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Characte.ization of nove. Brown midrib 6 mutations affe.ting lignin biosynthe.is in sorghum

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Journal of Inte.rative.Plant Biology 2016年第2期58卷 136-149页

作者： e.in D. Scully Tammy Grie. deanna L. Funne.l-Harris Zhanguo Xin Frank A. Kovacs Wilfre. Ve.me.ris Scott e. Sattle. Grain Forage and Bioenergy Research Unit USDA-ARS Lincoln NE 68583 USA De.artme.t of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE 68583 USA De.artme.t of Plant Pathology University of Nebraska-Lincoln Lincoln NE 68583 USA Plant Stre.s and Ge.mplasm De.e.opme.t Unit USDA-ARS Lubbock TX 79414 USA De.artme.t of Che.istry University of Nebraska-Kearney Kearney NE 68849 USA De.artme.t of Microbiology & Ce.l Scie.ce.and UF Ge.e.ics Institute University of Florida Gainesville FL 32610 USA

The.pre.e.ce.of lignin re.uce. the.quality of lignoce.lulosic biomass for forage.mate.ials and fe.dstock for biofue.s. In C4 grasse., the.brown midrib phe.otype.has be.n linke. to mutations to ge.e. in the.monolignol biosynthe.is pathway. For e.ample. the.Bmr6 ge.e.in sorghum （Sorghum bicolor） has be.n pre.iously shown to e.code.cinnamyl alcohol de.ydroge.ase.（CAD）, which catalyze. the.final ste. of the.monolignol biosynthe.is pathway. Mutations in this ge.e.have.be.n shown to re.uce.the.abundance.of lignin, e.hance.dige.tibility, and improve.saccharification e.ficie.cie. and e.hanol yie.ds. Nine.sorghum line. harboring five.diffe.e.t bmr6 alle.e. we.e.ide.tifie. in an e.S-mutage.ize. TILLING population. DNA se.ue.cing of Bmr6 re.e.le. that the.majority of the.mutations impacte. e.olutionarily conse.ve. amino acids while.thre.-dime.sional structural mode.ing pre.icte. that all of the.e.alle.e. inte.fe.e. with the.e.zyme.s ability to bind with its NAPPH cofactor. All of the.ne. alle.e. re.uce. in vitro CAD activity le.e.s and e.hance. glucose.yie.ds following saccharification. Furthe., many of the.e.line. we.e.associate. with highe. re.uctions in acid de.e.ge.t lignin compare. to line. harboring the.pre.iously characte.ize. bmr6-re. alle.e. The.e.bmr6 line. re.re.e.t ne. bre.ding tools for manipulating biomass composition to e.hance.forage.and fe.dstock quality.

关键词： Cinnamyl alcohol de.ydroge.ase.(CAD) e.S mutage.e.is biofue.s C4 grass forage

DNA damage.and me.abolic me.hanisms of cance. drug re.istance

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Cance. Drug Re.istance 2022年第2期5卷 368-379页

作者： deanna Tie. Shi-Yuan Che.g The.Ke.&Ruth Dave. De.artme.t of Ne.rology Lou and Jean Malnati Brain Tumor Institute at Northwestern MedicineRobert H.Lurie Comprehensive Cancer Centerand Simpson Querry Institute for EpigeneticsNorthwestern UniversityFeinberg School of Medicine303 E Superior StChicagoIL 60611USA

Cance. drug re.istance.is one.of the.main barrie.s to ove.come.to e.sure.durable.tre.tme.t *** many pivotal advance. have.be.n made.in first combination the.apie.,the. targe.e. the.apie.,and now broade.ing out to immunomodulatory drugs or me.abolic targe.ing compounds,drug re.istance.is still ultimate.y unive.sally *** this brie. re.ie.,we.will discuss diffe.e.t strate.ie. that have.be.n use. to fight drug re.istance.from synthe.ic le.hality to tumor microe.vironme.t modulation,focusing on the.DNA damage.re.ponse.and tumor me.abolism both within tumor ce.ls and the.r surrounding *** this way,with a be.te. unde.standing of both targe.able.mutations in combination with the.me.abolism,smarte. drugs may be.de.igne. to combat cance. drug re.istance.

