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Clinical characteristics and outcomes of patients with hepatic angiomyolipoma:A literature review

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World Journal of Gastroenterology 2021年第19期27卷 2299-2311页

作者： Paul Calame Gaelle Tyrode delphine weil verhoeven Sophie Felix Anne Julia Klompenhouwer Vincent Di Martino Eric Delabrousse Thierry Thevenot Department of Radiology Jean Minjoz University HospitalBesançon 25030France Department of Hepatology Jean Minjoz University HospitalBesançon 25030France Department of Pathology Jean Minjoz University HospitalBesançon 25000France Department of Surgery Erasmus University Medical CenterRotterdam PO Box 2040The Netherlands

First reported in 1976,hepatic angiomyolipoma(HAML)is a rare mesenchymal liver tumor occurring mostly in middle-aged *** of the liver mass is often incidental on abdominal imaging due to the frequent absence of specific *** 10%of HAMLs are associated with tuberous sclerosis *** contains variable proportions of blood vessels,smooth muscle cells and adipose tissue,which renders radiological diagnosis *** express positivity for HMB-45 and actin,thus these tumors are integrated into the group of perivascular epithelioid cell ***,a HAML appears on magnetic resonance imaging(or computed tomography scan)as a hypervascular solid tumor with fatty areas and with washout,and can easily be misdiagnosed as other liver tumors,particularly hepatocellular *** therapeutic strategy is not clearly defined,but surgical resection is indicated for symptomatic patients,for tumors showing an aggressive pattern(i.e.,changes in size on imaging or high proliferation activity and atypical epithelioid pattern on liver biopsy),for large(>5 cm)biopsy-proven HAML,and if doubts remain on imaging or *** management may be justified in other conditions,since most cases follow a benign clinical *** summary,the correct diagnosis of HAML is challenging on imaging and relies mainly on pathological findings.

关键词： Angiomyolipoma Liver Tuberous sclerosis complex Imaging Pathology Potentially malignant

Impact of inorganic and organic pollutants from a Belgian wastewater treatment plant on adjacent surface and groundwaters

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 75-90页

作者： Mingyue Luo Yiqi Su delphine Jenny Vandeputte Yuwei Jia Guanlei Li Willy Baeyens Marijke Huysmans Marc Elskens Yue Gao Analytical Environmental and Geo-Chemistry Department(AMGC)Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium Hydrology and Hydraulic Engineering(HYDR) Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium

Under the pressure of global droughts and water shortage,it is essential to evolve toward a sustainable and robust water *** possible avenue is the maximum reuse of treated wastewater,but the quality of which determines its ***,inorganic(Cd,Pb,Cr,Ni,Cu,and As)and organic(xenoestrogens and polycyclic aromatic contaminants,PACs)contaminants were monthly monitored in an effluent of the wastewater treatment plant(WWTP),the surrounding surface waters and the local groundwater in *** and particulate concentrations of inorganic contaminants in these water bodies were *** addition,Diffusive Gradients in Thin-films(DGT)was used in situ to obtain bioavailable metal *** the WWTP effluent and surface waters,only Ni exceeds the Annual Average-Environmental Quality Standard(AA-EQS),while in the groundwater,dissolved As was the predominant ***,in the surface and effluent waters the highest lability degrees were observed for Cd and *** concentrations of these metal species in the effluent water were lower than in the other water ***-organic pollutants,xenoestrogens and PACs were analyzed by dual Estrogen and Aryl hydrocarbon Receptor-Chemical Activated LUciferase gene eXpression(ER&AhR-CALUX)*** the annual averaged(AA)bioequivalent concentration of E2(0.18 ng/L)is below the AA-EQS standard(0.4 ng/L),and the bioequivalent concentration of benzo[a]pyrene never exceeded the maximum admissible concentration(MAC),the reclamation and reuse of treated wastewater for groundwater replenishment and agricultural irrigation should pose no environmental problems,at least in a short-term.

