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Exploring the potential of porous silicas as a carrier system for dissolution rate enhancement of artemether

Asian Journal of Pharmaceutical Sciences 2016年第6期11卷 760-770页

作者： Jaywant N.Pawar Harita R.Desai kailas k.Moravkar deepak k.khanna Purnima D.Amin Department of Pharmaceutical Sciences and Technology Institute of Chemical Technology(Elite Status)N.P.MargMatunga(E)Mumbai 400019India Applied Technology Inorganic MaterialsEvonik Degussa India Pvt.Ltd.Krislon HouseSakivihar RoadSakinakaAndheri(East)Mumbai 400069India

Malaria is a parasitic and vector determined blood-conceived infectious disease transmitted through infected mosquitoes. Anti-malarial drug resistance is a major health problem, which hinders the control of malaria. A Results of a survey of drug-resistant malaria demonstrated safe proclivity to nearby all anti-malarial regimes accessible except from artemisinin and its derivatives. Artemether is a BCS class IV drug effective against acute and severe falciparum malaria;hence there is a strong need to improve its solubility. Silica is one of the most widely studied excipients. Silica can be used in solubility enhancement by preparing its solid solution/dispersion with the drug. The objective of this research was to improve dissolution rate of Artemether using non-precipitated porous silica(Aeroperl 300 Pharma) and precipitated silica like EXP. 9555, EXP. 9560, and EXP. 9565. Specific surface area calculated from BET method of porous silicas viz. APL 300(A), Exp. 9555(B), Exp. 9560(C), Exp. 9565(D) was found to be 294.13 m^2/g(A), 256.02 m^2/g(B), 213.62 m^2/g(C) and 207.22 m^2/g(D) *** drug release from the developed formulation was found to be significantly higher as compared to neat ARM. This improved solubility and release kinetics of ARM may be attributed to high surface area, improved wettability and decreased crystallinity. Solid-state characterization of the developed optimized formulation F3 was carried out with respect to FTIR chemical imaging, XRD,SEM, and DSC. All the porous silicas which we have explored in the present context showed a significant capability as a carrier for solubility enhancement of ARM.

关键词： Artemether Solubility Solid dispersion Porous silica Aeropearl 300

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Evaluation of mine scale longwall top coal caving parameters using continuum analysis

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Mining Science and Technology 2011年第6期21卷 787-796页

作者： Manoj khanal deepak Adhikary Rao Balusu Earth Science and Resource Engineering Commonwealth Scientific and Industrial Research OrganizationQueensl and Center for Advanced Technology1Technology CourtPullenvaleQLD4069Australia

A mine-scale analysis of Longwall Top Coal Caving (LTCC) is performed using a continuum mechanics finite element solver called COSFLOW. The uniqueness of COSFLOW is that it incorporates Cosserat continuum theory in its formulation for describing the load deformation of bedded rocks. It is shown that such a continuum based code is valuable for assessing the feasibility of introducing LTCC in any mine. Various LTCC parameters, for example chock convergences, top coal failure behavior, strata cavingmechanism, abutment stresses and vertical stresses, were evaluated for a mine using COSFLOW.

关键词： LTCC COSFLOW Cosserat FEM Modeling Simulation

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A two-stage metaheuristic algorithm for the dynamic vehicle routing problem in Industry 4.0 approach

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Journal of Management Analytics 2021年第1期8卷 69-83页

作者： Maryam Abdirad krishna krishnan deepak Gupta Department of Industrial Systemsand Manufacturing EngineeringWichita State UniversityWichitaKSUSA

Industry 4.0 is a concept that assists companies in developing a modern supply chain(MSC)system when they are faced with a dynamic *** Industry 4.0 focuses on mobility and real-time integration,it is a good framework for a dynamic vehicle routing problem(DVRP).This research works on *** aim of this research is to minimize transportation cost without exceeding the capacity constraint of each vehicle while serving customer demands from a common ***,new orders arrive at a specific time into the system while the vehicles are executing the delivery of existing *** paper presents a two-stage hybrid algorithm for solving the *** the first stage,construction algorithms are applied to develop the initial *** the second stage,improvement algorithms are *** results were designed for different sizes of *** results show the effectiveness of the proposed algorithm.

关键词： dynamic vehicle routing problem Industry 4.0 two-stage algorithm heuristic algorithms

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A Comprehensive Survey on Federated Learning in the Healthcare Area: Concept and Applications

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2239-2274页

作者： deepak Upreti Eunmok Yang Hyunil kim Changho Seo Department of Convergence Science Kongju National UniversityChungcheongnam-doGongju-si32588South Korea Department of Information Security Cryptologyand MathematicsKookmin UniversitySeoul02707South Korea Department of Information and Communication Engineering Chosun UniversityGwangju61452South Korea Basic Science Research Institution Kongju National UniversityChungcheongnam-doGongju-si32588South Korea

Federated learning is an innovative machine learning technique that deals with centralized data storage issues while maintaining privacy and *** involves constructing machine learning models using datasets spread across several data centers,including medical facilities,clinical research facilities,Internet of Things devices,and even mobile *** main goal of federated learning is to improve robust models that benefit from the collective knowledge of these disparate datasets without centralizing sensitive information,reducing the risk of data loss,privacy breaches,or data *** application of federated learning in the healthcare industry holds significant promise due to the wealth of data generated from various sources,such as patient records,medical imaging,wearable devices,and clinical research *** research conducts a systematic evaluation and highlights essential issues for the selection and implementation of federated learning approaches in *** evaluates the effectiveness of federated learning strategies in the field of *** offers a systematic analysis of federated learning in the healthcare domain,encompassing the evaluation metrics *** addition,this study highlights the increasing interest in federated learning applications in healthcare among scholars and provides foundations for further studies.

