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International Journal of Minerals,Metallurgy and Materials 2015年第4期22卷 389-394页

作者： S.deepak Kumar A.Mandal M.Chakraborty School of Mechanical Sciences Indian Institute of Technology Bhubaneswar School of Minerals Metallurgical and Materials Engineering Indian Institute of Technology Bhubaneswar

The key factor in semi-solid metal processing is the solid fraction at the forming temperature because it affects the microstructure and mechanical properties of the thixoformed components. Though an enormous amount of data exists on the solid fraction-temperature re- lationship in A356 alloy, information regarding the solid fraction evolution characteristics of A356-TiB2 composites is scarce. The present article establishes the temperature-solid fraction correlation in A356 alloy and A356-xTiB2 （x = 2.5wt% and 5wt%） composites using dif- ferential thermal analysis （DTA）. The DTA results indicate that the solidification characteristics of the composites exhibited a variation of 2℃ and 3℃ in liquidus temperatures and a variation of 3℃ and 5℃ in solidus temperatures with respect to the base alloy. Moreover, the eutectic growth temperature and the solid fraction（fs） vs. temperature characteristics of the composites were found to be higher than those of the base alloy. The investigation revealed that in-situ formed TiB2 particles in the molten metal introduced more nucleation sites and reduced undercooling.

关键词： particle reinforced composites aluminum alloys titanium boride casting solid fraction differential thermal analysis

Least-Square Support Vector Machine and Wavelet Selection for Hearing Loss Identification

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Computer Modeling in Engineering & Sciences 2020年第10期125卷 299-313页

作者： Chaosheng Tang deepak Ranjan Nayak Shuihua Wang School of Computer Science and Technology Henan Polytechnic UniversityJiaozuo454000China Department of Computer Science and Engineering Malaviya National Institute of TechnologyJaipur302017India School of Mathematics and Actuarial Science University of LeicesterLeicesterLE17RHUK Department of Information Systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia

Hearing loss(HL)is a kind of common illness,which can significantly reduce the quality of *** example,HL often results in mishearing,misunderstanding,and communication ***,it is necessary to provide early diagnosis and timely treatment for *** study investigated the advantages and disadvantages of three classical machine learning methods:multilayer perceptron(MLP),support vector machine(SVM),and least-square support vector machine(LS-SVM)approach andmade a further optimization of the LS-SVM model via wavelet *** investigation illustrated that themultilayer perceptron is a shallowneural network,while the least square support vector machine uses hinge loss function and least-square ***,a wavelet selection method was proposed,and we found db4 can achieve the best *** experiments showed that the LS-SVM method can identify the hearing loss disease with an overall accuracy of three classes as 84.89±1.77,which is superior to SVM *** results show that the least-square support vector machine is effective in hearing loss identification.

关键词： Hearing loss wavelet entropy multilayer perceptron least square support vector machine

Towards the development of cavitation technology for upgrading bitumen： Viscosity change and chemical cavitation yield measurements

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Petroleum Science 2017年第2期14卷 404-411页

作者： deepak M. Kirpalani Dipti Prakash Mohapatra Energy Mining and Environment Portfolio National Research Council of Canada 1200 Montreal Road Ottawa ON K1A 0R6 Canada

Among the different methods used for reducing viscosity of bitumen,acoustic cavitation during sonication is well *** chemical methods were used to detect the production of reactive species such as hydroxyl radicals and hydrogen peroxide during acoustic cavitation ***,quantification of cavitation yield in sonochemical systems is generally limited to low frequencies and has not been applied to bitumen *** empirical determination of the cavitation yield in midto high-frequency range（378,574,850,992,and1173 k Hz）was carried out by measuring the amount of iodine liberated from the oxidation of potassium iodide（KI）.Further,cavitation yield and the effects of different sonic operating conditions such as power input（16.67%–83.33%）and solute concentration on cavitation yield were carried out in KI solution and sodium carboxymethyl cellulose–water mixture to obtain benchmark changes in rheology and chemistry using these two model *** findings were then applied to bitumen upgrading through *** this study,it was found that the chemical cavitation yield peaked with a sonication frequency of 574 k *** was also found that cavitation yield and viscosity change were correlated directly in bitumen and a 38%lower bitumen viscosity could be obtained by acoustic cavitation.

