *** these PSs having been thoroughly studied in the past by other research groups,in order to compare their effects in an appropriate way,we matched the number of photons they *** found that methylene blue leads to the major inactivation of Escherichia ***,we evaluated the production of singlet axygen and hydroxyl radicals in the photoinactivation process.

关键词： Photodynamic inactivation E.coli ROS photons

绿色创新对企业绩效的影响 ——来自中国和墨西哥制造业的研究比较

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绿色创新对企业绩效的影响 ——来自中国和墨西哥制造业的研究比较

作者： denisse Alvarez Vilchis 大连理工大学

学位级别：硕士

墨西哥和中国都是制造业发达的发展中国家,同时也是世界上环境污染严重的国家。为了解决环境污染问题,中国和墨西哥都要求相关企业对生产过程和产品进行绿色创新,但是企业普遍担心这是否会为他们带来财务和环境绩效。本文旨在研究绿色... 详细信息

墨西哥和中国都是制造业发达的发展中国家,同时也是世界上环境污染严重的国家。为了解决环境污染问题,中国和墨西哥都要求相关企业对生产过程和产品进行绿色创新,但是企业普遍担心这是否会为他们带来财务和环境绩效。本文旨在研究绿色创新活动对制造业企业绩效的影响。本文通过分析企业的绿色过程创新以及绿色产品创新来测量企业的绿色创新,企业绩效则使用财务绩效和环境绩效两个变量来评估。本研究的调查问卷发给了中国和墨西哥的企业,以此研究绿色创新和企业绩效之间的关系。利用相关分析和回归分析方法分别对中国和墨西哥的调查数据进行处理分析。结果显示,中国和墨西哥的绿色创新都对制造业企业的环境绩效和财务绩效都有正向影响。进一步,在墨西哥,绿色过程创新对制造业企业绩效的影响更显著,而在中国,绿色产品创新对制造业企业绩效的影响则更显著。最后,对两个国家的不同结果进行了对比分析,发现每个国家注重不同的因素,分别促成了绿色产品创新或绿色过程创新的成功。本研究在管理方面的意义是,绿色创新对制造业企业绩效的影响取决于企业所在国家的不同。来自某些国家的企业更加注重产品创新,而来自其他一些国家的企业更加注重过程创新,正如本文所研究的中国和墨西哥。因此,制造业企业为了实现企业绩效,在管理上应当同时关注绿色过程和绿色产品创新。

关键词：财务绩效环境绩效绿色创新绿色产品创新绿色过程创新

Exploring Cultural Factors Behind Success of Entrepreneurs:A Regional Comparison

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Exploring Cultural Factors Behind Success of Entrepreneurs:A...

作者： Lisette denisse Llerena Ojeda 上海交通大学

学位级别：硕士

This research aims to investigate the perspective of entrepreneurs emphasizing emerging economies such as Asia and Latin *** purpose is to find hints regarding culture and identity that entrepreneurs applied *** topic provides interest to the population that is related with the business ***,it is significant to realize a research that extends a cross-cultural comparison that has not been studied *** though,we recognize these countries currently are developing their economies and the case of each scenario for a new company is completely ***: Creating entrepreneurial businesses,is the principal source of the economic growth in a *** organized business proposal（or business plan）does not guarantee success;it clearly identifies the idea around which the entrepreneur is creating the new *** the plan will address guidelines for new investments,however,it is noticeable that many of the new companies or start up’s are profitable without a business *** attainment is to discover the lower risk of ***,it is crucial to identify the cultural factors behind success of entrepreneurs,examining further standards,instead of revenues and *** a glance,an Entrepreneur is the intermediary between capital and labor who stimulates economic progress and gains a greater yield by undertaking a significant project or *** entrepreneur has certain characteristics such as: Initiative,imagination,creativity and flexibility,these features allow him to identify,explore and exploit opportunities;in brief,it disrupts market with innovation,disrupting includes ＜development and（re）shaping contexts in which their entrepreneurial action takes place＞.Nowadays,globalization is determined by constant competition in a way to accomplish changes and develop better *** comparison to workers,entrepreneurs are used to deal with spin-offs,seeking the best way for the evolution of their compani

关键词：企业家成功因素文化结构区域特性

Assessing the Oxidative Stability of Commercial Chia Oil

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Journal of Food Science and Engineering 2013年第7期3卷 349-356页

作者： Maria A. Grompone Bruno Irigaray denisse Rodriguez Norma Sammain Departamento de Ciencia y Tecnologia de los Alimentos Facultad de Quimica Universidad de la Repfiblica Montevideo Gral.Flores 2124 Uruguay Departamento Bioqulmica de la Nutrici6n Instituto Superior de Investigaciones Biol6gicas (INSIBIO) Universidad Nacional deTucumc~n Tucumc~n Chacabuco 461 Argentina

The fatty acid composition as well as the antioxidant composition and content of two commercially available chia oils of different origins were studied. The purpose of this work was the study of the oxidative stability from different methods and the antioxidant content of the chia oils compared with other commercial oils. The oxidative stability of the oils was determined based on the oxidative stability index test （OSI test） conducted at 110 ~C and isothermal as well as non-isothermal differential scanning calorimeter （non-isothermal DSC） for the chia oil and the linseed oil. The OSI induction time of chia oil was compared with that of commercially available linseed, canola, sunflower and high-oleic sunflower oils, chia oil being the least stable oil among those studied. The inherent stability value and oxidazibility for linseed oil was lower than the chia oil A may be ascribed to a lower linolenic acid content of the former. The induction time （It） quotient at 110 ~C calculated for chia oil A and linseed oil were similar, suggesting a high degree of consistency between the results obtained by the two methods. The activation energy and specific reaction rate constant of chia and linseed oils were compared based on the results of isothermal and non-isothermal DSC. An apparent inconsistency in the experimental data results from the temperature-dependence of the activation energy of each fatty acid which can explain because the methods conditions were different.

关键词： Chia oil tocopherol oxidation DSC.

Ecological Zonation of Phytoplankton and Biomass Based on Bio-Optical Parameters off Baja California during Three Summer Seasons

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Open Journal of Marine Science 2019年第3期9卷 121-136页

作者： Sánchez-Pérez Elvia denisse Millán-Núnez Eduardo Department of Marine Ecology Centro de Investigación Científica y de Educación Superior de EnsenadaEnsenadaMéxico Department of Plankton and Marine Ecology CONACyT-Instituto Politécnico Nacional-Centro Interdisciplinario de Ciencias MarinasLa PazMéxico

An ecological zonation of phytoplankton was determined from its normalized spectral absorption shape (aphn) during the summers of 2001-02-03 off the west coast of Baja California. In the first two seasons, the highest abundances of the main taxonomic groups of phytoplankton were detected towards the coastal stations, but for 2003, diatoms showed higher abundances towards the oceanic region. The ecological provinces (Pv) were the footprint of the zonation in the structure of the phytoplankton community;likewise, it was observed that the spectral shape was independent of the chlorophyll-a (mg·m-3). The effect of coastal upwelling south of Vizcaíno Bay favored the increase of phytoplankton cells. However, the composition of the community decreased in cells abundance and diversity due to the influence of the phenomenon called El Nino “débil” reported to the south of the California Current for the years 2002-03.

关键词： Ecological Zonation Phytoplankton Bio-Optics El Nino Débil