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Platelet activation relieves liver portal hypertension via the lymphatic system though the classical vascular endothelial growth factor receptor 3 signaling pathway

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World Journal of Gastroenterology 2025年第10期31卷 86-102页

作者： Min Chen Jin-Bo Zhao Guang-Bo Wu Zheng-Hao Wu Gu-Qing luo Zhi-feng Zhao Chi-Hao Zhang Jia-Yun Lin Hong-Jie Li Xiao-Liang Qi Hai-Zhong Huo Abudukadier Tuersun Qiang Fan Lei Zheng Meng luo Department of General Surgery Ninth People’s Hospital Affiliated to Shanghai Jiao Tong UniversitySchool of MedicineShanghai Jiao Tong UniversityShanghai 200011China Department of Urology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Xijing Hospital of Digestive Diseases Air Force Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

BACKGROUND Liver cirrhosis and portal hypertension(PHT)can lead to lymphatic abnormalities and coagulation *** lymphangiogenesis may relieve liver cirrhosis and PHT,the present study investigated the gene expression alterations in the lymphatic system and the effectiveness of platelet-mediated lymphangiogenesis in improving liver cirrhosis and *** To investigate the role of lymphangiogenesis in preclinical PHT *** Immunohistochemistry and transcriptome sequencing of bile duct ligation(BDL)and control lymphatic samples were conducted to reveal the indicated signaling *** enrichment analyses were performed on the differentially expressed genes and hub *** infection of vascular endothelial growth factor C(VEGF-C),plateletrich plasma(PRP),and VEGF3 receptor(VEGFR)inhibitor MAZ-51 was used as an intervention for the lymphatic system in PHT ***,hemodynamic tests and western blot analyses were performed to demonstrate the effects of lymphatic intervention in PHT *** Lymphangiogenesis was increased in the BDL rat *** sequencing analysis of the extrahepatic lymphatic system revealed its close association with platelet adherence,aggregation,and *** role of PHT in the rat model was investigated by activating(PRP)and inhibiting(MAZ-51)the lymphatic *** promoted lymphangiogenesis,which increased lymphatic drainage,alleviated portal pressure,reduced liver fibrosis,inhibited inflammation,inhibited angiogenesis,and suppressed mesenteric artery ***-51 reversed the above *** Via VEGF-C/VEGFR-3,platelets impede fibrosis,angiogenesis,and mesenteric artery remodeling,ultimately alleviating ***,platelet intervention is a therapeutic approach for cirrhosis and PHT.

关键词： Portal hypertension Cirrhosis Lymphangiogenesis Platelets Vascular endothelial growth factor C

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Quasi-in-situ Observation and SKPFM Studies on Phosphate Protective Film and Surface Micro-Galvanic Corrosion in Biological Mg-3Zn-xNd Alloys

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 648-664页

作者： Zhaochen Yu Kaixuan feng Shuyun deng Yang Chen Hong Yan Honggun Song Chao luo Zhi Hu School of Advanced Manufacturing Nanchang UniversityNanchang330031China Institute for Advanced Study Nanchang UniversityNanchang330031China

The phosphate protective film and micro-galvanic corrosion of biological Mg-3Zn-xNd (x = 0, 0.6, 1.2) alloys were investigated by scanning and transmission electron microscopy, quasi-in-situ observation, scanning Kelvin probe force microscopy (SKPFM) and electrochemical tests. The results revealed the Mg-Zn-Nd phases formed in Mg-3Zn alloy contained with Nd. Adding Nd resulted in a significant decline in the cracks of the phosphate protective film and micro-galvanic corrosion of alloys, which were recorded by quasi-in-situ observation. In addition, the Volta potential difference of Mg-Zn-Nd/α-Mg (~ 188 mV) was lower than MgZn/α-Mg (~ 419 mV) and Zn-rich/α-Mg (~ 260 mV), and the corrosion rates of alloys markedly decreased after the addition of 0.6 wt% Nd. The improvement in corrosion resistance of Nd-containing alloys was mainly attributed to the following: (i) the addition of Nd reduced the Volta potential difference (second phases/α-Mg);(ii) the phosphate protective film containing Nd_(2)O_(3) deposited on the surface of the alloys, effectively preventing the penetration of harmful anions.

