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Effectiveness of omega-3 polyunsaturated fatty acids against microbial pathogens

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第4期19卷 253-262页

作者： Warren chanda Thomson P.JOSEPH Xue-fang GUO Wen-dong WANG Min LIU Miza S.VUAI Arshad A.PADHIAR Min-tao ZHONG Department of Microbiology College of Basic Medical Sciences Dalian Medical University

Microorganisms provide both beneficial and harmful effects to human beings. Beneficial effects come from the symbiotic relationship that exists between humans and microbiota, but then several human illnesses have turned some friendly microbes into opportunistic pathogens, causing several microbial-related diseases. Various efforts have been made to create and utilize antimicrobial agents in the treatment and prevention of these infections, but such efforts have been hampered by the emergence of antimicrobial resistance. Despite extensive studies on drug dis- covery to alleviate this problem, issues with the toxicity and tolerance of certain compounds and continuous microbial evolution have forced researchers to focus on screening various phytochemical dietary compounds for antimicrobial activity. Linolenic acid and its derivatives （eicosapentaenoic acid and docosahexaenoic acid） are omega-3 fatty acids that have been studied due to their role in human health, being important for the brain, the eye, the cardiovascular system, and general human growth. However, their utilization as antimicrobial agents has not been widely appreciated, perhaps due to a lack of understanding of antimicrobial mechanisms, toxicity, and route of administration. Therefore, this review focuses on the efficacy, mechanism, and toxicity of omega-3 fatty acids as alternative therapeutic agents for treating and preventing diseases associated with pathogenic microorganisms.

关键词： Linolenic acid Omega-3 fatty acid Eicosapentaenoic acid (EPA) Docosahexaenoic acid (DHA) Antimicrobial agent Fatty acid

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Post-Therapy Profile of BMI-for-Age of Indian Survivors of Pediatric Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphoma

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Food and Nutrition Sciences 2012年第10期3卷 1413-1419页

作者： chanda D. Gokhale Shobha A. Udipi Ramakrishna Y. Ambaye Suresh K. Pai Suresh H. Advani Consultant Jaslok Hospital Mumbai India Former Consultant Department of Medical Oncology Tata Memorial Hospital Mumbai India Professor and Head University Dept of Food Science and Nutrition S.N.D.T Women’s University Mumbai India Research Advisor in Pharmacology Departmenst of Pharmaceutical Sciences and Technology Institute of Chemical Technology Mumbai India Smt. P.N. Doshi Women’s College S.N.D.T Women’s University Mumbai. Formerly University Dept of Food Science and Nutrition S.N.D.T Women’s University Mumbai India

Background: Obesity in pediatric ALL survivors is a well recognized late effect. Hence the present study examines the BMI-for-age of Indian childhood ALL and NHL survivors. Method: A retrospective study of 118 ALL/NHL survivors and 138 age sex matched was carried out. From the recorded heights and weights were body mass index (BMI) was computed. The survivor data was compared with 138 controls from the data set collected by investigators previously. Results: 82.8% of patients had BMI-for-age in 5th-84th percentile (healthy) at time of diagnosis and at inclusion in the study. Comparison of BMI of survivors with matched controls was not significant. However, The mean BMI-for-age for younger patients (3 to 12 years) was significantly higher than mean BMI-for-age of matched controls. Distribution of data by time elapsed from therapy was significant. Overweight/obesity was observed among the survivors who were off therapy for two years with increase in after four years post-therapy. Conclusion: Our preliminary study indicates late effects of therapy and points to the need of long term assessment of the survivors, even though majority of them were within the normal weight range.

