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Prevalence of Dyslipidemia among Patients Received at the Biochemistry Unit of the Charles de Gaulle Pediatric University Hospital in Ouagadougou

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Advances in Biological Chemistry 2024年第1期14卷 16-26页

作者： Fabienne Marie Soudre Arnaud Kouraogo Alice Kiba Ollo Da Mahutin Benoîte Hounhoui Diema Nadia Karama Seraphine Mano denis claude drabo Augustin Kyetega Raoul Karfo Elie Kabre Jean Sakande Health Sciences Training and Research Unit Joseph Ki-Zerbo University Ouagadougou Burkina Faso Charles de Gaulle Pediatric University Hospital Ouagadougou Burkina Faso Health Sciences Institute Nazi BONI University Bobo Dioulasso Burkina Faso Biochemistry Unit Sourou Sanou University Hospital Bobo Dioulasso Burkina Faso Tengandogo University Hospital Ouagadougou Burkina Faso Faculty of Health Sciences Saint Thomas d’Aquin University Ouagadougou Burkina Faso Yalgado Ouedraogo University Hospital Ouagadougou Burkina Faso National Agency for Environmental Food Labor and Health Product Safety Ouagadougou Burkina Faso

Introduction: Cardiovascular disease represents a major public health burden worldwide. Research and management of risk factors contribute to the prevention of these diseases. The aim of this study was to assess the prevalence of dyslipidemia in the biochemistry unit of the Charles De Gaulle Pediatric University Hospital (CHUP-CDG) in Ouagadougou. Material and Methods: This was a descriptive and analytical cross-sectional study, with retrospective data collection from January 1, 2020 to December 31, 2022. Patients of all ages who performed a lipid panel in the CHUP-CDG biochemistry unit during the study period have been included. Results: A total of 2872 patients have been included. The mean age of the study population was 27.72 ± 19.51 years and the M/F sex ratio was 0.81. Among the patients, 22.84% had at least one dyslipidemia. The prevalences of hypercholesterolemia, hypo-HDL cholesterolemia and hyper-LDL cholesterolemia were 11.57%, 49.19% and 57.50% respectively. Hypertriglyceridemia and mixed hyperlipidemia were present in 9.04% and 2.08% of patients. Hypercholesterolemia was significantly more frequent in the female sex (p = 0.0077);hyper-LDL cholesterolemia (p = 0.0255) and mixed hyperlipidemia (p Conclusion: The relatively high prevalence of dyslipidemia in the study indicates a worrying situation. It would therefore appear essential to extend the search for risk factors nationwide, particularly those that can be modified, in order to reduce morbidity and mortality linked to cardiovascular disease.

关键词： Dyslipidemia Lipid Profile Lipid Abnormalities Prevalence Burkina Faso

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Acousto-optically driven lensless single-shot ultrafast optical imaging

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Light(Science & Applications) 2022年第4期11卷 628-643页

作者： Mohamed Touil Said Idlahcen Rezki Becheker denis Lebrun claude Roze Ammar Hideur Thomas Godin ORIA CNRS UMR6614-University de Rouen Normandie-INSA Rouen76800 Saint Etienne du RouvrayFrance

Driven by many applications in a wide span of scientifc fields,a myriad of advanced ultrafast imaging techniques have emerged in the last decade,featuring record-high imaging speeds above a trllion-frame-per-second with long sequence *** bringing remarkable insights into various ultrafast phenomena,their application out of a laboratory environment is however limited in most cases,either by the cost,complexity of the operation or by heavy data *** then report a versatile single-shot imaging technique combining sequentially timed lloptical mapping photography(STAMP)with acousto-optics programmable dispersive fhItering(AOPDF)and digital in-line holography(DIH).On the one hand,a high degree of simplicity is reached through the AOPDF,which enables full control over the acquisition parameters via an electrically driven phase and amplitude spectro-temporal tailoring of the imaging ***,contrary to most single-shot techniques,the frame rate,exposure time,and frame intensities can be independently adjusted in a wide range of pulse durations and chirp values without resorting to complex shaping stages,making the system remarkably agile and *** the other hand,the use of DIH,which does not require any reference beam,allows to achieve an even higher technical simplicity by allowing its lensless operation but also for reconstructing the object on a wide depth of field,contrary to classical techniques that only provide images in a single *** imaging speed of the system as well as its flexibility are demonstrated by visualizing ultrashort events on both the picosecond and nanosecond *** virtues and limitations as welll as the potential improvements of this on-demand ultrafast imaging method are critically discussed.

