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Spontaneous retroperitoneal hemorrhage after hemodialysis involving anticoagulant agents

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第5期13卷 408-412页

作者： Wen-xing FAN Zheng-xu deng Fang liu Rong-bo liu Ling HE Bogati AMRIT Li ZANG Jing-wen LI Xian-rong liu Song-min HUANG Ping FU Department of Nephrology West China HospitalSichuan UniversityChengdu 610041China Department of Radiology West China Hospital Sichuan University Chengdu 610041China

In this paper, we described the symptoms and treatment of a patient with diabetic nephropathy accom- panied by spontaneous retroperitoneal hemorrhage after hemodialysis. An elderly female patient with diabetic neph- ropathy presented with severe pain, numbness, and an increasing swelling in the left hip and left thigh after six ses- sions of hemodialysis involving the use of an antiplatelet drug and an anticoagulant agent. Her hemoglobin decreased to 46 g/L. An abdominal ultrasound showed a hematoma in the left retroperitoneal space, and computed tomography (CT) findings revealed a 6 cm×8 cm×10 cm hematoma in the left psoas muscle. After aggressive supportive therapy [the administration of packed red blood cell transfusion, carbazochrome sodium sulfonate injection, and continuous venovenous hemofiltration (CVVH)], the patient's vital signs stabilized and her hemoglobin increased to 86 g/L. Repeat CT showed that the hematoma had been partially absorbed after two weeks. Eventually, the patient was discharged with stable vital signs. Physicians should be aware of the possibility of spontaneous retroperitoneal hemorrhage, particularly in patients with diabetic nephropathy undergoing hemodialysis involving the use of anticoagulant agents.

关键词： Spontaneous retroperitoneal hemorrhage Diabetic nephropathy Hemodialysis Nadroparin calcium

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荧光磁性碳点对卵巢癌细胞的靶向成像与检测

无机化学学报 2024年第8期40卷 1483-1490页

作者：钟思意林小文刘嘉欣王如意梁涛邓峥峰钟傲韩翠平徐州医科大学医学影像学院徐州221004 徐州医科大学基础医学国家级实验教学示范中心徐州221004 徐州医科大学附属医院影像科徐州221000

利用高温碳化法制备了荧光磁性钆掺杂碳点(Gd-CDs),其具有明亮的绿色荧光发射,荧光量子产率为32.6%,T1弛豫效率高达9.02 L·mmol^(-1)·s^(-1)。将Gd-CDs与卵巢癌特异性抗体Anti-HE4连接,得到的Anti-HE4/Gd-CDs纳米探针能对SKOV-3卵巢... 详细信息

利用高温碳化法制备了荧光磁性钆掺杂碳点(Gd-CDs),其具有明亮的绿色荧光发射,荧光量子产率为32.6%,T1弛豫效率高达9.02 L·mmol^(-1)·s^(-1)。将Gd-CDs与卵巢癌特异性抗体Anti-HE4连接,得到的Anti-HE4/Gd-CDs纳米探针能对SKOV-3卵巢癌细胞进行特异性的荧光成像和T1加权成像,其荧光信号强度与SKOV-3的细胞浓度成正比,对SKOV-3细胞的检测限为658 cell·mL^(-1)。以该方法检测了血液样品中的SKOV-3细胞。

关键词：钆掺杂碳点靶向探针荧光成像磁共振成像卵巢癌细胞

Separation and Anti-Hantaan Virus Activity of Extracts from Alternanthera philoxcroides in vitro and in vivo

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Wuhan University Journal of Natural Sciences 2007年第6期12卷 1143-1147页

作者： liu Yingjuan YANG Zhanqiu deng Haiying XIAO Hong QU Chunfeng State Key Laboratory of Virology/Institute of Medical Virology School of Medicine Wuhan University Wuhan 43007 l Hubei China

A water-soluble substance was extracted from the Chinese herb, Alternantheraphiloxcroides with hot water and alcohol. Aliquots of this initial extract were further fractionated by treatment with ether, ethyl acetate and alcohol respectively. The four extracts were assayed for anti-viral activity against three serum, Hantaan virus 114 （HV114）, HV435 and A9 strains. Results show that the four extracts are capable of inhibiting Hantaan virus propagation, of which extract No. 1 has the best efficiency. The three dosage of extract No. 1, which are used upon three Hantaan virus serum IC50, are 153, 157, 154 μg/mL. New-born mice were made to be infected with HV114 and then fed in vivo with extract No.l on the 3rd, 10th and 14th days after being infected by the virus. The treatment continued for 8 days with a dosage of 2.5 g/kg. Result shows that survival rates of mice were 75%, 50% and 0, respectively. The median time to death （MTDs） of the three groups were 37, 30, 23 days.

