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Hypoxia activates the hypoxia-inducible factor-1α/vascular endothelial growth factor pathway in a prostatic stromal cell line:A mechanism for the pathogenesis of benign prostatic hyperplasia

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Current Urology 2024年第3期18卷 185-193页

作者： Tao Zhang Changlin Mao Yao Chang Jiaju Lyu delong zhao Sentai Ding Department of Urology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanChina Department of Urology Mindong Hospital Affiliated to Fujian Medical UniversityFuanChina

Background The development of benign prostatic hyperplasia(BPH)is closely related to hypoxia in the prostatic stroma,and the hypoxia-inducible factor-1α/vascular endothelial growth factor(HIF-1α/VEGF)pathway has been shown to significantly activate in response to *** underlying mechanism for activation of this pathway in the pathogenesis of BPH remains *** and methods We constructed HIF-1αoverexpression and knockdown BPH stromal(WPMY-1)and epithelial(BPH-1)cell lines,which were cultured under different oxygen conditions(hypoxia,normoxia,and hypoxia+HIF-1αinhibitor).Quantitative real-time polymerase chain reaction(qPCR)and Western blotting were applied to detect the expression of the HIF-1α/VEGF *** proliferation and apoptosis were analyzed by Cell Counting Kit-8 and flow *** used the miRWalk 2.0 database and Western blotting to predict the potential miRNA that selectively targets the HIF-1α/VEGF pathway,and verified the prediction by qPCR and dual-luciferase *** In a BPH stromal cell line(WPMY-1),the expression of VEGF was in accordance with HIF-1αlevels,elevated in the overexpression cells and decreased in the knockdown ***-induced HIF-1αoverexpression,which could be reversed by a HIF-1α***,the HIF-1αinhibitor significantly depressed cellular proliferation and promoted apoptosis in hypoxic conditions,assessed by Cell Counting Kit-8 and flow ***,in the BPH epithelial cell line(BPH-1),the expression level of HIF-1αdid not influence the expression of ***,a potential miRNA,miR-17-5p,regulating the HIF-1α/VEGF pathway was predicted from the miRWalk 2.0 database and Western blotting,and verified by qPCR and dual-luciferase *** In hypoxia,activation of the HIF-1α/VEGF pathway plays a crucial role in regulating cell proliferation in a BPH stromal cell *** by miR-17-5p may be the potential mechanism for the activation of this *** of thi

关键词： Benign prostatic hyperplasia Hypoxia-inducible factor-1α Vascular endothelial growth factor Pathogenesis miR-17-5p

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基于体验式学习的青少年户外教育模式构建研究

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南京体育学院学报 2024年第4期23卷 67-73页

作者：赵得龙浙江中医学大学体育部浙江杭州310053

由户外运动所延伸出来的户外教育是一种新型的教育形式,尽管其相关研究已开展数年,但在实践深入和理论发展方面一直存在着诸多争议。研究以体验式学习为基本出发点,构建了一套包含教育理念、教育目标、教育内容和教育途径4个方面的青少... 详细信息

由户外运动所延伸出来的户外教育是一种新型的教育形式,尽管其相关研究已开展数年,但在实践深入和理论发展方面一直存在着诸多争议。研究以体验式学习为基本出发点,构建了一套包含教育理念、教育目标、教育内容和教育途径4个方面的青少年户外教育模式。(1)青少年户外教育的理念包括生命化、生活化和生态化;(2)青少年户外教育的目标不但要注重青少年的身体运动,还要更加关注其团队协作和情感交流等;(3)青少年户外教育的内容包括健康教育、生命教育、生活教育和生态教育;(4)青少年户外教育的途径是要让青少年走出去、动起来、思起来和讲出来。

关键词：体验式学习青少年户外运动户外教育

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基于WRF模式模拟研究天山山脉地形对降水过程的影响

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黑龙江科学 2024年第6期15卷 16-19,24页

作者：谢梦瑗赵德龙成鹏乌鲁木齐市气象局乌鲁木齐830039

以2016年7月31日20时新疆伊犁河谷地区一次降水过程为研究对象,基于WRF模式模拟开展地形敏感性试验,对比分析天山山脉地形对伊犁河谷地区降水天气的影响。得出以下结论:向西开口的“喇叭口”地形会阻挡西风气流,有利于水汽在河谷内部堆... 详细信息

