检索结果-南通市图书馆

Journal of Integrative Agriculture 2024年第6期23卷 2144-2148页

作者： Yanjing Liu Qingqing Yu Xiangyu Zhou Wenxin Li Xinwen He Yan Wang Guohua deng Jianzhong shi Guobin Tian Xianying Zeng Hualan Chen College of Veterinary Medicine Gansu Agricultural UniversityLanzhou 730070China State Key Laboratory for Animal Disease Control and Prevention Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry DiseasesMinistry of Agriculture and Rural Affairs/Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150009China National Poultry Laboratory Animal Resource Center Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150009China Harbin Weike Biotechnology Co. Ltd.Harbin 150009China

H9N2 virus has been widely distributed in wild birds and poultry around the world since its first emergence in the United States of America in 1966(Gu et al.2017;Carnaccini and Perez 2020).The virus appeared in chickens in China in the early 1990s,and over the last two decades has gradually become the dominant epidemic subtype(Sun and Liu 2015;Bi et al.2020).Although H9N2 virus infection alone cannot cause severe disease or death in poultry,H9N2 virus-infected birds experience a degree of egg production drop and can be easily infected by other pathogens,thus causing economic losses for poultry industry.

关键词： H9N2 poultry policy

胆木叶和茎挥发性成分对比分析及其抗MRS活性的研究

在线全文

学校读者我要写书评

暂无评论

时珍国医国药 2010年第2期21卷 299-301页

作者：苏奎龚敏邓世明周静海南大学海洋学院海南海口570228 石河子大学食品学院新疆石河子832000

目的对比分析胆木叶和茎中的挥发性成分和抗菌活性。方法采用水蒸气蒸馏法提取胆木叶和茎中的挥发性成分,用GC-MS技术进行成分对比分析,用滤纸片琼脂扩散法检测挥发性成分的抗菌活性。结果鉴定了胆木叶中的14个化学成分和茎中的10个化... 详细信息

目的对比分析胆木叶和茎中的挥发性成分和抗菌活性。方法采用水蒸气蒸馏法提取胆木叶和茎中的挥发性成分,用GC-MS技术进行成分对比分析,用滤纸片琼脂扩散法检测挥发性成分的抗菌活性。结果鉴定了胆木叶中的14个化学成分和茎中的10个化学成分;挥发性成分具有抗耐甲氧西林金黄色葡萄球菌(MRS)、大肠杆菌、普通金黄色葡萄球菌、普通变形杆菌、枯草芽孢杆菌的活性。结论胆木叶和茎中的挥发性成分主要分别为烷酸46.30%和烯酸48.94%;在抗菌活性中,抗MRS的活性最强。

关键词：胆木挥发性成分抑菌气相色谱-质谱联用分析金黄色葡萄球菌

Etching Mechanism of Ti_(3)C_(2)Cl_(2) MXene Phases by CuCl_(2)-Lewis Molten Salt Method

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 863-868页

作者：严明 ZHU Yu HUANG Jiangtao CHEN Haoyu deng Yuxiao CHEN Yanlin 王娟 Jan-Michael Albina Hubei Provincial Key Laboratory of Green Materials for Light Industry Hubei University of TechnologyWuhan 430068China New Materials and Green Manufacturing Talent Introduction and Innovation Demonstration Base Hubei University of TechnologyWuhan 430068China Hubei Longzhong Laboratory Xiangyang 441000China

We described a method for obtaining fluorine-free Ti_(3)C_(2)Cl_(2)MXene phases by melting copper in CuCl_(2)instead of aluminum in Ti_(3)AlC_(2).XRD results show that when molten salt CuCl_(2)etches Ti_(3)AlC_(2),it forms an intermediate product Ti_(3)CuC_(2),and then reacts with Ti_(3)CuC_(2)to obtain Ti_(3)C_(2)Cl_(2).The reaction of Ti_(3)AlC_(2)and CuCl_(2)at a temperature of 800℃for 2 h to obtain Ti_(3)C_(2)Cl_(2)with an optimal lamellar structure is shown in SEM *** pseudopotential plane-wave(PP-PW)method is used to calculate on the electronic *** etching mechanism is investigated by the total energies of each *** chemical reaction of Ti_(3)AlC_(2)and CuCl_(2)will first become Ti_(3)CuC_(2)and Cu,and then become Ti_(3)C_(2)Cl_(2)during the Lewis acid etching process,which are consistent with the experimental results.