关键词： antiviral activity Alternanthera philoxcroides Hantaan virus cell culture animal experiment

基于双浮标连续监测资料分析大亚湾西南部海域水体环境变化特征及其影响因素

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热带海洋学报 2024年第4期43卷 153-164页

作者：奚琛林宗轩萨如拉邓玺刘强倪亮罗来才马腾谢智杰陈思若陈松泽中广核研究院有限公司广东深圳518000 海洋地球古菌组学重点实验室南方科技大学广东深圳518055 广东省深圳生态环境监测中心站广东深圳518049 深圳市朗诚科技股份有限公司广东深圳518000 哈尔滨工程大学黑龙江哈尔滨150001 海洋科学与工程系南方科技大学广东深圳518055

水质环境监测对了解海洋生态系统变化至关重要。本文利用2022—2023年期间位于大亚湾西南部海域的2个浮标的连续监测数据,分析了水质环境的时间序列变化。结果表明,大亚湾西南部海域的温度、盐度可能受太阳辐射与降水的影响,具有明显的... 详细信息

水质环境监测对了解海洋生态系统变化至关重要。本文利用2022—2023年期间位于大亚湾西南部海域的2个浮标的连续监测数据,分析了水质环境的时间序列变化。结果表明,大亚湾西南部海域的温度、盐度可能受太阳辐射与降水的影响,具有明显的季节性差异,即夏季温度高、盐度低,冬季温度低、盐度较高;而Chl a具有明显的昼夜节律,溶解氧和pH存在相似的日变化模式。在夏、秋季,大鹏澳较杨梅坑海域呈现出高温、低盐、低溶解氧、低pH和高Chl a的特点。Pearson相关性分析表明,夏、秋季的温度、盐度、溶解氧、pH和Chl a之间存在显著的相关性,且存在区域差异,湾口附近,海浪、上升流等水体运动可能是主要影响因素;近岸,径流输入可能是导致水质环境变化的主导因素。此外,本文还记录了远距离台风引起的海浪及降水事件,继而对大亚湾海域环境造成影响。解析沿海环境参数时间序列的变化特征,对海洋生态系统的演变特征研究具有重要指示作用。

关键词：大亚湾近岸海域环境参数在线监测分布特征

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Visible Light Responsive DNA Thermotropic Liquid Crystals Based on a Photothermal Effect of Gold Nanoparticles

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Journal of Analysis and Testing 2021年第2期5卷 181-187页

作者： Lei Zhang Yang Qu Yun liu Yawen deng Jingjing Gu Zhongtao Wu Jiehua Lin Xiliang Luo Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science MOEShandong Key Laboratory of Biochemical AnalysisCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China Guangdong Key Laboratory for Research and Development of Natural Drugs Guangdong Medical UniversityZhanjiang 524023China

Solvent free DNA-surfactant melts are receiving continuous attractions in recent *** physical properties could be regulated via changing the alkyl chain length of *** an ideal external stimulus,light has been used in the regulation of mechanical properties of DNA thermotropic liquid crystal(TLC)containing an azobenzene motif,while in this case,the UV light is the only effective excitation ***,in comparison with visible light,UV light causes damage to DNA and has low tissue-penetration efficiency *** this work,a new type of DNA-didodecyldimethylammonium bromide(DNA-DDAB)TLCs fabricating with gold nanoparticles(AuNPs)was *** visible light-induced photothermal effect of AuNPs could change the mechanical properties of AuNPs/DNA-DDAB TLCs,as shown by clearly boundary motion activity and viscoelasticity ***,the ratio of AuNPs and charge stoichiometry of DNA:DDAB also affected photocurrent generation property of these DNA *** development of this visible light responsive DNA melt might facilitate the related studies in biomedicine and biomaterials.

