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METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs

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International Journal of Oral Science 2024年第3期16卷 528-538页

作者： Yizhou Jin Xiao han Yuejun Wang Zhipeng Fan Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Beijing Stomatological HospitalSchool of StomatologyCapital Medical UniversityBeijingChina Beijing Laboratory of Oral Health Capital Medical UniversityBeijingChina Research Unit of Tooth Development and Regeneration Chinese Academy of Medical SciencesBeijingChina

Bisphosphonate-related osteonecrosis of jaw(BRONJ)is characterized by impaired osteogenic differentiation of orofacial bone marrow stromal cells(BMSCs).Corin has recently been demonstrated to act as a key regulator in bone development and orthopedic ***,the role of corin in BRONJ-related BMSCs dysfunction remains unclarified.A m6A epitranscriptomic microarray study from our group shows that the CORIN gene is significantly upregulated and m6A hypermethylated during orofacial BMSCs osteogenic *** knockdown inhibits BMSCs osteogenic differentiation,whereas corin overexpression or soluble corin(sCorin)exerts a promotion ***,corin expression is negatively regulated by bisphosphonates(BPs).Corin overexpression or sCorin reverses BPs-impaired BMSCs differentiation ***,we find altered expression of phos-ERK in corin knockdown/overexpression BMSCs and BMSCs under sCorin ***98059(a selective ERK inhibitor)blocks the corin-mediated promotion *** regard to the high methylation level of corin during osteogenic differentiation,we apply a non-selective m6A methylase inhibitor,Cycloleucine,which also blocks the corin-mediated promotion ***,we demonstrate that METTL7A modulates corin m6A modification and reverses BPs-impaired BMSCs function,indicating that METTL7A regulates corin expression and thus contributes to orofacial BMSCs differentiation *** conclude,our study reveals that corin reverses BPs-induced BMSCs dysfunction,and METTL7A-mediated corin m6A modification underlies corin promotion of osteogenic differentiation via the ERK *** hope this brings new insights into future clinical treatments for BRONJ.

关键词： impaired cor mediated

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Understanding Discrepancy of Power System Dynamic Security Assessment with Unknown Faults: A Reliable Transfer Learning-based Method

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 427-431页

作者： Chao Ren han Yu Yan Xu Zhao Yang Dong School of Computer Science and Engineering Nanyang Technological UniversitySingapore School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore

This letter proposes a reliable transfer learning(RTL)method for pre-fault dynamic security assessment(DSA)in power systems to improve DSA performance in the presence of potentially related unknown *** takes individual discrepancies into consideration and can handle unknown faults with incomplete *** experiment results demonstrate high DSA accuracy and computational efficiency of the proposed RTL *** analysis shows RTL can guarantee system performance.

关键词： Adversarial training dynamic security assessment maximum classifier discrepancy missing data transfer learning

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Novel medium entropy perovskite oxide Sr(FeCoNiMo)_(1/4)O_(3−δ)for zinc-air battery cathode

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Journal of Energy Chemistry 2024年第9期96卷 669-678页

作者： Kaixin Li Juntao Gao Xu han Qi Shao Zhe Lü School of Physics Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Heilongjiang Provincial Key Laboratory of Advanced Quantum Functional Materials and Sensor Components Harbin 150001HeilongjiangChina

It is widely recognized that the development of ZABs is impeded by the kinetic bottleneck of oxygen evolution reaction(OER)and oxygen reduction reaction(ORR).The application of conformational entropy strategy to oxides often involves introducing multiple elements with different properties,thereby providing outstanding bifunctional catalytic activity for OER/***,the possible underlying catalytic pathways and potential interactions between various components are still poorly *** paper presents an excellent medium-entropy perovskite oxide,Sr(FeCoNiMo)_(1/4)O_(3−δ)(lower overpotential of 301 mV at 10 mA cm^(−2)).Zinc-air batteries employing it as a cathode catalyst demonstrate excellent round-trip efficiency(62%).By combining theoretical calculation with experiments,we aim to establish the link between the electronic structure of perovskite oxides with different elemental compositions and their OER *** reveals that the conformational entropy strategy can simultaneously shift the O 2p-band center and metal d-band center of perovskite oxide towards the vicinity of the Fermi energy level,thereby triggering a more favorable lattice oxygen-participated mechanism(LOM)during the OER *** outcomes of this work provide crucial insights into the role of conformational entropy strategies in oxygen catalysis and offer potential avenues for constructing efficient and stable electrocatalysts.

