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Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis (BASIS): protocol of a prospective, multicentre, randomised, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 66-74页

作者： Xuan Sun Ming Yang Dapeng Sun Guangge Peng yiming deng Xingquan Zhao Liping Liu Ning Ma Feng Gao Dapeng Mo Wengui Yu Yongjun Wang Yilong Wang Zhongrong Miao Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Neurology Comprehensive Stroke&Cerebrovascular CenterUniversity of California IrvineIrvineCaliforniaUSA Chinese Institute for Brain Research BeijingChina National Center for Neurological Diseases BeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Laboratory of Oral Health Capital Medical UniversityBeijingChina

Background The superiority of balloon angioplasty plus aggressive medical management(AMM)to AMM alone for symptomatic intracranial artery stenosis(sICAS)on efficacy and safety profiles still lacks evidence from randomised controlled trials(RCTs).Aim To demonstrate the design of an RCT on balloon angioplasty plus AMM for *** Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis(BASIS)trial is a multicentre,prospective,randomised,open-label,blinded end-point trial to investigate whether balloon angioplasty plus AMM could improve clinical outcome compared with AMM alone in patients with *** eligible in BASIS were 35–80 years old,with a recent transient ischaemic attack within the past 90 days or ischaemic stroke between 14 days and 90 days prior to enrolment due to severe atherosclerotic stenosis(70%–99%)of a major intracranial *** eligible patients were randomly assigned to receive balloon angioplasty plus AMM or AMM alone at a 1:1 *** groups will receive identical AMM,including standard dual antiplatelet therapy for 90 days followed by long-term single antiplatelet therapy,intensive risk factor management and life-style *** participants will be followed up for *** outcomes Stroke or death in the next 30 days after enrolment or after balloon angioplasty procedure of the qualifying lesion during follow-up,or any ischaemic stroke or revascularisation from the qualifying artery after 30 days but before 12 months of enrolment,is the primary *** BASIS trail is the first RCT to compare the efficacy and safety of balloon angioplasty plus AMM to AMM alone in sICAS patients,which may provide an alternative perspective for treating *** registration number NCT03703635;https://***.

关键词： balloon prospective centre

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德国与英国电力市场平衡机制对比分析及启示

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电力系统自动化 2024年第14期48卷 8-15页

作者：刘秋华姜亚熙张正延杨圣城邓一鸣李铭钦南京工程学院经济与管理学院江苏省南京市211167 南京工程学院电力工程学院江苏省南京市211167

随着新能源大规模并网,电力系统电力电量平衡面临新的挑战,迫切需要优化市场结构,建立新型电力系统平衡机制。鉴于德国和英国电力市场的成功经验,文中从平衡单元构成、平衡责任方权限、现货市场时序和范围、平衡市场、不平衡结算以及市... 详细信息

随着新能源大规模并网,电力系统电力电量平衡面临新的挑战,迫切需要优化市场结构,建立新型电力系统平衡机制。鉴于德国和英国电力市场的成功经验,文中从平衡单元构成、平衡责任方权限、现货市场时序和范围、平衡市场、不平衡结算以及市场透明度6个方面对德国和英国电力市场平衡机制进行了介绍和对比分析。最后,针对中国电力电量平衡现状,从市场化平衡模式、新平衡主体培育、平衡主体的责权利、精细化的现货市场和不平衡结算等方面提出了中国构建新的电力电量平衡机制的相关建议。

关键词：电力市场平衡平衡机制不平衡结算对比分析

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A Data Intrusion Tolerance Model Based on an Improved Evolutionary Game Theory for the Energy Internet

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Computers, Materials & Continua 2024年第6期79卷 3679-3697页

作者： Song deng yiming Yuan Institute of Advanced Technology Nanjing University of Posts and TelecommunicationsNanjing210003China College of Automation Nanjing University of Posts and TelecommunicationsNanjing210003China