关键词： Bitumen Cavitation yield CMC-water KI solution Viscosity correlation

TDP-35,a truncated fragment of TDP-43,induces dose-dependent toxicity and apoptosis in flies

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Neural Regeneration Research 2022年第11期17卷 2441-2442页

作者： deepak Chhangani Diego E.Rincon-Limas Department of Neurology McKnight Brain Instituteand Norman Fixel Institute for Neurological DiseasesUniversity of Florida Department of Neuroscience Center for Translational Research in Neurodegenerative DiseaseGenetics InstituteUniversity of Florida

TAR DNA-binding protein 43(TDP-43)is an essential 414 amino acid protein that regulates multiple aspects of RNA biogenesis,processing,and *** localizes primarily in the nucleus,but abnormal translocation and accumulation in the cytosol occur under pathological conditions(Tziortzouda et al.,2021).TDP-43 abnormalities are typical pathological hallmarks of amyotrophic lateral sclerosis(ALS)and frontotemporal lobar *** in the TDP-43-encoding gene TARDBP cause familial ALS。

关键词： degeneration TDP

Your CAPTCHA Recognition Method Based on DEEP Learning Using MSER Descriptor

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Computers, Materials & Continua 2022年第8期72卷 2981-2996页

作者： deepak Kumar Ramandeep Singh Sukhvinder Singh Bamber Faculty of Science and Technology Lovely Professional UniversityPhagwara144411India Lovely Professional University Phagwara144411India Department of Computer Science and Engineering Panjab University SSG Regional CentreHoshiarpur146021India

Individuals and PCs(personal computers)can be recognized using CAPTCHAs(Completely Automated Public Turing test to distinguish Computers and Humans)which are mechanized for distinguishing ***,CAPTCHAs are intended to be solved by the people,but are unsolvable by the *** a result,using Convolutional Neural Networks(CNNs)these tests can similarly be ***,the CNNs quality depends majorly on:the size of preparation set and the information that the classifier is found out ***,it is almost unmanageable to handle issue with CNNs.A new method of detecting CAPTCHA has been proposed,which simultaneously solves the challenges like preprocessing of images,proper segmentation of CAPTCHA using strokes,and the data *** hyper parameters such as:Recall,Precision,Accuracy,Execution time,F-Measure(H-mean)and Error Rate are used for computation and *** preprocessing,image enhancement and binarization are performed based on the stroke region of the *** key points of these areas are based on the SURF *** exploratory outcomes show that the model has a decent acknowledgment impact on CAPTCHA with foundation commotion and character grip bending.

关键词： Captcha MSER ANN SURF SNN

A prototype online database-enabled design framework for wind analysis/design of low-rise buildings

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Frontiers of Structural and Civil Engineering 2016年第1期10卷 121-130页

作者： Dae Kun KWON Ahsan KAREEM deepak KUMAR Yukio TAMURA NatHaz Modeling Laboratory Department of Civil & Environmental Engineering & Earth Sciences University of Notre DameNotre Dame IN 46556 USA Department of Ocean Engineering Indian Institute of Technology Madras Chennai 600036 India Department of Architectural Engineering Tokyo Polytechnic University Tokyo 243-0297 Japan

This study presents a development of an advanced cyberbased database-enabled design module for low- rise buildings （DEDM-LR） which provides estimation of the wind-induced responses for main wind force resisting frames by making direct use of pressure time histories measured at a large number of pressure taps over a suite of building models. These responses may be considered in lieu of code-specified load effects in which the overall accuracy may be influenced by the inherent simplifications in codes. In addition, this new automated approach is particularly attractive and advantageous as it allows a web-based online analysis/design via intuitive user-friendly interfaces for both the input and output in terms of familiar web-style forms that are nowadays very common in most of web-based services. Presently, the DEDM-LR hosts an aerodynamic database developed by the Tokyo Polytechnic University （TPU）, Japan for a variety of building configurations like flat, gable, and hip roofs under suburban terrain flow condition with immediate application to other databases. The paper shows the efficacy and validity of the DEDM-LR by walking through its details and examples on selected gable-roofed buildings. The architecture of DEDM-LR platform offers the ability to pool resources by hosting other databases that may become available in the near future.

关键词： wind loads low-rise building pressure measurement aerodynamics building design structural response,building codes information technology (IT)

A QUANTIFIER-ELIMINATION BASED HEURISTIC FOR AUTOMATICALLY GENERATING INDUCTIVE ASSERTIONS FOR PROGRAMS

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Journal of Systems Science & Complexity 2006年第3期19卷 307-330页

作者： deepak KAPUR Department of Computer Science University of New MexicoAlbuquerqueUSA

A method using quantifier-elimination is proposed for automatically generating program invariants/inductive assertions. Given a program, inductive assertions, hypothesized as parameterized formulas in a theory, are associated with program locations. Parameters in inductive assertions are discovered by generating constraints on parameters by ensuring that an inductive assertion is indeed preserved by all execution paths leading to the associated location of the program. The method can be used to discover loop invariants-properties of variables that remain invariant at the entry of a loop. The parameterized formula can be successively refined by considering execution paths one by one; heuristics can be developed for determining the order in which the paths are considered. Initialization of program variables as well as the precondition and postcondition, if available, can also be used to further refine the hypothesized invariant. The method does not depend on the availability of the precondition and postcondition of a program. Constraints on parameters generated in this way are solved for possible values of parameters. If no solution is possible, this means that an invariant of the hypothesized form is not likely to exist for the loop under the assumptions/approximations made to generate the associated verification condition. Otherwise, if the parametric constraints are solvable, then under certain conditions on methods for generating these constraints, the strongest possible invariant of the hypothesized form can be generated from most general solutions of the parametric constraints. The approach is illustrated using the logical languages of conjunction of polynomial equations as well as Presburger arithmetic for expressing assertions.

