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Genes & Diseases 2024年第5期11卷 74-77页

作者： ke deng Haibo Ruan Feifei Yu Zhenle Pei Congjian Xu Shuo Zhang Shanghai Ji Ai Genetics&IVF Institute Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200000China Shanghai key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200000China The First People’s Hospital of Wenling WenlingZhejiang 317500China Rushan Hospital of Traditional Chinese Medicine RushanShandong 264599China Department of Obstetrics and Gynecology Fudan UniversityShanghai 200000China.

Hereditary spastic paraplegia(HSP)is a group of disorders with genetic heterogeneity,lower-extremity weakness,and spasticity are the most common signs and *** is the most frequently disease-causing *** is a microtubule-severing enzyme encoded by SPAST that cleaves long microtubules into short fragments by interacting with other proteins or *** spastic paraplegia type 4(SPG4),which is autosomal dominant,is the clinical subtype associated with SPAST ***4 accounts for up to one-third of all HSP cases and usually presents with isolated lower extremity spasticity,with or without bladder or sensory dysfunction.1 The main cause of SPG4 is believed to be spastin haploinsufficiency,which results from mutations in the SPAST gene.

关键词： bladder insufficiency clinical

Network analysis reveals context-dependent structural complexity of social calls in serrate-legged small treefrogs

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Current Zoology 2024年第2期70卷 253-261页

作者： ke deng Qiao-Ling He Tong-Liang Wang Ji-Chao Wang Jian-Guo Cui CAS key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration and Biodiversity Conservation key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China University of Chinese Academy of Science Beijing 100049China Ministry of Education key Laboratory for Ecology of Tropical lslands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou 571158China

Vocal communication plays an important role in survival,reproduction,and animal social *** and mammals produce com-plex vocal sequence to convey context-dependent *** are conspicuous features of the behavior of most anuran species(frogs and toads),and males usually alter their calling strategies according to ecological context to improve the attractiveness/***,very few studies have focused on the variation of vocal sequence in *** the present study,we used both conventional method and network analysis to investigate the context-dependent vocal repertoire,vocal sequence,and call network structure in serrate-legged small treefrogs Kurixalus *** found that male *** modified their vocal sequence by switching to different call types and increasing repertoire size in the presence of a competitive ***,compared with before and after the playback of advertisement calls,males emited fewer advertisement calls,but more aggressive calls,encounter calls,and compound calls during the playback *** analysis revealed that the mean degree,mean closeness,and mean betweenness of the call networks significantly decreased during the playback period,which resulted in lower *** addition,the increased proportion of one-way motifs and average path length also indicated that the connectivity of the call network decreased in competitive ***,the vocal sequence of *** did not display a clear small-world network structure,regardless of *** study presents a paradigm to apply network analysis to vocal sequence in anurans and has important implications for understanding the evolution and function of sequence patterns.

关键词： call network centrality Kurixalus odontotarsus vocal repertoire vocal sequence.

Root cause of corrosion failure of tin coating on wire clamp in marine atmosphere

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Journal of Iron and Steel Research(International) 2024年第4期31卷 998-1014页

作者： Zhen Zhong Wang-yan Ly Teng-yuan Liu Yi Xie Yang Yang Zhen-zhu Wang deng-ke Li Xiao-bo Li Tang-qing Wu School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105HunanChina Electric Power Research Institute of Guangdong Power Grid Co. Ltd.Guangzhou 510080GuangdongChina Shenyang National L aboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina School of Materials Science and Engineering.University of Science and Technology of China Shenyang 110016LiaoningChina Electric Power Research Institute State Grid Hunan Electric Power CompanyChangsha 410007HunanChina School of Mechanical Engineering and Mechanics Xiangtan UniversityXiangtan 411105HunanChina School of Information Science and Engineering Changsha Normal UniversityChangsha 410199HunanChina

