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Combination of graphene oxide and platelet-rich plasma improves tendon-bone healing in a rabbit model of supraspinatus tendon reconstruction

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Regenerative Biomaterials 2021年第6期8卷 15-25页

作者： Dingsu Bao Jiacheng Sun Min Gong Jie Shi Bo Qin kai deng Gang Liu Shengqiang Zeng Zhou Xiang Shijie Fu Department of Orthopedics Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhouSichuan 646000PR China Department of Orthopedics West China HospitalSichuan UniversityChengduSichuan 610041PR China Department of Orthopedics Hospital of Chengdu University of Traditional Chinese MedicineChengduSichuan 610075PR China

The treatment of rotator cuff tear is one of the major challenges for orthopedic *** key to treatment is the reconstruction of the tendon-bone interface(TBI).Autologous platelet-rich plasma(PRP)is used as a therapeutic agent to accelerate the healing of tendons,as it contains a variety of growth factors and is easy to *** oxide(GO)is known to improve the physical properties of biomaterials and promote tissue *** this study,PRP gels containing various concentrations of GO were prepared to promote TBI healing and supraspinatus tendon reconstruction in a rabbit *** incorporation of GO improved the ultrastructure and mechanical properties of the PRP *** gels containing 0.5 mg/ml GO(0.5 GO/PRP)continuously released transforming growth factor-b1(TGF-b1)and platelet-derived growth factor(PDGF)-AB,and the released TGF-b1 and PDGF-AB were still at high concentrations,1063.451 pg/ml and814.217 pg/ml,respectively,on the 14th *** vitro assays showed that the 0.5 GO/PRP gels had good biocompatibility and promoted bone marrow mesenchymal stem cells proliferation and osteogenic and chondrogenic *** 12 weeks of implantation,the magnetic resonance imaging,microcomputed tomography and histological results indicated that the newly regenerated tendons in the 0.5 GO/PRP group had a similar structure to natural ***,the biomechanical results showed that the newly formed tendons in the 0.5 GO/PRP group had better biomechanical properties compared to those in the other groups,and had more stable TBI ***,the combination of PRP and GO has the potential to be a powerful advancement in the treatment of rotator cuff injuries.

关键词： platelet-rich plasma graphene oxide controlled release rotator cuff tear tendon-bone interface healing

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Effects of dietary yeast β-glucan on nutrient digestibility and serum profiles in pre-ruminant Holstein calves

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Journal of Integrative Agriculture 2015年第4期14卷 749-757页

作者： MA Tao TU Yan ZHANG Nai-feng GUO Jiang-peng deng kai-dong ZHOU Yi YUN Qiang DIAO Qi-yu Feed Research Institute Chinese Academy of Agricultural Sciences/Key Laboratory of Feed BiotechnologyMinistry of Agriculture Beijing General Station of Animal Husbandry

This study aimed to investigate the effects of dietary supplementation of yeast 13-glucan on the nutrient digestibility and serum profiles in pre-ruminant Holstein calves. Forty-two neonatal Holstein calves （（39.6＋4.2） kg） were randomly allotted to six groups, and each was offered one of the following diets： a basal diet （control） or the basal diet supplemented with 25, 50, 75, 100 or 200 mg of yeast 13-glucan kg-~ feed （dry matter basis）. The basal diet consisted of a milk replacer and a starter feed. The trial lasted for 56 d. Two digestibility trials were conducted from d 14 to 20 and from d 42 to 48. Blood samples were collected on d 0, 14, 28 and 42 for serum profile analyses. On d 56, three calves from each group were slaughtered, and intestinal samples were collected to assess the villous height, crypt depth and mucosal thickness. Although feed intake was not affected by dietary treatment （P〉0.05）, the average daily gain （ADG） and gain-to-feed ratios were higher （P〈0.05） for the calves fed 75 mg of yeast β-glucan kg^-1 feed than those in the other groups. The supplementation of yeast β-glucan at 75 mg kg^-1 feed increased the apparent digestibility of dry matter （DM）, crude protein （CP）, ether extract （EE）, and phosphorus （P）（P〈0.05） and the ratio of intestinal villous height to crypt depth （V/C）（P〈0.05） when compared with the control group. No effects of yeast β-glucan on the serum concentrations of total protein （TP）, albumin （ALB）, serum urea nitrogen （SUN） and glucose （GLU） were observed （P〉0.05）. Compared with the control group, supplementation of yeast β-glucan decreased （P〈0.05） the serum concentrations of triglycerides （TG） and total cholesterol （TC）. The serum concentration of immunoglobulin G （IgG） and immunoglobulin M （IgM） increased quadratically （P〈0.05）, whereas the serum concentration of immunoglobulin A （IgA） was unaffected by dietary treatments （P〉0.05）. The supplementation of yeast β-glucan stimu- lated the enzymatic activity of alkaline p

