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Glycated haemoglobin (HbA1c) for postmortem diagnosis of diabetes

Forensic Sciences Research 2018年第2期3卷 170-177页

作者： delia lepik Mailis Tonisson Anne Kuudeberg Marika Vali Department of Pathological Anatomy and Forensic Medicine Faculty of MedicineInstitute of Biomedicine and Translational MedicineUniversity of TartuTartuEstonia Department of Internal Medicine Faculty of MedicineInstitute of Clinical MedicineUniversity of TartuTartuEstonia Southern Estonian Forensic Medical Examination Department Estonian Forensic Science InstituteTallinnEstonia Management Board Estonian Forensic Science InstituteTallinnEstonia

The study was conducted at the Estonian Forensic Science Institute in 2008-2014 as continuous part of our previous study of alcohol and premature death in Estonian *** data from 504 cases of male deaths (ages 19-79) were collected and blood and urine samples for glycated haemoglobin (HbA1c),liver enzymes and alcohol concentration were *** aim of our research was to find undiagnosed diabetes and diabetes risk cases postmortem on the basis of increased values of ***1c was within the reference value 4.8%-5.9% (29-42 mmol/mol),in 88.1% (n =444) of cases,below reference value in 2.4% (n =12),in the risk group of diabetes,HbA1c 6.0%-6.4% (42-46 mmol/mol) was within 5.8% (n =29),and HbA1c result of ≥6.5% (48 mmol/mol) manifested in 3.8% (n =19) of *** higher the age,the more cases with HbA1c value ≥6.0% (42 mmol/mol) *** the group of external causes of death (n =348),the HbAlc value of ≥6.5% (48 mmol/mol) HbA1c occurred in four *** HbA1c value was ≥6.5% (48 mmol/mol) in 78.9% of 156 cases when the cause of death was disease,of which 58% were cardiovascular *** prevalence of diabetes and diabetes risk was found lower compared to population-based study,as majority of the deceased were young and middle-aged males and no females were *** the case of poisoning with narcotic substances,HbA1c was within the reference range.A negative correlation occurred between alcohol intoxication and HbA1c value.A positive correlation between ALT and HbA1c was found-the higher stage of liver damage correlated with the higher HbA1c level.

关键词： Forensic science forensic pathology postmortem diabetes glycated haemoglobin

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