关键词： Automated software analysis and verification inductive assertion loop invariant quantifier elimination.

Delivery strategies for CRISPR/Cas genome editing tool for retinal dystrophies:challenges and opportunities

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Asian Journal of Pharmaceutical Sciences 2022年第2期17卷 153-176页

作者： Aayushi Lohia deepak Kumar Sahel Mohd Salman Vivek Singh Indumathi Mariappan Anupama Mittal deepak Chitkara Department of Pharmacy Birla Institute of Technology and SciencePilani(BITS-Pilani)Vidya Vihar CampusPilani 333031India Prof.Brien Holden Eye Research Center Champalimaud Translational Centre for Eye ResearchL.V.Prasad Eye InstituteKallam Anji Reddy CampusHyderabad 500034India

CRISPR/Cas,an adaptive immune system in bacteria,has been adopted as an efficient and precise tool for site-specific gene editing with potential therapeutic *** has been explored for a variety of applications,including gene modulation,epigenome editing,diagnosis,mRNA editing,*** has found applications in retinal dystrophic conditions including progressive cone and cone-rod dystrophies,congenital stationary night blindness,X-linked juvenile retinoschisis,retinitis pigmentosa,age-related macular degeneration,leber’s congenital amaurosis,*** of the therapies for retinal dystrophic conditions work by regressing symptoms instead of reversing the ***/Cas9 through indel could impart beneficial effects in the reversal of gene mutations in dystrophic *** research has also consolidated on the approaches of using CRISPR systems for retinal dystrophies but their delivery to the posterior part of the eye is a major concern due to high molecular weight,negative charge,and in vivo stability of CRISPR ***,non-viral vectors have gained interest due to their potential in tissue-specific nucleic acid(miRNA/siRNA/CRISPR)*** review highlights the opportunities of retinal dystrophies management using CRISPR/Cas nanomedicine.

关键词： CRISPR/Cas9 Gene editing Retinal dystrophies Non-viral nanocarriers

Multilevel Augmentation for Identifying Thin Vessels in Diabetic Retinopathy Using UNET Model

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Intelligent Automation & Soft Computing 2023年第2期35卷 2273-2288页

作者： A.deepak Kumar T.Sasipraba Faculty of Computer Science and Engineering Sathyabama Institute of Science and TechnologyChennai600119India Department of Computer Science and Engineering St.Joseph’s Institute of TechnologyChennai600119India

Diabetic Retinopathy is a disease,which happens due to abnormal growth of blood vessels that causes spots on the vision and vision *** techniques are applied to identify the disease in the early stage with different methods and *** Learning(ML)techniques are used for analyz-ing the images andﬁnding out the location of the *** restriction of the ML is a dataset size,which is used for model *** problem has been overcome by using an augmentation method by generating larger datasets with multidimensional *** models are using only one augmentation tech-nique,which produces limited features of dataset and also lacks in the association of those data during DR detection,so multilevel augmentation is proposed for *** proposed method performs in two phases namely integrated aug-mentation model and dataset correlation(***).It eliminates overﬁt-ting problem by considering relevant *** method is used for solving the Diabetic Retinopathy problem with a thin vessel identiﬁcation using the UNET *** based image segmentation achieves 98.3%accuracy when com-pared to RV-GAN and different UNET models with high detection rate.

关键词： Image segmentation diabetic retinopathy image augmentation semantic segmentation CNN

Constitutive modeling of particle reinforced rubber-like materials

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Theoretical & Applied Mechanics Letters 2022年第6期12卷 419-422页

作者： Sankalp Gour deepak Kumar Department of Mechanical Engineering Maulana Azad National Institute of Technology BhopalMadhya Pradesh462003India

The present study is focused on the constitutive modeling for the mechanical behavior of rubber reinforced with filler particles.A filler-dependent energy density function is proposed with all the continuum mechanics-based necessities of an effective hyperelastic material *** proposed invariant-based energy function comprises a single set of material parameters for a material subjected to several modes of loading *** model solution agrees well with existing experimental ***,the effect of varying concentrations of filler particles in the rubber matrix is also studied.

关键词： Hyperelastic material Constitutive modeling Strain energy function