关键词： Federated learning artificial intelligence machine learning privacy healthcare

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Numerical Modeling of Porous Flow in Fractured Rock and Its Applications in Geothermal Energy Extraction

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Journal of Earth Science 2015年第1期26卷 20-27页

作者： Yucang Wang Shimin Wang Sheng Xue deepak Adhikary Earth Science and Resource Engineering CSIROKenmore Qld 4069BrisbaneAustralia key Laboratory of Computational Geodynamics University of Chinese Academy of Sciences

Understanding the characteristics of hydraulic fracture, porous flow and heat transfer in fractured rock is critical for geothermal power generation applications, and numerical simulation can provide a powerful approach for systematically and thoroughly investigating these problems. In this paper, we present a fully coupled solid-fluid code using discrete element method （DEM） and lattice Boltzmann method （LBM）. The DEM with bonded particles is used to model the deformation and fracture in solid, while the LBM is used to model the fluid flow. The two methods are two-way coupled, i.e., the solid part provides a moving boundary condition and transfers momentum to fluid, while the fluid exerts a dragging force to the solid. Two widely used open source codes, the ESyS Particle and the OpenLB, are integrated into one code and paralleled with Message Passing Interface （MPI） library. Some preliminary 2D simulations, including particles moving in a fluid and hydraulic fracturing induced by injection of fluid into a borehole, are carried out to validate the integrated code. The preliminary results indicate that the new code is capable of reproducing the basic features of hydraulic fracture and thus offers a promising tool for multiscale simulation of porous flow and heat transfer in fractured rock.

关键词： discrete element method lattice Boltzmann method hydraulic fracturing geothermalenergy extraction multiscale modelling.

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Estimation of de-trapped charge for diagnosis of transformer insulation using short-duration polarisation current employing detrended fluctuation analysis

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High Voltage 2020年第5期5卷 636-641页

作者： Saurabh Dutta deepak Mishra Arijit Baral Sivaji Chakravorti Department of Electrical Engineering Indian Institute of Technology(ISM)DhanbadIndia Department of Electrical Engineering Jadavpur UniversityKolkataIndia

Researchers have shown that the value of charge carriers,de-trapped from the oil-paper interface of power transformer insulation,is useful in carrying out the ***,the evaluation of the de-trapped charge requires the analysis of polarisation-depolarisation *** an off-line time-consuming process,the measurement and analysis of polarisation and depolarisation current(PDC)data are not practically *** study presents a detrended fluctuation analysis-based technique to estimate the magnitude of normalised de-trapped charge using the polarisation current measured for a short *** the proposed technique,the requirement of measuring the complete PDC data,for diagnosis purposes,can be ***,the technique also eliminates the requirement of depolarisation current which in turn facilitates a reduction in equipment shutdown *** applicability of the proposed technique is tested on the data obtained from several real-life power transformers.

关键词： charge insulation diagnosis

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Novel Lyapunov-based rapid and ripple-free MPPT using a robust model reference adaptive controller for solar PV system

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Protection and Control of Modern Power Systems 2023年第1期8卷 205-229页

作者： Saibal Manna Ashok kumar Akella deepak kumar Singh Department of Electrical Engineering National Institute of Technology JamshedpurJharkhand 831014India

The technological,economic,and environmental benefits of photovoltaic(PV)systems have led to their wide-spread adoption in recent years as a source of electricity ***,precisely identifying a PV system’s maximum power point(MPP)under normal and shaded weather conditions is crucial to conserving the maximum generated *** of the biggest concerns with a PV system is the existence of partial shading,which produces multiple peaks in the P–V characteristic *** these circumstances,classical maximum power point tracking(MPPT)approaches are prone to getting stuck on local peaks and failing to follow the global maximum power point(GMPP).To overcome such obstacles,a new Lyapunov-based Robust Model Reference Adaptive Controller(LRMRAC)is designed and implemented to reach GMPP rapidly and *** proposed controller also achieves MPP accurately under slow,abrupt and rapid changes in radiation,temperature and load *** and OPAL-RT real-time simulators in various scenarios are performed to verify the superiority of the proposed approach over the other state-of-the-art methods,i.e.,ANFIS,INC,VSPO,and P&*** and GMPP are accomplished in less than 3.8 ms and 10 ms,*** on the results presented,the LRMRAC controller appears to be a promising technique for MPPT in a PV system.

