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Epithelium-specific ets transcription factor 2 upregulates cytokeratin 18 expression in pulmonary epithelial cells through an interaction with cytokeratin 18 intron 1

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Cell Research 2005年第6期15卷 423-429页

作者： deanna YANIW,Jim HU Programme in Lung Biology Research and the Canadian Institutes of Health Research Group in Lung development 24] Canada m5S 1A 8] Canada m5S 1A Hospital for Sick Children Toronto Canada m5G 1X8 Institute of m.dical Science University of Toronto Toronto Programme in Lung Biology Research and the Canadian Institutes of Health Research Group in Lung development Hospital for Sick Children Toronto Canada m5G 1X8 Institute of m.dical Science University of Toronto Toronto Canada m5S 1A1 departments of Paediatrics University of Toronto Toronto Canada m5S 1A1 Laboratory m.dicine and Pathbiology University of Toronto Toronto

The role of Ese-2, an Ets family transcription factor, in gene regulation is not known. In this study, the interactionbetween Ese-2 and cytokeratin 18 (K18) intron 1 was characterized in lung epithelial cells. Reporter gene assays showedEse-2 was able to upregulate K18 intron 1 enhanced reporter gene expression by approximately 2-fold. We found thatfull length Ese-2 did not bind dNA strongly, therefore truncated versions of the protein, containing the ETS domain orPointed domain, were created and tested in electrophoresis mobility shift assays. multiple interactions between the ETSdomain and putative dNA binding sites within K18 intron 1 were observed, which led to the determination of a possibleEse-2 dNA binding consensus sequence. These experiments suggest that Ese-2 could play a role in the regulation ofK18 expression in lung epithelial cells.

关键词： transcription factor epithelial cells cytokeratin 18 airway gene regulation.

Beclin 1-Vps34 complex architecture： Understanding the nuts and bolts of therapeutic targets

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Frontiers in Biology 2015年第5期10卷 398-426页

作者： deanna H. morris Calvin K. Yip Yi Shi Brian T. Chait Qing Jun Wang department of molecular and Cellular Biochemistry University of Kentucky Lexington KY 40536 USA department of Biochemistry and molecular Biology The University of British Columbia Vancouver BC V6TIZ3 Canada Laboratory of mass Spectrometry and Gaseous Ion Chemistry The Rockefeller University New York NY 10065 USA department of Toxicology and Cancer Biology University of Kentucky Lexington KY 40536 USA markey Cancer Center University of Kentucky Lexington KY 40536 USA

Autophagy is an important lysosomal degradation pathway that aids in the maintenance of cellular homeostasis by breaking down and recycling intracellular contents. dysregulation of autophagy is linked to a growing number of human diseases. The Beclin 1-Vps34 protein-protein interaction network is critical for autophagy regulation and is therefore essential to cellular integrity. manipulation of autophagy, in particular via m.dulation of the action of the Beclin I-Vps34 complexes, is considered a promising route to combat autophagy-related diseases. Here we summarize recent findings on the core components and structural architecture of the Beclin 1-Vps34 complexes, and how these findings provide valuable insights into the molecular mechanisms that underlie the multiple functions of these complexes and for devising therapeutic strategies.

关键词： Beclin 1 Vps34 Nrbf2 complex structure CX-mS Em inhibitor drag design

Retrospective Assessment of Changes in Perceived Health Status during Continuous Use of a dietary Supplement

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Food and Nutrition Sciences 2023年第6期14卷 542-560页

作者： Brett J. West melissa m. Reid Fernando A. Swartz deanna m. Latson Research and development department PartnerCo Midvale USA

dietary factors play an important role in human health. Specifically, nutritional interventions may have an impact on the hypothalamic-pituitary axis resulting in positive health outcomes. A retrospective health status survey of 386 respondents was conducted to investigate the potential of a dietary supplement, NutrifiiTm Renew, for improving various health outcomes in comparison to a multivitamin/mineral control group. Among those who ingested Renew, 95% reported experiencing at least some improvement in one or more health categories. Compared to the multivitamin/mineral group, the Renew group reported earlier and/or greater improvements in several health status categories including sleep, reproductive health, memory, energy/stamina, skin and hair quality, flexibility, exercise recovery and feeling rested in the morning. A clear majority (84.9%) of Renew consumers reported experiencing noticeable improvement in some aspect of their health within one month. Among those who felt an improvement in sleep, most reported experiencing a change within one week. These improvements were likely due to the synergistic effects of L-arginine, L-citrulline, L-lysine, and botanical extracts on nitric oxide production, growth hormone (GH) release, and sleep quality. The observed improvements in skin elasticity and hair growth may be related to increased GH levels and IGF-1 production. Overall, these findings suggest that Renew may have potential as a dietary intervention for improving various health outcomes beyond those provided by multivitamin/mineral supplementation alone. Further studies are needed to confirm these findings and elucidate the underlying mechanisms of action.

