检索结果-南通市图书馆

疗效评价标准及其在淋巴瘤中的应用:第一部分

在线全文

学校读者我要写书评

暂无评论

中华核医学与分子影像杂志 2019年第3期39卷 187-192页

作者： Mateen C.Moghbel laie Kostakoglu Katherine Zukotynski delphine l.chen Helen Nadel Ryan Niederkohr Erik Mittra 李慧玲(译) 兰晓莉刘振(审校) Stanford University Medical Center Stanford California Mount Sinai Medical Center New York New York McMaster University Hamilton Ontario Canada Washington University St. Louis Missouri University of British Columbia Vancouver British Columbia Canada Kaiser Permanente Santa Clara California 华中科技大学同济医学院附属协和医院核医学科武汉430022

无论对于个体患者还是人群.癌症治疗的有效性都需要一种系统的、可重复的疗效评价方法。为满足这一需求,学界制定了一些评估疗效的指导原则,主要从解剖和代谢方面来量化治疗后的变化。过去几年针对特定的肿瘤组织制定了相应的疾病疗效... 详细信息

无论对于个体患者还是人群.癌症治疗的有效性都需要一种系统的、可重复的疗效评价方法。为满足这一需求,学界制定了一些评估疗效的指导原则,主要从解剖和代谢方面来量化治疗后的变化。过去几年针对特定的肿瘤组织制定了相应的疾病疗效分类标准迄今为止,恶性淋巴瘤可能是疾病疗效分类应用最普遍的肿瘤类型.该文对现有的淋巴瘤疗效评价标准进行概述,重点介绍这些评价标准各自的方法及其适用性。针对阻碍疗效评价标准化发展的问题,该文也对其中许多标准的技术复杂度和主观阈值判定的内容进行了评述。

关键词：淋巴瘤 PET CT RECIST PERCIST

在线全文

学校读者我要写书评

暂无评论

肺PET图像的定量分析:挑战和机遇

中华核医学与分子影像杂志 2019年第11期39卷 698-704页

作者：陈聪霞(译) 李文婵(译) 郭悦(译) 姚稚明(审校者) delphine l.chen Joseph Cheriyan Edwin R.Chilvers Gourab Choudhury Christopher Coello Martin Connell Marie Fisk Ashley M.Groves Roger N.Gunn Beverley F.Holman Brian F.Hutton Sarah lee William MacNee Divya Mohan David Parr Deepak Subramanian Ruth Tai-Singer Kris Thielemans Edwin J.R.van Beek laurence Vass Jeremy W.Wellen Ian Wilkinson Frederick J.Wilson 北京医院核医学科、国家老年医学中心 100730 Mallinckrodt Institute of Radiology Washington University School of MedicineSt.LouisMissouri Department of Medicine University of CambridgeCambridgeUnited Kingdom Cambridge University Hospitals NHS Foundation Trust CambridgeUnited Kingdom Queen's Medical Research Institute University of EdinburghEdinburghUnited Kingdom Imanova ltd. London y United Kingdom Institute of Nuclear Medicine University College LondonLondonUnited Kingdom Department of Medicine Imperial College LondonLondonUnited Kingdom Medical Image Analysis Consultant LondonUnited Kingdom Clinical Discovery Respiratory Therapy Area UnitGlaxoSmithKline R&DKing of PrussiaPennsylvania University Hospitals Coventry and Warwickshire CoventryUnited Kingdom Derby Teaching Hospitals NHS Foundation Trust DerbyUnited Kingdom Worldwide Research and Development PfizerInc.CambridgeMassachusetts Experimental Medicine Imaging GlaxoSmithKlineStevenageUnited Kingdom

数百万人受呼吸系统疾病的影响,导致巨大的全球性健康困扰。由于目前对导致呼吸系统疾病发展和进展的潜在机制认识不足,治疗选择仍然有限。为克服此局限和理解相关分子变化,将无创影像技术如PET和SPECT用于探索生物标志物,其中18F-脱氧... 详细信息