关键词： Body Mass Index Children Indian Acute Lymphoblastic Leukemia Non-Hodgkin’s Lymphoma

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供临床应用的凝血酶原复合物浓缩物

国际输血及血液学杂志 1982年第3期05卷 158-162页

作者： chanda S Brummelhuis HGJ 肖昆华

自 Didisheim 等人首先报告适用于临床的凝血酶原复合物的制备方法以来,在过去的10年中,制备方法已有不少改进,现已有很多临床适用的制品。凝血酶原复合物浓缩剂(PCC)又称 PP-SB 或因子Ⅸ浓缩剂,它主要是由凝血因子Ⅱ、Ⅶ、Ⅸ和 X 组成... 详细信息

自 Didisheim 等人首先报告适用于临床的凝血酶原复合物的制备方法以来,在过去的10年中,制备方法已有不少改进,现已有很多临床适用的制品。凝血酶原复合物浓缩剂(PCC)又称 PP-SB 或因子Ⅸ浓缩剂,它主要是由凝血因子Ⅱ、Ⅶ、Ⅸ和 X 组成。这些凝血因子在肝脏内合成,均为依赖维生素 K 性糖蛋白;除因子Ⅶ外,它们均系丝氨酸蛋白酶酶原,而因子Ⅶ则是一种活性酶。这些因子的分子量为54,000～70,000,具有酸性等电点。

关键词： PCC 肝素蛋白多糖凝血酶原复合物激活型血栓性混合血浆抗乙型肝炎抗原乙型肝炎抗体病毒性肝炎非甲非乙型肝炎凝血因子浓缩物临床应用

The Correlation of NT-Pro BNP with Echocardiographic Indices Including 3D Vena Contracta Width in the Assessment of Severity of Mitral Regurgitation

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World Journal of Cardiovascular Diseases 2018年第7期8卷 390-401页

作者： Narendra chanda D. Rajasekhar A. Ravi Kanth V. Vanajakshamma C. Kapil T. Suresh Babu K. Sreedhar Naik Department of Cardiology Sri Venkateswara Institute of Medical Sciences Tirupati India

Introduction: Mitral regurgitation (MR) is a common valvular disease that causes significant morbidity and mortality. The use of multiple echocardiographic indices and hormonal parameters in combination can provide an accurate assessment of MR severity and LV dysfunction in most cases. Aim of study: The aim of this study was to correlate the levels of serum NT-pro BNP with various echocardiographic parameters including 3D vena contracta width in patients with MR. Methods: 74 Patients diagnosed with primary mitral regurgitation in sinus rhythm with no conduction disturbance were included in the study. 2D and Doppler echocardiography indices were calculated. A full-volume 3D color Doppler acquisition was obtained and 3D vena contracta width was calculated and serum BNP levels were obtained. Results: NT-pro BNP levels were increased with symptoms in patients with mitral regurgitation (NYHAI: 4.48 ± 0.06, NYHAII: 5.54 ± 0.78, NYHAIII: 6.68 ± 1.21 pg/ml, p 0.01). NT-pro BNP plasma levels were significantly correlated with MPI (r = 0.945, p 0.01), LVESV (r = 0.706, p 0.01), LVESVI (r = 0.677, p 0.01), LAVI (r = 0.709, p 0.01), MR 2D VC (r = 0.430, p 0.01), 3D VC (r = 0.441, p 0.01), PISA (r = 0.440, p 0.01) and negative correlation with LV ejection fraction (r = 0.846, p 0.01), dp/dt (r = 0.795, p BNP plasma level and LA jet area ratio (P = 0.33). It was observed that there was a significant correlation between 3D VC and PISA levels in patients of mitral regurgitation. However correlation is better in MR with central jet compared to eccentric jet in moderate and severe MR (r = 0.807, 0.817 vs r = 0.617, 0.572). Conclusion: This study showed that NT-pro BNP measurement has the same sensitivity and specificity as echocardiographic indices. Three-dimensional VCA may provide a reliable measurement of ROA, independent of geometric and flow assumptions.