关键词： dietary Supplement Health Status Retrospective Survey

Reference quality assembly of the 3.5-Gb genome of Capsicum annuum from a single linked-read library

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Horticulture Research 2018年第1期5卷 890-902页

作者： Amanda m.Hulse-Kemp Shamoni maheshwari Kevin Stoffel Theresa A.Hill david Jaffe Stephen R.Williams Neil Weisenfeld Srividya Ramakrishnan Vijay Kumar Preyas Shah michael C.Schatz deanna m.Church Allen Van deynze department of Plant Sciences University of CaliforniaDavisCAUSA USdA-ARS Genomics and Bioinformatics Research Unit RaleighNCUSA department of Crop and Soil Sciences North Carolina State UniversityRaleighNCUSA 10x Genomics Inc7068 Koll Center ParkwaySuite 401PleasantonCAUSA department of Computer Science Johns Hopkins UniversityBaltimoreMDUSA

Linked-Read sequencing technology has recently been employed successfully for de novo assembly of human genomes,however,the utility of this technology for complex plant genomes is *** evaluated the technology for this purpose by sequencing the 3.5-gigabase(Gb)diploid pepper(Capsicum annuum)genome with a single Linked-Read *** genomes,including pepper,are characterized by long,highly similar repetitive ***,significant effort is used to ensure that the sequenced plant is highly homozygous and the resulting assembly is a haploid *** a phased assembly approach,we targeted a heterozygous F1 derived from a wide cross to assess the ability to derive both haplotypes and characterize a pungency gene with a large insertion/*** Supernova software generated a highly ordered,more contiguous sequence assembly than all currently available *** reference *** 83%of the final assembly was anchored and oriented using four publicly available de novo linkage maps.A comparison of the annotation of conserved eukaryotic genes indicated the completeness of *** validity of the phased assembly is further demonstrated with the complete recovery of both 2.5-Kb insertion/deletion haplotypes of the PUN1 locus in the F1 sample that represents pungent and nonpungent peppers,as well as nearly full recovery of the BUSCO2 gene set within each of the two *** most contiguous pepper genome assembly to date has been generated which demonstrates that Linked-Read library technology provides a tool to de novo assemble complex highly repetitive heterozygous plant *** technology can provide an opportunity to cost-effectively develop high-quality genome assemblies for other complex plants and compare structural and gene differences through accurate haplotype reconstruction.

关键词： Capsicum pepper insertion

master’s degree, a New Requirement to Become an RdN by 2024: A Comparison of Nutrition Graduate Programs Offered in the USA

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Food and Nutrition Sciences 2019年第1期10卷 1-14页

作者： monica Sanchez deanna L. Pucciarelli department of Nutrition and Health Science Ball State University Muncie IN USA

Background: The registered dietetic four-year degree educational structure has been intact since 1926. master level nutrition programs exist in the U.S., but are not standardized or accredited unlike four-year degrees. Academic requirements for nutrition graduate programs vary regionally across the nation. Objective: To 1) quantify and describe the availability of master level nutrition programs regionally;and 2) examine the current m.A. and m.S. program requirements for a nutrition graduate degree in the U.S. methods: Nutrition graduate programs (n = 201) were analyzed and compared by geographical region. data were collected between August 2017 and may 2018. Inclusion criteria were defined as: nutrition graduate programs listed in the American Society of Nutrition (ASN) database that had a nutrition graduate program website. descriptive statistical analysis measured evaluated variables. Results: A total of 201 nutrition graduate programs in the U.S. were identified. The title of the programs was categorized into 29 main themes. The most common nutrition graduate program title was a m.S. in Nutrition, 55 institutions (27.4%). A total of 181 institutions offered a m.S. with a required thesis, whereas 95 offered a m.S. with a non-thesis option, and only eight offered a m.A. Region 3-South offered the highest number of nutrition graduate programs (66), followed by region 2-m.dwest with 49 programs, region 1-Northeast offered a total of 46 programs, and 37 programs were offered in region 4-West. Conclusion: In 2024, as part of the Rd eligibility criteria, it will be required that students possess a master’s degree. To date, only one master’s program in the U.S. is accredited, which assures the student a measure of confidence of program rigor and accountability. dietitians’ three major professional concerns: respect, recognition and rewards are predicated on rigorous educational programs that meet ACENd standards. It is unlikely that all U.S. master level programs will b