The failure cause of a tinned copper wire clamp in marine atmosphere was studied systematically by X-ray photoelectron spectroscopy,scanning electron microscopy with energy dispersive spectroscopy and electrochemical *** main components of the green rust on the surface of the damaged wire clamp are SnO_(2),CuO,Cu_(2)Cl(OH)_(3) and CuCO(OH)_(2).Much of green rust distributes at the platform edge along the axial direction on the crimp connection,and severe corrosion and corrosion pits occur at the platform edge zone along the axial *** enriching Cl-at the marine atmosphere and the existing O_(2) in air collectively enhance the corrosion process of the tin coating and the copper *** element model results show that the residual stress and strain of the tin coating are the largest at the platform edge along the axial direction on the crimp connection,and the corresponding electrode potential of the tin coating at this zone drops *** above results indicate that the residual strain increases the driving force of the corrosion electrochemical reactions and accelerates the corrosion rate and the pit corrosion of the tin coating at this zone.

关键词： Tin coating Marine atmosphere Residual strain-Chloride ion Corrosion failure

Low friction under ultrahigh contact pressure enabled by self-assembled fluorinated azobenzene layers

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Friction 2024年第7期12卷 1434-1448页

作者： Dandan XUE Zhi XU Linyuan GUO Wendi LUO Liran MA Yu TIAN Ming MA Qingdao ZENG ke deng Wenjing ZHANG Yichun XIA Shizhu WEN Jianbin LUO State key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China National Center for Nanoscience and Technology Beijing 100190China

Extensive efforts have been made to pursue a low-friction state with promising applications in many fields,such as mechanical and biomedical *** which,the load capacity of the low-friction state has been considered to be crucial for industrial ***,we report a low friction under ultrahigh contact pressure by building a novel self-assembled fluorinated azobenzene layer on an atomically smooth highly-oriented pyrolytic graphite(HOPG)*** friction coefficients could be as low as 0.0005 or even lower under a contact pressure of up to 4 *** demonstrates that the low friction under ultrahigh contact pressure is attributed to molecular *** fluorination leads to effective and robust lubrication between the tip and the self-assembled layer and enhances tighter rigidity which can reduce the stress concentration in the substrate,which was verified by density functional theory(DFT)and molecular dynamics(MD)*** work provides a new approach to avoid the failure of ultralow friction coefficient under relatively high contact pressure,which has promising potential application value in the future.

关键词： ultrahigh contact pressure self-assembled layer fluorination robust lubrication

网络民营企业数据合规的风险防范与体系建设——以Z公司非法获取计算机信息系统数据案为视角

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苏州大学学报（哲学社会科学版） 2024年第1期45卷 64-75页

作者：谢登科吉林大学理论法学研究中心吉林长春130012

数据合规作为信息网络社会中企业合规的具体类型之一,它通过促进信息网络公司依法依规处理信息数据,实现企业利益与国家安全、个人信息保护的有效平衡,有利于实现个人信息保护和数据安全领域的“国家监管”向“合规治理”模式转变。信... 详细信息

数据合规作为信息网络社会中企业合规的具体类型之一,它通过促进信息网络公司依法依规处理信息数据,实现企业利益与国家安全、个人信息保护的有效平衡,有利于实现个人信息保护和数据安全领域的“国家监管”向“合规治理”模式转变。信息网络公司作为数字经济时代和网络社会的“看门人”,数据合规是其履行信息网络安全管理义务的必要途径。从数据的完整生命周期来看,数据合规风险主要包括数据收集中的合规风险、数据提供中的合规风险、数据跨境中的合规风险等不同类型。企业需要根据《数据安全法》《个人信息保护法》等法律法规来制定相应的合规政策,在数据分类分级基础上确立不同类型数据的处理流程和内部规则,建立贯穿数据收集、存储、处理、提供、销毁等完整生命周期的数据合规体系,在公司治理结构中设置以数据安全负责人/个人信息保护负责人为核心的数据合规组织机构。