关键词： me.abolism damage drugs

Me.anonychia in Patie.ts Infe.te. with Human Immunode.icie.cy Virus Original Communication

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Advance. in Infe.tious Dise.se. 2011年第2期1卷 15-19页

作者： Parvane. e.sanzade.-Che.me. Richard M. grimes Paul Rowan Yu-Jing Huang e. Jame. e.sie. Stanle. T. Le.is 不详

This study e.amine. whe.he. me.anonychia was more.pre.ale.t in 1) HIV positive.individuals compare. to HIV ne.ative.pe.sons, 2) HIV positive. e.pose. to zidovudine.and/or stavudine.and 3) those.with darke. skin pigme.tation. Proce.ure.. 267 HIV positive.and 273 HIV ne.ative.patie.ts we.e.e.amine. for pre.e.ce.or abse.ce.of me.anonychia and le.e. of skin pigme.tation using the.Fitzge.ald scale. Pharmacy re.ords we.e.e.amine. for de.e.mining e.posure.to zidovudine.or stavudine. Chi square. odds ratios and logistic re.re.sion we.e.use. to e.amine.the.study que.tions Main Findings. Me.anonychia appe.re. in 49.1% of 267 HIV positive.and 21.8% of 273 HIV ne.ative.subje.ts. Adjusting for skin pigme.tation, HIV positive. we.e.4.1 time. more.like.y to have.me.anonychia than HIV ne.ative.. Me.anonychia was pre.e.t in 54% of those.re.e.ving zidovudine.and in 42% of those.re.e.ving stavudine.(OR = 2.73, p = 0.05). In a multivariate.mode. in HIV positive. which include. skin type. pre.cription of zidovudine.and/or Stavudine. only dark skin (OR = 14.62, p e.(OR = 2.65, p e.e.significant. Principal Conclusions. HIV infe.te. pe.sons are.prone.to me.anonychia. This is more.fre.ue.t in darke. skinne. pe.sons and is e.hance. in those.e.pose. to zidovudine.

关键词： Zidovudine Stavudine Me.anonychia HIV/AIDS Skin Pigme.tation

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高钻压牙轮钻头提高硬岩层中的机械钻速

探矿工程译丛 1993年第3期 45-49页

作者： grimes,e.余先贵

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高分新托福口语120 第2版 2版

Comparative.analysis of the.glucoce.e.rosidase.ge.e.mutations in canadian and Chine.e.populations with Parkinson's dise.se

丛书名：高分新托福120系列

2013年

作者：江璞（美）格里姆斯（grimes J.）

本书分6个章节，分别介绍口语考试的背景；口语考试题型介绍；口语独立题型的答题策略；口语综合题型的答题策略；综合题型的推荐应答模板；口语全真模拟题；考生回答样本及评价；问题范例。

ISBN: (数字)9787030372666

ISBN: (纸本)9787030372666

关键词：口语自学参考资料 TOe.L

来源：畅想之星图书光盘版（南... 评论

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Comparative analysis of the glucocerebrosidase gene mutation...

中国神经科学学会第十届全国学术会议

作者： Fabin Han Zhe.Yu Ting Wang Jun Xu We. Wang Guifang Wang Le.ue. Racacho Lili Zhe.g Li Pan Dianrong Gong Xue.i Li Huaiqian Qu Fang Li Bin Zhang David grimes De.nis Bulman We.dong Le Ce.tre.for Ste. ce.ls and Re.e.e.ative.Me.icine The Affiliated Liaocheng Hospital Taishan Medical University De.artme.t of Ne.rology Liaocheng People's Hospital The.Affiliate. Liaoche.g Hospital Taishan Medical University Re.e.e.ative.Me.icine.Program Ottawa Health Research Institute University of Ottawa De.artme.t of Ne.rology The Ottawa Hospital University of Ottawa Institute.of Ne.rology The Affiliated Reijing Hospital Shanghai Jiaotong University School of Medicine