Malicious attacks against data are unavoidable in the interconnected,open and shared Energy Internet(EI),Intrusion tolerant techniques are critical to the data security of *** intrusion tolerant techniques suffered from problems such as low adaptability,policy lag,and difficulty in determining the degree of *** address these issues,we propose a novel adaptive intrusion tolerance model based on game theory that enjoys two-fold ideas:(1)it constructs an improved replica of the intrusion tolerance model of the dynamic equation evolution game to induce incentive weights;and (2)it combines a tournament competition model with incentive weights to obtain optimal strategies for each stage of the game *** experiments are conducted in the IEEE 39-bus system,whose results demonstrate the feasibility of the incentive weights,confirm the proposed strategy strengthens the system’s ability to tolerate aggression,and improves the dynamic adaptability and response efficiency of the aggression-tolerant system in the case of limited resources.

关键词： Energy Internet Intrusion tolerance game theory racial competition adaptive intrusion response

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Efficacy and safety profiles of dolutegravir plus lamivudine ***/emtricitabine/tenofovir alafenamide in therapy-naïve adults with HIV-1

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Chinese Medical Journal 2023年第22期136卷 2677-2685页

作者： Yinghua Wei Jin Li Ruhong Xu Li Wen yiming deng Lixia He Huijun Zhong Yanhao Wang Department of Infectious Diseases The First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Department of Infectious Diseases The Ninth People’s Hospital of DongguanDongguanGuangdong 523000China Center for Disease Control and Prevention of Jiulongpo District Chongqing 400050China

Background:Dual regimen dolutegravir(DTG)plus lamivudine(3TC)has demonstrated non-inferior efficacy compared to DTG-based three-drug regimens(3DRs),yet directly comparative data regarding the efficacy and safety of DTG+3TC and bictegravir/emtricitabine/tenofovir alafenamide(B/F/TAF)for therapy-naïve people with human immunodeficiency virus(HIV)-1(PWH)are still *** aimed to assess the antiviral potency and safety profiles of DTG+3TC vs.B/F/TAF based on antiretroviral therapy(ART)-naïve PWH in ***:This retrospective multicenter study enrolled PWH initiating ART with DTG+3TC or B/F/TAF from 2020 to 2022 in Guangdong and *** analyzed response rates based on target not detected(TND)status using intention-to-treat(ITT)*** were formed based on baseline viral load(VL)(<100,000 vs.≥100,000 copies/mL)and CD4^(+)cell count(<200 vs.≥200 cell/µL).Median time to TND VL was assessed by Kaplan-Meier *** also measured changes from baseline in CD4^(+)cell counts,CD4/CD8 ratio,lipid parameters,weight,creatinine(Cr),estimated glomerular filtration rate(eGFR),and drug-related adverse effects(DRAEs).Results:We enrolled 280 participants,including 137(48.9%)on DTG+3TC and 143(51.1%)on B/F/*** week 48,96.4%(132/137)on DTG+3TC and 100%(143/143)on B/F/TAF achieved TND(P=0.064).At week 12,TND responses were higher with B/F/TAF(78.3%[112/143])than DTG+3TC(30.7%[42/137])(P<0.001).This trend held across subgroups.B/F/TAF achieved TND faster(12 weeks)than DTG+3TC(24 weeks)(P<0.001).No differences were seen in CD4^(+)cell count and CD4/CD8 ratio,except in the high-VL subgroup,where B/F/TAF showed better *** were significantly lower with B/F/TAF(4.9%[7/143])than with DTG+3TC(13.1%[18/137])(P=0.016).Lipid parameters,body weight,and Cr increased in both groups over 48 weeks,with DTG+3TC showing a more favorable effect on triglycerides,high-density lipoprotein(HDL)cholesterol,and weight ***:In this real-life study,B/F/TAF led to a

关键词： HIV-1 Antiretroviral therapy Dolutegravir Bictegravir Efficacy Safety Target not detected

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Metallogenic model and prognosis of the Shuiyindong super-large strata-bound Carlin-type gold deposit, southwestern Guizhou Province, China

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Chinese Journal Of Geochemistry 2010年第2期29卷 157-166页

