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Novel approaches to combat chemoresistance against glioblastomas

Cancer Drug Resistance 2020年第4期3卷 686-698页

作者： Rheal A.Towner Michelle Zalles debra saunders Nataliya Smith Advanced Magnetic Resonance Center Oklahoma Medical Research FoundationOklahoma CityOK 73104USA Oklahoma Center for Neuroscience University of Oklahoma Health Sciences CenterOklahoma CityOK 73104USA

The poor prognosis of glioblastoma multiforme(GBM)patients is in part due to resistance to current standard-of-care treatments including chemotherapy[predominantly temozolomide(TMZ;Temodar)],radiation therapy and an anti-angiogenic therapy[an antibody against the vascular endothelial growth factor(bevacizumab;Avastin)],resulting in recurrent *** recurrent GBM tumors are commonly resistant to either TMZ,radiation or bevacizumab,which contributes to the low survival rate for GBM *** review will focus on novel targets and therapeutic approaches that are currently being considered to combat GBM *** of these therapeutic options is a small molecule called OKlahoma Nitrone 007(OKN-007),which was discovered to inhibit the transforming growth factor β1 pathway,reduce TMZ-resistance and enhance ***-007 is currently an investigational new drug in clinical trials for both newly-diagnosed and recurrent GBM *** novel target is ELTD1(epidermal growth factor,latrophilin and seven transmembrane domain-containing protein 1;alternatively known as ADGRL4,Adhesion G protein-coupled receptor L4),which we used a monoclonal antibody against,where a therapy against it was found to inhibit Notch 1 in a pre-clinical GBM xenograft *** 1 is known to be associated with chemoresistance in *** potential therapeutic targets to combat GBM chemoresistance include the phosphoinositide 3-kinase pathway,nuclear factor-κB,the hepatocyte/scatter factor(c-MET),the epidermal growth factor receptor,and the tumor microenvironment.

关键词： Glioblastoma pre-clinical models OKlahoma Nitrone 007 transforming growth factor-β1 ELTD1 magnetic resonance imaging

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Tau's function and dysfunction in the brain:when small changes have big consequences

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Neural Regeneration Research 2024年第1期19卷 152-153页

作者： Miguel Portillo debra Toiber Department of Life Sciences Ben-Gurion University of the NegevBeer ShevaIsraelThe Zlotowski Center for NeuroscienceBen-Gurion University of the NegevBeer ShevaIsrael

With the increase of life expectancy and population growth,neurodegenerative diseases have risen too and are projected to be a major health public concern by *** diseases are characterized by the progressive decline of cognitive function leading to the subsequent loss of *** the underlying causes of neurodegeneration are not well understood,aging is the main risk factor.

关键词： diseases consequences function

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Microglial dysfunction and genetic risk for neurodegenerative disease

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Neural Regeneration Research 2025年第5期20卷 1401-1402页

作者： debra S.MacDonald Jay Penney Department of Biomedical Sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations *** tremendous progress has been made,our understanding of the mechanisms that underlie the development of these diseases remains far from com *** troubling,despite the growing emotional and financial toll being to ken by neurodegenerative disorders,existing treatment options are limited almost exclusively to those that help manage symptoms but that lack the ability to alter the progression of the disease(Liu et al.,2022).

关键词： degenerative diseases

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A randomized controlled trial of Promoting Physical Activity in Regional and Remote Cancer Survivors(PPARCS)

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Journal of Sport and Health Science 2024年第1期13卷 81-89页

作者： Sarah J.Hardcastle Chloe Maxwell-Smith Vinicius Cavalheri Terry Boyle Marta Leyton Román Cameron Platell Michael Levitt Christobel saunders Frank Sardelic Sophie Nightingale Jacob McCormick Craig Lynch Paul A.Cohen Max Bulsara Dana Hince Sport and Physical Activity Research Centre Sheffield Hallam UniversitySheffieldS102BPUK Institute for Health Research The University of Notre DameFremantleWA 6959Australia Curtin School of Population Health Curtin UniversityPerthWA 6845Australia Curtin School of Allied Health Curtin UniversityPerthWA 6845Australia Allied Health South Metropolitan Health ServiceMurdochWA 6150Australia Australian Centre for Precision Health University of South AustraliaAdelaideSA 5001Australia Department of Didactics of Musical Plastic and Body ExpressionUniversity of ExtremaduraCaceres 10071Spain St.John of God Subiaco Hospital PerthWA 6008Australia Department of Surgery University of MelbourneMelbourneVIC 3010Australia Tamara Private Hospital TamworthNSW 2340Australia Peter MacCallum Cancer Centre MelbourneVIC 3000Australia College of Health and Medicine Australian National UniversityCanberraACT 2600Australia Division of Obstetrics and Gynaecology Medical SchoolUniversity of Western AustraliaPerthWA 6009Australia