关键词： Nutrition Graduate Program Requirements Graduate Program Curriculum Rigor Registered dietitian Nutritionist Credential (RdN) RdN Requirements Accreditation

Characteristics of HIV Infected Patients with Biopsy diagnosed Spongiotic dermatitis

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World Journal of AIdS 2011年第4期1卷 146-148页

作者： Gus W. Krucke Benjamin L. Cooper deanna E. Grimes Richard m. Grimes 不详

Purpose. Twenty-six HIV patients with biopsy diagnosed spongiotic dermatitis (Sd) were studied to determine their demographic and clinical characteristics. The condition was also investigated to determine if it was linked to the immune reconstitution inflammatory syndrome (IRIS). methods. All patients whose skin biopsies were diagnosed by a pathologist as Sd were identified. m.dical records were reviewed to extract demographic descriptors, viral loads and Cd4+ counts at the time that Sd occurred. In an attempt to determine if the condition could be linked to Immune Reconstitution Syndrome (IRIS), the time from nadir Cd4+ count to the occurrence of Sd was determined. Results. Sd patients were found to be older than expected but were similar to other clinic patients with regard to race/ethnicity and gender. Cd4+ counts, viral loads were not related to Sd. Sd did not seem to be related to IRIS because few cases occurred within the time frame associated with IRIS. Sd frequently appeared on the limbs although the literature suggests a more frequent appearance on the trunk and buttocks. discussion. HIV clinicians may expect to see Sd on occasion and it may appear in unusual body sites and at any time during the course of the infection.

关键词： Spongiotic dermatitis HIV Infection Immune Reconstitution Inflammatory Syndrome

Chaetomium-like fungi causing opportunistic infections in humans:a possible role for extremotolerance

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Fungal diversity 2016年第1期76卷 11-26页

作者： Sarah A.Ahm.d Ziauddin Khan Xue-wei Wang Tarek A.A.moussa Hassan S.Al-Zahrani Omar A.A.lmaghrabi deanna A.Sutton S.Ahm.d Johannes Z.Groenewald A.Alastruey-Izquierdo Anne van diepeningen S.B.J.menken m.J.Najafzadeh Pedro W.Crous Oliver Cornely Axel Hamprecht maria J.G.T.Vehreschild A.J.Kindo G.Sybren de Hoog Faculty of m.dical Laboratory Sciences University of KhartoumKhartoumSudan CBS-KNAW Fungal Biodiversity Centre P.O.Box 851673508 AD UtrechtThe Netherlands Institute for Biodiversity and Ecosystem.dynamics University of AmsterdamAmsterdamThe Netherlands department of microbiology Faculty of MedicineKuwait UniversityKuwaitKuwait State Key Laboratory of mycology Institute of MicrobiologyChinese Academy of SciencesBeijingChina Biological Sciences department Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Botany and microbiology department Faculty of ScienceCairo UniversityGizaEgypt Fungus Testing Laboratory Department of PathologyUniversity of Texas Health Science Center at San AntonioSan AntonioTXUSA mycology Reference Laboratory National Centre for MicrobiologyCarlos III Institute of Health(Servicio deMicologíaCentro Nacional de MicrobiologíaInstituto de Salud Carlos III)MadridSpain department of Parasitology and mycology Mashhad University of Medical SciencesMashhadIran German Centre for Infection Research(dZIF)at Cologne/Bonn First Department of Internal MedicineUniversity Hospital of CologneCologneGermany Institute for m.dical microbiology Immunology and HygieneUniversity of CologneCologneGermany department of microbiology Sri Ramachandra UniversityPorurChennaiIndia Peking University Health Science Center Research Center for Medical MycologyBeijingChina Sun Yat-Sen memorial Hospital Sun Yat-Sen UniversityGuangzhouChina Shanghai Institute of m.dical mycology Changzheng HospitalSecond Military Medical UniversityShanghaiChina 17 Basic Pathology DepartmentFederal University of ParanáStateCuritibaParanáBrazil