关键词： simplicity resort bringing

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Double ischemic ileal stenosis secondary to mesenteric injury after blunt abdominal trauma

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World Journal of Gastroenterology 2008年第1期14卷 143-145页

作者： Valérie Bougard claude Avisse Martine Patey denis Germain Nathalie Levy-Chazal Jean-Franois Delattre Service de Chirurgie Viscérale Digestive et Endocrinienne CHU Reims Hpital Robert Debré Reims France Martine Patey Laboratoire Central d’Anatomie et de Cytologie Pathologiques CHU Reims Hpital Robert Debré Reims France denis Germain Laboratoire Photographique CHU ReimsHpital Robert Debré Reims France

The authors describe a rare case in which blunt abdominal trauma resulted in mesenteric injury with delayed double ischemic ileal stenosis. Abdominal computed tomography demonstrated stenotic ileal loop with mural thickening. At surgery, a double stenotic bowel loop was found adjacent to a healed defect in the mesentery. Histological examination of the two resected segments showed fibrotic and ischemic lesions within the mesentery. Ischemic intestinal stenosis from mesenteric injury should be considered in the differential diagnosis in patients suffering from intestinal occlusion with a history of blunt abdominal trauma.

关键词： Blunt abdominal trauma Mesenteric injury Intestinal stenosis Obstruction

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围术期神经肌肉阻滞的管理:欧洲麻醉和重症监护学会临床指南

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中华麻醉学杂志 2024年第6期44卷 641-656页

作者： Thomas Fuchs-Buder Carolina S.Romero Heidrun Lewald Massimo Lamperti Arash Afshari Ana-Marjia Hristovska denis Schmartz Jochen Hinkelbein Dan Longrois Maria Popp Hans Dde Boer Massimiliano Sorbello Radmilo Jankovic Peter Kranke 法国南锡大学医学院附属医院麻醉学、重症监护与围术期医学科法国南锡54000 巴伦西亚大学综合医院麻醉与重症监护科西班牙巴伦西亚46014 慕尼黑工业大学麻醉学与重症监护科德国慕尼黑80333 克利夫兰阿布扎比诊所麻醉学研究所阿联酋阿布扎比31250 哥本哈根大学医院小儿和产科麻醉科丹麦哥本哈根2100 哥本哈根大学医院麻醉学与重症监护科丹麦赫维德2650 布鲁塞尔自由大学Erasme医院麻醉科比利时布鲁塞尔1070 科隆大学医院麻醉学与重症监护科德国科隆50937 巴黎大学附属比查特克劳德伯纳德医院麻醉学与重症监护医学科法国巴黎75018 维尔茨堡大学医院麻醉学、危重病医学、急诊医学和疼痛医学科德国维尔茨堡97080 格罗宁根大学医院麻醉学、疼痛医学与程序性镇静与镇痛科荷兰格罗宁根9713 GZ 卡坦尼亚大学医院麻醉与重症监护科意大利卡坦尼亚95123 尼什大学医学院尼什临床中心麻醉学与重症治疗科塞尔维亚尼什18000

近来的研究表明,由于围术期神经肌肉阻滞管理不当,肌肉松弛药(肌松药)残留阻滞及其术后并发症的发生率居高不下。需要重视神经肌肉功能监测仪、肌松药及其拮抗剂的合理应用,以利于改善神经肌肉阻滞管理。欧洲麻醉和重症监护学会(Europea... 详细信息

近来的研究表明,由于围术期神经肌肉阻滞管理不当,肌肉松弛药(肌松药)残留阻滞及其术后并发症的发生率居高不下。需要重视神经肌肉功能监测仪、肌松药及其拮抗剂的合理应用,以利于改善神经肌肉阻滞管理。欧洲麻醉和重症监护学会(European Society of Anaesthesiology and Intensive Care,ESAIC)首次发布围术期神经肌肉阻滞管理临床指南,旨在为临床医生提供最佳医疗管理的循证建议,以提高围术期患者安全。本指南主要聚焦在3个临床问题:肌松药是否有助于成人气管插管?神经肌肉阻滞深度是否影响腹部手术患者的预后?肌松药残留阻滞的诊断和治疗策略有哪些?根据PICO原则(患者、干预、对照、结局;patient,intervention,comparator,outcome;PICO)构建临床问题并进行文献检索。初始纳入的临床研究为24 000篇,采用逐步筛选策略,最终临床研究88篇纳入指南分析。应用GRADE方法学(Grading of Recommendations,Assessment,Development and Evaluation,GRADE)对结局指标证据、质量等级进行评价。运用两轮德尔菲法收集专家组建议并形成统一推荐:R1推荐应用肌松药辅助气管插管(1A)。R2推荐应用肌松药以减少气管插管导致的咽部和(或)喉部损伤(1C)。R3推荐在快速顺序诱导插管(rapid sequence induction intubation,RSII)时使用短效肌松药,例如琥珀胆碱1 mg/kg或罗库溴铵0.9~1.2 mg/kg(1B)。R4推荐在需要改善外科手术条件时,加深神经肌肉阻滞深度(1B)。R5尚无足够的证据推荐深度神经肌肉阻滞可减轻术后疼痛或降低围术期并发症的发生率(2C)。R6推荐在拇内收肌处刺激尺神经,定量监测神经肌肉阻滞深度以排除肌松药残留阻滞(1B)。R7推荐应用舒更葡糖钠逆转甾体类肌松药(罗库溴铵、维库溴铵)诱导的深、中及浅度神经肌肉阻滞(1A)。R8推荐在使用新斯的明前,TOFr自行恢复至>0.2,并继续定量监测神经肌肉功能,直至TOFr超过0.9(1C)。