关键词： calf digestibility intestinal development serum profile yeast β-glucan

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Concentrations of Polybrominated Diphenyl Ethers in Maternal Blood,Placental Size,and Risk for Fetal Growth Restriction:A Nested Case-control Study

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Biomedical and Environmental Sciences 2020年第11期33卷 821-828页

作者： JIN Yu Ting deng Xiao kai ZHAO Ying Ya LI Jia Lin SONG Qi ZHANG Yun Hui YANG Qing CHEN Shang Qin Department of Neonatology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027ZhejiangChina Department of Pediatrics Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310052ZhejiangChina Key Laboratory of Public Health Safety Ministry of EducationSchool of Public HealthFudan UniversityShanghai 200032China The Maternal and Child Healthcare Institute of Songjiang District Shanghai 201600China

Objective To explore the effects of prenatal exposure to polybrominated diphenyl ethers(PBDEs)on placental size and birth *** Based on the perspective Wenzhou Birth Cohort,this nested case-control study included 101 fetal growth restriction(FGR)and 101 healthy *** serum samples were collected during the third trimester and measured for PBDEs by gas chromatography tandem mass *** basic information of mother-newborn pairs was collected from questionnaires,whereas the placental size and birth outcomes of newborns were obtained from hospital *** A total of 19 brominated diphenyle ether(BDE)congeners were detected in maternal serum *** concentrations of BDE-207,-208,-209,and∑19PBDEs were detected in FGR cases than in *** BDE-207,-208,-209,and∑19PBDEs levels in maternal serum were related to decreased placental length,breadth,surface area,birth weight,birth length,gestational age,and Quetelet index of *** adjusting for confounders,BDE-207 and∑19PBDE concentrations in maternal serum were significantly associated with an increased risk of *** A negative association was found between PBDE levels in maternal serum and placental size and birth *** PBDE exposure may be associated with elevated risk of the incidence of FGR birth.

关键词： Polybrominated diphenyl ethers Fetal growth restriction Maternal serum Birth outcome

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The Effect of Administration of Rutin on Plasma Levels of Estrogen, Prolactin, Growth Hormone and Gene Expression of Their Receptors in Mammary Glands in Ovariectomized Rats

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Journal of Integrative Agriculture 2012年第10期11卷 1700-1706页

作者： GUO Xu-dong DIAO Qi-yu WANG Yue-ying TU Yan deng kai-dong WANG Xin-jian FU Tong YAN Gui-long Key Laboratory of Feed Biotechnology Ministry of Agriculture/Feed Research Institute Chinese Academy of Agricultural Sciences Key Laboratory of Animal Growth and Development Ministry of Agriculture/Henan Agricultual University College of Animal Sciences Jinling Institute of Technology College of Animal Sciences Hebei North University