关键词： Sr(FeCoNiMo)_(1/4)O_(3−δ) Bifunctional catalyst Medium entropy LOM Rechargeable zinc-air batteries

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Learning Vector Quantization-Based Fuzzy Rules Oversampling Method

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Computers, Materials & Continua 2024年第6期79卷 5067-5082页

作者： Jiqiang Chen Ranran han Dongqing Zhang Litao Ma School of Mathematics and Physics Hebei University of EngineeringHandan056038China

Imbalanced datasets are common in practical applications,and oversampling methods using fuzzy rules have been shown to enhance the classification performance of imbalanced data by taking into account the relationship between data ***,the creation of fuzzy rules typically depends on expert knowledge,which may not fully leverage the label information in training data and may be *** address this issue,a novel fuzzy rule oversampling approach is developed based on the learning vector quantization(LVQ)*** this method,the label information of the training data is utilized to determine the antecedent part of If-Then fuzzy rules by dynamically dividing attribute intervals using ***,fuzzy rules are generated and adjusted to calculate rule *** number of new samples to be synthesized for each rule is then computed,and samples from the minority class are synthesized based on the newly generated fuzzy *** results in the establishment of a fuzzy rule oversampling method based on *** evaluate the effectiveness of this method,comparative experiments are conducted on 12 publicly available imbalance datasets with five other sampling techniques in combination with the support function *** experimental results demonstrate that the proposed method can significantly enhance the classification algorithm across seven performance indicators,including a boost of 2.15%to 12.34%in Accuracy,6.11%to 27.06%in G-mean,and 4.69%to 18.78%in *** show that the proposed method is capable of more efficiently improving the classification performance of imbalanced data.

关键词： Oversampling fuzzy rules learning vector quantization imbalanced data support function machine

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A dynamic exploratory hybrid modelling framework for simulating complex and uncertain system

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Journal of Safety Science and Resilience 2024年第2期5卷 167-178页

作者： Gangqiao Wang han Xing Yongqiang Chen Yi Liu Institute of Big Data Inteligent Management and Decision-making College of ManagementShenzhen UniversityShenzhen 518060China School of Safety Science Tsinghua UniversityBejing 100084China Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBejing 100871China

Complex disaster systems involve various components and mechanisms that could interact in complex ways and change over time,leading to significant deep *** to deep uncertainty,decision-makers have severe inadequacy of knowledge and often encounter unpredictable surprises that may emerge in the future,thus making it difficult to specify appropriate models and parameters to describe the system of *** this paper,we propose a dynamic exploratory hybrid modeling framework that fits data,models,and computational ex-periments together to simulate complex systems with deep *** the framework,one needs to develop multiple plausible models from a hybrid modeling perspective and perform enormous computational experi-ments to explore the diversity of future ***-time data is then incorporated into diverse forecasts to dynamically adjust the simulation *** ultimately enables an ongoing modeling and analysis process in which deep uncertainty would be gradually *** approach has been applied to a human-involved car-following system simulation under complex traffic *** results show that the proposed approach can improve the prediction accuracy while enhancing the sensitivity of the simulation system to uncertain changes in the system of interest.

