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Biological effect of human serum collected before and after oral intake of Pygeum africanum on various benign prostate cell cultures

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Asian Journal of Andrology 2012年第3期14卷 499-504,I0010页

作者： Stephane Larre Philippe Camparo Eva Comperat delphine Boulbes Mohammed Haddoum Sylvain Baulande Pascal Soularue Pierre Costa Olivier Cussenot Nuffield Department of Surgical Science University of Oxford Oxford OX3 9DU UK ER2 UMPC CeRePP Paris 75000 France Department of Pathology Val de Grace Hospital Paris 75000 France Department of Pathology La Pitie Salpetriere Hospital Paris 75000 France Laboratoire Solvay Pharma Paris 75000 France partnerChip Genople Evry 91000 France Department of Urology CHU Caremeau NTmes 30000 France

Pygeum africanum （Tadenan） is a popular phytotherapeutic agent used in the treatment of symptomatic benign prostatic hyperplasia. The active compounds of the drug have not been identified, and determining the plasma concentration of the drug is, therefore, not possible. Because there are conflicting results on the efficacy of this drug, we aimed to investigate its effect on prostate cell growth in vitro using human serum collected before and after Pygeum africanum intake. We used primary and organotypic cultures of human prostatic stromal myofibroblast cell line WPMY and prostatic epithelial cell line PNT2. We also used fresh benign prostatic tissue. The serum of a treated man induced decreases in the proliferation of primary cells, organotypic cells and WPMY cells but not PNT2 cells. We also analysed the effect of treated serum on the gene expression profile of WPMY cells. The transcriptome analysis revealed an upregulation of genes involved in multiple tumour suppression pathways and a downregulation of genes involved in inflammation and oxidative-stress pathways. The oral intake of Pygeum africanum resulted in serum levels of active substances that were sufficient to inhibit the proliferation of cultured myofibroblasts prostatic cells. This inhibition was associated with changes in the transcriptome. Asian Journal of Andrology（2012） 14, 499-504; doi：lO.1038/aja.2011.132; published online 26 December 2011

关键词： benign prostatic hyperplasia organotypic culture primary culture PNT2 Pygeum africanum transcriptome WPMY

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Aggregation behavior of Harmonia axyridis under non-wintering conditions

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Insect Science 2015年第5期22卷 670-678页

作者： delphine Durieux Berenice Fassotte Jean-Louis Deneubourg Yves Brostaux Axel Vandereycken Emilie Joie Eric Haubruge Frangois J. Verheggen Functional and Evolutionary Entomology Gembloux Agro-Bio Tech University of Liege Gembloux Belgium Unit of Social Ecology Universite libre de Bruxelles Brussels Belgium and Applied Statistics Computer Science and Mathematics Gembloux Agro-Bio Tech University of Liege Gembloux Belgium

The invasive multicolored Asian ladybeetle, Harmonia axyridis （Pallas）（Coleoptera： Coceinellidae）, aggregates inside dwellings during winter to avoid cold weather. This adaptive behavior disturbs homeowners, because of the large numbers of individuals that aggregate, which induces allergic reactions. The migratory flight patterns of this species have been well documented, with individuals preferentially moving toward prominent and high color contrast elements. However, the factors involved in the selection of aggregation sites by this species have yet to be elucidated. Here, we evaluated the influ- ence of （i） the density of individuals and （ii） the type of available shelters on decisions by H. axyridis to settle and aggregate under shelters. A dual choice bioassay conducted in the laboratory demonstrated the presence of mutual attraction to conspecifics. We also found that individuals preferentially settled under red covered shelters compared to transparent shelters, and that the type of shelter outweighed the effect of social interactions among conspecifics. Moreover, this experiment was performed under non-wintering conditions, providing the first evidence that aggregative behavior in this species can also occur under those specific conditions.