关键词： Metal contaminants DGT Labile metal fractions ERE/AhR-CALUX BEQ Xenoestrogens and polycyclic aromatic contaminants

High-speed silicon photonic electro-optic Kerr modulation

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Photonics Research 2024年第1期12卷 51-60页

作者： JONATHAN PELTIER WEIWEI ZHANG LEOPOLD VIROT CHRISTIAN LAFFORGUE LUCAS DENIEL delphine MARRIS-MORINI GUY AUBIN FARAH AMAR DENH TRAN XINGZHAO YAN CALLUM G.LITTLEJOHNS CARLOS ALONSO-RAMOS KE LI DAVID J.THOMSON GRAHAM REED LAURENT VIVIEN University Paris-Saclay CNRSCentre for Nanoscience and Nanotechnology(C2N)Palaiseau 91120France University Grenoble Alpes CEALETIGrenoble 38000France Optoelectronics Research Centre Zepler Institute for Photonics and NanoelectronicsFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

Silicon-based electro-optic modulators contribute to easing the integration of high-speed and low-power consumption circuits for classical optical communications and data *** the plasma dispersion modulation,an alternative solution in silicon is to exploit the DC Kerr effect,which generates an equivalent linear electro-optical effect enabled by applying a large DC electric *** some theoretical and experimental studies have shown its existence in silicon,limited contributions relative to plasma dispersion have been achieved in high-speed modulation so *** paper presents high-speed optical modulation based on the DC Kerr effect in silicon PIN *** contributions of both plasma dispersion and Kerr effects have been analyzed in different waveguide configurations,and we demonstrated that the Kerr induced modulation is dominant when a high external DC electric field is applied in PIN ***-speed optical modulation response is analyzed,and eye diagrams up to 80 Gbit/s in NRZ format are obtained under a *** of 30 *** work paves the way to exploit the Kerr effect to generate high-speed Pockels-like optical modulation.

关键词： waveguide dispersion effect

Efficacy of Botanicals on Parasitoids of Mango Fruit Flies in Burkina Faso

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Advances in Entomology 2024年第1期12卷 24-37页

作者： Rabieta Simde delphine Ouattara Elias Mano Georges Kambou Georges Kambou Souleymane Nacro Institute of Environment and Agricultural Research (INERA) Central Horticulture Laboratory of the Regional Center of Excellence in Fruits and Vegetables of Bobo-Dioulasso Bobo-Dioulasso Burkina Faso Institute of Research in Applied Sciences and Technologies (IRSAT) Laboratory of Natural Substances and Technologies of Natural Products and the Environment (LABTECH-PRONE) Ouagadougou Burkina Faso Kamboinsé Environmental Agricultural Research and Training Center Ouagadougou Burkina Faso

The effect of Capsicum annuum and Strophantus hispidus formulations was evaluated on Diachasmimorpha longicaudata. The formulations were obtained from the crude total extracts of C. annuum;S. hispidus and the adjuvant previously developed. The formulations were prepared according to three concentrations of extracts of each plant species (low, medium and high). These concentrations were calculated on the basis of 1.5 mg/mL of each formulation causing 18% and 15% mortality respectively in Ceratitis cosyra within 72 h. The effect of the formulations on D. longicaudata was tested using a Fisher block design with 8 treatments (C. annuum (3.75;7.5;12.5 g/L);S. hispidus (4.5;9;15 g/L);Success bait 2.4 g/L;control) and 5 replicates. For each formulation, 1.5 mL was poured into a vial containing 0.25 g of cotton. Then 20 adults of the parasitoid were added and the whole was covered with muslin and held in place with rubber bands. The parasitoids were examined after 24 and 72 hours, and those that did not react to the touch of a fine brush were considered dead. The results showed a difference between the treatments. After 24 hours of exposure, the parasitoid showed high mortality at the S. hispidus concentrations (15 g/L;4.5 g/L) followed by the Success bait. These concentrations resulted in mortality rates of 22.50% for S. hispidus and 20.50% for Success bait. After 72 h, low parasitoid mortality (35.81%) was obtained with 3.75 g/L C. annuum, but high mortality was observed with S. hispidus (59.95%;64.20%;57.15%) and Success bait (54.80%). The use of C. annuum formulations at 3.75 g/L could be recommended for conserving D. longicaudata in the nature.

