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Antibacterial activities of mangrove leaf endophytic fungi from Luzon Island,Philippines

Studies in Fungi 2020年第1期5卷 320-331页

作者： Ramirez CSP Notarte KIR dela cruz tee The Graduate School University of Santo TomasEspaña Blvd.1008 ManilaPhilippines Fungal Biodiversity Ecogenomics and Systematics GroupResearch Center for the Natural and Applied SciencesUniversity of Santo TomasEspaña Blvd.1008 ManilaPhilippines Department of Biological Sciences College of ScienceUniversity of Santo TomasEspaña Blvd.1008 ManilaPhilippines

Fungi associated with mangroves are untapped sources of bioactive secondary *** this study,628 mangrove leaf endophytic fungi(MLEF)were recorded from 19 mangrove hosts collected from the provinces of Zambales,Batangas,Cavite,and Quezon in Luzon Island,*** MLEF morphospecies were identified as belonging to the genera Aspergillus,Cladosporium,Colletotrichum,Fusarium,Nigrospora,Penicillium,Pestalotiopsis,Phialophora,and *** revealed that the MLEF crude culture extracts were promisingly potent against the gram-positive bacteria Staphylococcus aureus and Micrococcus luteus(ZOI>19 mm)with no or partial activity against the gram-negative bacteria Klebsiella oxytoca and Pseudomonas *** findings showed that mangrove leaf endophytic fungi are potential sources of bioactive compounds.

关键词： bioactivities fungal endophytes mangrove forests secondary metabolites

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Foliose lichens along the trails of Casaroro Falls and Pulangbato Falls in Valencia,Negros Oriental,Philippines

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Studies in Fungi 2019年第1期4卷 43-49页

作者： Paguirigan JAG Bernal KD Dayto CGA Ramos MED Vigo GDS dela cruz tee Department of Biological Sciences College of ScienceUniversity of Santo TomasEspaña 1015 ManilaPhilippines

Lichens are abundant and highly diverse in tropical areas such as the Philippines due to its climate and geographical ***,several regions of the country remained underexplored or unexplored and many species remained undiscovered in the country’s many unique *** study determines the occurrence of foliose lichens in Casaroro Falls and Pulangbato Falls in Valencia,Negros Oriental,*** lichen morphologies were characterized using available taxonomic *** the 26 lichen samples collected from the two falls,23 specimens were identified based on their morphological and biochemical *** these,8 species were specific to Casaroro Falls and 13 species to Pulangbato Falls,with only 2 species of lichens found on both ***,17 species are new records for the Philippines.

关键词： foliose lichen identification Negros Oriental new records Philippines tropics

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Single nucleotide polymorphism(SNP)in genes of lupus:A Philippine study(SIGLA-PH)

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Rheumatology & Autoimmunity 2022年第1期2卷 22-30页

作者： Michael L.tee Cherica A.tee Jose B.Nevado Jr Angeline Therese Santiago Aedrian A.Abrilla Carlo M.Lapid Francis A.Tablizo Joshua A.Dizon El K.B.Morado Eva Maria Cutiongco-dela Paz College of Medicine University of the Philippines ManilaManilaPhillipines Institute of Human Genetics National Institutes of HealthUniversity of the Philippines ManilaManilaPhillipines College of Medicine and Philippine General Hospital University of the Philippines ManilaManilaPhillipines Core Facility for Bioinformatics Philippine Genome CenterUniversity of the PhilippinesManilaPhillipines National Institutes of Health University of the Philippines ManilaManilaPhillipines

Background:Systemic lupus erythematosus(SLE)is a complex prototypic autoimmune disease,with a prevalence of 20–150 per 100,000,most commonly affecting women at child-bearing ***-wide association studies and fine mapping of candidate regions have paved the way for greater understanding of SLE as a disease of genetic–environmental susceptibility and the functions of the genes ***:This study was conducted to determine the association of selected single nucleotide polymorphisms(SNPs)from established genomic databases based on theoretical risk and protective odds ratios>2.5 or<0.40)to susceptibility of developing SLE among ***:We analyzed data from 310 SLE patients and 318 *** identified eight significant SNPs namely rs9271100,rs9271366,rs9272105,rs9275328,rs2647087,rs12734338,rs17885098,and rs3883013 to be associated with an increased risk of developing SLE among ***:Eight SNPs were found to be associated with the development of SLE among *** to previous genetic studies in lupus patients,majority of the SNPs were found in the major histocompatibilty complex genes in the HLA *** study identified two unique SNPs that will be validated as potential diagnostic markers for *** findings of this study may contribute to the development of a polygenic risk score in determining susceptibility to SLE among Filipinos.

关键词： genetics lupus SLE SNP susceptibility

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