数百万人受呼吸系统疾病的影响,导致巨大的全球性健康困扰。由于目前对导致呼吸系统疾病发展和进展的潜在机制认识不足,治疗选择仍然有限。为克服此局限和理解相关分子变化,将无创影像技术如PET和SPECT用于探索生物标志物,其中18F-脱氧葡萄糖(FDG)PET显像的研究最多。由于肺内组织、气体、血液和水的构成比变异,定量分析肺的分子影像数据仍具挑战性。这些成分的比例随着肺部疾病的不同而不同,因此有不同的定量分析方法来显示这种变化,但迄今为止还没有开发出对数据标准化的方法。该文回顾了肺部疾病中18F-FDG PET定量分析方法的数据,聚焦于解释肺内成分变化的方法,解读衍生参数。分析的疾病包括急性呼吸窘迫综合征、慢性阻塞性肺疾病、肺间质性疾病如特发性肺纤维化。基于对既往文献、进行中的研究以及作者间讨论的回顾,作者提出了建议性的注意事项,以协助解读从这些方法及未来研究设计中衍生的参数。

关键词：肺肺部炎症分子成像正电子发射计算机断层显像

Full Torus Electromagnetic Gyrokinetic Particle Simulations with Kinetic Electrons

在线全文

学校读者我要写书评

暂无评论

Communications in Computational Physics 2009年第1期5卷 183-194页

作者： Y.Nishimura Z.lin l.chen Department of Physics and Astronomy University of CaliforniaIrvine92697-4575USA

The full torus electromagnetic gyrokinetic particle simulations using the hybrid model with kinetic electrons in the presence of magnetic shear is *** fluid-kinetic electron hybrid model employed in this paper improves numerical properties by removing the tearing mode,meanwhile,preserves both linear and nonlinear wave-particle resonances of electrons with Alfven wave and ion acoustic wave.

关键词： Gyrokinetic particle simulation plasma turbulence electromagnetic gyrokinetic theory

One-step multi-compositional oxidation of YSi alloy:Experiments and ab initio computation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2023年第27期158卷 253-262页

作者： W.J.Wang J.C.luo l.chen G.J.Yang State Key laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China Xi’an Jiaotong University Suzhou Institute Suzhou 215123China

YSi alloy is a promising candidate as oxidation resistant coatings for both the bond coat of environmental barrier coatings(EBCs)and anti-ablation coatings at a high temperature of∼1300℃.In this study,a one-step multi-compositional oxidation by rapid heating oxidation mode is proposed to reduce the oxidation rate by 3.6 times compared to conventional slow heating oxidation *** show that preferentially formed Y_(2)O_(3) oxide initiates a multi-step oxidation,produces a cracking and porous oxides,and thereby resulting in a fast oxidation with *** one-step multi-compositional oxidation with a compact and dense Y_(2)Si_(2)O_(7)scale contributes to the much better oxidation resistance for rapid heating oxidation mode of YSi *** stable formation of Y_(2)Si_(2)O_(7)scale is comprehensively understood by the energy barrier,charge density and electronic level based on density functional *** study demonstrates a promising application of YSi alloy by rapid heating oxidation mode.

关键词： YSi alloy One-step oxidation Multi-compositional scale Y_(2)Si_(2)O_(7) Energy barrier

ENERGETIC PARTIClE STABIlIZATION OF m=1 INTERNAl KINK MODE IN TOKAMAKS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics letters 1987年第12期4卷 561-564页

作者： R.J.Hastie chen Yanping KE Fujiu CAI Shidong l.chen United Kingdom Atomic Energy Authority Culham LaboratoryAbingdomBerkshireEngland Institute of Physics Academic SinicaBeijing Plasma Physics laboratory Princeton UniversityPrincetonNew Jersey 08544

The stability of m=1 internal kink mode in a tokamak plasma with an anisotropic energetic particle component has been analyzed using the generalized energy *** is found that employing barely trapped energetic particle... 详细信息

关键词： properties TOKAMAK tokamak

FHl2 deficiency aggravates Candida albicans infection through decreased myelopoiesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China life Sciences 2025年

作者： Rongmei Gao Kanchao chen Yimin Wang Rongxia Guo Xiaoyu Zhang Peng Wu Weili Wang Qingxiang Huang Xuemei Xie Shangda Yang Yanling lü Qian Ren Fei liu Song chen Fengxia Ma Tao cheng Hui cheng State Key laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College CAMS Center for Stem Cell Medicine PUMC Department of Stem Cell and Regenerative Medicine

Hematopoiesis is a finely tuned process that generates all blood cell types through self-renewal and differentiation, which is crucial for maintaining homeostasis. Acute infections can prompt a hematopoietic response known as emergency myelopoiesis. In this study, using a Candida albicans (C. albicans) infection model, we demonstrated for the first time that disruption of Fhl2 led to increased fungal burden,heightened inflammatory response and reduced survival rates. Impaired myeloid hematopoiesis and immune cell production were evident, as proved by the decreased numbers of hematopoietic stem and progenitor cells (HSPCs) and granulocytes in the bone marrow of Fhl2-deficient mice. In conclusion, FHl2 regulated emergency myelopoiesis in response to C. albicans, affecting the host’s defense against pathogens.

