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The importance of timely diagnosis of aspirin-exacerbated respiratory disease for patient health and safety

World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第4期6卷 203-206页

作者： Kathleen Buchheit Jillian C.Bensko Erin Lewis deborah gakpo Tanya M.Laidlawa Deportment of Medicine Division of Allergy and Clinical ImmunologyBrishom and Women's HospitalBostonMAUSA Harvard Medical School BostonM AUSA

Backgroud:Aspirin-exacerbated respiratory disease(AERD)is a difficult-to-treat syndrome where timely diagnosis and initiation of disease-specific therapies are pertinent to improved patient ***:To characterize the most common timeline for development of the clinical triad[asthma,nasal polyposis,and reactions to nonsteroidal anti-inflammatory drugs(NSAIDs)],identify barriers to prompt diagnosis of AERD,and describe indications for an aspirin challenge to facilitate accurate ***:Six hundred ninety-seven patients with diagnosed AERD and history of at least one sinus surgery to remove nasal polyps were identified in the Brigham and Women’s Hospital AERD *** reported age at disease onset of asthma,nasal polyposis,and age of first NSAID reaction were obtained from 2013 to 2019 at ***:Of the 697 patients identified,diagnosis of asthma preceded diagnosis of nasal polyposis and first NSAID reaction,although there was considerable variability between ***:Prompt diagnosis of AERD is important for patient and provider education and improved care of this difficult-to-treat population of *** diagnostic aspirin challenge in patients without historical reactions to NSAIDs who have an otherwise compatible clinical history,specifically in patients who take daily low-dose aspirin,leukotriene modifiers,avoid NSAIDs,or who are severely symptomatic at baseline where it would be difficult to identify an acute worsening of symptoms.

关键词： Aspirin-exacerbated respiratory disease(AERD) Aspirin(acetylsalicylic acid ASA) Chronic rhinosinusitis with nasal polyps Samter’s triad Anosmia Aspirin hypersensitivity Aspirin challenge NSAID hypersensitivity NSAID challenge

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