以2016年7月31日20时新疆伊犁河谷地区一次降水过程为研究对象,基于WRF模式模拟开展地形敏感性试验,对比分析天山山脉地形对伊犁河谷地区降水天气的影响。得出以下结论:向西开口的“喇叭口”地形会阻挡西风气流,有利于水汽在河谷内部堆积,导致河谷内降水增加;大地形对低层风速和风向影响较大,修改地形后会改变中低层天气系统的位置和强度;天山山脉的海拔高度会影响其附近区域地表及中高层的气温,进而改变各层温压场配置,影响气块垂直运动,通过热力作用影响降水过程;地形会对高低空急流的强度和位置产生影响,使得气流的辐合辐散及垂直运动发生改变,通过影响不稳定能量的释放影响降水的形成。

关键词：天山山脉伊犁河谷地形数值模拟

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Ground-high altitude joint detection of ozone and nitrogen oxides in urban areas of Beijing

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Journal of Environmental Sciences 2013年第4期25卷 758-769页

作者： Pengfei Chen Qiang Zhang Jiannong Quan Yang Gao delong zhao Junwang Meng Beijing Weather Modification Office Institute of Urban Meteorology China Meteorological AdministrationPost-Doctoral Scientific Research Workstation of Urban Meteorology and Urban Disasters

Based on observational data of ozone （O3） and nitrogen oxide （NOx） mixing ratios on the ground and at high altitude in urban areas of Beijing during a period of six days in November 2011, the temporal and spatial characteristics of mixing ratios were analyzed. The major findings include： urban O3 mixing ratios are low and NOx mixing ratios are always high near the road in November. Vertical variations of the gases are significantly different in and above the planetary boundary layer. The mixing ratio of O3 is negatively correlated with that of NOx and they are positively correlated with air temperature, which is the main factor directly causing vertical variation of O3 and NOx mixing ratios at 600-2100 m altitude. The NOx mixing ratios elevated during the heating period, while the O3 mixing ratios decreased： these phenomena are more significant at high altitudes compared to lower altitudes. During November, air masses in the urban areas of Beijing are brought by northwesterly winds, which transport O3 and NOx at low mixing ratios. Due to Beijing＇s natural geographical location, northwest air currents arc beneficial to the dilution and dispersion of pollutants, which can result in lower O3 and NOx background values in the Beijing urban area.

关键词： atmospheric pollution ozone nitrogen oxides spatial distribution aircraft sound

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不同前蛋白转化酶枯草溶菌素9抑制剂在高胆固醇血症中的应用研究

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实用临床医药杂志 2024年第9期28卷 29-33,39页

作者：赵德龙周海燕岳凤娟李伟贵州医科大学附属医院心血管内科贵州贵阳550004 贵州医科大学附属医院临床医学研究中心贵州贵阳550004 贵州省人民医院体检中心贵州贵阳550002

目的探讨不同前蛋白转化酶枯草溶菌素9抑制剂(PCSK9)在高胆固醇血症(FH)中的应用价值。方法经倾向性匹配评分排除性别、年龄等基线资料混杂因素后,将82例FH患者依照使用的PCSK9抑制剂分为阿利西尤组和依洛尤组,每组41例,且均治疗3个... 详细信息

目的探讨不同前蛋白转化酶枯草溶菌素9抑制剂(PCSK9)在高胆固醇血症(FH)中的应用价值。方法经倾向性匹配评分排除性别、年龄等基线资料混杂因素后,将82例FH患者依照使用的PCSK9抑制剂分为阿利西尤组和依洛尤组,每组41例,且均治疗3个月。比较2组疗效,治疗前后血脂指标[甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(Apo A1)、载脂蛋白B(Apo B)]、冠状动脉血流储备[绝对流量储备(CFR)、相对流量储备(rCFR)、分数流量储备(FFR)]、内皮功能指标[血清一氧化氮(NO)、内皮素1(ET-1)、内皮舒张功能(FMD)]以及不良反应。结果治疗3个月后,阿利西尤组LDL-C总达标率为97.56%(40/41),依洛尤组为92.68%,差异无统计学意义(P>0.05)。治疗后,2组TG、TC、LDL-C、Apo B及ET-1水平均降低,HDL-C、Apo A1、CFR、rCFR、FFR及NO、FMD水平均升高,且阿利西尤组TG、TC、LDL-C、Apo B及ET-1水平均低于依洛尤组,HDL-C、Apo A1、CFR、rCFR、FFR及NO、FMD水平均高于依洛尤组,差异均有统计学意义(P0.05)。结论阿利西尤单抗与依洛尤单抗分别联合瑞舒伐他汀治疗FH,均能有效改善脂代谢、冠状动脉血流储备功能及血管内皮功能,但阿利西尤单抗效果更佳。

关键词：阿利西尤单抗依洛尤单抗瑞舒伐他汀临床疗效血脂指标

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低碳背景下环境监测与保护策略研究

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环境科学与管理 2024年第9期49卷 123-128页