关键词：

THE MICROSTRUCTURE AND COMPRESSIVE PROPERTIES IN NiAl(Co) MATRIX COMPOSITE

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English letters) 1996年第6期9卷 653-657页

作者： l.chen Y.F. Han C.H Tao and M.l. Xie(Beijing Institute of Aeronautical Materials, Beijing 100095, ) Beijing Inst of Aeronautical Materials Beijing China

The microstructures of NiAl(Co)-TiB_2 composite prepared using exothermal dispersion (XD) method have been studied by optical microscopy, XRD, EDS, and TEM The results show that, TiB_2 paritcles are typically single crystal, and fairly uniformly distributed. The matrix mainly consists of β-NiAl phase, ll_2γ′Ni_3Al phase and δ-Ni_3Al phase. The δNi_3Al has a fcc crystal structure with lattice parameter a=*** data of compressive testing at room temperature show that the room temperature ductility of NiAl(Co) matrix composite is much better than that of stoichiometric NiAl.

关键词： intermetallic compound exothermal dispersion method

AWECS:A linear Gyrokinetic df Particle-in-Cell Simulation Code for the Study of Alfvenic Instabilities in High-β Tokamak Plasmas

在线全文

学校读者我要写书评

暂无评论

Communications in Computational Physics 2008年第8期4卷 457-495页

作者： A.Bierwage l.chen Department of Physics and Astronomy University of CaliforniaIrvineCA 92697USA Institute for Fusion Theory and Simulation ZhejiangUniversityHangzhouChina

A 1-Dlinear gyrokinetic code called AWECS is developed to study the kinetic excitation of Alfvenic instabilities in a high-β tokamak plasma,with β being the ratio of thermal to magnetic *** is designed to describe physics associated with a broad range of frequencies and *** example,AWECS is capable of simulating kinetic ballooning modes,Alfvenic ion-temperature-gradient-driven modes,as well as Alfven instabilities due to energetic *** addition,AWECS may be used to study drift-Alfven instabilities in the low-β ***,the layout of the code and the numerical methods used are *** is benchmarked against other codes and a convergence study is carried out.

关键词： linear gyrokinetic simulation tokamak plasma drift-Alfv´en waves shear Alfv´en waves energetic particles

Spatial associations of tree species in a subtropical evergreen broad-leaved forest

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2012年第3期5卷 346-355页

作者： Zheng R.luo Ming J.Yu De l.chen You G.Wu Bing Y.Ding Key laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education and College of Life ScienceZhejiang UniversityHangzhou 310058China Management of Baishanzu Fengyangshan-Baishanzu National Nature ReserveQingyuan 323800China Department of Biology Science The School of Life and Environmental ScienceWenzhou UniversityWenzhou 325027China

Aims The spatial segregation hypothesis and the low-frequency hypothesis are two important proposed mechanisms that delay or prevent competitive exclusion in *** tree species interact with their neighbors,the importance of these potential processes can be investigated by analyzing the spatial structures of tree *** The distribution of the adults of 27 common tree species in a fully mapped 5-ha subtropical forest plot in Baishanzu,eastern China,was analyzed to investigate the community-level intra-and interspecific spatial association *** first tested for the overall spatial pattern in the 5-to 40-m neighborhoods and classified first-order bivariate associations with a diametric scheme based on Ripley’s K and nearest-neighbor statistic(G-function).Then heterogeneous Poisson null models were used to distinguish second-order interactions from overall spatial associations(including first-order effects).Finally,we analyzed correlations between the existence of species interactions and some attributes of the species *** Findings Partial overlap and segregation increased with scale,whereas mixing *** 70%of the species pairs occurred less than expected at random,and only 3.4%of the species pairs were well mixed;11.0%of all species pairs showed significant small-scale interactions,which was a greater frequency than expected by chance if species are abundant or prefer the same habitat,but less frequent than expected if species are highly *** suggests that both spatial segregation and low frequency of species facilitate species coexistence by reducing the opportunity that trees of two species encounter each *** study also revealed that positive interactions were more prevalent than negative interactions in the forest,which indicates that positive interactions may have important effects on forest species assemblies.

关键词： Baishanzu point pattern analysis spatial segregation low frequency interaction opportunity