Obje.tive.Mutations in the.glucoce.e.rosidase.GBA) ge.e.are.associate. with Gauche.’s *** studie. indicate.that pathological variants in GBA have.incre.se. the.risk for patie.ts with Parkinson’s dise.se.PD).To characte.ize.the.mutations of the.GBA ge.e.and compare.the.GBA mutation rate. in PD patie.ts and control individuals from Canadian and Chine.e.populations,we.pe.forme. a comple.e.se.ue.cing analysis of the.11 e.ons of the.GBA ge.e.in 401 familial and sporadic PD patie.ts and 178 normal control individuals from Canada and *** Ge.omic DNA was isolate. from the.whole.bloods of 401 PD patie.ts and 178 control individuals and was amplifie. by PCR to cove. all 11 e.ons of the.GBA *** DNA se.ue.cing and bioinformatics analysis we.e.pe.forme. to de.e.t the.GBA variants in e.ch patie.t and control *** analysis was pe.forme. to compare.the.mutation fre.ue.cie. of PD patie.ts and control individuals of Canadian and Han-Chine.e.*** Totally 18 diffe.e.t GBA mutations including 10 nove. mutations we.e.ide.tifie. in 40 of 401 PD patie.ts of Canadian and Han-Chine.e.*** GBA mutation rate. in Canadian and Han-Chine.e.PD cohorts are.12.77%and 8.62%re.pe.tive.y,but the.e.is no significant diffe.e.ce.of the.GBA mutation fre.ue.cie. be.we.n the.Canadian and Han-Chine.e.PD cohorts(X=1.74,P=0.201).The.GBA mutation rate.in Han-Chine.e.PD patie.ts is significantly highe. that that in Han-Chine.e.Control individuals(X=4.21,P=0.045).The.fre.ue.cy of the.e.26K and T369M mutations(6.61%) in Canadian population of PD patie.ts is significantly highe. than that(0.57%) in Han-Chine.e.population of PD patie.ts(X=9.359,P=0.002),sugge.ting the.e.26K and T369M mutation rate.might be.affe.te. by diffe.e.t e.hnic *** is no significant diffe.e.ce.of the.non-pathological e.26K and T369M mutation rate. be.we.n the.PD patie.ts and control individuals of Canadian Origin(X=0.073,P=0.819).Inte.e.tingly,the.GBA mutation rate.

关键词： Parkinson dise.se.PD) glucoce.e.rosidase.GBA) se.ue.cing mutation de.e.ion

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紧急避孕方法

生殖与避孕 2006年第6期26卷 373-377页

作者： Gülme.oglu AM e.curra e.vanLook PFA 陈军玲程利南机构不详

非意愿妊娠是一个常见的问题。世界上每年约有5千万例流产(van Look 1995)。对这一问题的标准解决方法一直是预防(避孕),并以人工流产作为补救。但是长期以来在世界上避孕仅仅意味着事先避孕,意外妊娠的一级预防定义应该也必须扩展到事... 详细信息

非意愿妊娠是一个常见的问题。世界上每年约有5千万例流产(van Look 1995)。对这一问题的标准解决方法一直是预防(避孕),并以人工流产作为补救。但是长期以来在世界上避孕仅仅意味着事先避孕,意外妊娠的一级预防定义应该也必须扩展到事后避孕(grimes1997)。[第一段]

关键词：紧急避孕方法人工流产一级预防非意愿妊娠事后避孕意外妊娠意味着世界

一种新型的导电性(续) 除一般导电性与超导外还存在滑移电荷密度波

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物理实验 1985年第6期 244-246页

作者： e.e.e.som 杨本炜王爱莲吉林大学物理系

钉扎波1979年Be.l实验室的Fle.ing和grimes做了一个在此领域内成为最有成效的实验之一,他们将Nbse.试样加上直流电,并观察形成的电压降随时间的变化,得到二个重要的发现。其一是存在一个阈电场,高于阈电场就会发生电导增加。早期的实验... 详细信息

钉扎波1979年Be.l实验室的Fle.ing和grimes做了一个在此领域内成为最有成效的实验之一,他们将Nbse.试样加上直流电,并观察形成的电压降随时间的变化,得到二个重要的发现。其一是存在一个阈电场,高于阈电场就会发生电导增加。早期的实验已经指出,任意大小的直流电都能引起电导增加。仔细的分析表明,低于此阈值时,电导是由通常机制引起的,高于此阈值的电流才能使钉扎的电荷密度波解除钉扎。Fle.ing和grimes的第一个发现与其它实验室所做的工作符合得很好。***和***写过一篇理论性的论文,建议做一个实验来回答一个关

关键词：电荷密度波钉扎电子玻璃球轻子滑移量子隧道隧道效应导电性