关键词： Light responsive material Thermotropic liquid crystal Gold nanoparticle DNA melt Photothermal effect

VOCs evaporative emissions from vehicles in China:Species characteristics of different emission processes

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Environmental Science and Ecotechnology 2020年第1期1卷 9-19页

作者： Hanyang Man Huan liu He Niu Kai Wang Fanyuan deng Xiaotong Wang Qian Xiao Jiming Hao State Key Joint Laboratory of ESPC School of EnvironmentTsinghua UniversityBeijing100084China State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex Beijing100084China State Key Laboratory of Plateau Ecology and Agriculture Qinghai UniversityXining810003China Fujian Key Laboratory of Pollution Control&Resource Reuse Fujian Normal UniversityFuzhou350007China College of Environmental Sciences and Engineering Peking UniversityBeijing100871China China Automotive Technology and Research Center Beijing100070China

Vehicle evaporation is an essential source of VOCs in cities but is not well understood in *** emission factors from previous studies are not enough for understanding the atmospheric chemical process of vehicular evaporative *** this work,a serious of detailed VOCs speciation profiles are developed based on test processes and emission processes.A mass balance method was used to divide different emission processes during diurnal *** results show that headspace vapor of gasoline cannot represent the real-world vehicle evaporation because of the significant differences in VOCs speciation profiles,especially for *** further distinguish emissions from evaporation and exhaust,only the ratios of MTBE/benzene and MTBE/toluene can serve as indicators when considering species from all evaporative ***,emissions from different sources change significantly with the *** solve these problems,we developed a monthly comprehensive evaporation speciation *** individual profiles at the emission processes are weighted by the emission of the in-use vehicle fleet in Beijing to derive the comprehensive speciation profile of evaporative *** formation potential(OFP)and secondary organic aerosol potential(SOAP)were used to evaluate the environmental *** SOAP,100 g evaporative emissions are equal to 6.05-12.71 g toluene in different months,much higher than that given using headspace vapors,especially in winter(7.2 times higher in December).These findings would improve our understanding of the evaporative VOCs emissions in China and their environmental impacts(e.g.,O3 and SOA formation).

关键词： Vehicle evaporative emission VOC speciation profile Monthly comprehensive profile SOAP Ozone formation potential

Characterization of the positive SARP family regulator PieR for improving piericidin A1 production in Streptomyces piomogeues ***

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Synthetic and Systems Biotechnology 2019年第1期4卷 16-24页

作者： Yan Li Lingxin Kong Jufang Shen Qing Wang Qian liu Weinan Yang Zixin deng Delin You State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental SciencesSchool of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghaiChina

Piericidin A1,a member ofɑ-pyridone antibiotic,exhibits various biological activities such as antimicrobial,antifungal,and antitumor properties and possesses potent respiration-inhibitory activity against insects due to its competitive binding capacity to mitochondrial complex *** biosynthetic pathway of piericidin A1 has been reported in Streptomyces piomogeues ***,while the regulatory mechanism remains poorly *** this study,a Streptomyces antibiotic regulatory protein(SARP)family transcriptional regulator PieR was *** disruption and complementation manipulations revealed that PieR positively regulated the production of piericidin ***,the overexpression of pieR contributed to the improvement of piericidin A1 *** real-time quantitative PCR(RT-qPCR)was carried out and the data showed that pieR stimulated the transcription of all the biosynthesis-related genes for piericidin *** order to explore the regulatory mechanism,electrophoresis mobility shift assays(EMSA)and DNase I footprinting experiments have been conducted.A protected region covering 50 nucleotides within the upstream region of pieR was identified and two 5-nt direct repeat sequences(5′-CCGGA-3′)in the protected region were *** findings,taken together,set stage for transcriptional control engineering in the view of optimizing piericidin A1 production and thus provide a viable potent route for the construction of strains with high productivity.

