检索结果-南通市图书馆

Analysis of Open Access Landscape

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图书情报工作 2005年第12期49卷 6-13页

作者： Helen Doyle Andy Gass debra Lappin Rebecea Kennison Public Library of Science 185 Berry Street Suite 1300San FranciscoCA 94107USA

This paper is created by bounding 5 editorials of Public Library of Science (PLoS ) which have written on various aspects of open access. It covers wide range topics of important open access issues, such as from paying for open access to copyright to open access as a public issue, which may be more or less of interest of our audience.

关键词：公共图书馆公开文件文献资料图书馆管理

Selection in monoculture vs. mixture alters plant metabolic fingerprints

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Journal of Plant Ecology 2015年第5期8卷 549-557页

作者： debra Zuppinger-Dingley Dan F.B.Flynn Helmut Brandl Bernhard Schmid Institute of Evolutionary Biology and Environmental Studies University of ZurichWinterthurerstrasse 190CH-8057 ZurichSwitzerland The Arnold Arboretum of Harvard University 1300 Centre StreetBostonMA 02131USA

Aims In grassland biodiversity experiments,positive biodiversity effects on primary productivity increase over *** research has shown that differential selection in monoculture and mixed-species communities leads to the rapid emergence of monoculture and mix-ture types,adapted to their own biotic *** used eight plant species selected for 8 years in such a biodiversity experiment to test if monoculture and mixture types differed in metabolic pro-files using infrared *** Fourier transform infrared spectroscopy(FTIr)was used to assess metabolic fingerprints of leaf samples of 10 individuals of each species from either monocultures or *** FTIr spectra were analyzed using multivariate procedures to assess(i)whether indi-viduals within species could be correctly assigned to monoculture or mixture history based on the spectra alone and(ii)which parts of the spectra drive the group assignment,*** metabolic groups were subject to differential selection in monocultures *** Findings Plant individuals within each of the eight species could be classified as either from monoculture or mixture selection history based on their FTIr *** metabolic groups were differentially selected in the different species;some of them may be related to defense of patho-gens accumulating more strongly in monocultures than in *** rapid selection of the monoculture and mixture types within the eight study species could have been due to a sorting-out process based on large initial genetic or epigenetic variation within the species.

关键词： biodiversity plant evolution selection FTIr spectroscopy metabolic fingerprint

Understanding Organizational Behavior: : A Multimedia Approach/ ed.

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No more rotten eggs a dozen steps to grade AA talent management debra Thompson and Bill Greif. 1st edition

2002年

作者： Nelson debra L.

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Physical activity and chronic back conditions:A population-based pooled study of 60,134 adults

2010年

作者： debra Thompson and Bill Greif.

ISBN: (纸本)9780071664882

Your proven weapon in the battle for talent Take your business to the top by finding, developing, and keeping top employees. Almost every business runs on quality personnel, and it's up to you to acquire, develop, and retain top-performing employees to secure business success, growth, and profitability. "No More Rotten Eggs" provides step-by-step guidance for revolutionizing your hiring practices

关键词： EmployeesRecruiting.Employee motivation.Employee selection.Employee retention.EmployeesTraining of.

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Journal of Sport and Health Science 2019年第4期8卷 386-393页

作者： Hosam Alzahrani debra Shirley Sonia W.M.Cheng Martin Mackey Emmanuel Stamatakis Discipline of Physiotherapy Faculty of Health SciencesThe University of SydneySydneyNSW 2006Australia Physiotherapy Department College of Applied Medical ScienceTaif UniversityTaif21974Saudi Arabia Charles Perkins Centre Prevention Research CollaborationSchool of Public HealthThe University of SydneySydneyNSW 2006Australia