作者： ZHANG Yu XIA Yong SU Wenchao TAO Yan ZHANG Xingchun LIU Jianzhong deng yiming State Key Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China Geological Party 105 Guizhou Provincial Bureau of Geology and Mineral Exploration ＆ Development Guiyang 550018 China Zijin Mining Stock Company Limited Guizhou Zhenfeng 562200 China

The Shuiyindong deposit is one of the largest (more than 100 tonnes of Au) and highest grade (more than 7×10-6-10×10-6), strata-bound Carlintype gold deposits in southwestern Guizhou Province, China. The deposit is controlled by both structure and favorable lithology. It is situated near the axis of the striking Huijiabao anticline and is hosted in bioclastic limestone of the Permian Longtan Formation. Gold mineralization occurred under low temperature with Th of 220℃± and is closely associated with decarbonation, silicification, sulfidation and dolomitization. The deposit has a characteristic elemental assemblage of Au-As-Hg-Tl. Studies of geochemistry and isotope compositions indicated that the ore-bearing materials and fluids of the gold deposit mainly originated from a plutonic source, and possess a mixing feature with the strata matter during transportation from mantle to crust. Fluid inclusions in vein quartz from the gold deposit are rich in volatile flux, indicating that metallogenic fluid is an overpres-sured one. The activity and geothermal state of the Earth's crust in the long period of time are favorable for the formation of overpressured fluids in a large area, and extensive structures would drive the fluids into ore-forming sys-tem and make gold deposits formed. The complexity of structural movement in the upper crust of southwestern Guizhou Province resulted in complicated gold mineralization. Through metallogenic prognosis and exploration, the proven reserves of the deposit increased by tens of tonnes of Au and the deposit has become a super-large strata-bound Carlin-type gold deposit.

关键词：矿床预测成矿模型卡林型超大型水银洞西南部贵州省层控

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积极血管成形术在颅内动脉粥样硬化性急性大血管闭塞治疗中的应用价值——ANGEL-ACT亚组分析

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中华神经外科杂志 2024年第7期40卷 680-685页

作者：殷悦陈翰林邓一鸣王安心张怡君贾白雪罗岗马宁莫大鹏高峰缪中荣首都医科大学附属北京天坛医院神经介入中心北京100070 首都医科大学附属北京天坛医院国家神经系统疾病临床医学研究中心北京100070 首都医科大学北京市神经外科研究所北京100070

目的分析积极的血管成形术在颅内动脉粥样硬化性大血管闭塞性卒中(LVOS)治疗中的作用。方法从急性缺血性卒中血管内治疗关键技术及急救流程改进研究(ANGEL-ACT)数据库中纳入颅内动脉粥样硬化性LVOS患者475例,根据治疗方案分为积极血管... 详细信息

目的分析积极的血管成形术在颅内动脉粥样硬化性大血管闭塞性卒中(LVOS)治疗中的作用。方法从急性缺血性卒中血管内治疗关键技术及急救流程改进研究(ANGEL-ACT)数据库中纳入颅内动脉粥样硬化性LVOS患者475例,根据治疗方案分为积极血管成形术组[定义为在1次机械取栓(MT)后行血管成形术,或仅行血管成形术](194例)与消极血管成形术组(定义为只接受MT,或在≥2次MT后行血管成形术)(281例)。比较两组的有效性和安全性。有效性主要终点为术后即刻改良脑梗死溶栓(mTICI,≥2b级为再通成功)分级、术后90 d改良Rankin量表评分(mRS);安全终点为术后24 h内症状性颅内出血和术后90 d的病死率。采用二元logistic回归分析拟合模型,分别分析消极血管成形术组与积极血管成形术组发生上述终点事件的比值比(OR值)。以P<0.05为差异有统计学意义。结果475例患者中,积极血管成形术组与消极血管成形术组术后24 h内症状性颅内出血率分别为3.1%(6/194)、5.0%(14/281),P=0.329;术后即刻mTICI分级≥2b级的比率分别为96.9%(188/194)、91.8%(258/281),P=0.023。术后90 d,mRS 0~1分的比率分别为55.7%(108/194)、38.8%(109/281),P<0.001;病死率分别为10.8%(21/194)、18.9%(53/281),P=0.018。对年龄、性别、术前美国国立卫生研究院卒中量表评分、心房颤动、原发性高血压、串联病变因素校正后,二元logistic回归分析显示,消极血管成形术组与积极血管成形术组术后即刻mTICI分级2b~3级的OR值为0.33(95%CI:0.13~0.85,P=0.022),术后90 d病死率的OR值为1.82(95%CI:1.00~3.31,P=0.051),mRS 0~1分的OR值为0.55(95%CI:0.37~0.82,P=0.004)。结论颅内动脉粥样硬化性急性LVOS患者早期积极行血管成形术可降低患者术后90 d的病死率,提高患者的神经功能恢复及脑灌注的恢复,有效性及安全性均更佳。