Background:Physical activity(PA)is important for cancer *** of remotely delivered interventions are needed to assist in reaching under-served non-metropolitan cancer *** objective of this study was to ascertain whether wearable technology,coupled with health coaching was effective in increasing PA in breast and colorectal cancer survivors living in regional and remote areas in ***:Cancer survivors from 5 states were randomized to intervention and control *** participants were given a Fitbit Charge 2TMand received up to 6 telephone health coaching *** participants received PA print *** assessments at baseline and 12 weeks measured moderate-to-vigorous PA(MVPA),light PA,and sedentary ***:Eighty-seven participants were recruited(age=63±11 years;74(85%)female).There was a significant net improvement in MVPA of 49.8 min/week,favoring the intervention group(95%confidence interval(95%CI):13.6-86.1,p=0.007).There was also a net increase in MVPA bouts of 39.5 min/week(95%CI:11.9-67.1,p=0.005),favoring the intervention *** groups improved light PA and sedentary behavior,but there were no between-group ***:This’s the first study to demonstrate that,when compared to standard practice(i.e.,PA education),a wearable technology intervention coupled with distance-based health coaching,improves MVPA in non-metropolitan cancer *** results display promise for the use of scalable interventions using smart wearable technology in conjunction with phone-based health coaching to foster increased PA in geographically disadvantaged cancer survivors.

关键词： Behavior change Exercise Health disparities Oncology Wearable technology

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沟通不畅,害你损失

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空中英语教室（高级版．彭蒙惠英语） 2024年第5期 10-11,39,40页

作者： debra Roberts 不详

沟通技巧如何影响你的盈亏?根据Grammarly公司2022年的商务沟通状态显示,商业领袖评估职场沟通不畅会造成平均每名员工每周浪费7.47小时。“团队里的全职知识工作者据估平均年薪为66976美元,每周浪费7.47小时相当于每年每名员工12506美... 详细信息

沟通技巧如何影响你的盈亏?根据Grammarly公司2022年的商务沟通状态显示,商业领袖评估职场沟通不畅会造成平均每名员工每周浪费7.47小时。“团队里的全职知识工作者据估平均年薪为66976美元,每周浪费7.47小时相当于每年每名员工12506美元的沉没成本。”组织内部沟通不畅是由许多因素造成的。财务损失的程度取决于这个问题的广度与深度、问题未得到解决的时长,以及该问题对别人造成何种影响。

关键词：商业领袖沉没成本财务损失商务沟通知识工作者状态显示沟通技巧组织内部沟通

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为什么人们在洗澡时唱歌?

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中学生英语 2024年第3期 29-31页

作者： debra Ronca 笃景行(译) 不详

浴室里的每个人都是摇滚明星。承认吧。你在生活中有过一两次在洗澡时抓住淋浴喷头突然唱出一两首曲子的情况。洗澡时唱歌有一种完全令人满意的感觉。

关键词：淋浴喷头唱歌浴室

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Gene bank scheduling of seed regeneration: Interim report on a long term storage study

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Journal of Integrative Agriculture 2019年第7期18卷 1529-1540页

作者： Robert Redden debra Partington Australian Temperate Field Crops Collection Private Bag 260Agriculture Victoria

A major challenge for the management of gene banks is the maintenance of good seed health in the *** germplasm collections >10 000 accessions often have been acquired from different sources over a range of dates,may differ in germination at time of deposition in the gene bank,and may have genetic differences in seed *** major storage variables affecting seed longevity are temperature and seed moisture *** varieties of each pea(Pisum sativus L.),lentil(Lens culinaris Medikus ***),and chickpea(Cicer arietinum L.),were stored at three temperatures;40,20,and 2°C,each with three seed moisture levels of 10.9–13.8%(high),7.9–10.3%(medium),and 7–7.8%(low),in the Australian Temperate Field Crops Collection gene *** longevity at a given storage period was estimated by the corresponding germination percentage for each *** paper is an interim report on seed viability decline in the first seven years of this seed longevity study,in which viability decline towards zero was almost completed in the three seed moisture treatments at 40°C and the 20°C high seed moisture treatment,but had not declined in the other *** longevity positively responded to a reduction in temperature and then to a reduction in seed *** number of days in storage for seed germination decline to 85%(p85),and to 50%(p50) for mean seed viability,are reported by storage/varietal *** p85 and p50 showed significant inverse linear responses with seed moisture at 40°C for pea and lentil varieties,with intra-specific variation for *** long term trial aims to provide informed timing of seed regeneration for accessions in a gene bank.