关键词： Disaster modeling and analysis Deepuncertainty Hybrid modeling Adaptivesimulation

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Effective Activation of Melamine for Synchronous Synthesis of Catalytically Active Nanosheets and Fluorescence-Responsive Quantum Dots

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Transactions of Tianjin University 2024年第3期30卷 284-296页

作者： Jie Xuan Guijian Guan Ming-Yong han Institute of Molecular Plus Tianjin UniversityTianjin 300072China

Because of the low reactivity of cyclic nitrides,liquid-phase synthesis of carbon nitride introduces challenges despite its favorable potential for energy-efficient preparation and superior *** this study,we demonstrate a strong interaction between citric acid and melamine through experimental observation and theoretical simulation,which eff ectively activates melamine-condensation activity and produces carbon-rich carbon nitride nanosheets(CCN NSs)during hydrothermal *** a large specific surface area and increased light absorption,these CCN NSs demonstrate significantly enhanced photocatalytic activity in CO_(2) reduction,increasing the CO production rate by approximately tenfold compared with hexagonal melamine(h-Me).Moreover,the product selectivity of CCN NSs reaches up to 93.5%to generate CO from CO_(2).Furthermore,the annealed CCN NSs exhibit a CO conversion rate of up to 95.30μmol/(g h),which indicates an 18-fold increase compared with traditional carbon *** the CCN NS synthesis,nitrogen-doped carbon quantum dots(NDC QDs)are simultaneously produced and remain suspended in the supernatant after *** QDs disperse well in water and exhibit excellent luminescent properties(QY=67.2%),allowing their application in the design of selective and sensitive sensors to detect pollutants such as pesticide 2,4-dichlorophenol with a detection limit of as low as 0.04μmol/***,the simultaneous synthesis of CCN NSs and NDC QDs provides a cost-eff ective and highly efficient process,yielding products with superior capabilities for catalytic conversion of CO_(2) and pollutant detection,respectively.

关键词： Carbon nitride Hydrothermal reaction Photocatalysis Carbon dioxide Quantum dots

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Analyzing the spatiotemporal evolution and driving forces of gross ecosystem product in the upper reaches of the Chaobai River Basin

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 117-132页

作者： Jiacheng Li Qi han Liqiu Zhang Li Feng Guihuan Liu Beijing Key Laboratory for Source Control Technology of Water Pollution College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China Engineering Research Center for Water Pollution Source Control&Eco-remediation College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China Center of Eco-compensation Chinese Academy of Environmental PlanningMinistry of Ecology of EnvironmentBeijing 100041China

The Chaobai River Basin,which is a crucial ecological barrier and primary water source area within the Beijing-Tianjin-Hebei region,possesses substantial ecological *** gross ecosystem product(GEP)in the Chaobai River Basin is a reflection of ecosystem conditions and quantifies nature’s contributions to humanity,which provides a basis for basin ecosystem service management and *** study investigated the spatiotemporal evolution of GEP in the upper Chaobai River Basin and explored the driving factors influencing GEP spatial *** patterns from 2005 to 2020 were analyzed,and GEP was calculated for 2005,2010,2015,and *** driving factors influencing GEP spatial differentiation were identified using the optimal parameter-based geographical detector(OPGD)*** key findings are as follows:(1)From 2005 to 2020,the main ecosystem types were forest,grassland,and *** areas experienced significant changes,and conversions mainly occurred among urban,water,grassland and agricultural ecosystems.(2)Temporally,the GEP in the basin increased from 2005 to 2020,with regulation services *** the county(district)scale,GEP exhibited a north-west-high and south-east-low pattern,showing spatial differences between per-unit-area GEP and county(district)GEP,while the spatial variations in per capita GEP and county(district)GEP were similar.(3)Differences in the spatial distribution of GEP were influenced by regional natural geographical and socioeconomic *** these factors,gross domestic product,population density,and land-use degree density contributed *** among different driving forces noticeably impacted GEP spatial *** findings underscore the necessity of incorporating factors such as population density and the intensity of land-use development into ecosystem management decision-making processes in the upper reaches of the Chaobai River *** policies

关键词： Ecosystem pattern Gross ecosystem product(GEP) Spatiotemporal evolution Optimal parameter-based geographical detector(OPGD) Chaobai River Basin