关键词： Photovoltaic(PV) MPPT Partial shading Lyapunov-based robust model reference adaptive control(LRMRAC) Lyapunov stability

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Influence of tool rotation speeds on mechanical and morphological properties of friction stir processed nano hybrid composite of MWCNT-Graphene-AZ31 magnesium

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Journal of Magnesium and Alloys 2019年第3期7卷 487-500页

作者： Sanjay Sharma Amit Handa Sahib Sartaj Singh deepak Verma I.k.Gujral punjab technical university kapurthalaIndia punjabi university patialaindia graphic era hill university dehradunindia

The ever-increasing demand for light weighted hard materials for transportation industries encouraged researchers to develop composites with excellent mechanical properties which can transform it into more economical and *** the metals with carbonaceous nanomaterials are progressively in focus due to their excellent capability to inculcate and tailor the properties of *** the present research,a hybrid nanocomposite of MWCNT-Graphene-AZ31 Mg alloy has been developed by using variable tool rotation speeds with friction stir processing(FSP).Optimized reinforcement ratio of 1.6%*** and 0.3%*** graphene have been used with variable tool rotation speeds,whereas other processing parameters are kept *** developed specimens were investigated using standard testing equipment for evaluating and comparing the mechanical properties on the basis of the microstructure of the processing regions and their morphological analysis,according to the ASTM *** obtained results revealed an improvement of 19.72%in microhardness and 77.5% of compressive strength in comparison with the base metal AZ 31 Magnesium alloy,with a tool rotational speed of *** values of tensile stress and percentage area reduction were recorded as less than that of the base metal matrix,but an increasing trend has been observed in the values of both with the improvement on rotational speeds of the *** effectual strengthening mechanisms are analyzed on the bases of SEM images and observed that discussed and found that grain refinement strengthening is the major contributor to the strength of the nanocomposite.

关键词： MMCs(Metal Matrix composites) Friction stir processing(FSP) Multi-walled carbon nanotubes(MWCCT) Graphene Nano Particular Stir Zone(SZ) Thermo-mechanically affected zone(TMAZ) Heat Affected Zone(HAZ)

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Humans and Robots: A Mutually Inclusive Relationship in a Contagious World

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International Journal of Automation and computing 2021年第2期18卷 185-203页

作者： Akash Gupta Anshuman Singh deepak Bharadwaj Amit kumar Mondal Department of Mechanical Engineering University of Petroleum and Energy StudiesDehradun 248007India Department of Systems Engineering University of MarylandCollege ParkMaryland 20742USA Department of Mechatronics Engineering Manipal Academy of Higher EducationDubai 345050UAE

The coronavirus global pandemic has spread faster and more severely than experts had *** this has presented itself as a great challenge,researchers worldwide have shown ingenuity and dexterity in adapting technology and devising new strategies to combat this ***,implementing these strategies alone impedes the nature of everyone′s daily ***,an intersection between these strategies and the technological advantages of robotics,artificial intelligence,and autonomous systems is essential for near-to-normal *** this review paper,different applications of robotic systems,various aspects of modern technologies,including medical imaging,telemedicine,and supply chains,have been covered with respect to the COVID-19 ***,concerns over user′s data privacy,job losses,and legal aspects of the implementation of robotics are also been discussed.

关键词： COVID-19 coronavirus telepresence delivery robots medical robots

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Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus

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World Journal of Clinical Cases 2024年第3期12卷 525-537页

作者： Dharmsheel Shrivastav Desh deepak Singh Amity Institute of Biotechnology Amity University RajasthanJaipur 303002India

BACkGROUND Type 2 diabetes mellitus(T2DM)is a metabolic disease of impaired glucose *** high sugar levels lead to advanced glycation end products(AGEs),which affects several metabolic pathways by its receptor of advanced glycation end products(RAGE)and causes diabetic *** are small RNA molecules which regulate genes linked to diabetes and affect AGEs pathogenesis,and target tissues,influencing health and disease *** To explore miRNA roles in T2DM's metabolic pathways for potential therapeutic and diagnostic advancements in diabetes *** We systematically searched the electronic database PubMed using *** included free,full-length research articles that evaluate the role of miRNAs in T2DM and its complications,focusing on genetic and molecular disease *** assessing the full-length papers of the shortlisted articles,we included 12 research *** Several types of miRNAs are linked in metabolic pathways which are affected by AGE/RAGE axis in T2DM and its ***-96-5p,miR-7-5p,miR-132,has_circ_0071106,miR-143,miR-21,miR-145-5p,and more are associated with various aspects of T2DM,including disease risk,diagnostic markers,complications,and gene *** Targeting the AGE/RAGE axis,with a focus on miRNA regulation,holds promise for managing T2DM and its *** have therapeutic potential as they can influence the metabolic pathways affected by AGEs and RAGE,potentially reducing inflammation,oxidative stress,and vascular ***,miRNAs may serve as early diagnostic biomarkers for *** research in this area may lead to innovative therapeutic strategies for diabetes and its associated complications.

关键词： Type 2 diabetes mellitus MicroRNAs Advanced glycation end products Receptor for advanced glycation end products

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