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Outcome of repair of chronic tear of the pectoralis major using corkscrew suture anchors by box suture sliding technique

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World Journal of Orthopedics 2016年第10期7卷 670-677页

作者： deepak Joshi Jitesh Kumar Jain deepak chaudhary Utkarsh Singh Vineet Jain Ajay Lal Sports Injury Centre Safdarjung Hospital Sports Injury Centre Safdarjung Hospital and Vardhman Mahavir Medical College

AIM To assess the functional and clinical results of repair of chronic tears of pectoralis major using corkscrew and sliding suture technique. METHODS In this retrospective study, we reviewed the results of pectoralis major repair in 11 chronic cases(> 6 wk) done between September 2011 and December 2014 at our institute. In all cases repair was done by same surgeon using corkscrew suture anchors and box suture sliding technique. At 6 mo, after surgery magnetic resonance imaging was done to see the integrity of the repair. Functional evaluation was done using Penn and ASES scores. Pre and postoperative Isokinetic strength was *** Average follow-up was 48.27 ± 21.0 mo. The Wilcoxon signed rank test was used to evaluate the outcome scores. The average ASES score increased from an average of 54.63 ± 13.0 preoperatively to 95.09 ± 2.60 after surgery at their last follow-up. The average Penn score also increased from 5.72 ± 0.78, 2.81 ± 1.32 and 45.81 ± 1.72 to 9.36 ± 0.80, 8.27 ± 0.90 and 59 ± 1.34 for pain, satisfaction and function respectively. Follow up magnetic resonance imaging(MRI)(at 6 mo) showed continuity and the bulk of pectoralis major muscle in all cases. Average isokinetic strength deficiency in horizontal adduction at 60° was 13.63% ± 6.93% and at 120° was 10.18% ± 4.93% and in flexion at 60° was 10.72% ± 5.08% and at 120° was 6.63% + 3.74%. Results showed that both ASES and Penn score improved significantly(2 tailed P value = 0.0036).CONCLUSION We could conclude from this series that pectoralis major repair even in chronic cases using 5.5 mm corkscrew anchors give excellent functional and cosmetic results. In chronic cases the repairable length of the tendon is not available and sliding suture technique allows for fixation of worn out tendomuscular junction to bone without letting cutting through the muscle.

关键词： Pectoralis major tear Corkscrew suture anchors Chronic tears Bench press Tendon repair

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A six months old neglected anterior shoulder dislocation managed by closed reduction and Latarjet procedure

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Chinese Journal of Traumatology 2016年第5期19卷 295-297页

作者： deepak chaudhary deepak Joshi Vineet Jain Mukul Mohindra Nitin Mehta Sports Injury Center Safdarjung Hospital and VMM College New Delhi India

A neglected shoulder dislocation is a rarer entity and only few cases are reported in the literature. An anterior dislocation of the shoulder is rarely missed as patients present with limb in abduction and external rotation, an attitude very familiar to orthopaedic surgeon. Occasionally such cases are missed when they present with fracture of proximal humerus or when they receive treatment from unqualified practitioners who commonly practise in rural areas. Owing to very few reports there is paucity of literature and no standard treatment protocol exists for neglected anterior dislocation of the shoulder. though most such chronic cases are managed by open reduction. This case report describes a six months old neglected anterior dislocation with a significant Hill Sachs lesion, which was managed by closed reduction and Latarjet procedure.

关键词： Shoulder dislocation Humeral fractures Latarjet procedure

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Effect of Doxorubicin on Histomorphology of Liver of Wistar Albino Rats

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Journal of Pharmacy and Pharmacology 2016年第4期4卷 174-178页

作者： deepak chaudhary Saroj Khatiwada Surendra Kumar Sah Man Kumar Tamang Soumya Bhattacharya Chandra Bhushan Jha M.Sc. Human Anatomy Department of Anatomy Nobel Medical College Biratnagar Nepal MSc. Medical Biochemistry Department of Biochemistry Modern Technical College Lalitpur Nepal M Sc. Medical Biochemistry Department of Nutrition and Dietetics Central Campus of Technology Dharan Nepal MD Anatomy Department of Human Anatomy B P Koirala Institute of Health Sciences Dharan Nepal

Doxorubicin is associated with adverse effects on organs like liver. This study was done to find the effects of doxorubicin on liver of wistar albino rats. Sixty healthy wistar albino rats were taken for the study. The rats were randomly divided in to 4 groups （2 experimental groups; group AI and A2, and 2 control groups;group Bland B2 each containing 16 rats）. The experimental groups were given a single dose of doxorubicin i.e. 10 mg/kg body weight intraperitoneally and sacrificed after 7 days and 14 days for each group. Rats under control groups were given a single intraperitoneal dose of 2.5 ml/kg body weight normal saline and sacrificed with their respective experimental groups. A significant difference （p 〈 0.001） and （p = 0.005） in final body weight was observed among group A1 experimental and BI control rats, and among group A2 experimental and B2 control rats. As compared to group B2 control, group A2 experimental rats had significantly （p = 0.043） lower liver weight. Diameter ofhepatocyte （p 〈 0.001 for both groups） and nucleus （p=0.004 for group A1 and control BI, and p 〈 0.001 for group A2 and control B2） was significantly higher in experimental rats as compared to their respective controls. Cross-sections of the liver of both control groups had normal architecture. However, there was progressive destruction of liver architecture across the experimental groups. Doxorubicin causes the disruption of normal architecture of liver in rats. Thus care needs to be taken during doxorubicin chemotherapy to minimize effects on river.