关键词： Concentrations Exposure Mortality Parasitoid Formulations

含二硫化硒洗发水对中-重度头皮脂溢性皮炎外用糖皮质激素/水杨酸治疗后的疗效维持作用

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中华皮肤科杂志 2024年第5期57卷 483-484页

作者： Philippe Massiot Pascal Reygagne Corinne Chagnoleau Leila Kanoun-Copy Florence Pouradier Geneviève Loussouarn Catherine Queille-Roussel Hussein Jouni delphine Kerob L'Oréal Research and Innovation Saint-Ouen France. Centre Sabouraud Hôpital Saint-Louis 1 avenue Claude-Vellefaux 75010 Paris France. CPCAD Hôpital l'Archet Nice France. L'Oréal Research and Innovation Aulnay-sous-Bois France. Cosmetic Active International Levallois-Perret France.

脂溢性皮炎是一种慢性炎症性皮肤病,好发于头皮、面部和躯干等皮脂腺分布丰富的部位。头皮脂溢性皮炎主要表现为红斑和片状鳞屑,程度从轻度鳞屑到弥漫性大片黏着性鳞屑不等,伴有明显的瘙痒,并容易反复发作。目前认为脂溢性皮炎的发生与... 详细信息

脂溢性皮炎是一种慢性炎症性皮肤病,好发于头皮、面部和躯干等皮脂腺分布丰富的部位。头皮脂溢性皮炎主要表现为红斑和片状鳞屑,程度从轻度鳞屑到弥漫性大片黏着性鳞屑不等,伴有明显的瘙痒,并容易反复发作。目前认为脂溢性皮炎的发生与亲脂性马拉色菌定植增加以及遗传、环境和全身健康状况等因素相关,上述因素共同导致皮脂腺代谢活动异常、皮脂成分改变、表皮屏障功能障碍,最终加重炎症反应。

关键词：头皮脂溢性皮炎二硫化硒洗发水亲脂性炎症反应马拉色菌皮脂腺黏着性

Heterogeneous tunable Ⅲ-Ⅴ-on-silicon-nitride mode-locked laser emitting wide optical spectra

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Photonics Research 2024年第3期12卷 I0021-I0027页

作者： MAXIMILIEN BILLET STIJN CUYVERS STIJN POELMAN ARTUR HERMANS SANDEEP SEEMA SASEENDRA TASUKU NAKAMURA SHINYA OKAMOTO YASUHISA INADA KAZUYA HISADA TAKU HIRASAWA JOAN RAMIREZ delphine NÉEL NICOLAS VAISSIÈRE JEAN DECOBERT PHILIPPE SOUSSAN XAVIER ROTTENBERG GUNTHER ROELKENS JONØ.KJELLMAN BART KUYKEN Photonics Research Group Department of Information TechnologyGhent University-imec9052 GhentBelgium imec 3001 LeuvenBelgium Technology Division Panasonic Holdings CorporationMoriguchi-CityOsakaJapan Ⅲ-Ⅴ Lab F91767 PalaiseauFrance

We demonstrate a Ⅲ-Ⅴ-on-silicon-nitride mode-locked laser through the heterogeneous integration of a semiconductor optical amplifier on a passive silicon-nitride cavity using the technique of micro-transfer printing. In the initial phase of our study, we focus on optimizing the lasing wavelength to be centered at 1550 nm. This optimization is achieved by conducting experiments with 27 mode-locked lasers, each incorporating optical amplifiers featuring distinct multiple-quantum-well photoluminescence values. Subsequently we present a comprehensive study investigating the behavior of the mode-locking regime when the electrical driving parameters are varied. Specifically, we explore the impact of the gain voltage and saturable absorber current on the locking stability of a tunable mode-locked laser. By manipulating these parameters, we demonstrate the precise control of the optical spectrum across a wide range of wavelengths spanning from 1530 to 1580 nm. Furthermore, we implement an optimization approach based on a Monte Carlo analysis aimed at enhancing the mode overlap within the gain region. This adjustment enables the achievement of a laser emitting a 23-nm-wide spectrum while maintaining a defined 10 dB bandwidth for a pulse repetition rate of 3 GHz.