作者：李琪光张栩浩赵德龙张自雨金海娟黑龙江省绥化生态环境监测中心黑龙江绥化152000

在低碳发展的时代,环境监测与保护面临诸多技术性挑战。地理信息系统(GIS)、遗传技术和智能传感器等技术的应用提升了生态修复效率,但也带来了大数据管理和伦理等新问题。全球生态环境问题需国际社会共同应对。联合国等国际组织应推动... 详细信息

在低碳发展的时代,环境监测与保护面临诸多技术性挑战。地理信息系统(GIS)、遗传技术和智能传感器等技术的应用提升了生态修复效率,但也带来了大数据管理和伦理等新问题。全球生态环境问题需国际社会共同应对。联合国等国际组织应推动技术共享和经验交流,促进全球环境监测与保护水平的提升。文章揭示了低碳背景下环境监测与保护的科技挑战与国际合作的重要性,为构建可持续环境提供启示。

关键词：低碳背景环境监测环境保护策略

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二代抗雄新辅助治疗局部晚期前列腺癌1例报告

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泌尿外科杂志（电子版） 2024年第2期16卷 101-106页

作者：赵德龙郭安东曹吉双吴晨睿丁森泰山东第一医科大学附属省立医院泌尿外科山东济南250000 山东大学附属省立医院泌尿外科山东济南250000

以往局部晚期前列腺癌(locally advanced prostate cancer,LAPC)治疗经验为传统内分泌治疗,随着恩杂鲁胺等新型内分泌药物的问世,现阶段临床先给予LAPC患者新辅助治疗,再采用前列腺根治性切除术,这一方式成为新的治疗方案。本文报告1例... 详细信息

以往局部晚期前列腺癌(locally advanced prostate cancer,LAPC)治疗经验为传统内分泌治疗,随着恩杂鲁胺等新型内分泌药物的问世,现阶段临床先给予LAPC患者新辅助治疗,再采用前列腺根治性切除术,这一方式成为新的治疗方案。本文报告1例采用恩杂鲁胺联合雄激素剥夺治疗(androgen deprivation therapy,ADT)行新辅助内分泌治疗(neoadjuvant hormonal therapy,NHT)的病例。患者男,61岁,因体检发现前列腺特异性抗原(prostate specific antigen,PSA)升高2 d入院,PSA为1960 ng/ml。磁共振成像示前列腺病灶累及双侧精囊腺,邻近膀胱壁受累,伴有盆腔多发淋巴结转移。穿刺确诊为前列腺癌(prostate cancer,PCa),前列腺癌格利森评分4+4=8分,分期为T4N1M0。患者采用恩杂鲁胺联合戈舍瑞林3个月后,行前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)正电子发射计算机断层显像(positron emission computed tomography,PET-CT)示,在PCa内分泌治疗中,前列腺病灶累及左侧精囊腺,PSMA高表达,两侧髂血管旁多发淋巴结转移,右侧髂总血管旁淋巴结PSMA高表达,未见远处转移。后行根治性前列腺切除术。恩杂鲁胺联合ADT作为NHT,为患者赢得了手术条件。

关键词：局部晚期前列腺癌恩杂鲁胺前列腺切除术新辅助治疗

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The Microphysical Characteristics of Wintertime Cold Clouds in North China

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Advances in Atmospheric Sciences 2022年第12期39卷 2056-2070页

作者： Xuexu WU Minghuai WANG delong zhao Daniel ROSENFELD Yannian ZHU Yuanmou DU Wei ZHOU Ping TIAN Jiujiang SHENG Fei WANG Deping DING School of Atmospheric Sciences Nanjing UniversityNanjing 210023China Joint International Research Laboratory of Atmospheric and Earth System Sciences&Institute for Climate and Global Change Research Nanjing UniversityNanjing 210023China Beijing Weather Modification Office Beijing 100089China Institute of Earth Sciences The Hebrew University of JerusalemJerusalem 91904Israel

The microphysical characteristics of wintertime cold clouds in North China were investigated from 22 aircraft observation flights from 2014 to 2017,2020,and *** clouds were generated by mesoscale weather systems with little orographic *** the mixed-phase temperature range(–40℃to 0℃),the average fraction of liquid,mixedphase,and ice cloud was 4.9%,23.3%,and 71.8%,respectively,and the probability distribution of ice mass fraction was a half-U-shape,suggesting that ice cloud was the primary cloud *** wintertime mixed-phase clouds in North China were characterized by large cloud droplet number concentration,small liquid water content(LWC),and small effective diameter of cloud *** main reason for larger cloud droplet number concentration and smaller effective diameter of cloud droplets was the heavy pollution in winter in North China,while for smaller LWC was the lower temperature during flights and the difference in air mass *** the temperature increasing,cloud droplet number concentration,LWC,and the size of ice particles increased,but ice number concentration and effective diameter of cloud droplets decreased,similar to other mid-latitude regions,indicating the similarity in the temperature dependence of cloud properties of mixed-phase *** variation of the cloud properties and ice habit at different temperatures indicated the operation of the aggregation and riming processes,which were commonly present in the wintertime mixed-phase *** study fills a gap in the aircraft observation of wintertime cold clouds in North China.

