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Casticin Attenuates Stemness in Cervical Cancer Stem-Like Cells by Regulating Activity and Expression of DNMT1

Chinese Journal of Integrative Medicine 2023年第3期29卷 224-232页

作者： WANG Xue-li CAO Xiao-zheng WANG Dao-yuan QIU Ye-bei deng kai-yu CAO Jian-guo LIN Shao-qiang XU Yong REN kai-qun Medical College Hunan University of MedicineHuaihuaHunan Province(418000)China Clinical Department of Guangdong Metabolic Disease Research Centre of Integrated Chinese and Western Medicine the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou(510062)China Institute of Chemical Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou(510530)China The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province Medical CollegeHunan Normal UniversityChangsha(410013)China The Key Laboratory of Study and Discover of Small Targeted Molecules of Hunan Province Medical CollegeHunan Normal UniversityChangsha(410013)China

Objective:To explore whether casticin(CAS)suppresses stemness in cancer stem-like cells(CSLCs)obtained from human cervical cancer(CCSLCs)and the underlying ***:Spheres from He La and Ca Ski cells were used as *** methyltransferase 1(DNMT1)activity and m RNA levels,self-renewal capability(Nanog and Sox2),and cancer stem cell markers(CD133 and CD44)were detected by a colorimetric DNMT activity/inhibition assay kit,quantitative real-time reverse transcription-polymerase chain reaction,sphere and colony formation assays,and immunoblot,*** and overexpression of DNMT1 by transfection with sh RNA and c DNA,respectively,were performed to explore the mechanism for action of CAS(0,10,30,and 100 nmol/L).Results:DNMT1 activity was increased in CCSLCs compared with He La and Ca Ski cells(P<0.05).In addition,He La-derived CCSLCs transfected with DNMT1 sh RNA showed reduced sphere and colony formation abilities,and lower CD133,CD44,Nanog and Sox2 protein expressions(P<0.05).Conversely,overexpression of DNMT1 in He La cells exhibited the oppositive ***,CAS significantly reduced DNMT1 activity and transcription levels as well as stemness in He La-derived CCSLCs(P<0.05).Interestingly,DNMT1 knockdown enhanced the inhibitory effect of CAS on *** expected,DNMT1 overexpression reversed the inhibitory effect of CAS on stemness in He La ***:CAS effectively inhibits stemness in CCSLCs through suppression of DNMT1 activation,suggesting that CAS acts as a promising preventive and therapeutic candidate in cervical cancer.

关键词： cervical cancer cancer stem cell casticin DNA methyltransferase 1 therapeutic action

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COMPrompter: reconceptualized segment anything model with multiprompt network for camouflaged object detection

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Science China(Information Sciences) 2025年第1期68卷 189-203页

作者： Xiaoqin ZHANG Zhenni yu Li ZHAO deng-Ping FAN Guobao XIAO Zhejiang Province Key Laboratory of Intelligent Informatics for Safety and Emergency Wenzhou University Nankai International Advanced Research Institute (SHENZHEN FUTIAN) College of Computer Science Nankai University School of Computer Science and Technology Tongji University

We rethink the segment anything model(SAM) and propose a novel multiprompt network called COMPrompter for camouflaged object detection(COD). SAM has zero-shot generalization ability beyond other models and can provide an ideal framework for COD. Our network aims to enhance the single prompt strategy in SAM to a multiprompt strategy. To achieve this, we propose an edge gradient extraction module, which generates a mask containing gradient information regarding the boundaries of camouflaged objects. This gradient mask is then used as a novel boundary prompt, enhancing the segmentation process. Thereafter, we design a box-boundary mutual guidance module, which fosters more precise and comprehensive feature extraction via mutual guidance between a boundary prompt and a box prompt. This collaboration enhances the model's ability to accurately detect camouflaged objects. Moreover, we employ the discrete wavelet transform to extract high-frequency features from image embeddings. The high-frequency features serve as a supplementary component to the multiprompt ***, our COMPrompter guides the network to achieve enhanced segmentation results, thereby advancing the development of SAM in terms of COD. Experimental results across COD benchmarks demonstrate that COMPrompter achieves a cutting-edge performance, surpassing the current leading model by an average positive metric of 2.2% in COD10K. In the specific application of COD, the experimental results in polyp segmentation show that our model is superior to top-tier methods as well. The code will be made available at https://***/guobaoxiao/COMPrompter.