关键词：数据合规网络民营企业数据分类分级数据生命周期

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环境行政公益诉讼请求权基础研究

中国地质大学学报（社会科学版） 2024年第4期24卷 22-34页

作者：邓可祝安徽工业大学公共管理与法学院安徽马鞍山243002

环境公益诉讼的请求权基础,有环境法原则说、公益诉讼条款说和环境权说等,但这些请求权基础不够明确,尤其不符合我国环境行政公益诉讼的实践样态。环境行政公益诉讼,无法从作为原告的检察机关的权力角度来确定请求权基础,需要实现从原... 详细信息

环境公益诉讼的请求权基础,有环境法原则说、公益诉讼条款说和环境权说等,但这些请求权基础不够明确,尤其不符合我国环境行政公益诉讼的实践样态。环境行政公益诉讼,无法从作为原告的检察机关的权力角度来确定请求权基础,需要实现从原告权利(力)向被告义务的转向,以行政机关法定义务作为请求权基础。以行政机关法定义务作为请求权基础,符合行政公益诉讼的诉讼结构,体现行政法律关系内容的义务性,也有利于统一审查行政机关的义务与职责。行政机关环境义务主要来源于行政法律一般性规范和环境法律规范,作为请求权基础的法律规范类型多样,需要对之进行体系化构造,这样才能准确判断行政机关的义务,确定环境行政公益诉讼的请求权基础并对之进行审查。

关键词：环境行政公益诉讼请求权基础行政义务

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双波导辐射对岩石裂纹扩展机理的影响

工程科学与技术 2024年第2期56卷 108-117页

作者：温森杜林王倩张敏邓珂河南大学土木建筑学院河南开封475004

通过微波辐射能够使岩石迅速升温并产生扩展裂纹,从而大幅降低岩石强度,有助于解决全断面隧道掘进机(TBM)在破碎高强度硬岩地层时面临滚刀磨损严重、破岩效率低下、工程成本剧增等问题。为此,本文采用离散元软件PFC2D建立玄武岩的三相矿... 详细信息

通过微波辐射能够使岩石迅速升温并产生扩展裂纹,从而大幅降低岩石强度,有助于解决全断面隧道掘进机(TBM)在破碎高强度硬岩地层时面临滚刀磨损严重、破岩效率低下、工程成本剧增等问题。为此,本文采用离散元软件PFC2D建立玄武岩的三相矿物(斜长石、橄榄石、辉石)模型,并进行双波导辐射模拟,探究波导间距(60、70、80、90及100 mm)、辐射时间(0、0.04、0.06、0.08及0.10 s)和围岩压力(5、10、15及20 MPa)对岩石损伤裂纹扩展的影响规律。结果表明:采用微波功率密度1×1010W/m3对玄武岩进行辐射加热时,为达到辅助破岩的效果,辐射时间不宜低于起裂时间(0.04 s)。微波辐射导致强吸波矿物(辉石)和弱吸波矿物(斜长石)间形成较大的温度梯度和热应力且最易产生损伤裂纹,所以裂纹产生的位置主要与岩石矿物的位置分布具有重要关系。在微波辐射岩石过程中,裂纹首先在辐射区域产生,继而在热膨胀和热应力作用下扩展延伸并在波导间的岩石区域形成裂纹贯通;随着波导间距的增加,波导间岩石裂纹贯通时所需要的微波辐射时间逐渐增加。围岩压力对裂纹的产生和扩展具有抑制和约束作用,其变化对岩样损伤裂纹的生成位置和扩展路径无明显影响,通过延长微波辐射的时间可以弥补因围压增加而减少的裂纹。

关键词：微波辅助 PFC2D 裂纹辐射时间波导间距围压

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Disruption of PABPN1 phase separation by SNRPD2 drives colorectal cancer cell proliferation and migration through promoting alternative polyadenylation of CTNNBIP1

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Science China(Life Sciences) 2024年第6期67卷 1212-1225页