关键词： NT-Pro BNP Mitral Regurgitation Proximal Isovelocity Surface Area Effective Regurgitant Orifice Area

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孟莫克SULFOX技术在德克萨斯州清洁能源项目上的应用

作者： (印)纳扬·昌达(Nayan chanda)

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孟莫克SULFOX技术在德克萨斯州清洁能源项目上的应用

Antibacterial and anti-biofilm activity of the lipid extract from Mantidis ootheca on Pseudomonas aeruginosa

第九届全国有色金属工业冶炼烟气治理专利技术推广及三废无害化处置研发技术研讨会

作者： Garrett Palmquist Kassie chanda John Horne 孟莫克上海有限公司

孟莫克SULFOX提供的硫酸工艺技术被选择为位于美国德州奥德萨的清洁能源煤气化项目(TCEP)的配套工艺。MECS SULFOX是一家由MECS公司和Kanzler Verfahrenstechnik GmbH(KVT)公司共同组建的合资公司,旨在向市场提供一种传统超级克劳斯工...

孟莫克SULFOX提供的硫酸工艺技术被选择为位于美国德州奥德萨的清洁能源煤气化项目(TCEP)的配套工艺。MECS SULFOX是一家由MECS公司和Kanzler Verfahrenstechnik GmbH(KVT)公司共同组建的合资公司,旨在向市场提供一种传统超级克劳斯工艺的替代技术。在TCEP项目中,SULFOX装置将处理来自气化炉下游低温甲醇洗装置的含硫化氢(HS)尾气,将其转化成为93%浓度的商品级硫酸用于当地市场销售,硫酸的产能为55短吨,天。SULFOX工艺简单,设备紧凑,采用模块化设计,装置的操作弹性很大,并可保证"超低"的酸雾排放指标。酸浓缩管组部分的高机械强度设计最大限度的减少了装置的维修成本。由于SULFOX装置高效的废热回收和蒸汽产率,相比传统克劳斯装置,运行SULFOX具有非常高的经济效益。配合SULFOX装置,TCEP项目中的整体煤气化联合循环发电(IGCC)装置可以发电400MW,其中部分电力用于驱动现场的动设备,生产农用化肥生产所需的合成氨,尿素以及商品级硫酸;余下电量并入德克萨斯州电网,其电价不高于普通电价。TCEP项目的碳捕集率将达到90%。平均每小时每兆瓦产生的二氧化碳排放值将远远低于天然气火电厂和目前最新的美国联邦气候立法属所规定的适用于加利福尼亚州和华盛顿州的二氧化碳排放标准。TCEP项目还得到了美国能源部洁净煤发电2010计划授予的4.5亿美元的资助。

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第5期19卷 364-371页

作者： Wen-dong WANG Nan-nan ZHANG Warren chanda Min LIU Syed Riaz ud DIN Yun-peng DIAO Lei LIU Jing CAO Xiao-li WANG Xing-yun LI An-hong NING Min HUANG Min-tao ZHONG Department of Medical Microbiology Dalian Medical UniversityDalian 116044China Department of Otolaryngology Dalian Central HospitalDalian 116033China School of Pharmacy Dalian Medical UniversityDalian 116044China

The aim of this study is to assess the antibacterial and anti-biofilm properties of the lipid extract from Man- tidis ootheca against the gentamycin resistant Pseudomonas aeruginosa. The chemical composition of the lipid extract and its relative proportion were determined using the technique of gas chromatography coupled with mass spec- trometry （GC-MS）. Antibacterial susceptibility tests were performed using a disc diffusion assay and the minimum inhibition concentration （MIC） was determined by way of the agar dilution method. The anti-biofilm test was carried out with crystal violet staining and scanning electron microscopy （SEM）. There were 16 compounds detected, and the most abundant components were sesquiterpenoids, monoterpenes, and trace aromatic compounds. The MIC for P. aeruginosa was 4 mg/ml and the eradication effect on preformed biofilms was established and compared with a ciprofloxacin control. The results of our study indicated that a lipid extract from M. ootheca could be used as a topical and antibacterial agent with anti-biofilm activity in the future.