Background:Little is known about the association between different types of physical activity(PA)and chronic back conditions(CBCs)at the population *** investigated the association between levels of total and type-specific PA participation and ***'.The sample comprised 60,134 adults aged>16 years who participated in the Health Survey for England and Scottish Health Survey from 1994 to *** logistic regression models,adjusted for potential confbunders,were used to examine the association between total and type-specific PA volume(walking,domestic activity,sport/exercise,cycling,football/rugby,running/jogging,manual work,and housework)and the prevalence of ***'.We found an inverse association between total PA volume and prevalence of *** with inactive participants,the fully adjusted odds ratio(OR)for very active participants(≥15 metabolic equivalent h/week)was 0.77(95%confidence interval(CI):0.69—0.85).Participants reporting≥300 min/week of moderate-intensity activity and≥75 min/week of vigorous-intensity activity had 24%(95%CI:6%—39%)and 21%(95%C1:11%—30%)lower odds of CBCs,*** odds of CBCs were observed for participation in high-level manual domestic activity(OR=1.22;95%CI:1.00-1.48).Sport/exercise was associated with CBCs in a less consistent manner(e.g.,OR=1.18(95%CI:1.06—1.32)for low levels and OR=0.82(95%CI:0.72—0.93)for high levels of sport/exercise).Conclusion'.PA volume is inversely associated with the prevalence of CBCs.

关键词： Activity Chronic low back pain Chronic musculoskeletal conditions Epidemiology Exercise

Novel approaches to combat chemoresistance against glioblastomas

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Cancer Drug Resistance 2020年第4期3卷 686-698页

作者： Rheal A.Towner Michelle Zalles debra Saunders Nataliya Smith Advanced Magnetic Resonance Center Oklahoma Medical Research FoundationOklahoma CityOK 73104USA Oklahoma Center for Neuroscience University of Oklahoma Health Sciences CenterOklahoma CityOK 73104USA

The poor prognosis of glioblastoma multiforme(GBM)patients is in part due to resistance to current standard-of-care treatments including chemotherapy[predominantly temozolomide(TMZ;Temodar)],radiation therapy and an anti-angiogenic therapy[an antibody against the vascular endothelial growth factor(bevacizumab;Avastin)],resulting in recurrent *** recurrent GBM tumors are commonly resistant to either TMZ,radiation or bevacizumab,which contributes to the low survival rate for GBM *** review will focus on novel targets and therapeutic approaches that are currently being considered to combat GBM *** of these therapeutic options is a small molecule called OKlahoma Nitrone 007(OKN-007),which was discovered to inhibit the transforming growth factor β1 pathway,reduce TMZ-resistance and enhance ***-007 is currently an investigational new drug in clinical trials for both newly-diagnosed and recurrent GBM *** novel target is ELTD1(epidermal growth factor,latrophilin and seven transmembrane domain-containing protein 1;alternatively known as ADGRL4,Adhesion G protein-coupled receptor L4),which we used a monoclonal antibody against,where a therapy against it was found to inhibit Notch 1 in a pre-clinical GBM xenograft *** 1 is known to be associated with chemoresistance in *** potential therapeutic targets to combat GBM chemoresistance include the phosphoinositide 3-kinase pathway,nuclear factor-κB,the hepatocyte/scatter factor(c-MET),the epidermal growth factor receptor,and the tumor microenvironment.

关键词： Glioblastoma pre-clinical models OKlahoma Nitrone 007 transforming growth factor-β1 ELTD1 magnetic resonance imaging

The Need for a National Guideline for the Management of NSCLC ALK-Positive Lung Cancer in the UK: Results of Patient-Driven Surveys

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Journal of Cancer Therapy 2022年第7期13卷 476-485页

作者： debra Montague ALK Positive Lung Cancer (UK) Surrey UK

Introduction: There are currently no national guidelines specifically for the management of NSCLC ALK-positive lung cancer in the UK. National guidelines exist for lung cancer in general and reference is made to ALK-positive lung cancer. However, the generic nature of these guidelines is not sufficient for the optimal management of this specific type of lung cancer, with its unique disease management requirements. Method: In 2021, members of the charity ALK POSITIVE LUNG CANCER (UK) completed anonymised surveys to gather real-world data about their treatment. Results: Data were gathered on the prescribing of blood thinners (n = 127);frequency of brain MRI scans (n = 123);prescribing bone strengthening medication (n = 127);frequency of CT scans (n = 123);mental health (n = 132). There was significant variation in each of these five aspects of treatment. Conclusions: The findings, from a representative population of ALK-positive patients, provide new information on the significant disparities in the treatment that patients receive. This health inequality is likely to have a detrimental effect on the survival outcomes for some of these patients. It would improve patient outcomes and overall survival if ALK-positive lung cancer disease management national guidelines were established and utilised across the NHS in the UK. The evidence presented.