作者： Zhijie Hu Mengxia Li Yufeng Chen Liutao Chen Yuting Han Chengyong Chen Xin Lu Nan You Yawen Lou Yingye Huang Zhanfeng Huo Chao Liu Cheng Liang Susu Liu ke deng Liangfu Chen Shangwu Chen Guohui Wan Xiaojian Wu Yonggui Fu Anlong Xu State key Laboratory of Biocontrol Guangdong Province Key Laboratory of Pharmaceutical Functional GenesDepartment of BiochemistrySchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Department of General Surgery(Colorectal Surgery)&Guangdong Provincial key Laboratory of Colorectal and Pelvic Floor Diseases&Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation National Engineering Research Center for New Drug and Druggability(cultivation)Guangdong Province Key Laboratory of New Drug Design and EvaluationSchool of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China

Generally shortened 3′UTR due to alternative polyadenylation(APA)is widely observed in cancer,but its regulation mechanisms for cancer are not well ***,with profiling of APA in colorectal cancer tissues and poly(A)signal editing,we firstly identified that the shortened 3′UTR of CTNNIBP1 in colorectal cancer promotes cell proliferation and *** found that liquid-liquid phase separation(LLPS)of PABPN1 is reduced albeit with higher expression in cancer,and the reduction of LLPS leads to the shortened 3′UTR of CTNNBIP1and promotes cell proliferation and ***,the splicing factor SNRPD2 upregulated in colorectal cancer,can interact with glutamic-proline(EP)domain of PABPN1,and then disrupt LLPS of PABPN1,which attenuates the repression effect of PABPN1 on the proximal poly(A)*** results firstly reveal a new regulation mechanism of APA by disruption of LLPS of PABPN1,suggesting that regulation of APA by interfering LLPS of 3′end processing factor may have the potential as a new way for the treatment of cancer.

关键词： alternative polyadenylation colorectal cancer CTNNBIP1 PABPN1 liquid-liquid phase separation SNRPD2

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社会化研究框架下算法公平性的实现策略研究

科学学研究 2024年第2期42卷 248-255页

作者：张贵红邓克涛中国科学技术大学人文与社会科学学院安徽合肥230026

算法公平性是当下人工智能领域和信息伦理学界共同关注的一个话题,它来自于算法决策系统中的算法歧视现象。尽管技术人员在避免算法歧视方面取得了许多进展,但对于如何在技术层面实现算法公平性,至今仍没有达成共识。基于此,本研究首先... 详细信息

算法公平性是当下人工智能领域和信息伦理学界共同关注的一个话题,它来自于算法决策系统中的算法歧视现象。尽管技术人员在避免算法歧视方面取得了许多进展,但对于如何在技术层面实现算法公平性,至今仍没有达成共识。基于此,本研究首先分析了从技术路径实现算法公平性的方法及其缺陷,接着,沿着当前对于单从技术路径实现算法公平性的批评及修正,提出一种基于布雷的“披露性的计算机伦理学”的社会化研究框架,为算法公平性问题提供了一个更为合理的解决方案。

关键词：算法公平性算法歧视算法伦理公平

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算法透明度:从理论到实践的探索与反思

科学学研究 2024年第7期42卷 1354-1360页

作者：邓克涛张贵红中国科学技术大学科技哲学系安徽合肥230026

尽管越来越多重要的任务和决策被委托给了算法,但因算法的计算复杂性和不透明性,使得用户无法理解算法的决策过程和结果,导致其难以信任算法,甚至出现了“算法厌恶”的现象。相应地,算法透明度通常被视为可信任人工智能的基础,并在过去... 详细信息

尽管越来越多重要的任务和决策被委托给了算法,但因算法的计算复杂性和不透明性,使得用户无法理解算法的决策过程和结果,导致其难以信任算法,甚至出现了“算法厌恶”的现象。相应地,算法透明度通常被视为可信任人工智能的基础,并在过去几年的学术辩论中获得了相当多的呼吁。然而,在实践层面,算法透明度的实施却存在诸多挑战,并且还可能引发一定的伦理风险。基于此,本研究通过分析算法透明度实践层面的挑战和风险,指出至少可以从披露、审查以及设计这三个维度来化解当前实践层面的困境。

关键词：算法透明度算法伦理算法决策可信任人工智能