关键词：卒中动脉闭塞性疾病颅内动脉硬化急性血管成形术治疗结果

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基于YOLO v5-TL的褐菇采摘视觉识别-测量-定位技术

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农业机械学报 2022年第11期53卷 341-348页

作者：卢伟邹明萱施浩楠王玲 deng yiming 南京农业大学人工智能学院南京210031 密歇根州立大学东兰辛48824

为实现褐菇高效、精准、快速的自动化采摘,针对工厂化褐菇的种植特点,提出一种基于YOLO v5迁移学习(YOLO v5-TL)结合褐菇三维边缘信息直径动态估测法的褐菇原位识别-测量-定位一体化方法。首先,基于YOLO v5-TL算法实现复杂菌丝背景下的... 详细信息

为实现褐菇高效、精准、快速的自动化采摘,针对工厂化褐菇的种植特点,提出一种基于YOLO v5迁移学习(YOLO v5-TL)结合褐菇三维边缘信息直径动态估测法的褐菇原位识别-测量-定位一体化方法。首先,基于YOLO v5-TL算法实现复杂菌丝背景下的褐菇快速识别;再针对锚框区域褐菇图像进行图像增强、去噪、自适应二值化、形态学处理、轮廓拟合进行褐菇边缘定位,并提取边缘点和褐菇中心点的像素坐标;最后基于褐菇三维边缘信息的直径动态估测法实现褐菇尺寸的精确测量和中心点定位。试验结果表明单帧图像平均处理时间为50 ms,光照强度低、中、高情况下采摘对象识别平均成功率为91.67%,其中高光强时识别率达100%,菇盖的尺寸测量平均精度为97.28%。研究表明,本文提出的YOLO v5-TL结合褐菇三维边缘信息直径动态估测法可实现工厂化种植环境下褐菇识别、测量、定位一体化,满足机器人褐菇自动化采摘需求。

关键词：褐菇目标识别定位图像处理尺寸测量 YOLO v5-TL

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基于卷积神经网络面部图像识别的拖拉机驾驶员疲劳检测

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农业工程学报 2018年第7期34卷 192-199页

作者：卢伟胡海阳王家鹏王玲 yiming deng 南京农业大学工学院南京210031 江苏省现代设施农业技术与装备工程实验室南京210031 Michigan State University College of EngineeringEast Lansing48824

针对疲劳驾驶极易造成拖拉机交通事故这一问题,该文提出了一种基于卷积神经网络面部特征识别的拖拉机驾驶员疲劳检测方法。首先,利用伽马亮度校正对驾驶员面部图像进行光照预处理,再通过小波包去除图像中的椒盐噪声和高斯噪声,对预处理... 详细信息