关键词： Antibacterial Lipid extract Manfidis ootheca Pseudomonas aeruginosa

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Prevalence and Antimicrobial Susceptibility Status of Gram-Negative and Gram-Positive Bacteria on Handheld Shopping Trolleys and Baskets in Supermarkets in Ndola, Zambia

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Open Journal of Epidemiology 2023年第4期13卷 235-249页

作者： Shivangi Patel Victor Daka Steward Mudenda Mulemba Samutela Misheck Chileshe Warren chanda Imukusi Mutanekelwa Ephraim Chikwanda Titus Haakonde Tobela Mudenda Scott Matafwali Samson Mwale Ruth Lindizyani Mfune Public Health Department School of Medicine Copperbelt University Ndola Zambia School of Health Sciences University of Zambia Lusaka Zambia Mary Begg Health Services Ndola Zambia School of Medicine and Health Sciences Mulungushi University Livingstone Zambia Tropical Disease Research Centre Ndola Zambia Environmental Health Section School of Applied and Health Sciences Evelyn Hone College of Applied Arts and Commerce Lusaka Zambia Pathology and Laboratory Department Ndola Teaching Hospital Ndola Zambia Clinical Research Department Faculty of Infectious and Tropical Diseases London School of Hygiene & Tropical Medicine London UK

Background: Supermarkets are a place visited by individuals with different health conditions daily where microbiological contaminants through touch onto fomites such as trolleys and baskets can be passed on to other people hence potentially spreading infectious diseases. This study aimed to investigate the presence of Gram-negative and Gram-positive bacteria on handheld shopping trolleys and baskets and their antimicrobial susceptibility status against commonly used antibiotics in Zambia. Methods: A cross-sectional study was conducted. Trolleys and basket handles were swabbed and standard microbiological methods were used to identify the bacteria and disc diffusion to determine their antimicrobial susceptibility status. Data was collected from December 2021 to April 2022. Data was analysed using IBM Statistical Package for Social Sciences (SPSS) Version 22. Results: Twenty-eight percent of the 200 total samples were found to be culture-positive and predominant isolates were Staphylococcus aureus (17.3%), Pseudomonas species (4.5%), Escherichia coli (2%), Corynebacterium species (2%), Staphylococcus species (1.5%) and Enterobacter aerogenes (0.5%). Staphylococcus aureus showed the most resistance to azithromycin (17%) followed by ciprofloxacin (2.8%), nitrofurantoin (2.8%) and chloramphenicol (2.8%). Escherichia coli showed 100% resistance to amoxicillin, cloxacillin and ampicillin, 75% resistance to ciprofloxacin and the least resistance to azithromycin (25%) while it was susceptible to nitrofurantoin. Staphylococcus species, Corynebacterium species, Enterobacter aerogenes and Pseudomonas species showed no resistance to any antibiotics. Conclusion: The study showed the presence of microorganisms with considerable antimicrobial resistance to antibiotics in Zambia on trolley and basket handles indicating the need for more initiatives to address proper hygiene in public environmental sites for better infection prevention and control.

关键词： Antimicrobial Resistance Coliform Bacteria Staphylococcus aureus Escherichia coli Supermarket Shopping Trolleys and Baskets

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肉芽肿病性坏死性血管炎

国外医学.皮肤病学分册 1985年第3期11卷 145-148页

作者： chanda JJ 苏敬泽黄霞静

血管炎系包括伴不同程度坏死有血管炎症之共同特点的广谱疾患。本文综述一类伴有组织的肉芽肿性坏死及血管中心性肉芽肿病的血管炎。仅近日才将坏死性血管炎伴肉芽肿病(NVG)为特征的疾病列为一特定的类型。NVG疾病列于附表。除中枢神经... 详细信息

血管炎系包括伴不同程度坏死有血管炎症之共同特点的广谱疾患。本文综述一类伴有组织的肉芽肿性坏死及血管中心性肉芽肿病的血管炎。仅近日才将坏死性血管炎伴肉芽肿病(NVG)为特征的疾病列为一特定的类型。NVG疾病列于附表。除中枢神经系统罕见肉芽肿性血管炎外,所有这些疾病均以呼吸系

关键词：肉芽肿病 NVG 肉芽肿性发病机理中枢神经系统坏死性血管炎坏死性肉芽肿