关键词：神经肌肉阻滞神经肌肉功能肌松药临床指南罗库溴铵琥珀胆碱外科手术定量监测

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More constructions of APN and differentially 4-uniform functions by concatenation

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Science China Mathematics 2013年第7期56卷 1373-1384页

作者： CARLET claude LAGA University of Paris 13CNRS (UMR 7539)France Department of Mathematics University of Paris 8 2 rue de la liberté 93526 Saint-Denis Ced-exFrance

We study further the method of concatenating the outputs of two functions for designing an APN or a differentially 4-uniform (n, n)-function for every even n. We deduce several specific constructions of APN or differentially 4-uniform (n, n)-functions from APN and differentially 4-uniform (n/2, n/2)-functions. We also give a construction of quadratic APN functions which includes as particular cases a previous construction by the author and a more recent construction by Pott and Zhou.

关键词： block cipher vectorial function substitution box almost perfect nonlinear almost bent

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Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation

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World Journal of Gastroenterology 2014年第21期20卷 6560-6572页

作者： Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte claude Darcha denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud Clermont Université UMR1071 Inserm/Ud’Auvergne and INRA USC201863000 Clermont-FerrandFrance Centre Hospitalier Universitaire 63000 Clermont-FerrandFrance

AIM: To provide further insight into the characterization of mucosa-associated Escherichia coli (E. coli) isolated from the colonic mucosa of cancer patients.

关键词： B2 Escherichia coli Carcinoembryonic antigen-related cell adhesion molecule 6 Cell proliferation Colon cancer Polyketide synthase genomic island

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Development of a Fast and Facile Analytical Approach to Quantify Radiometabolites in Human Plasma Samples Using Ultra High Performance Liquid Chromatography

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American Journal of Analytical Chemistry 2019年第5期10卷 185-201页

作者： Cé cile Malherbe Rudy Bidault claude Netter denis Guilloteau Johnny Vercouillie Nicolas Arlicot UMR 1253 iBrain Universit&#233 de Tours Inserm Tours France CHRU de Tours Unit&#233 de Radiopharmacie Tours France Thermo Fisher Scientific Waltham MA USA CHRU de Tours Service de M&#233 decine Nuclé aire in Vitro Tours France INSERM CIC 1415 University Hospital Tours France

Introduction: Conventional metabolite analyses often require manual sample preparation, generating variability of measurements. This study describes a new method to quantify radiometabolites in blood, combining ultra high performance liquid chromatography (UHPLC) and turbulent flow chromatography, an alternative fully automated process allowing analyte’s extraction. Methods: A new radiotracer for dopamine transporter imaging, namely LBT-999, was used to demonstrate the method’s robustness. Matrix effect, Turboflow column loading, linearity, specificity and precision were evaluated with in vitro samples of LBT-999 in human plasma. Radiodetector sensitivity and preliminary evaluation were respectively determined by analysis of calibrated samples of [18F]LBT-999 and blood samples from 4 healthy subjects injected with [18F]LBT-999, withdrawn at 5, 15, 30 and 45 min pi. Results: With three sequential loadings (3 × 100 μL) of the Turboflow column, mean coefficients of variation were 1%, below 2%, 2% and 30.9% for matrix effect, specificity, repeatability and intermediate precision, respectively. Correlation coefficients for linearity were superior to 0.97. Limits of detection and quantification of the radiodetector were fixed at 3 and 9 c/s. Retention times for [18F]LBT-999 and the two radiometabolites detected by radio-UHPLC were 6.5, 4.8 and 9.6 min. Forty-five min after the injection, parent fraction was still predominant with 57.8% ± 25% of the total radioactivity. Conclusions: An innovative approach, allying UHPLC and Turboflow column, was developed and its sensitivity, linearity, specificity and repeatability validated. Preliminary results of the clinical trial are in accordance with literature data, demonstrating its efficiency in radiometabolites quantification.