关键词： molten salt method CuCl_(2) MXene first-principles calculations etching mechanism

Repurposing Loperamide as an Anti-Infection Drug for the Treatment of Intracellular Bacterial Pathogens

在线全文

学校读者我要写书评

暂无评论

Engineering 2024年第8期39卷 180-193页

作者： Hongtao Liu Siqi Li Le deng Zhenxu shi Chenxiao Jiang Jingyan Shu Yuan Liu Xuming deng Jianfeng Wang Zhimin Guo Jiazhang Qiu State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases&Key Laboratory of Zoonosis Research Ministry of EducationInstitute of ZoonosisCollege of Veterinary Medicine&Jilin UniversityChangchun 130062China Center for Pathogen Biology and Infectious Diseases The First Hospital of Jilin UniversityChangchun 130031China Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Institute of Comparative MedicineCollege of Veterinary MedicineYangzhou UniversityYangzhou 225009China

Infections caused by intracellular bacterial pathogens are difficult to treat since most antibiotics have low cell permeability and undergo rapid degradation within *** rapid development and dissemination of antimicrobial–resistant strains have exacerbated this *** the increasing knowledge of host–pathogen interactions,especially bacterial strategies for survival and proliferation within host cells,host-directed therapy(HDT)has attracted increased interest and has emerged as a promising antiinfection method for treating intracellular ***,we applied a cell-based screening approach to a US Food and Drug Administration(FDA)-approved drug library to identify compounds that can inhibit the intracellular replication of Salmonella Typhimurium(***).This screening allowed us to identify the antidiarrheal agent loperamide(LPD)as a potent inhibitor of *** intracellular *** treatment of infected cells markedly promoted the host autophagic response and lysosomal activity.A mechanistic study revealed that the increase in host autophagy and elimination of intracellular bacteria were dependent on the high expression of glycoprotein nonmetastatic melanoma protein B(GPNMB)induced by *** addition,LPD treatment effectively protected against *** infection in Galleria mellonella and mouse ***,our study suggested that LPD may be useful for the treatment of diseases caused by intracellular bacterial ***,LPD may serve as a promising lead compound for the development of anti-infection drugs based on the HDT strategy.

关键词： Intracellular bacteria US Food and Drug Administration(FDA)-approved drugs Drug repurposing Loperamide Autophagy Glycoprotein nonmetastatic melanoma protein B

High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第2期67卷 286-300页

作者： Bi-Ang Kang Hua-ming Li Ya-Ting Chen Meng-Jie deng Yan Li Yue-ming Peng Jian-Jun Gao Zhi-Wei Mo Jia-Guo Zhou Zhi-Jun Ou Jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Laboratory of Assisted Circulation(Sun Yat-sen University) Guangzhou 510080China Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis by affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tube formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhibition of O2^(·-)generation,and ultimately increasing in EC migration and tube formation.d HDL showed opposite effects compared to n HDL and ultimately inhibited EC migration and tube *** found that autophagy-related protein 5(ATG5)was a direct target of ***5 silencing or miR-181a-5p mimic inhibited n HDL-induced autophagy,e NOS expression,NO production,EC migration,tube formation,and enhanced O2^(·-)generation,whereas overexpression of ATG5 or miR-181a-5p inhibitor reversed the above effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limbs of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57BL/6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was able to stimulate autophagy by suppressing miR-181a-5p,subsequently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhibited angiogenesis,at least partially,by increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATG5 miRNA endothelial nitric oxide synthase

In-Plane Dynamic Crushing Behaviors of a Vertex-Based Hierarchical Auxetic Honeycomb

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 2024年第1期37卷 53-62页

作者： Yichen Zan Xiuhui Hou Zichen deng School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072China MIIT Key Laboratory of Dynamics and Control of Complex Systems Northwestern Polytechnical UniversityXi'an 710072China School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024China

Auxetic metamaterials,which exhibit the negative Poisson’s ratio(NPR)effect,have found wide applications in many engineering ***,their high porosity inevitably weakens their bearing capacity and impact *** improve the energy absorption efficiency of auxetic honeycombs,a novel vertex-based hierarchical star-shaped honeycomb(VSH)is designed by replacing each vertex in the classical star-shaped honeycomb(SSH)with a newly added self-similar *** analytical model is built to investigate the Young’s modulus of VSH,which shows good agreement with experimental results and numerical *** in-plane dynamic crushing behaviors of VSH at three different crushing velocities are investigated,and empirical formulas for the densification strain and plateau stress are *** results reveal more stable deformation modes for VSH,attributed to the addition of self-similar star-shaped ***,compared with SSH under the same relative densities,VSH exhibits better specific energy absorption and higher plateau ***,VSH is verified to be a better candidate for energy absorption while maintaining the auxetic *** study is expected to provide a new design strategy for auxetic honeycombs.

关键词： Vertex-based hierarchical star-shaped honeycomb Auxetic honeycomb Energy absorption Plateau stress Negative Poisson's ratio

Bearing mechanism of roof and rib support structure in automatically formed roadway and its support design method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University 2024年第7期31卷 2467-2487页

作者： JIANG Bei WANG ming-zi WANG Qi XIN Zhong-xin XING Xue-yang deng Yu-song YAO Liang-di State Key Laboratory for Tunnel Engineering China University of Mining and Technology-BeijingBeijing 100083China Research Center of Geotechnical and Structural Engineering Shandong UniversityJi􀆳nan 250061China College of Civil Engineering and Architecture Shandong University of AeronauticsBinzhou 256600China