关键词： group effect invasive species luminosity multicolored Asian ladybeetle shelter selection social behavior

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Vertical Heterogeneity of Genotypic Structure and Toxic Potential within Populations of the Harmful Cyanobacterium Microcystis aeruginosa

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Advances in Microbiology 2013年第6期3卷 27-37页

作者： Benjamin Misson delphine Latour Clermont Université Université Blaise Pascal LMGE Clermont-Ferrand France

We investigated the vertical variability of toxic potential (i.e. proportions of cells containing microcystin genes) and genotypic structure within different populations of Microcystis aeruginosa that developed in deep artificial reservoirs on the Loire River (France). We demonstrated that a great qualitative vertical heterogeneity could exist within a single bloom of this cyanobacterium in deep lakes. Indeed, we observed important vertical shifts of both toxic potential and genotypic structure, whatever the bloom magnitude. These variations occurred mainly within the euphotic zone and proved to occur independently from abundance vertical shifts. One of the most striking results of this study is that the genotypic structure of a population of M. aeruginosa was more variable between different depths sampled at a single site than between different sites of the same reservoir sampled on top of the water column. In the same way the proportion of potentially toxic cells was sometimes more variable vertically than horizontally. The occurrence of such vertical heterogeneity in three different blooms suggests that this could be a frequent pattern within populations of M. aeruginosa.

关键词： Cyanobacteria Microcystis aeruginosa Genetic Structure Toxic Potential Vertical Heterogeneity

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Le 20 mai

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法语学习 2011年第2期 42-43页

作者： delphine de Vigan

La voix traverse le sommeil,oscille à la *** femme caresse les cartes retournées sur la table,elle répète plusieurs fois,sur ce ton de certitude :le 20 mai,votre vie va *** ne sait pas si elle est encore dans le r... 详细信息

关键词： Le 20 mai

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Le 20 mai

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法语国家与地区研究 2010年第3期 6-8页

作者： delphine de Vigan

La voix traverse le sommeil,oscille à la *** femme caresse les cartes retournées sur la table,elle répète plusieurs fois,sur ce ton de certitude :le 20 mai,votre vie va changer.

关键词： Le 20 mai

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Clinical characteristics and outcomes of patients with hepatic angiomyolipoma:A literature review

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World Journal of Gastroenterology 2021年第19期27卷 2299-2311页

作者： Paul Calame Gaelle Tyrode delphine Weil Verhoeven Sophie Felix Anne Julia Klompenhouwer Vincent Di Martino Eric Delabrousse Thierry Thevenot Department of Radiology Jean Minjoz University HospitalBesançon 25030France Department of Hepatology Jean Minjoz University HospitalBesançon 25030France Department of Pathology Jean Minjoz University HospitalBesançon 25000France Department of Surgery Erasmus University Medical CenterRotterdam PO Box 2040The Netherlands

First reported in 1976,hepatic angiomyolipoma(HAML)is a rare mesenchymal liver tumor occurring mostly in middle-aged *** of the liver mass is often incidental on abdominal imaging due to the frequent absence of specific *** 10%of HAMLs are associated with tuberous sclerosis *** contains variable proportions of blood vessels,smooth muscle cells and adipose tissue,which renders radiological diagnosis *** express positivity for HMB-45 and actin,thus these tumors are integrated into the group of perivascular epithelioid cell ***,a HAML appears on magnetic resonance imaging(or computed tomography scan)as a hypervascular solid tumor with fatty areas and with washout,and can easily be misdiagnosed as other liver tumors,particularly hepatocellular *** therapeutic strategy is not clearly defined,but surgical resection is indicated for symptomatic patients,for tumors showing an aggressive pattern(i.e.,changes in size on imaging or high proliferation activity and atypical epithelioid pattern on liver biopsy),for large(>5 cm)biopsy-proven HAML,and if doubts remain on imaging or *** management may be justified in other conditions,since most cases follow a benign clinical *** summary,the correct diagnosis of HAML is challenging on imaging and relies mainly on pathological findings.