关键词： Radiometabolite Ultra High Performance Liquid Chromatography Turboflow Method Validation [18F]LBT-999

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Endovascular Repair of an Infected Broken Pseudoaneurysm of the Extracranial Internal Carotid Artery

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Open Journal of Radiology 2012年第4期2卷 113-116页

作者： claude Michel Alain Parot Patrick Jue denis Pierre-Yves Laffy Jean-Yves Riou Gilbert Leblanc Cardio-Vascular Radiology Department Marie Lannelongue Hospital Le Plessis Robinson France Vascular Radiology Department Europe Medico-Surgical Center Le Port Marly France Vascular Surgery Department Europe Medico-Surgical Center Le Port Marly France

The formation of pseudoaneurysms after carotid endarterectomy is extremely rare. Treating those pseudoaneuryms is necessary because of the risks for continued expansion, rupture and distal embolism. Traditional surgical repair of carotid artery pseudoaneurysms is associated with a high morbidity and mortality. An endovascular approach to these infected pseudoaneurysms limits the risk for operative damage to surrounding structures and potential blood loss.

关键词： Carotid Artery Pseudoaneurysm Covered Self Expandable Stent

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Influence of Exogenous Auxins on Phenolic Compounds Contents and Polyphenol oxidasic and Peroxidasic Activities in Root Differentiation in <i>Gnetum</i>spp.

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Agricultural Sciences 2019年第8期10卷 1073-1089页

作者： Minyaka Emile Simo claude Medueghue Fofou Apollin Oumar Doungous Jetro Nkengafac Njukeng Niemenak Nicolas Omokolo Ndoumou denis Department of Biochemistry Faculty of Sciences University of Douala Douala Cameroon Laboratory of Plant Physiology Department of Biological Sciences Higher Teacher’s Training College Yaoundé Cameroon Department of Plant Biology Faculty of Science Douala Cameroon Institute of Agricultural Research for Development (IRAD) Buea Cameroon

Root failure is a key limiting factor in Gnetum spp. domestication and production of plants materials for farming. To overcome, root failure in Gnetum spp. may depend on adequate strategies set up and understanding of biochemical markers controlling the rooting process. The present work is principally based on phenolic compounds contents, peroxidasic and polyphenol oxidasic activities during rooting of cuttings (pretreated with IBA, ANA and IAA) at induction, initiation and expression phases of roots formation in Gnetum africanum Welw. and G. buchholzianum Engl. The study revealed that cuttings pretreated with IBA (150 mg/l) were more effective than IAA and NAA. Phenolic compounds analysis revealed that cuttings pretreated with IBA exhibited high phenolic compound contents at initiation and expression phases for both Gnetum species. Indicating that IBA pretreatment promotes phenolic compounds synthesis and accumulation necessary for roots differentiation. Enzyme contents appear to be high during the initiation stage for both species when they are pretreated with IBA (150 mg/l). Peroxidasic and Polyphenol oxidasic activities evolved on the synchroneous maner. This allows us to know that the implication of these enzymes in the rooting process is fundamental makers.

关键词： Gnetum (spp.) Biodiversity Rhizogenesis Biochemical Markers Hormones

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Investigation of the hydro-mechanical behaviour of fouled ballast

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第4期14卷 244-255页

作者： Yu-jun CUI Trong Vinh DUONG Anh Minh TANG Jean-claude DUPLA Nicolas CALON Alain ROBINET Laboratoire Navier/CERMES Ecole des Ponts ParisTechBlaise PascalCité DescartesChamps-sur-Marne 77455 Marne-la-Vallée Cedex-France French National Railway Company 93574La Plaine St DenisFrance

In this study,a fouled ballast taken from the site of Sénissiat,France,was *** the hydraulic behaviour,a large-scale cell was developed allowing drainage and evaporation tests to be carried out with monitoring of both suction and volumetric water content at various positions of the *** was observed that the hydraulic conductivity of fouled ballast is decreasing with suction increase,as for common unsaturated *** effect of fines content was found to be *** the mechanical behaviour,both monotonic and cyclic triaxial tests were carried out using a large-scale triaxial *** water contents were *** results were interpreted in terms of shear strength and permanent axial *** appeared that the water content is an important factor to be accounted for since any increase of water content or degree of saturation significantly decreases the shear strength and increases the permanent *** modelling has been attempted based on the experimental *** model in its current state is capable of describing the effects of stress level,cycle number and water content.

关键词： Fouled ballast Degree of saturation Hydraulic behaviour Mechanical behaviour Fines content Constitutive modelling

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