关键词： Magnesium alloys Quasi-in-situ observation Phosphate protective film Scanning Kelvin probe force microscopy(SKPFM) Micro-galvanic corrosion

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深埋长大隧道地温预测的机器学习算法对比研究

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安全与环境工程 2025年第1期32卷 137-147页

作者：周权罗锋柴波周爱国中国地质大学(武汉)地质调查研究院湖北武汉430074 中铁第一勘察设计院集团有限公司陕西西安710043

地热对隧道施工、工程结构及运营安全等均有较大的危害,随着我国基础设施建设布局西移,隧道建设的地质条件愈发复杂,隧道埋深和长度不断增加,隧道施工期高温热害问题频发。针对传统地温预测方法中预测精度不高、数据运用不充分,单一机... 详细信息

地热对隧道施工、工程结构及运营安全等均有较大的危害,随着我国基础设施建设布局西移,隧道建设的地质条件愈发复杂,隧道埋深和长度不断增加,隧道施工期高温热害问题频发。针对传统地温预测方法中预测精度不高、数据运用不充分,单一机器学习模型解译性差等问题,以A隧道为研究对象,将决策树(decision tree,DT)、支持向量机(support vector machine,SVM)、随机森林(random forest,RF)进行耦合,提出了基于DT-SVM-RF模型的深埋长大隧道地温预测方法。在分析隧道综合测井、地应力及岩石热物理试验、航空物探数据后,选取深度、声波波速等10个影响因子作为模型的输入,采用随机交叉验证和空间交叉验证对模型的鲁棒性、泛化能力进行检验,构建LASSO回归、随机森林、互信息3种回归模型,分析10个影响因子的特征重要性排序。结果表明:在测试集上多元线性回归、支持向量机、人工神经网络和决策树-支持向量机-随机森林(decision tree-support vector machinerandom forest,DT-SVM-RF)模型决定系数(R^(2))分别为0.76、0.91、0.88、0.93,均方误差MSE分别为17.64、6.25、8.46、5.20,DT-SVM-RF模型具有相对更优的预测性能,深度、岩石导温系数、岩石导热系数、最大水平主应力特征较为重要,说明DT-SVM-RF模型能有效地提高地温预测的准确率。研究结果可为类似隧道地温预测提供一种精度更高的可行新思路。

关键词：隧道热害隧道安全多元线性回归支持向量机(SVM) 随机森林(RF) 人工神经网络(ANN) 特征选择

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Preparation and characterization of 3-(triethoxysilyl) propyl isocyanate self-assembled monolayer on surface of chip

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Chinese Science Bulletin 2009年第5期54卷 738-742页

作者： XIE Yao GENG LiNa QU feng luo AiQin deng YuLint School of Life Science and Technology Beijing Institute of Technology Beijing 100081 China

Monolayer of 3-(triethoxysilyl) propyl isocyanate was prepared on the slide by self-assembled tech-nique. X-ray photoelectron spectroscopy (XPS) was employed to analyze the elementary composition of the film. Contact angle of distilled water was measured to characterize the surface state. It was shown that 3-(triethoxysilyl) propyl isocyanate had been successfully assembled on the slide. The in-crease of contact angle to 80° demonstrated that the hydrophobicity of the surface of chip was in-creased significantly. Moreover, further self-assembly of bovine serum albumin (BSA) on 3-(trietho- xysilyl) propyl isocyanate was also carried out with the advantages such as simple and convenient preparation. Therefore, the potential of broader applications in the modification of micro-channel in the μ-TAS system, the immobilization of protein or peptide and the surface modification of materials are all expectative.

关键词：三乙氧基(3-异氰酸丙基)硅自组装单分子膜共价健制备

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Ileal conduit stomal variceal bleeding managed by endovascular embolization

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World Journal of Gastroenterology 2013年第44期19卷 8156-8159页

作者： deng-Hua Yao Xue-feng luo Biao Zhou Xiao Li Department of Gastroenterology and Hepatology Institution of Intervention Radiology West China Hospital Sichuan University

Ileal conduit stomal varices are rare,and may result in *** standard treatment modality for management of this type of hemorrhage has not been *** present the case of a 70-year-old woman with progressive ileal conduit stomal variceal bleeding which was successfully managed by endovascular embolization via the transjugular transhepatic *** conclusion,transjugular transhepatic endovascular embolization is a good choice in patients with ileal conduit stomal variceal bleeding who have failed conservative therapy.