关键词： ALK-Positive Non-Small Cell Lung Cancer Oncogene-Driven Guidelines

Arabidopsis thaliana T-DNA Mutants Implicate GAUT Genes in the Biosynthesis of Pectin and Xylan in Cell Walls and Seed Testa

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Molecular Plant 2009年第5期2卷 1000-1014页

作者： Kerry H. Caffall Sivakumar Pattathil Sarah E. Phillips Michael G. Hahn debra Mohnen Department of Biochemistry and Molecular Biology University of Georgia Athens GA 30602 USA Complex Carbohydrate Research Center BioEnergy Science Center 315 Riverbend Road University of Georgia Athens GA 30602 USA Department of Plant Biology University of Georgia Athens GA 30602 USA

Galacturonosyltransferase 1 （GAUT1） is an α1,4-D-galacturonosyltransferase that transfers galacturonic acid from uridine 5＇-diphosphogalacturonic acid onto the pectic polysaccharide homogalacturonan （Sterling et al., 2006）. The 25-member Arabidopsis thaliana GAUT1-related gene family encodes 15 GAUT and 10 GAUT-like （GATL） proteins with, respectively, 56-84 and 42-53% amino acid sequence similarity to GAUT1. Previous phylogenetic analyses of AtGAUTs indicated three clades： A through C. A comparative phylogenetic analysis of the Arabidopsis, poplar and rice GAUT families has sub-classified the GAUTs into seven clades： clade A-1 （GAUTs 1 to 3）; A-2 （GAUT4）; A-3 （GAUTs 5 and 6）; A-4 （GAUT7）; B-1 （GAUTs 8 and 9）; B-2 （GAUTs 10 and 11）; and clade C （GAUTs 12 to 15）. The Arabidopsis GAUTs have a distribution comparable to the poplar orthologs, with the exception of GAUT2, which is absent in poplar. Rice, however, has no orthologs of GAUTs 2 and 12 and has multiple apparent orthologs of GAUTs 1, 4, and 7 compared with eitherArabidopsis or poplar. The cell wall glycosyl residue compositions of 26 homozygous T-DNA insertion mutants for 13 of 15 Arabidopsis GAUTgenes reveal significantly and reproducibly different cell walls in specific tissues of gaut mutants 6, 8, 9, 10, 11, 12, 13, and 14 from that of wild-type Arabidopsis walls. Pectin and xylan polysaccharides are affected by the loss of GAUT function, as demonstrated by the altered galacturonic acid, xylose, rhamnose, galactose, and arabinose composition of distinct gaut mutant walls. The wall glycosyl residue compositional phenotypes observed among the gaut mutants suggest that at least six different biosynthetic linkages in pectins and/or xylans are affected by the lesions in these GAUTgenes. Evidence is also presented to support a role for GAUT11 in seed mucilage expansion and in seed wall and mucilage composition.

关键词： Carbohydrate metabolism cell walls Arabidopsis biosynthesis mutant pectin mucilage

Chinese nurses’ perceived impact of international educational experiences and cultural beliefs following a 1-year study abroad program: an exploratory study

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Frontiers of Nursing 2020年第1期7卷 23-29页

作者： debra MWolf Hui-Xin Wub Kathleen Spadaro Diane FHunker Nursing and Healthcare Informatics Chatham UniversityPittsburghPennsylvania 15232USA School of Nursing Davis&Elkins CollegeElkinsWest Virginia 26241USA School of Nursing Chatham UniversityPittsburghPennsylvania 15232USA

Objectives:To examine the perceived impact of international educational experiences and cultural beliefs before and after completing a 1-year Masters of Science in Nursing ***:An exploratory study was conducted among Chinese nurses studying abroad in a private medium-sized university in the United *** 27-item electronic pre-survey was administered within 1 week of starting the program and the post-survey was administered 1 year later at the completion of the ***:Majority of participants(n=25)were female,23–36 years of *** revealed that the perceived impact of international educational experiences assessed at the start of the program was similar to the perceived impact measured at the end of the 1-year program,suggesting that the students learned and experienced what they *** was a significant impact on cultural beliefs from the start of the program compared with the end of the program suggesting that a 1-year study abroad program does influence cultural ***:Understanding what is important to provide in a study abroad program and providing the educational experiences identified by students as impactful are avenues to help host universities best develop their *** suggested that the 1-year program can influence foreign students’cultural beliefs,yet the professional and personal impact of this change warrants further study.

关键词： international Chinese nurses cultural beliefs learning needs educational impact