关键词： segment anything model camouflaged object detection boundary prompt

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Structural engineering of high-entropy alloys for advanced electrocatalytic reactions

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Tungsten 2025年第1期7卷 1-31页

作者： Qiao Xie Ying-Jie yu Hai-Jun Zhang Ya-Ping deng Wen Lei The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology Department of Chemical Engineering Waterloo Institute for Sustainable Energy Waterloo Institute for Nanotechnology University of Waterloo

High-entropy alloys(HEAs) have emerged as promising candidates to replace traditional precious metal catalysts,owing to their unique chemical and physical *** review commences by revisiting the fundamental concepts of HEAs,including their synthesis methods and structural control strategies in *** underscores the critical role of meticulously manipulating both macroscopic and microscopic structures of the HEAs to optimize their catalytic performance.A deep understanding of the structure-activity relationship in HEAs across various configurations is pivotal in developing more effective *** review methodically encapsulates the research progress of structural control strategies for HEAs in achieving efficient energy conversion,with the aim of gaining a better understanding of the relationship between structure and *** review concludes by summarizing the current achievements and challenges,and suggestions for potential future directions of HEAs in the fields of energy conversion and environmental purification.

关键词： Electrocatalytic Energy conversion High-entropy alloys Structural modulation

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PTEN和K-ras与子宫内膜癌关系的研究进展

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中华肿瘤防治杂志 2011年第15期18卷 1217-1220页

作者：邓开玉田小英怀化医学高等专科学校妇产科教研室湖南怀化418000

目的:总结近年来国内外关于PTEN、K-ras在子宫内膜癌中表达及相互关系的研究进展。方法:应用PubMed及CNKI全文数据库检索系统,以"子宫内膜癌、PTEN和K-ras"为关键词,检索1988-01-2011-06的相关文献,共检索到英文文献457篇,中文文献176... 详细信息

目的:总结近年来国内外关于PTEN、K-ras在子宫内膜癌中表达及相互关系的研究进展。方法:应用PubMed及CNKI全文数据库检索系统,以"子宫内膜癌、PTEN和K-ras"为关键词,检索1988-01-2011-06的相关文献,共检索到英文文献457篇,中文文献176篇。文献纳入标准:1)PTEN及K-ras的生物学特性及作用机制;2)PTEN、K-ras分别在子宫内膜癌中的表达;3)PTEN和K-ras在子宫内膜癌中的共同表达。根据纳入标准符合分析文献26篇。结果:在子宫内膜癌组织中存在PTEN的表达缺失,而且在子宫内膜癌中PTEN突变率(23.5%～55.0%)高。PTEN缺失或突变诱导了细胞持续增殖和恶性转化,促进肿瘤的形成。K-ras的突变往往发生于子宫内膜癌的早期,K-ras基因的表达与其组织学分级及临床分期有关,组织学分级越差、临床分期越晚,K-ras基因的阳性表达率越高。结论:PTEN和K-ras同属于子宫内膜癌的早期分子事件,在子宫内膜癌发生、发展过程中起着协同效应。

关键词：子宫内膜肿瘤基因,PTEN 基因,K-ras 综述文献

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跨遵义火车站下承式钢管混凝土系杆拱桥设计

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山西建筑 2008年第15期34卷 313-314页

作者：邓开宇中铁二院昆明勘察设计研究院有限责任公司

介绍了外部简支下承式钢管混凝土系杆拱桥上部结构的主要设计内容,利用桥梁博士结构计算软件,对跨遵义火车站下承式钢管混凝土系杆拱桥进行了结构分析计算,检算结果表明,该桥的结构设计满足规范要求,选定的结构形式和截面尺寸拟定是合... 详细信息

介绍了外部简支下承式钢管混凝土系杆拱桥上部结构的主要设计内容,利用桥梁博士结构计算软件,对跨遵义火车站下承式钢管混凝土系杆拱桥进行了结构分析计算,检算结果表明,该桥的结构设计满足规范要求,选定的结构形式和截面尺寸拟定是合理可行的。

关键词：火车站钢管混凝土系杆拱结构设计

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产品创新设计的可拓推理设计方法

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机械设计 2018年第4期35卷 113-118页

作者：吴通陈登凯余隋怀西北工业大学陕西省工业设计工程实验室陕西西安710072

为解决产品设计中的模糊不确定性问题,将可拓创新方法引入设计过程中,提出基于可拓变换及推理的产品创新设计方法。在建立产品设计知识表示模型的基础上,通过基元的转化和推理解决设计问题,并研究了产品设计的可拓变换和推理的一般原则... 详细信息

为解决产品设计中的模糊不确定性问题,将可拓创新方法引入设计过程中,提出基于可拓变换及推理的产品创新设计方法。在建立产品设计知识表示模型的基础上,通过基元的转化和推理解决设计问题,并研究了产品设计的可拓变换和推理的一般原则。将可拓设计过程模型和可拓推理机制应用于产品的功能设计和色彩设计中,分别得到对应于产品功能设计和色彩设计的可拓推理设计方法及流程。该方法完善了产品创新设计方法体系,可为产品设计提供创新解决方案。

关键词：产品创新设计可拓推理功能设计色彩设计

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K-ras及PTEN在45岁以下妇女子宫内膜癌中的表达

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中国现代医学杂志 2011年第14期21卷 1647-1651页