The development of mammary glands, endocrine hormone concentrations and the gene expression of related receptors were measured in ovariectomized virgin rats after adminstration of an estrogen-like plant extract, rutin. Thirty-two ovariectomized virgin Wistar rats were randomly assigned to 4 treatments with 8 animals each： gastric infusion of 2 mL normal saline per unovariectomized rat per day （Sham）, gastric infusion of 2 mL normal saline per ovariectomized rat per day （Ova）, gastric infusion of 60 mg rutin kg-1 body weight （BW） per ovariectomized rat per day （Ova＋Rut）, or intramuscular injection of 60 ug estradiol kg-1 BW per ovariectomized rat weekly （Ova＋Est）. Samples of blood and mammary glands were harvested to determine the levels of estrogen （E2）, prolactin （PRL） and growth hormone （GH）, and the gene expression of estrogen receptors （ER）, prolactin receptors （PRLR） and growth hormone receptors （GHR） with radioimmunoassy （RIA） and RT-PCR technology, respectively. The E2 concentration in plasma and gland tissues from the rats of Ovx＋Rut or Ovx＋Est was higher than that of Ovx （P〈0.05）, but the plasma E2 concentration from the rats of Ovx＋Rut was lower than that of Sham （P〈0.05）. The order of the PRL concentration in plasma and gland tissues was Ovx〈Ovx＋Rut〈Ovx＋Est 〈Sham, and the difference in each treatment （P〈0.05）. The plasma GH concentration was lower in Ovx than in Ovx＋Rut or Ovx＋Est, and lower in Ovx＋Rut than in Sham （P〈0.05）. The GH concentration in gland tissues was lower in Ovx than in Ovx＋Rut or Ovx＋Est （P〈0.05）, and lower in Ovx＋Rut than in Sham （P〈0.05）. The gene expression of ER in gland tissues was increased in an order as Ovx〈Ovx＋Rut〈Ovx＋Est〈Sham （P〈0.05）, and PRLR, GHR showed the same trend. In conclusion, adminstration of rutin increased the E2 concentration in plasma and mammary glands, promoted pituitary PRL and GH release, up-regulated the gene expression of ER, PRLR and GHR, and stimulated mammary development in ovariectomized virgin rats.

关键词： rutin rats mammary gland development hormones receptors

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多模态磁共振成像评价宫颈癌宫旁浸润的研究进展

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中国CT和MRI杂志 2025年第1期23卷 201-203页

作者：吴星臣张晓燕徐晨董桂青曲倩倩邓凯山东第二医科大学医学影像学院山东潍坊261053 山东第一医科大学第一附属医院(山东省千佛山医院)放射科山东济南250014 山东第一医科大学(山东省医学科学院) 山东济南250117 济宁医学院临床医学院山东济宁272067 山东第一医科大学第一附属医院(山东省千佛山医院)医学工程部山东济南250014

宫颈癌是一种发生在女性生殖系统中的常见恶性肿瘤,它在发展中国家的发病率特别高。宫旁浸润(PMI)是宫颈癌复发的危险因素,其与治疗和预后的相关性已受到广泛的临床关注。多模态磁共振成像结合了多种成像模式,能够获取多种不同的成像参... 详细信息

宫颈癌是一种发生在女性生殖系统中的常见恶性肿瘤,它在发展中国家的发病率特别高。宫旁浸润(PMI)是宫颈癌复发的危险因素,其与治疗和预后的相关性已受到广泛的临床关注。多模态磁共振成像结合了多种成像模式,能够获取多种不同的成像参数,提供更全面、更准确的诊断信息,这些不同的成像模式也可以提供关于组织结构、代谢状态、血流情况等多方面的信息,对准确评估患者的病情具有重要意义。磁共振的广泛应用与影像组学的发展,对宫旁浸润的诊断表现出明显的优势。本文将对多模态磁共振成像技术在宫颈癌宫旁浸润的研究现状及进展进行综述,以提高对宫颈癌宫旁浸润的诊断准确性。

关键词：磁共振成像宫颈癌宫旁浸润影像组学

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Method for vessel attitude estimation by spatial correlation function for bottom reverberation

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Chinese Journal of Acoustics 2006年第2期25卷 171-183页

作者： FENG Lei deng kai WANG Changhong Institute of Acoustics Chinese Academy of Sciences Beijing 100080 Graduate School of the Chinese Academy of Sciences Beijing 100039 不详

Under the assumption that the sea bottom is an almost-fiat and randomly rough thin layer, a spatial correlation model for bottom reverberation is constructed. At high signal noise ratio, the phase of the spatial correlation function is the product of sound wave number and the vertical vector between two hydrophones. In a nominally horizontal plane, roll and pitch bring on the vertical vector between the hydrophones. Then an equation including roll, pitch and the phase of the spatial correlation function is found. If a parallelogram can be constructed by 3 hydrophones and the ratios of its acreage to diagonals are not smaller than half of the wavelength, roll and pitch can be obtained analytically or by optimal method. However, the ranges of roll and pitch are restricted because of the phase ambiguity. Using Fisher information matrix, the Cramer-Rao lower bound is obtained. Results from computer simulation and sea test data prove the feasibility of the method.