关键词： ɑ-pyridone antibiotic Transcriptional regulation SARP family regulator Secondary metabolic Streptomyces

Establishment of a new molecular model for mercury determination verified by single crystal X-ray diffraction,spectroscopic analysis and biological potentials

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Chinese Chemical Letters 2021年第1期32卷 87-91页

作者： Jiapei Gu Feifan Zhang Ziman Zheng Xiangqian Li Runxuan deng Zhan Zhou Lufang Ma Wanqiang liu Qianming Wang College of Chemistry and Chemical Engineering Henan Key Laboratory of Function-Oriented Porous MaterialsLuoyang Normal UniversityLuoyang 471934China Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006China School of Chemistry and Chemical Engineering Hunan University of Science and TechnologyXiangtan 411201China Guangdong Provincial Key Laboratory of Optical Information Materials and Technology&Institute of Electric Paper Displays South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China

A wide variety of molecular probes have been developed for real-time analysis,but most of organic fluorophores possess small Stokes shifts and self-absorption or inner filter effect that could not be *** this study,a new dicyanoisophorone-based derivative(E)-0-(4-(2-(3-(dicyanomethylene)-5,5-dimethylcyclohex-1-en-1-yl)vinyl)phenyl)diphenylphosphinothioate(λ_(ex)=405 nm,X_(em)=551 nm,denoted as ICM-S) with strong push-pull electron effect has been afforded and it exhibits red shift for absorption from 407 nm to 426 nm with distinct color change from pale yellow to deep yellow upon exposure to Hg~(2+).Moreover,an easily distinguishable fluorescence color change follows the route from green,yellow to red in the presence of Hg~(2+) over the range of 0-90 μmol/L(detection limit=137 nmol/L)can be observed by the naked eye under a UV lamp *** and sublimedsulfur are incorpo rated as re s ponsive sites and P-O bond has been cleaved upon the addition of mercu ry *** the recognition process,such dicyanoisophorone dye(ICM-S) has been evolved to 2-(3-(4-hydroxystyryl)-5,5-dimethylcyclohex-2-enylidene) malononitrile(ICM-OH).Clear evidences in the chemical processes can be identified via single crystal X-ray diffraction,spectroscopic analysis,photophysical studies and titration *** the aim of exploring its potential in biological systems,its in vitro responses to Hg~(2+) have been evaluated in 293 T cells and the effectiveness in zebrafish model has also been verified.

关键词： Dicyanoisophorone Ratiometric fluorescent probe Mercury ions Cell imaging Zebrafish

七叶皂苷钠联合中药熏洗对髌骨骨折术后疗效研究

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长春中医药大学学报 2021年第5期37卷 1063-1066页

作者：刘登郑昱新惠银银吴秀芳张超高宁阳王丽萍上海中医药大学附属静安区临汾路街道社区卫生服务中心上海200435 上海中医药大学附属曙光医院上海200021 上海市宝山区顾村镇社区卫生服务中心上海201900 上海市第三康复医院上海200070 新疆维吾尔自治区喀什地区巴楚县人民医院新疆巴楚843800

目的探究七叶皂苷钠、中药熏洗对髌骨骨折术后患者功能恢复及膝关节僵硬的影响。方法选择76例髌骨骨折患者,随机分为对照组与观察组,各38例。对照组给予常规基础治疗及康复训练,观察组在对照组基础上给予七叶皂苷钠联合中药熏洗治疗,2... 详细信息

目的探究七叶皂苷钠、中药熏洗对髌骨骨折术后患者功能恢复及膝关节僵硬的影响。方法选择76例髌骨骨折患者,随机分为对照组与观察组,各38例。对照组给予常规基础治疗及康复训练,观察组在对照组基础上给予七叶皂苷钠联合中药熏洗治疗,2组均连续治疗1个月。比较2组治疗前与治疗后3个月膝关节恢复情况,HSS评分及ROM;比较2组治疗前与治疗1个月后膝关节肿胀值、VAS评分、血清BMP、IGF、VEGF水平的差异;比较2组不良反应发生情况。结果治疗后3个月,观察组膝关节恢复优良率(92.11%,35/38)显著高于对照组(71.05%,27/38)(P0.05)。结论七叶皂苷钠联合中药熏洗可有效缓解髌骨骨折术后患者膝关节僵硬,改善膝关节功能,缓解患侧膝关节肿胀与疼痛,提高血清IGF、BMP与VEGF水平。

关键词：髌骨骨折七叶皂苷钠中药熏洗膝关节