作者：邓开玉徐大宝陈芸怀化医学高等专科学校妇产科教研室湖南怀化418000 中南大学湘雅三医院妇产科湖南长沙410013 云南省肿瘤医院病理科云南昆明650100

目的探讨K-ras及PTEN在45岁以下妇女子宫内膜癌组织中的表达及相关性。方法选取因子宫病变行子宫全切的标本66例,其中子宫内膜腺癌42例、子宫内膜非典型增生6例、正常子宫内膜18例。采用免疫组织化学SP法测定K-ras及PTEN在45岁及以下妇... 详细信息

目的探讨K-ras及PTEN在45岁以下妇女子宫内膜癌组织中的表达及相关性。方法选取因子宫病变行子宫全切的标本66例,其中子宫内膜腺癌42例、子宫内膜非典型增生6例、正常子宫内膜18例。采用免疫组织化学SP法测定K-ras及PTEN在45岁及以下妇女子宫内膜组织中的表达。结果①K-ras在子宫内膜不典型增生及子宫内膜癌中的表达明显高于正常子宫内膜,差异有显著性(P0.05)。K-ras阳性表达与PTEN阳性表达不一致。结论 K-ras及PTEN的异常表达发生在年轻妇女子宫内膜癌的早期,与预后无关。

关键词：子宫内膜癌 K-ras PTEN

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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li kai-yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

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意外妊娠终止后继发不孕的原因及影响因素分析

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中国妇幼保健 2010年第31期25卷 4559-4560页

作者：邓开玉田小英卢彦怀化医学高等专科学校湖南怀化418000 湖南省怀化市第一人民医院

目的:探讨意外妊娠终止后继发不孕的原因及影响因素。方法:以2006年8月～2008年8月到怀化市第一人民医院就诊的82例意外妊娠后继发不孕的妇女作为观察组,进行问卷调查,以同期入院的58例原发性不孕妇女作为对照组,采用SPSS13.0软件进行... 详细信息

目的:探讨意外妊娠终止后继发不孕的原因及影响因素。方法:以2006年8月～2008年8月到怀化市第一人民医院就诊的82例意外妊娠后继发不孕的妇女作为观察组,进行问卷调查,以同期入院的58例原发性不孕妇女作为对照组,采用SPSS13.0软件进行统计分析。结果:观察组初次性生活年龄早于对照组(P<0.001);避孕失败原因依次为未避孕(占57.32%)、避孕套失败(占18.29%)、安全期避孕(10.98%)、体外排精(9.76%);避孕失败后终止妊娠的方式主要为人工流产、药物流产,而输卵管妊娠后继发不孕者亦占一定比例;继发不孕的原因居前4位的分别是输卵管梗阻、慢性输卵管炎、慢性盆腔炎、输卵管积水。结论:意外妊娠终止后继发不孕的主要原因是盆腔炎性疾病后遗症,导致输卵管梗阻或不通畅。初次性生活年龄过早,未避孕或避孕方法不当,多次人工流产、药物流产、输卵管妊娠史是意外妊娠后继发不孕的重要影响因素。

关键词：意外妊娠不孕症影响因素

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MoS2 synaptic transistor with one-step manufacture

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Science China(Information Sciences) 2025年第1期68卷 357-365页

作者： Yihao GUO Yang WANG Wenjie deng Yi WU Jingtao LI Kexin LI yuehui ZHAO Songlin yu Xiaoting WANG Yongzhe ZHANG Hui YAN Key Laboratory of Optoelectronics Technology of Education Ministry of China Faculty of Information TechnologyBeijing University of Technology Key Laboratory of Advanced Functional Materials Ministry of Education Faculty of Materials and ManufacturingBeijing University of Technology The 11th Research Institute of Electronics Technology Group Corporation

The synaptic transistor,which is a neuromorphic device with brain-like functions,has garnered significant attention due to characteristics such as low energy consumption,high integration,multiple functions,and high computational ***,the current synaptic transistor possesses a complicated structure and involves complex manufacturing steps,which is not conducive to low-cost,large-scale bionic ***,we introduce a simple MoS2synaptic transistor exhibiting robust synaptic *** transistor utilizes magnetron sputtering manufacture to combine the process of device metal electrode deposition and the introduction of defect states,which helps streamline the manufacturing process into a single *** long-term potentiation and long-term depression in photoelectric coordination are initially ***,biological functions,such as double pulse facilitation and the transformation behavior of short-term memory to long-term memory,are thoroughly evaluated,along with learning-forgetting-relearning ***,the device exhibits robust synaptic plasticity until incident light angles down to 30° to imitate the multi-to-one axon-cellular ***,a classical simulation of Pavlov's dog conditioned reflex is demonstrated along with the multiview extraction *** experimental results demonstrate a promising synaptic transistor with a simple structure,manufacturing technique,and excellent *** further indicates the potential for large-scale integration of bionic neuromorphic systems.

关键词： process optimization artificial synaptic device one-stepmanufacture synaptic plasticity bionic simulation

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