关键词： Ectopic variceal bleeding Ileal conduit Stomal bleeding Cirrhosis Hemostasis Transjugular transhepatic embolization

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生物炭添加对红壤硅磷形态转化、有效性及大豆植株吸收的影响

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华南农业大学学报 2025年第02期46卷 141-150页

作者：罗家欣邓金环田纪辉蔡昆争华南农业大学资源环境学院/农业农村部华南热带农业环境重点实验室

【目的】大量研究证实添加生物炭能够提高土壤肥力、增加养分有效性及促进作物生长。中国南方地区红壤硅、磷元素有效性低，有必要研究生物炭添加对其化学形态和植物吸收的影响。【方法】以富硅的稻秆生物炭和稻壳生物炭为供试材料，研... 详细信息

【目的】大量研究证实添加生物炭能够提高土壤肥力、增加养分有效性及促进作物生长。中国南方地区红壤硅、磷元素有效性低，有必要研究生物炭添加对其化学形态和植物吸收的影响。【方法】以富硅的稻秆生物炭和稻壳生物炭为供试材料，研究添加不同质量分数(0、1%、2%、4%)的生物炭对红壤硅、磷形态转化和有效性以及大豆植株养分吸收的影响。【结果】不同种类、不同剂量生物炭处理均显著降低土壤交换性酸含量，提高土壤pH和C/N，增加土壤有效阳离子交换量及盐基饱和度，且添加量越大，涨幅越显著；稻秆生物炭的效果显著高于稻壳生物炭。生物炭处理的土壤有效态硅和活性磷组分NaHCO3-Po的含量分别较对照增加4.1%～85.0%和175.2%～2 139.6%。添加生物炭显著增加大豆植株的干物质积累，改善根系形态，提高大豆根系和叶片的硅含量，促进根系对硅、磷元素的吸收转运，其中秸秆生物炭效果更为显著。【结论】施用秸秆和稻壳生物炭显著影响酸性土壤的磷素和硅素形态及转化，提高了养分有效性，促进植株对硅和磷的吸收和利用，其中秸秆生物炭的效果更佳。

关键词：生物炭红壤有效态硅活性磷养分吸收

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Effects of vitamin C deficiency or excess on growth performance, anti-oxidative response and fatty acid composition of juvenile abalone Haliotis discus hannai Ino

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Journal of Oceanology and Limnology 2020年第6期38卷 1936-1944页

作者： LI Xinxin feng Xiuni luo Kai MA Shuoli deng Junming ZHANG Wenbing MAI Kangsen Key Laboratory of Mariculture(Ministry of Education) Key Laboratory of Aquaculture Nutrition and Feeds(Ministry of Agriculture)Fisheries CollegeOcean University of ChinaQingdao 266003China Jiaozhou Fisheries Technology Promotion Station Qingdao 266003China College of Animal Science and Technology Yunnan Agricultural UniversityKunming 650201China

A 240-day feeding trial was conducted to investigate the effects of dietary vitamin C on growth performance,anti-oxidative response,and fatty acid composition of juvenile abalone Haliotis discus hannai Ino(initial body weight:0.93±0.00 g).Three semi-purified experimental diets were formulated containing 0.00,94.52,and 9649.58 mg/kg of vitamin C supplied as *** results show that there was no significant difference in weight gain ratio,daily increment in shell length,and survival rate among the three *** dietary vitamin C(9649.58 mg/kg)significantly increased the activities of superoxide dismutase(SOD),glutathine peroxidase(GPX),glitathione-S-transferase(GST),glutathione reductase(GR),alkaline phosphatase(AKP),and lysozyme in viscera(P<0.05).In muscle,activities of phenoloxidase,catalase,SOD,GST,GR,and AKP were increased in the treatment with 9649.58 mg/kg of dietary vitamin C(P<0.05).The highest concentrations of ascorbic acid in viscera and muscle were found in the group with 9649.58 mg/kg of dietary vitamin C(P<0.05).The contents of crude protein and crude lipid in the soft body were significantly increased in the 9649.58 mg/kg group(P<0.05).Dietary vitamin C supplementation significantly decreased the contents of saturated fatty acids(14:0,16:0,and 18:0),and increased the composition of 18:2n-6 and 22:6n-3 in the soft body of abalone(P<0.05).Therefore,although there were no significant effects on the growth performance,dietary vitamin C supplementation improved the anti-oxidation and immune responses,increased specific unsaturated fatty acid(i.e.,16:1,18:1n-7,18:1n-9,18:2n-6 and 22:6n-3),and decreased specific saturated fatty acid(i.e.,14:0,16:0 and 18:0)contents in the soft body of abalone.