关键词： Angiomyolipoma Liver Tuberous sclerosis complex Imaging Pathology Potentially malignant

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Microbial markers in colorectal cancer detection and/or prognosis

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World Journal of Gastroenterology 2018年第22期24卷 2327-2347页

作者： Romain Villéger Amélie Lopès Julie Veziant Johan Gagnière Nicolas Barnich Elisabeth Billard delphine Boucher Mathilde Bonnet Université Clermont Auvergne Research Biologics Sanofi R&D Chirurgie digestive Centre Hospitalier Universitaire Université Clermont Auvergne Institut Universitaire de Technologie de Clermont-Ferrand

Colorectal cancer(CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure. Beyond its beneficial functions for the host, increasing evidence suggests that the intestinal microbiota is a key factor associated with carcinogenesis. Many clinical studies have reported a disruption in the gut microbiota balance and an alteration in the faecal metabolome of CRC patients, suggesting the potential use of a microbialbased test as a non-invasive diagnostic and/or prognostic tool for CRC screening. This review aims to discuss the microbial signatures associated with CRC known to date, including dysbiosis and faecal metabolome alterations, andthe potential use of microbial variation markers for noninvasive early diagnosis and/or prognostic assessment of CRC and advanced adenomas. We will finally discuss the possible use of these markers as predicators for treatment response and their limitations.

关键词： Colorectal cancer microbiota F.nucleatum Colibactin-producing E.coli prognostic markers diagnostic markers dysbiosis

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Palynological and Physicochemical Characterization of Honey in the Sudano-Guinean Zone of Cameroon

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Food and Nutrition Sciences 2015年第15期6卷 1339-1350页

作者： Dongock Nguemo delphine Tchoumboue Joseph Laboratory of Biodiversity and Sustainability Development Department of Biological Sciences University of Ngaoundere Ngaoundere Cameroon Laboratory of Animal Physiology Department of Animal Production University of Dschang Dschang Cameroon

The palynological and physico-chemical characterization of honey was investigated in the Sudano- Guinean zone of Cameroon through the melissopalynology analysis. Results showed that honey with the dark amber color was the most represented. Sweet honey with less odour considered as pleasant highly predominate. The pH of honey is low and varies from 3.95 to 5.00;this ranking confirms the hypothesis that honey is from plant through visit of honeybees. The sugar content is very high ranging from 77.93% to 83.13%;the mean value is 78.90% and this value confirms that the honey is floral honey. The density value ranges from 1.39 to 1.43 and does not exceed the average standard (1.39 to 1.44 at 20℃). Water contents correspond to the standards norms. For free acidity, the highest value is 48.68 ± 0.28. There is a low positive correlation (r = 0.2) between free acidity and the pH of honey. Pollen analysis of honeys led to the identification of 41 pollen species belonging to 25 families. The highly represented families are Asteraceae and Myrtaceae. Two thirds of honey is monofloral and characteristics of three dominant species: Nymphaea maculata, Terminalia avicennioides and Syzygium guineense. The pollens of Syzygium guineense are present in all honey samples analysed.

关键词： Honey Melissopalynology Palynological Analysis Physicochemical Analysis Cameroon

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Type I interferons promote the survival and proinflammatory properties of transitional B cells in systemic lupus erythematosus patients

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Cellular & Molecular Immunology 2019年第4期16卷 367-379页

作者： Mei Liu Qiang Guo Chunmei Wu delphine Sterlin Shyamal Goswami Ying Zhang Teng Li Chunde Bao Nan Shen Qiong Fu Xiaoming Zhang Key Laboratory of Molecular Virology&Immunology Institut Pasteur of ShanghaiChinese Academy of Sciences/University of Chinese Academy of SciencesShanghai 200031China Department of Rheumatology Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200001China