关键词： cold clouds aircraft observation microphysical character North China

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Evolution of planetary boundary layer under different weather conditions,and its impact on aerosol concentrations

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Particuology 2013年第1期11卷 34-40页

作者： Jiannong Quan Yang Gao Qiang Zhang Xuexi Tie Junji Cao Suqin Han Junwang Meng Pengfei Chen delong zhao Beijing Weather Modification Office Institude of Urban Meteorology CMA Key Laboratory of Aerosol SKLLQGInstitute of Earth EnvironmentChinese Academy of Sciences National Center for Atmospheric Research BoulderUSA Key Laboratory of Aerosol SKLLQGInstitute of Earth Environment.Chinese Academy of Sciences Tianjin Institute of Meteorological Sciences

A field experiment was conducted in Tianjin, China from September 9-30, 2010, focused on the evolution of Planetary Boundary Layer （PBL） and its impact on surface air pollutants. The experiment used three remote sensing instruments, wind profile radar （WPR）, microwave radiometer （MWR） and micro-pulse lidar （MPL）, to detect the vertical profiles of winds, temperature, and aerosol backscattering coefficient and to measure the vertical profiles of surface pollutants （aerosol, CO, SO2, NOx）, and also collected sonic anemometers data from a 255-m meteorological tower. Based on these measurements, the evolution of the PBL was estimated. The averaged PBL height was about 1000-1300 m during noon/afternoon-time, and 200-300 m during night-time. The PBL height and the aerosol concentrations were anti-correlated during clear and haze conditions. The averaged maximum PBL heights were 1.08 and 1.70 km while the averaged aerosol concentrations were 52 and 17 μg/m＆3 under haze and clear sky conditions, respectively, The influence of aerosols and clouds on solar radiation was observed based on sonic anemometers data collected from the 255-m meteorological tower. The heat flux was found significantly decreased by haze （heavy pollution） or cloud, which tended to depress the development of PBL, while the repressed structure of PBL further weakened the diffusion of pollutants, leading to heavy pollution. This possible positive feedback cycle （more aerosols→lower PBL height → more aerosols） would induce an acceleration process for heavy ground pollution in megacities.

关键词： Planetary boundary layer (PBL) Interaction between the PBL and aerosols

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Microphysical characteristics of precipitating cumulus cloud based on airborne Ka-band cloud radar and droplet measurements

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Atmospheric and Oceanic Science Letters 2022年第2期15卷 65-70页

作者： Lei Wei Mengyu Huang Rong Zhang Yuhuan Lü Tuanjie Hou Hengchi Lei delong zhao Wei Zhou Yuan Fu Beijing Weather Modification Center BeijingChina Key Laboratory for Cloud Physics of China Meteorological Administration BeijingChina Wuqing Meteorological Observatory of Tianjin TianjinChina Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Zhejiang Meteorological Observatory HangzhouChina Beijing Key Laboratory of Cloud Precipitation and Atmospheric Water ResourcesBeijingChina Beijing Meteorological Bureau BeijingChina

Based on cloud-probe data and airborne Ka-band cloud radar data collected in Baoding on 5 August 2018,the microphysical structural characteristics of cumulus(Cu)cloud at the precipitation stage were *** cloud droplets in the Cu cloud were found to be significantly larger than those in stratiform(STF)*** the Cu cloud,most cloud particles were between 7 and 10μm in diameter,while in the STF cloud the majority of cloud particles grew no larger than 2μ*** sensitivity of cloud properties to aerosols varied with *** cloud droplet effective radius showed a negative relationship with the aerosol number concentration(Na)in the cloud planetary boundary layer(PBL)and upper layer above the ***,the cloud droplet concentration(Nc)varied little with decreased Na in the high liquid water content region above 1500 *** Na values of between 300 and 1853 cm-3 were found in the PBL,and the maximum Na was sampled near the surface in August in the Hebei region,which was lower than that in autumn and *** radar reflectivity corresponded to large FCDP(fast cloud droplet probe)particle concentrations and small aerosol particle concentrations,and vice versa for low radar *** updrafts in the Cu cloud increased the peak radius and Nc,and broadened cloud droplet spectrum;lower air temperature was favorable for particle condensational growth and produced larger droplets.

关键词： Airplane observation Microphysical processes Ka-band cloud radar Cumulus

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