关键词： abalone ascorbic acid anti-oxidative capability fatty acid

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基于表面平整度控制的超大型环件轧制曲线自优化方法研究

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塑性工程学报 2025年第1期32卷 92-99页

作者：羊冠立钱东升田汉邓加东王丰武汉理工大学材料科学与工程学院湖北武汉430070 武汉理工大学现代汽车零部件技术湖北省重点实验室湖北武汉430070 武汉理工大学湖北省材料绿色精密成形工程技术研究中心湖北武汉430070

针对超大型环件轧制过程中出现的环件外表面不平整缺陷,基于ABAQUS有限元软件建立超大型环件径轴向轧制热-力耦合有限元模型,研究了轧制过程中环件外表面平整性演变规律,进一步揭示了轴向与径向变形速率比对环件外表面不平整度变化的影... 详细信息

针对超大型环件轧制过程中出现的环件外表面不平整缺陷,基于ABAQUS有限元软件建立超大型环件径轴向轧制热-力耦合有限元模型,研究了轧制过程中环件外表面平整性演变规律,进一步揭示了轴向与径向变形速率比对环件外表面不平整度变化的影响规律。提出了一种两段式轧制曲线设计方法,进而建立了一种基于环件外表面平整状态反馈的轧制曲线自优化控制模型,将自优化过程中环件外表面不平整度与预设S型轧制曲线所得不平整度进行了比较,结果表明,自优化控制方法得到的轧制曲线提升了环件外表面的平整度,轧制结束时环件中间高度与下端面处不平整度分别降低了36.6%和25.5%。

关键词：超大型环件径-轴向轧制平整度数值模拟

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立德树人背景下高校爱国主义教育的创新探索

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科教文汇 2025年第2期 55-58页

作者：邓庆标高锋广东司法警官职业学院警察系广东广州510520 广东司法警官职业学院应急管理系广东广州510520

爱国主义是中华民族宝贵的精神财富,也是推动中华民族前进的精神动力。爱国主义教育作为高校思政教育工作的主要内容和重要主题,其高效开展是高校实现铸魂育人教育目标、落实立德树人根本任务的重要抓手。基于此,高校应不断加强爱国主... 详细信息

爱国主义是中华民族宝贵的精神财富,也是推动中华民族前进的精神动力。爱国主义教育作为高校思政教育工作的主要内容和重要主题,其高效开展是高校实现铸魂育人教育目标、落实立德树人根本任务的重要抓手。基于此,高校应不断加强爱国主义教育研究,深化爱国主义思想认识;丰富爱国主义教育载体,扩充爱国主义教育空间;营造爱国主义教育氛围,在以文化人中厚植爱国情感;增强爱国主义教育实践,在知行合一中强化爱国行动。

关键词：立德树人爱国主义教育高校创新探索

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Stabilization for multi-group coupled stochastic models by delay feedback control and nonlinear impulsive control

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Science China(Information Sciences) 2018年第7期61卷 119-129页

作者： Chaolong ZHANG Feiqi deng Yiping luo Department of Computational Science Zhongkai University of Agriculture and Engineering Systems Engineering Institute South China University of Technology College of Electrical and Information Engineering Hunan Institute of Engineering

Stabilization for multi-group coupled models stochastic by delay feedback control and nonlinear impulsive control are considered in this paper. Using graph theory and Lyapunov method, some sufficient conditions are acquired by some control methods. Those criteria are easier to verify and no need to solve any linear matrix inequalities. These results can be designed more easily in practice. At last, the effectiveness and advantage of the theoretical results are verified by an example.

关键词： stabilization graph theory stochastic impulsive delay

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