关键词： correlation function Fisher information matrix computer simulation correlation model phase ambiguity noise ratio lower bound thin layer test data

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The Optimizing for Forecast of Fishery Products in China Based on Grey Model

The Optimizing for Forecast of Fishery Products in China Bas...

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2015中国渔业经济专家研讨会——认识经济新常态运筹渔业十三五

作者： LIAN Peng deng Hua-kai College of marine science & technology Dalian Ocean University College of science Dalian Ocean University

The optimizing for forecast of fishery products in China from 1979 to 2014 was conducted using the theories of grey correlation *** this paper,there are five kinds of the yield:yield of marine capture,yield of distance fisheries,yield of freshwater capture,yield of mariculture and yield of freshwater culture,which were classified by a method of grey correlation *** ranged fishery data from 1979 to 2014,and then we standardized data before ***’s more,we modeled the method of obtaining fishes and years by grey model,which figured out the correlation degree of model by least square ***,we analyzed influencing mechanism include many degree and received solution of our equation.

关键词： Grey model correlation degree least square method MGM(l,n)model

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Energy Requirements for Maintenance and Growth of German Mutton Merino Crossbred Lambs

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Journal of Integrative Agriculture 2013年第4期12卷 670-677页

作者： deng kai-dong DIAO Qi-yu JIANG Cheng-gang TU Yan ZHANG Nai-feng LIU Jie MA Tao ZHAO Yi-guang XU Gui-shan Feed Research Institute Chinese Academy of Agricultural Sciences College of Animal Science Jinling Institute of Technology

A comparative slaughter trial and a metabolism trial were conducted to determine the requirement of net energy （NE） and metabolizable energy （ME） by the crossbreed of German Mutton Merino×Inner Mongolia Merino for fattening from 35 to 50 kg of body weight （BW）. 49 crossbred female lambs （（33.9＋2.3）（SD） kg BW） of German Mutton Merino×lnner Mongolia Merino were used. 34 lambs were randomly chosen for comparative slaughter, which were offered an identical mixture diet （concentrate：roughage=55：45） at 100, 75 or 55% of ad libitum intake, whereas the remainders were used in the metabolism trial to evaluate the ME of the diet after methane production was measured by open-circuit respirometry. As feed intake decreased from 100 to 75 and 55% of ad libitum intake, the apparent digestibility of dry matter （DM） linearly increased （P=-0.010） from 60.8 to 63.6 and 66.9%, respectively, and methane production decreased from 52.1 to 44.3 and 39.9 L d-l, respectively, but the ratio of methane energy to gross energy intake increased linearly （P=0.010） from 8.20 to 8.96 and 10.97%, respectively. Consequently, the ME values of the diet increased from 9.35 to 9.64 and 9.85 MJ kg-~ DM, respectively. The NE requirement for maintenance （NEro） was 255 kJ kg-1 BW0.75, and the ME requirement for maintenance （MEre） was 352 kJ kg-I BW~.75, with a partial energy efficiency for maintenance （km） of 0.72. The NE requirement for growth （NEg） ranged from 1.26 to 4.66 MJ d-1as average daily gains increased from 100 to 300 g d-1, with a partial energy efficiency for growth （ks） of 0.45. These results indicated that the NEg required by crossbred female lambs of German Mutton Merinoxlnner Mongolia Merino was lower than the recommendation of the American or British nutritional system.