members of the family Chaetomiaceae are ubiquitous ascosporulating fungi commonly,which reside in soil enriched with manure or cellulosic *** role as human pathogens is largely ***,the ability of some species to grow at high temperature enables them to play an important role as opportunistic *** family contains several genera and species that have never been reported to cause human ***,three new species are described;two belong to the genus Subramaniula and one represents a Chaetomium *** asteroides was isolated from various sources including eye and skin infections as well as from the natural environment,and *** was isolated from a toe *** anamorphosum was isolated from a kidney transplant patient suffering from fungal *** species described were previously misidentified as Papulaspora *** to the formation of cellular clumps or bulbil-like structures,which are characteristic of *** isolates failed to form sexual fruit bodies and ascospores remained absent,which is an unusual feature for the generally ascosporulating genera Chaetomium and Subramaniula;minute conidia from phialides were sometimes observed.

关键词： Chaetomium desert fungi Keratitis Papulaspora Peritonitis Sterile fungi Subramaniula

2014年美国纽波特沙门菌感染暴发与黄瓜的关联性

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上海预防医学 2018年第10期30卷 885-887页

作者： Kristina m. Angelo Alvina Chu m.dhu Anand Thai-An Nguyen Lyndsay Bottichio matthew Wise Ian Williams Sharon Seelman Rebecca Bell marianne Fatica Susan Lance deanna Baldwin Kyle Shannon Hannah Lee Eija Trees Errol Strain Laura Gieraltowski 罗宝章(翻译) 厉曙光(审校) Epidemic Intelligence Service CDC division of Foodborne Waterborne and Environmental Diseases National Center for Emerging and Zoonofic Infectious Diseases CDC maryland department of Health and mental Hygiene New York State department of Health Food and drug Administration maryland department of Agriculture 不详

2014年8月,美国国家食源性疾病分子分型监测网络（national molecular subtyping network for foodborne disease surveillance）———PulseNet,发现多个州出现纽波特沙门菌血清型聚集性感染,检测到的脉冲场凝胶电泳（pulse-field gel electrophoresis,PFGE）带型（限制性内切酶Xba I,带型为JJPX01.0061）难以鉴别。与疾病暴发相关的PF-GE带型曾与德玛瓦半岛地区弗吉尼亚东海岸生产销售的西红柿具有相关性,但尚未发现与黄瓜或其他农产品的相关性。

关键词：美国纽约特沙门菌感染黄瓜关联性

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美国新港沙门菌感染的暴发与黄瓜的关联性

上海预防医学 2016年第5期28卷 348-350页

作者： Kristina m.Angelo Alvina Chu m.dhu Anand Thai-An Nguyen Lyndsay Bottichio matthew Wise Ian Williams Sharon Seelman Rebecca Bell marianne Fatica Susan Lance deanna Baldwin Kyle Shannon Hannah Lee Eija Trees Errol Strain Laura Gieraltowski 罗宝章(译) 厉曙光(审校) Epidemic Intelligence Service CDC division of Foodborne Waterborne and Environmental Diseases National Center for Emerging and Zoonotic infectious Diseases CDC maryland department of Health and mental Hygiene New York State department of Health Food and drug Administration maryland department of Agriculture 不详

2014年8月,美国国家食源性疾病监测分子分型网络（PulseN et）检测到一个跨州的新港沙门菌血清型感染的群组,其具有无法区分的脉冲场凝胶电泳（Pulse-Field Gel Electrophoresis,PFGE）带型（限制性内切酶XbaI,带型为JJPX01.0061。信息... 详细信息

2014年8月,美国国家食源性疾病监测分子分型网络（PulseN et）检测到一个跨州的新港沙门菌血清型感染的群组,其具有无法区分的脉冲场凝胶电泳（Pulse-Field Gel Electrophoresis,PFGE）带型（限制性内切酶XbaI,带型为JJPX01.0061。信息来源http：//***/pulsenet）。

关键词：沙门菌感染新港沙门菌美国脉冲场凝胶电泳黄瓜暴发限制性内切酶分子分型

维普期刊数据库