关键词： tunable amplifier mode

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全球日晒行为调查研究

中华皮肤科杂志 2024年第7期57卷 672-673页

作者： Thierry Passeron Henry W. Lim Chee Leok Goh Hee Young Kang Fatimata Ly Akimichi Morita Jorge Ocampo-Candiani Susana Puig Sergio Schalka Wei Liu Anne-Laure Demessant-Flavigny Caroline Le Floc’h delphine Kerob Brigitte Dreno Jean Krutmann Department of Dermatology Côte d'Azur University Nice University Hospital Center Nice France INSERM U1065 C3M Côte d'Azur University Nice France Department of Dermatology Henry Ford Health Detroit Michigan USA National Skin Centre Singapore City Singapore Department of Dermatology Ajou University School of Medicine Suwon South Korea Department of Dermatology Cheikh Anta Diop Dakar University EPS Institute of Social Hygiene Dakar Senegal Department of Geriatric and Environmental Dermatology Nagoya City University Graduate School of Medical Sciences Nagoya Japan Universidad Autonoma de Nuevo León Facultad de Medicina University Hospital “Dr. Jose E. González” Monterrey Mexico Dermatology Department Hospital Clinic de Barcelona Barcelona University Barcelona Spain Medcin Skin Research Center and Biochemistry Department Chemistry Institute of Sao Paulo University Sao Paulo Brazil Department of Dermatology The General Hospital of Air Force PLA Beijing China La Roche-Posay International Levallois-Perret France Nantes University Univ Angers INSERM Immunology and New Concepts in ImmunoTherapy INCIT UMR 1302 Nantes France IUF Leibniz Research Institute for Environmental Medicine Duesseldorf Germany Medical Faculty Heinrich-Heine-University Duesseldorf Germany

适量的日光照射有益于维生素D合成和情绪调节,但日光中的紫外线可能引发多种机体损伤,包括红斑、晒伤、光免疫抑制和光变态反应等急性损伤,以及皮肤癌、黄褐斑、炎症后色素沉着和光老化等慢性损伤。近期研究还显示,可见光(紫色至红色,40... 详细信息

适量的日光照射有益于维生素D合成和情绪调节,但日光中的紫外线可能引发多种机体损伤,包括红斑、晒伤、光免疫抑制和光变态反应等急性损伤,以及皮肤癌、黄褐斑、炎症后色素沉着和光老化等慢性损伤。近期研究还显示,可见光(紫色至红色,400~700nm)和红外线(700nm~1mm)也是皮肤光老化和光损伤的影响因素,可见光会导致黄褐斑等色素性疾病加重。

关键词：色素性疾病皮肤光老化光变态反应慢性损伤日光照射黄褐斑机体损伤维生素D

The Entomological Efficacy of Piperonyl Butoxide (PBO) Combined with a Pyrethroid in Insecticide-Treated Nets for Malaria Prevention: A Village-Based Cohort Study Prior to Large-Scale Deployment of New Generation Mosquito Nets in Burkina Faso

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Advances in Entomology 2024年第3期12卷 224-248页

作者： Aristide S. Hien Samina Maiga Koama Bayili Adissa Y. Ouattara Dieudonné D. Soma Richard Bationo Georges Benson Meda delphine O. Karama Tiecoura Camara Georges Anicet Ouedraogo Roch K. Dabiré Abdoulaye Diabaté Malaria and Neglected Tropical Disease Department Institut de Recherche en Sciences de la Sant (IRSS) Bobo-Dioulasso Burkina Faso Sciences and Techniques Department Institut du Developpement Rural Universit Nazi Boni Bobo-Dioulasso Burkina Faso Vector Control Department Permanent Secretariat for Malaria Elimination Ouagadougou Burkina Faso