关键词： efficiency growth maintenance metabolizable energy net energy sheep

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空间差异视角下西部地区高新技术企业创新环境的外生优势分析

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统计与信息论坛 2018年第9期33卷 88-96页

作者：邓凯西安财经学院计划财务处陕西西安710100

高新技术企业的创新环境在不同区域存在较大的空间差异性,西部地区创新环境的评价分析是调整并发挥其创新驱动外生优势的重要依据和理论支撑,因此在梳理创新环境影响因素的基础上,构建创新环境的维度体系,以揭示创新环境外生优势的作用... 详细信息

高新技术企业的创新环境在不同区域存在较大的空间差异性,西部地区创新环境的评价分析是调整并发挥其创新驱动外生优势的重要依据和理论支撑,因此在梳理创新环境影响因素的基础上,构建创新环境的维度体系,以揭示创新环境外生优势的作用机理。利用主成分分析法提取西部地区高新技术企业创新环境的特征信息,进行外生优势排名;通过空间自相关分析研究西部地区创新环境的可视化空间差异性特征。研究结果表明,从创新环境外生优势的综合排名来看,四川、陕西、重庆位居前三;创新环境外生优势较高的地区趋于空间集聚,而集聚核心地区与周边边缘地区存在较大空间差异特征。

关键词：西部地区高新技术企业创新环境空间差异

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Predictive value of Th17 and Treg cells at baseline for HBsAg loss in chronic hepatitis B patients with low HBsAg quantification treated with pegylated interferon and nucleos(t)ide analogue

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Liver Research 2023年第2期7卷 136-144页

作者： Li-Li Wu Xiao-Yan Li kai deng Bing-Liang Lin Hong deng Dong-Ying Xie Geng-Lin Zhang Qi-Yi Zhao Zhi-Shuo Mo Yue-Hua Huang Zhi-Liang Gao Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Provincial Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Institute of Human Virology Key Laboratory of Tropical Disease Control of Ministry of EducationZhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdongChina Key Laboratory of Tropical Disease Control(Sun Yat-sen University) Ministry of EducationGuangzhouGuangdongChina

Background and aims:The primary goal of chronic hepatitis B(CHB)treatment is to reduce hepatitis B surface antigen(HBsAg).T helper 17(Th17)and regulatory T(Treg)cells are essential for the development of ***,how Th17 and Treg cells contribute to HBsAg loss is still ***,this study aimed to search for the predictive value of Th17 and Treg cells for HBsAg loss in CHB patients with low HBsAg ***:The study included 99 hepatitis B e antigen(HBeAg)-negative CHB patients who had completed a year of nucleos(t)ide analogue(NA)monotherapy and had received both NA and pegylated interferon(PEG-IFN)treatment for less than 96 weeks(96 wk).In the cured group,48 patients lost HBsAg within 48 wk,while 51 patients did not(uncured group).Blood samples and clinical data were collected for ***:During PEG-IFN and NA combination therapy,the proportion of Th17 cells in the cured group increased significantly,while the proportion of Treg cells in the uncured group *** 0 to 24 wk,the proportion of Th17 cells in the cured group was significantly higher than in the uncured group,while the opposite was true for Treg *** with alanine aminotransferase(ALT)2.5 upper limit of normal(ULN)at 12 wk had a higher proportion of Th17 cells and a lower proportion of Treg cells than those with ALT<2.5 ULN at 12 ***,the proportion of Th17 cells is inversely associated with the level of HBsAg,whereas the level of Treg cells is positively related to HBsAg *** clinical cure index,including age,HBsAg quantification,and the proportions of Th17 and Treg cells,had a higher area under the curve(0.957)for predicting HBsAg loss when compared to the proportions of Th17 and Treg cells and HBsAg quantification ***:Combined with quantification of HBsAg,the proportions of Th17 cells and Treg cells at baseline can be used as good predictors of HBsAg loss in patients with low HBsAg quantification treated with

关键词： Chronic hepatitis B(CHB) T helper 17(Th17)cell Regulatory T(Treg)cell Hepatitis B surface antigen(HBsAg)loss Clinical cure Pegylated interferon(PEG-IFN) Nucleos(t)ide analogue(NA)

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