关键词： Doxorubicin Histomorphometry Liver Wistar albino rot.

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Comparison of abdominal ultrasound,endoscopic ultrasound andmagnetic resonance imaging in detection of necrotic debris in walled-off pancreatic necrosis

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Gastroenterology Report 2016年第1期4卷 50-53,I0002页

作者： Surinder S Rana Vinita chaudhary Ravi Sharma Vishal Sharma Puneet Chhabra deepak K Bhasin Department of Gastroenterology Post Graduate Institute of Medical Education and Research(PGIMER)ChandigarhIndia

Background:Walled-off pancreatic necrosis(WOPN)is an important complication of acute pancreatitis that is diagnosed by imaging modalities such as endoscopic ultrasound(EUS)or magnetic resonance imaging(MRI),which can clearly visualize necrotic *** effectiveness of abdominal ultrasound(USG)in detecting solid debris in WOPN is not ***:A total of 52 patients(37 males,mean age 38.9612.6 years)with symptomatic WOPN were prospectively studied using EUS,MRI and *** investigations were done at a mean of 11.765.5 weeks of onset of acute pancreatitis and within two ***:WOPN was detected by EUS&MRI in all patients,whereas USG could not detect it in 4(7.6%)patients(3 had predominantly solid WOPN,whereas one had air foci in WOPN).USG,MRI and EUS could detect solid debris in all patients with detectable *** and USG detected40%debris in 8 patients(15%)compared to 5(11%)patients having>40%debris on *** detected collaterals around WOPN that were not detected on USG or ***:USG can characterize the majority of WOPN,with accuracy comparable to that of EUS/*** its limitations are the inability to detect collaterals around WOPN and characterize collections with high solid content or air.

关键词： endoscopic ultrasound abdominal ultrasound magnetic resonance imaging pancreatic necrosis acute pancreatitis

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Influence of tool rotational speed on mechanical and corrosion behaviour of friction stir processed AZ31/Al_(2)O_(3)nanocomposite

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Journal of Magnesium and Alloys 2023年第7期11卷 2585-2599页

作者： Ashish Kumar V.P.Singh Akhileshwar Nirala R.C.Singh Rajiv chaudhary Abdel-Hamid I.Mourad B.K.Sahoo deepak Kumar Department of Mechanical Engineering Delhi Technological UniversityDelhi 110042India Department of Mechanical Engineering Galgotias College of Engineering and Technology Greater Noida 201310India Department of Mechanical Engineering National Institute of Technology MizoramAizawl 796012India Department of Mechanical Engineering IES College of Technology Bhopal462044India Mechanical and Aerospace Engineering Department College of EngineeringUnited Arab Emirates UniversityAl-Ain 15551United Arab Emirates Materials Engineering Division CSIR-National Metallurgical Laboratory(NML)Jamshedpur831007India Department of Mechanical Engineering Carnegie Mellon UniversityPittsburghPA 15213USA

Nano-sized reinforcements improved the mechanical characteristics efficiently by promoting more implicit particle hardening mechanisms compared to micron-sized ***-sized particles lessen the critical particle solidification velocity for swamp and thus offers better *** the present investigation,the friction stir processing(FSP)is utilized to produce AZ31/Al_(2)O_(3)nanocomposites at various tool rotation speeds(i.e.,900,1200,and 1500 rpm)with an optimized 1.5%volume alumina(Al_(2)O_(3))reinforcement *** mechanical and corrosion behavior of AZ31/Al_(2)O_(3)-developed nanocomposites was investigated and compared with that of the AZ31 base *** AZ31 alloy experienced a comprehensive dynamic recrystallization during FSP,causing substantial grain ***-size strengthening is the primary factor contributed to the enhancement in the strength of the fabricated *** strength and yield strength values were lower than those for the base metal matrix,although an upward trend in both values has been observed with an increase in tool rotation *** 19.72%increase in hardness along with superior corrosion resistance was achieved compared to the base alloy at a tool rotational speed of 1500 *** corrosion currents(Jcorr)of all samples dropped with increase in the rotational speed,in contrast to the corrosion potentials(Ecorr),which *** values of Jcorr of AZ31/Al_(2)O_(3)were 42.3%,56.8%,and 65.5%lower than those of AZ31 alloy at the chosen rotating speeds of 900,1200,and 1500 rpm,*** corrosion behavior of friction stir processed nanocomposites have been addressed in this manuscript which has not been given sufficient attention in the existing ***,this work offers an effective choice for the quality assurance of the FSP process of AZ31/Al_(2)O_(3)*** obtained results are relevant to the development of lightweight automobile and aerospace structures and components