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Resilience effects for household food expenditure and dietary diversity in rural western China

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Journal of Integrative Agriculture 2024年第2期23卷 384-396页

作者： Xiao han Kaiyu Lyu Fengying Nie Yuquan Chen Institute of Agricultural Economics and Development Chinese Academy of Agricultural SciencesBeijing 100081China Agricultural Information Institute Chinese Academy of Agricultural SciencesBeijing 100081China Academy of Global Food Economics and Policy China Agricultural UniversityBeijing 100083China

A more resilient livelihood is increasingly recognized as an efficient way to improve vulnerable households’food security and optimize their dietary *** study quantifies rural household resilience in western China,identifies the three pillars(absorptive capacity,adaptive capacity,and transformative capacity)contribution to resilience,and then establishes the estimated Resilience Capacity Index(RCI)linked with food security and dietary diversity supported by the multiple indicator multiple cause(MIMIC)*** show that,despite geographical heterogeneity,the RCI consistently increased from 2015 to *** with a higher RCI inheriting better capacity to deal with risk and shocks are significantly and positively correlated with increasing food expenditure and diversifying food *** can be because resilient households will allocate more money to food expenditure instead of saving for livelihood ***,policymakers can provide more incentives for rural households to adopt more dynamic and effective risk management ***,in turn,could yield positive spillover effects by preventing human capital loss associated with dietary-related chronic diseases and mortality.

关键词： resilience food expenditure dietary diversity China risk management

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Gravity Change Caused by Heavy Rainfall Detected by A gPhone Gravimeter in Zhengzhou,China

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Journal of Earth Science 2024年第4期35卷 1273-1276页

作者： Lelin Xing Yufei han Xiaowei Niu Lei Bai Innovation Academy for Precision Measurement Science and Technology Chinese Academy of SciencesWuhan430077China Wuhan Geodesy National Observation and Research Station Wuhan430077China China Earthquake Networks Center Beijing100045China

The short-term effect of heavy rainfall on gPhone gravimeter observation at Zhengzhou Seismic Station is *** to the observation data during Jul.17–20,2021,the corrected gravity residual reflects the gravimetric response caused by heavy *** observed gravity change is dominated by the local effect considering topographic effect on *** deduced water depth near the observation station is about 300 mm.

关键词： gravity gravity change gravimeter heavy rain Zhengzhou

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Small-signal Stability Constrained Optimal Power Flow Considering Eigenvalue Distribution

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1052-1062页

作者： Zheng Huang Kewen Wang Yi Wang Jing han Jun Liang the School of Electrical and Information Engineering Zhengzhou UniversityZhengzhou 450001China Cardiff University Cardiff CF243AAU.K.

In the existing small-signal stability constrained op-timal power flow(SSSC-OPF)algorithms,only the rightmost ei-genvalue or eigenvalues that do not satisfy a given threshold,e.g.,damping ratio threshold and real-part threshold of eigen-value,are considered in the small-signal stability *** effect of steady-state,i.e.,operating point,changes on eigen-values is not fully taken into *** this paper,the small-signal stability constraint that can fully reflect the eigenvalue change and system dynamic performance requirement is formed by analyzing the eigenvalue distribution on the complex *** small-signal stability constraint is embedded into the standard optimal power flow model for generation *** simultaneous solution formula of the SSSC-OPF is es-tablished and solved by the quasi-Newton approach,while pen-alty factors corresponding to the eigenvalue constraints are de-termined by the stabilization degree of constrained *** improve the computation speed,a hybrid algorithm for ei-genvalue computation in the optimization process is proposed,which includes variable selection for eigenvalue estimation and strategy selection for eigenvalue *** effectiveness of the proposed algorithm is tested and validated on the New England 10-machine 39-bus system and a modified practical 68-machine 2395-bus system.

关键词： Damping ratio eigenvalue optimal power flow quasi-Newton approach sensitivity small-signal stability

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