A hallmark of systemic lupus erythematosus(SLE)is the breaking of B-cell tolerance with the generation of high-affinity autoantibodies;however,the antibody-independent features of the B-cell compartment in SLE are less *** this study,we performed an extensive examination of B-cell subsets and their proinflammatory properties in a Chinese cohort of new-onset SLE *** observed that SLE patients exhibited an increased frequency of transitional B cells compared with healthy donors and rheumatoid arthritis *** from SLE patients potently promoted the survival of transitional B cells in a type I IFN-dependent manner,which can be recapitulated by direct IFN-α***,the effect of IFN-αon enhanced survival of transitional B cells was associated with NF-κB pathway activation and reduced expression of the pro-apoptotic molecule *** B cells from SLE patients harbored a higher capacity to produce proinflammatory cytokine IL-6,which was also linked to the overactivated type I IFN *** addition,the frequency of IL-6-producing transitional B cells was positively correlated with disease activity in SLE patients,and these cells were significantly reduced after short-term standard ***,the current study provides a direct link between type I IFN pathway overactivation and the abnormally high frequency and proinflammatory properties of transitional B cells in active SLE patients,which contributes to the understanding of the roles of type I IFNs and B cells in the pathogenesis of SLE.

关键词： Systemic lupus erythematosus type I interferons transitional B cells apoptosis interleukin 6

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Interplay of S and As in Mekong Delta sediments during redox oscillations

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Geoscience Frontiers 2019年第5期10卷 1715-1729页

作者： Van T.H. Phan Fabrizio Bardelli Pierre Le Pape Raoul-Marie Couture Alejandro Fernandez-Martinez delphine Tisserand Rizlan Bernier-Latmani Laurent Charlet University Grenoble Alpes CNRSIRDIFSTTARISTerre38000GrenobleFrance Ho Chi Minh City University of Technology (HCMUT) Vietnam National UniversityHo Chi Minh City (VNU-HCM)268 Ly Thuong KietDistrict 10Ho Chi Minh CityViet Nam Institute of Nanotechnology (CNR-Nanotec) 00186RomeItaly Institut de Mineralogie de Physique des Materiaux et de Cosmochimie (IMPMC)UMR 7590 CNRS-UPMC-IRD-MNHN4 Place Jussieu75252Paris cedex 05France Département de chimie Université Laval1045 Avenue de la MédecineQuébecQCG1V 0A6Canada Ecole Polytechnique Fédérale de Lausanne (EPFL) e Environmental Microbiology Laboratory (EML) EPFL-ENAC-IIE-EMLStation 6CH-1015LausanneSwitzerland

The cumulative effects of periodic redox cycling on the mobility of As,Fe,and S from alluvial sediment to groundwater were investigated in bioreactor *** particular sediments from the alluvial floodplain of the Mekong Delta River were investigated: Matrix A (14 m deep) had a higher pyrite concentration than matrix B (7 m deep) *** present in matrix B but absent in matrix *** the reactors,the sediment suspensions were supplemented with As(III) and SO4^2-,and were subjected to three full-redox cycles entailing phases of nitrogen/CO2,compressed air sparging,and cellobiose *** differences in As concentration and speciation were observed upon redox *** support the fact that initial sediment composition is the main factor controlling arsenic release and its speciation during the redox ***,a high pyrite content associated with a low SO4^2- content resulted in an increase in dissolved As concentrations,mainly in the form of As(III),after anoxic half-cycles;whereas a decrease in As concentrations mainly in the form of As(V),was instead observed after oxic *** addition,oxic conditions were found to be responsible for pyrite and arsenian pyrite oxidation,increasing the As pool available for *** same processes seem to occur in sediment with the presence of gypsum,but,in this case,dissolved As were sequestered by biotic or abiotic redox reactions occurring in the FeeS system,and by specific physico-chemical condition (***).The contrasting results obtained for two sediments sampled from the same core show that many complexes and entangled factors are at work,and further refinement is needed to explain the spatial and temporal variability of As release to groundwater of the Mekong River Delta (Vietnam).

关键词： Redox oscillation Pyrite oxidation Gypsum dissolution Isotope sulfur Isotope oxygen

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