针对疲劳驾驶极易造成拖拉机交通事故这一问题,该文提出了一种基于卷积神经网络面部特征识别的拖拉机驾驶员疲劳检测方法。首先,利用伽马亮度校正对驾驶员面部图像进行光照预处理,再通过小波包去除图像中的椒盐噪声和高斯噪声,对预处理后的图像分别通过PCA-SCM人脸特征识别定位算法和基于人脸核心特征库及肤色模型的人脸识别算法进行驾驶员面部的识别定位,并通过比对这2种算法识别的偏差大小校验算法识别的有效性,以减小拖拉机工作振动时采样对图像中人脸定位精度的影响。将提取到的驾驶员面部图像输入到卷积神经网络进行深度学习和训练,并建立驾驶员疲劳视觉检测模型,从而实现基于拖拉机驾驶员面部图像的疲劳检测。统计训练过程中各项参数变化情况并进行T-SNE降维迭代分析,与其他常规方法相比,CNN在检测准确度和检测效率方面都有较为明显的优势。试验表明,所提出的检测模型准确率98.9%,图片识别效率38 ms/帧(Inter i7-4510U双核处理器),能够实现拖拉机驾驶员疲劳状况的实时检测,该研究可为解决疲劳驾驶这一安全问题提供参考。

关键词：拖拉机图像处理算法疲劳驾驶 PCA-SCM 卷积神经网络面部识别

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怒江机场高填方挡墙边坡稳定性分析

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岩土工程技术 2024年第4期38卷 447-452页

作者：邓夷明张东明李元彪杨仲国彭海艳中国建筑西南勘察设计研究院有限公司四川成都610052

怒江机场地处西南高烈度地震山区,该机场建设采用高填方边坡形式,边坡在高填方荷载及地震荷载作用下的稳定性是制约机场建设的关键因素。采用理论分析及数值模拟方法对挡墙高填方边坡的稳定性进行分析,结果表明,高填方荷载下,挡墙基底... 详细信息

怒江机场地处西南高烈度地震山区,该机场建设采用高填方边坡形式,边坡在高填方荷载及地震荷载作用下的稳定性是制约机场建设的关键因素。采用理论分析及数值模拟方法对挡墙高填方边坡的稳定性进行分析,结果表明,高填方荷载下,挡墙基底大部分区域地基承载力不满足要求,挡墙差异沉降大;填土界面综合抗剪强度参数需满足c≥50kPa,φ≥25°时才能确保回填土体稳定;地震作用对回填土应力和变形影响较大,挡墙变形增加0.6~1.1mm,可能引起挡墙开裂。建议对基底岩体进行加固,并对挡墙进行抗震设计。

关键词：高填方边坡挡墙稳定性

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Anisotropic shearing mechanism of Kangding slate:Experimental investigation and numerical analysis

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1487-1504页

作者： Ping Liu Quansheng Liu Penghai deng Yucong Pan yiming Lei Chenglei Du Xianqi Xie The Key Laboratory of Geotechnical and Structural Engineering Safety of Hubei Province School of Civil EngineeringWuhan UniversityWuhan430072China State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan430072China

The shear mechanical behavior is regarded as an essential factor affecting the stability of the surrounding rocks in underground *** shear strength and failure mechanisms of layered rock are significantly affected by the foliation *** shear tests were conducted on cubic slate samples with foliation angles of 0°,30°,45°,60°,and 90°.The effect of foliation angles on failure patterns,acoustic emission(AE)characteristics,and shear strength parameters was *** on AE characteristics,the slate failure process could be divided into four stages:quiet period,step-like increasing period,dramatic increasing period,and remission period.A new empirical expression of cohesion for layered rock was proposed,which was compared with linear and sinusoidal cohesion expressions based on the results made by this paper and previous *** comparative analysis demonstrated that the new expression has better prediction ability than other *** proposed empirical equation was used for direct shear simulations with the combined finite-discrete element method(FDEM),and it was found to align well with the experimental *** both computational efficiency and accuracy,it was recommended to use a shear rate of 0.01 m/s for FDEM to carry out direct shear *** balance the relationship between the number of elements and the simulation results in the direct shear simulations,the recommended element size is 1 mm.

关键词： Anisotropy Empirical expression of cohesion foliation angles Combined finite-discrete element method(FDEM) Shear rate Element size

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