Non-pillar mining technology with automatically formed roadway is a new mining method without coal pillar reservation and roadway *** stability control of automatically formed roadway is the key to the successful application of the new *** order to realize the stability control of the roadway surrounding rock,the mechanical model of the roof and rib support structure is established,and the influence mechanism of the automatically formed roadway parameters on the compound force is *** this basis,the roof and rib support structure technology of confined lightweight concrete is proposed,and its mechanical tests under different eccentricity are carried *** results show that the bearing capacity of confined lightweight concrete specimens is basically the same as that of ordinary confined concrete *** bearing capacity of confined lightweight concrete specimens under different eccentricities is 1.95 times higher than those of U-shaped steel *** comparing the test results with the theoretical calculated results of the confined concrete,the calculation method of the bearing capacity for the confined lightweight concrete structure is *** design method of confined lightweight concrete support structure is established,and is successfully applied in the extra-large mine,Ningtiaota Coal Mine,China.

关键词： automatically roadway with non-pillar confined lightweight concrete roof and rib support mechanical model bearing behaviour

A new method to solve the Reynolds equation including mass-conserving cavitation by physics informed neural networks(PINNs)with both soft and hard constraints

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Friction 2024年第6期12卷 1165-1175页

作者： Yinhu XI Jinhui deng Yiling LI School of Mechanical Engineering Anhui University of Science and TechnologyHuainan 232001China Ericsson AB Datalinjen 3Linköping 58330Sweden

In this work,a new method to solve the Reynolds equation including mass-conserving cavitation by using the physics informed neural networks(PINNs)is *** complementarity relationship between the pressure and the void fraction is *** are several difficulties in problem solving,and the solutions are ***,the difficulty for considering the pressure inequality constraint by PINNs is solved by transferring it into one equality constraint without introducing *** the void fraction inequality constraint is considered by using the hard constraint with the max-min ***,to avoid the fluctuation of the boundary value problems,the hard constraint method is also utilized to apply the boundary pressure values and the corresponding functions are ***,for avoiding the trivial solution the limitation for the mean value of the void fraction is *** results are validated against existing data,and both the incompressible and compressible lubricant are *** agreement can be found for both the domain and domain boundaries.

关键词： Reynolds equation mass-conserving cavitation physics informed neural networks hard constraints trivial solution

Research on Shortest Path BFS Strategy in Multi-AGV Scheduling System

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Electronic Research and Application 2024年第3期8卷 78-82页

作者： shi deng Di Wu Beijing Huahang Weishi Robot Technology Co. Ltd.Shanghai BranchShanghai 201700China Gu Fang(Shanghai)Software Technology Studio(Limited Partnership) Shanghai 211206China

With the increasing maturity of automated guided vehicles(AGV)technology and the widespread application of flexible manufacturing systems,enhancing the efficiency of AGVs in complex environments has become *** paper analyzes the challenges of path planning and scheduling in multi-AGV systems,introduces a map-based path search algorithm,and proposes the BFS algorithm for shortest path *** optimization using the breadth-first search(BFS)algorithm,efficient scheduling of multiple AGVs in complex environments is *** addition,this paper validated the effectiveness of the proposed method in a production workshop *** experimental results show that the BFS algorithm can quickly search for the shortest path,reduce the running time of AGVs,and significantly improve the performance of multi-AGV scheduling systems.

关键词： AGV Path planning AGV scheduling system BFS algorithm

Frequency-domain analysis of fluid-structure interaction in aircraft hydraulic pipeline systems: numerical and experimental studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第8期25卷 605-617页

作者： Yang deng Zongxia JIAO Yuanzhi XU School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Research Institute for Frontier Science Beihang UniversityBeijing 100191China Key Laboratory of Advanced Airborne Systems Beihang UniversityBeijing 100191China Ningbo Institute of Technology Beihang UniversityNingbo 315800China Tianmushan Laboratory Hangzhou 310023China

The fluid-structure interaction(FSI)in aircraft hydraulic pipeline systems is of great concern because of the damage it *** accurately predict the vibration characteristic of long hydraulic pipelines with curved segments,we studied the frequency-domain modeling and solution method for FSI in these pipeline *** partial differential equations(PDEs)are utilized to model the pipeline FSI,considering both frequency-dependent friction and bending-flexibility *** address the numerical instability encountered by the traditional transfer matrix method(TMM)in solving relatively complex pipelines,an improved TMM is proposed for solving the PDEs in the frequency domain,based on the matrix-stacking strategy and matrix representation of boundary *** proposed FSI model and improved solution method are validated by numerical cases and *** experimental rig of a practical hydraulic system,consisting of an aircraft engine-driven pump,a Z-shaped aero-hydraulic pipeline,and a throttle valve,was constructed for *** magnitude ratio of acceleration to pressure is introduced to evaluate the theoretical and experimental results,which indicate that the proposed model and solution method are effective in practical *** methodology presented in this paper can be used as an efficient approach for the vibrational design of aircraft hydraulic pipeline systems.

关键词： Fluid-structure interaction(FSI) Frequency-domain analysis Aircraft hydraulic pipeline Pipeline vibration Transfer matrix method(TMM)