The efficacy of insecticide-treated nets (ITNs) is increasingly compromised by the prevalence of malaria vectors resistant to pyrethroids. In response to this issue, a new generation of ITNs has been developed that incorporate synergistic components, such as piperonyl butoxide (PBO). The purpose of this study is to provide entomological evidence for the efficacy of a PBO-based ITN brand at the village level, serving as a basis for decision-making before large-scale net deployment. During the high malaria transmission period, ITNs were distributed in each group and vector sampling was conducted biweekly in selected households. Bionomic data were collected to assess the resistance of wild An. gambiae populations to various chemical insecticides. There was a significant disparity in total An. gambiae sl. collected between the ITN arms, the intervention arm (ITN arms), and the control arm (P = 0.003). An. coluzzi was identified as the predominant species in the study area, as confirmed by PCR analysis. Analysis of the blood-feeding inhibition rate revealed that 100% permethrin + PBO ITN exhibited significantly greater inhibition than 66.81% permethrin only ITN. According to the log-time probit regression analysis, permethrin exhibited a knockdown time of 256 min without synergists, while it decreased to 139 min (P = 0.001) when pre-exposed to PBO. The evidence from this trial supports the use of PBO ITNs over standard ITNs for pyrethroids to combat pyrethroid resistance and improve protection against malaria for both individuals and communities, particularly in areas with high pyrethroid resistance.

关键词： Pyrethroid Resistance Permethrin + PBO ITNs Permethrin ITN Bionomic Data Insecticide Susceptibility Data Burkina Faso

Screening for hypertension-mediated organ damage and aetiology:still of value after 65 years of age?

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Journal of Geriatric Cardiology 2022年第11期19卷 791-801页

作者： delphine Thiolliere Brahim Harbaoui Claire Falandry Marc Bonnefoy Jean-Christophe Lega Pierre Lantelme Pierre-Yves Courand Fédération de cardiologie Hôpital de la Croix-Rousse et Hôpital Lyon SudHospices Civils de LyonLyonFrance Universitéde Lyon CREATISCNRS UMR5220INSERM U1044INSA-LyonUniversitéClaude Bernard LyonFrance Service Universitaire de Gériatrie Hôpital Lyon SudHospices Civils de LyonLyonFrance CarMeN UniversitéClaude Bernard Lyon 1OullinsFrance Service de médecine interne et pathologies vasculaires Groupe d’Etude Multidisciplinaires des Maladies Thrombotiques(GEMMAT)Hôpital Lyon SudHospices Civils de LyonLyonFrance Universitéde Lyon Equipe Evaluation et Modélisation des Effets ThérapeutiquesLaboratoire de Biologie et Biométrie EvolutiveCNRS UMR 5558UniversitéClaude BernardLyonFrance

BACKGROUND Secondary forms and hypertension-mediated organ damage(HMOD) may differ between younger and older hypertensive *** aim of the present study was to explore the specificity of HMOD and secondary forms in patients≥ 65 years in comparison to younger ones in a contemporary *** We analysed 938 patients recruited between 2004 and 2014(Cardiology department,Croix-Rousse Hospital,Lyon)who had at baseline HMOD and secondary forms screening among them 190 were≥ 65 *** The mean(2.1±0.8 vs.1.2±0.9,P 10 m/s was the most frequent HMOD in patients≥ 65 years(90.1%),while echocardiographic left ventricular hypertrophy was the most common in the younger patients(45.0%).Among ECG left ventricular indexes,only R wave in aVL lead was significantly more frequently observed in patients≥ 65 years(32.6%) than in younger ones(19.0%,P <0.001).The frequency of secondary hypertension was not significantly different between younger and older patients(respectively;30.5% vs.27.8%,P=0.487).The most frequent aetiology was primary aldosteronism regardless of age,followed by renovascular hypertension(6.3% vs.3.3%,P=0.038).Among older patients,3.2% were treated with adrenalectomy and 6.3% with percutaneous transluminal renal *** Extensive screening of HMOD in older patients may be questionable as nearly all patients had one;aetiology must however be explored as a third of older patients had a secondary form.

关键词： Extensive screening of HMOD in older patients may be questionable as nearly all patients had one aetiology must however be explored as a third of older patients had a secondary form