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Septic cardiomyopathy phenotype in the critically ill may depend on antimicrobial resistance

Journal of Intensive Medicine 2024年第3期4卷 355-361页

作者： Vasiliki Tsolaki Kyriaki Parisi George E.Zakynthinos Efrosini Gerovasileiou Nikitas Karavidas Vassileios Vazgiourakis Epaminondas Zakynthinos demosthenes makris Intensive Care Unit University Hospital of LarissaUniversity of Thessaly Faculty of MedicineLarissaGreece Third Cardiology Clinic University of AthensSotiria HospitalAthensGreece Respiratory Department University Hospital of LarissaUniversity of Thessaly Faculty of MedicineLarissaGreece

Background Sepsis is a life-threatening organ dysfunction,and septic cardiomyopathy(SCM)may complicate the course of the *** with multidrug-resistant(MDR)pathogens has been linked with worse *** study aims to evaluate SCM in patients with infections caused by different antimicrobial-resistant *** This retrospective study included patients with sepsis/septic shock,hospitalized,and intubated in the intensive care unit of the University Hospital of Larissa between January 2022 and September 2023 with echocardiographic data during the first two days after infection *** patients were divided into two groups:non-MDR-SCM group and MDR-SCM *** cardiac function was compared between the two *** A total of 62 patients were included in the ***-four patients comprised the MDR-SCM and 18 the non-MDR-SCM ***-six patients(41.9%)presented with left ventricular(LV)systolic dysfunction,and≤35%right ventricular fractional area change(RVFAC)was present in 56.4%.LV systolic function was more severely impaired in the non-MDR-SCM group(left ventricular ejection fraction,35.8%±4.9%vs.45.6%±2.4%,P=0.049;LV outflow tract velocity time integral,[10.1±1.4]cm vs.[15.3±0.74]cm,P=0.001;LV-Strain,–9.02%±0.9%vs.–14.02%±0.7%,P=0.001).The MDR-SCM group presented with more severe right ventricular(RV)dilatation(right ventricular end-diastolic area/left ventricular end-diastolic area,0.81±0.03 vs.0.7±0.05,P=0.042)and worse RV systolic function(RVFAC,32.3%±1.9%vs.39.6%±2.7%,P=0.035;tricuspid annular plane systolic excursion,[15.9±0.9]mm vs.[18.1±0.9]mm,P=0.165;systolic tissue Doppler velocity measured at the lateral tricuspid annulus,[9.9±0.5]cm/s vs.[13.1±0.8]cm/s,P=0.002;RV-strain,–11.1%±0.7%vs.–15.1%±0.9%,P=0.002).Conclusion SCM related to MDR infection presents with RV systolic dysfunction predominance,while non-MDR-SCM is mainly depicted with LV systolic dysfunction impairment.

关键词： Septic cardiomyopathy Multidrug-resistant pathogen Left ventricular failure Right ventricular dysfunction Left/right ventricular longitudinal strain Ventriculoarterial Coupling

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Genetic Implications in COPD. The Current Knowledge

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Open Journal of Respiratory Diseases 2013年第2期3卷 52-62页

作者： Ioannis Sotiriou demosthenes makris Intensive Care Unit University Hospital of Larisa Larisa Greece

Chronic Obstructive Pulmonary Disease (COPD) is a multifactorial disease in the pathogenesis of which contributes a variety of causative factors including genetic and environmental ones. They may also be interactions of genetic susceptibilities and environmental influences. Towards to that in the pathogenesis of the disease except smoking, it seems to have a great impact the genetic predisposition of the individuals suffering from that serious progressive disease. Regarding to these observations and findings very interesting studies have been conducted in order to elucidate the implications of different genes, and their polymorphisms in disease aetiology. This is a review which elucidates the impact of genetic susceptibility in COPD.

关键词： Association Studies Chronic Obstructive Pulmonary Disease Genetics Genes Polymorphisms

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The future of training in intensive care medicine: A European perspective

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Journal of Intensive Medicine 2023年第1期3卷 52-61页

作者： demosthenes makris Vasiliki Tsolaki Ross Robertson George Dimopoulos Jordi Rello Medical School University of ThessalyLarisa 41110Greece Third Department of Critical Care Medical SchoolNational and Kapodistrian University of AthensAthens 12462Greece CRIPS Department Vall d'Hebron Institut of ResearchBarcelona 08035Spain Clinical Research CHU NîmesNîmes 30029France Medical School Universitat Internacional de CatalunyaCampus Sant CugatSant Cugat del VallesBarcelona 08195Spain

Introduction Intensive care medicine(ICM)is the science and art of preventing,caring for,and curing acutely ill *** specialty originated from the need to provide technology-centered organ support to the most fragile patients presenting with sequential and progressive organ failure.[1]Despite its genesis in Europe and extensive clinical and research achievements in the field,ICM has not been recognized as a distinct discipline in the European Union(EU).This has a negative impact on the free movement of intensivists across *** fact,it has been a major obstacle for knowledge and competence sharing,communication,and professional interweaving across borders—all of which are crucial requirements,especially when contending with pandemics and disasters.

关键词： acute originated spite

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Prevalence and sociodemographic determinants of selected noncommunicable diseases among the general population of Cyprus:A large population-based cross-sectional study

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慢性疾病与转化医学:英文版 2023年第3期9卷 222-237页

作者： Maria Kyprianidou demosthenes Panagiotakos Konstantinos Cmakris Maria Kambanaros Costas AChristophi Konstantinos Giannakou Department of Health Sciences School of SciencesEuropean University CyprusNicosiaCyprus Cyprus International Institute for Environmental and Public Health Cyprus University of TechnologyLimassolCyprus Department of Nutrition and Dietetics School of Health Sciences and EducationHarokopio UniversityAthensGreece Department of Allied Health and Human Performance University of South AustraliaAdelaideSouth AustraliaAustralia

Background:Noncommunicable diseases(NCDs)are the leading cause of morbidity and mortality *** aim of this study was to determine the prevalence of NCDs among the population of Cyprus and to identify the distribution of the socioeconomic and demographic determinants among individuals with the most frequent ***:A cross-sectional study was conducted using stratified *** and demographic characteristics and the presence of NCDs were collected through a standardized *** diseases were classified using the 10th revision of the International Classification of Diseases(ICD-10).Results:In total,1140 individuals participated in the study,among whom 590(51.7%)had at least one chronic *** most prevalent NCDs were hyperlipidemia(17.4%),hypertension(12.9%),and thyroid diseases(8.4%).We identified more males than females with hyperlipidemia aged 25–44 years old and>65 years old(p=0.024),more males compared to females with hypertension(p=0.001)and more females compared to males with thyroid diseases(p<0.001).Individuals with hypertension and hyperlipidemia were more likely to be married,to have completed a higher education,and to have a high annual ***:In Cyprus,the majority of the general population had at least one ***,hypertension,and thyroid disease are relatively common,even at younger ages,highlighting the need for the development of public health programs aimed at addressing and preventing NCDs.

关键词： chronic diseases hyperlipidemia hypertension noncommunicable diseases prevalence

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