关键词： gene bank storage moisture level temperature regeneration pea lentil chickpea

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The Siberian Traps and the End-Permian mass extinction:a critical review

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Chinese Science Bulletin 2009年第1期54卷 20-37页

作者： Andy saunders Marc REICHOW Department of Geological Sciences University of Leicester

The association between the Siberian Traps,the largest continental flood basalt province,and the largest-known mass extinction event at the end of the Permian period,has been strengthened by re-cently-published high-precision 40Ar/39Ar dates from widespread localities across the Siberian prov-ince[1]. We argue that the impact of the volcanism was amplified by the prevailing late Permian envi-ronmental conditions―in particular,the hothouse climate,with sluggish oceanic circulation,that was leading to widespread oceanic anoxia. Volcanism released large masses of sulphate aerosols and carbon dioxide,the former triggering short-duration volcanic winters,the latter leading to long-term warming. Whilst the mass of CO2 released from individual eruptions was small compared with the total mass of carbon in the atmosphere-ocean system,the long ‘mean lifetime’ of atmospheric CO2,com-pared with the eruption flux and duration,meant that significant accumulation could occur over periods of 105 years. Compromise of the carbon sequestration systems (by curtailment of photosynthesis,de-struction of biomass,and warming and acidification of the oceans) probably led to rapid atmospheric CO2 build-up,warming,and shallow-water anoxia,leading ultimately to mass extinction.

关键词：西伯利亚二叠纪温室气候海洋缺氧 CO2 SO2

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Control of hydrogen sulfide emissions using autotrophic denitrification landfill biocovers:engineering applications

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Frontiers of Environmental Science & Engineering 2011年第2期5卷 149-158页

作者： Daoroong SUNGTHONG debra R.REINHART Department of Environmental Science Faculty of ScienceSilpakorn UniversityNakhon Pathom73000Thailand Civil Environmental and Construction Engineering DepartmentUniversity of Central FloridaOrlandoFL 32826USA

Hydrogen sulfide(H_(2)S)emitted from construction and demolition waste landfills has received increasing *** its unpleasant odor,longterm exposure to a very low concentration of H_(2)S can cause a public health *** the case of construction and demolition(C&D)waste landfills,where gas collection systems are not normally required,the generated H_(2)S is typically not controlled and the number of treatment processes to control H_(2)S emissions in situ is *** attractive alternative may be to use chemically or biologically active landfill covers.A few studies using various types of cover materials to attenuate H_(2)S emissions demonstrated that H_(2)S emissions can be effectively *** this study,therefore,the costs and benefits of H_(2)S-control cover systems including compost,soil amended with lime,fine concrete,and autotrophic denitrification were *** on a case-study landfill area of 0.04 km^(2),the estimated H_(2)S emissions of 80900 kg over the 15-year period and costs of active cover system components(ammonium nitrate fertilizer for autotrophic denitrification cover,lime,fine concrete,and compost),ammonium nitrate fertilizer is the most cost effective,followed by hydrated lime,fine concrete,and yard waste *** concrete and yard waste compost covers are expensive measures to control H_(2)S emissions because of the large amount of materials needed to create a *** H_(2)S emissions using fine concrete and compost is less expensive at landfills that provide on-site concrete recovery and composting facilities;however,ammonium nitrate fertilizer or hydrated lime would still be more cost effective applications.

关键词： hydrogen sulfide emissions construction and demolition waste autotrophic denitrification landfill biocovers

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DNA damage and neurodegeneration:the unusual suspect

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Neural Regeneration Research 2017年第9期12卷 1441-1442页

作者： Daniel Stein debra Toiber Department of Life Sciences Ben-Gurion University of the Negev The Zlotowski Center for Neuroscience Ben-Gurion University of the Negev

Neurodegenerative diseases are caused by the loss of neuro- nal cells. As neurons deteriorate, a patient may experience relatively mild symptoms such as failing to name objects and people. However, with the progression of the disease, symp- toms worsen resulting in loss of independence and a sense of＂loss of oneself＂. Finally, the patient dies from a variety of complications.

关键词： DNA damage and neurodegeneration:the unusual suspect

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