关键词： Friction stir processing AZ31 alloy Al_(2)O_(3) Nanocomposite Mechanical properties Corrosion resistance

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Biotransformation,multifunctional recycling mechanism of nanostructures,and evaluation of the safety of nanoscale materials

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Particuology 2023年第11期82卷 76-86页

作者： Debjyoti Talukdar Parveen Kumar Benu chaudhary deepak Sharma Nishant Yadav Obaid Afzal Abdulmalik Saleh Alfawaz Altamimi Waleed Hassan Almalki Sami IAlzarea Imran Kazmi Ashutosh Pareek Gaurav Gupta Madan Mohan Gupta Department of Medical Research Armenian Russian International University“Mkhitar Gosh”YerevanArmenia Shri Ram College of Pharmacy KarnalHaryanaIndia Guru Gobind Singh College of Pharmacy YamunanagarHaryanaIndia Department of Pharmaceutical Technology SOMSAdamas UniversityBarasat-Barracpore RoadKolkataWest BengalIndia B.S.Anangpuria Institute of Pharmacy FaridabadHaryanaIndia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl Kharj11942Saudi Arabia Department of Pharmacology College of PharmacyUmm Al-Qura UniversityMakkahSaudi Arabia Department of Pharmacology College of PharmacyJouf UniversitySakakaAl-JoufSaudi Arabia Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Pharmacy Banasthali VidyapithBanasthali-RajasthanIndia School of Pharmacy Suresh Gyan Vihar UniversityJagatpura302017Mahal RoadJaipurIndia Department of Pharmacology Saveetha Dental CollegeSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia Uttaranchal Institute of Pharmaceutical Sciences Uttaranchal UniversityDehradunIndia School of Pharmacy Faculty of Medical SciencesThe University of the West IndiesSt.AugustineTrinidad and Tobago

Current evidence of concept analyses recommending nanotechnology for biomedical uses abounds in recent research. The area of biotechnology interfaces with nanostructures, reconfigures their composition, and alters their characteristics;which influences the dispersion of the particles, the biotransformation they cause, and their potential toxic effect. It is vital to link the idea of the lifecycle of nanostructures to the biological impacts and use methodologies to identify, estimate, and track the gradual bioprocessing of nanostructures in vivo, from a body-wide level to a nanoscopic size. This is necessary because understanding how nanostructures processing, degradation, persistence, and recycling predict potential exposure risks. The safe implementation of nanotechnology-based products in biomedical applications necessitates an extensive understanding of the recycling and transformations of nanomaterials in a living organism. Long-term fate in the body is crucial, as it governs potential environmental risks to human health. Strategies may be used to manage the long-term outcome of nanostructures in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. The lifespan of nanoparticles, a flexible and biocompatible category of nanostructures that have made it into clinical trials, is the subject of this article. Strategies may be used to manage the long-term outcome of nanoparticles in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. This review explained the safety of nanoscale materials, biotransformation, and the multifunctional recycling mechanism of nanostructures.

关键词： Nanostructure Nanoparticle Biotransformation Toxiceffect Environmental risk

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Targeting brain tumors with innovative nanocarriers:bridging the gap through the blood-brain barrier

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Oncology Research 2024年第5期32卷 877-897页

作者： KARAN WADHWA PAYAL CHAUHAN SHOBHIT KUMAR RAKESH PAHWA RAVINDER VERMA RAJAT GOYAL GOVIND SINGH ARCHANA SHARMA NEHA RAO deepak KAUSHIK Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtak124001India Department of Pharmaceutical Technology Meerut Institute of Engineering and Technology(MIET)NH-58Delhi-Roorkee HighwayMeerut250005India Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetra136119India Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani127021India MM College of Pharmacy Maharishi Markandeshwar(Deemed to be University)Mullana-AmbalaHaryana133207India Delhi Pharmaceutical Sciences and Research University(DIPSAR) Delhi Pharmaceutical Sciences and Research UniversityNew Delhi110017India

Background:Glioblastoma multiforme(GBM)is recognized as the most lethal and most highly invasive *** high likelihood of treatment failure arises fromthe presence of the blood-brain barrier(BBB)and stemcells around GBM,which avert the entry of chemotherapeutic drugs into the ***:Recently,several researchers have designed novel nanocarrier systems like liposomes,dendrimers,metallic nanoparticles,nanodiamonds,and nanorobot approaches,allowing drugs to infiltrate the BBB more efficiently,opening up innovative avenues to prevail over therapy problems and radiation ***:Relevant literature for this manuscript has been collected from a comprehensive and systematic search of databases,for example,PubMed,Science Direct,Google Scholar,and others,using specific keyword combinations,including“glioblastoma,”“brain tumor,”“nanocarriers,”and several ***:This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM *** of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.

关键词： Glioblastoma Brain tumor Blood-brain barrier Liposomes Metallic nanoparticles Nanocarriers

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